scholarly journals Polycystic ovarian syndrome and pituitary macroadenoma a deadly combination with good outcome

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Ansari Sumayya Shamim ◽  
◽  
Reena Jatin Wani ◽  
Hema Prakash Relwani ◽  
Kruti Doshi ◽  
...  
Keyword(s):  
Prolactin Level ◽  
Polycystic Ovarian Syndrome ◽  
Reproductive Age ◽  
Pituitary Macroadenoma ◽  
Management Options ◽  
Endocrine Disorder ◽  
Good Outcome ◽  
Compliant Patient ◽  
Ovarian Syndrome

We are presenting here a case of polycystic ovarian syndrome, an endocrine disorder, afflicting 5-13% females of reproductive age, causing 70-80% infertility associated with pituitary macroadenoma i.e. size >10 mm & prolactin level >250 ng/mI. PCOS has a higher relationship with metabolic disturbance and hypothalamic-pituitary-ovarian axis function disorder. Prolactinoma is present in about 50% women with hyperprolactinemia and 33% present with galactorrhea. Our patient was a 22 yrs nulligravida married since 3 yrs first presenting 5 yrs back with complaints of secondary amenorrhea with galactorrhea and infertility. On evaluation she was diagnosed as PCOS and pituitary macroadenoma on MRI. We medically treated her with tab. cabergoline in consultation with endocrinologist and neurosurgeons opinion. Being a compliant patient with regular follow up she conceived twice with good outcome and breastfed her babies on medical management only. Now she has 2 children (male child of 3 yrs and 1 month). Dilemma in management options will be discussed.

scholarly journals Polycystic ovarian syndrome and pituitary macroadenoma a deadly combination with good outcome

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Ansari Sumayya Shamim ◽  
◽  
Reena Jatin Wani ◽  
Hema Prakash Relwani ◽  
Kruti Doshi ◽  
...  
Keyword(s):  
Prolactin Level ◽  
Polycystic Ovarian Syndrome ◽  
Reproductive Age ◽  
Pituitary Macroadenoma ◽  
Management Options ◽  
Endocrine Disorder ◽  
Good Outcome ◽  
Compliant Patient ◽  
Ovarian Syndrome

We are presenting here a case of polycystic ovarian syndrome, an endocrine disorder, afflicting 5-13% females of reproductive age, causing 70-80% infertility associated with pituitary macroadenoma i.e. size >10mm& prolactin level >250 ng/mI. PCOS has a higher relationship with metabolic disturbance and hypothalamic-pituitary-ovarian axis function disorder. Prolactinoma is present in about 50% women with hyperprolactinemia and 33% present with galactorrhea. Our patient was a 22 yrs nulligravida married since 3 yrs first presenting 5 yrs back with complaints of secondary amenorrhea with galactorrhea and infertility. On evaluation she was diagnosed as PCOS and pituitary macroadenoma on MRI. We medically treated her with tab. cabergoline in consultation with endocrinologist and neurosurgeons opinion. Being a compliant patient with regular follow up she conceived twice with good outcome and breastfed her babies on medical management only. Now she has 2 children (male child of 3 yrs and 1 month). Dilemma in management options will be discussed. Summary: Inspite of having both Polycystic Ovarian Syndrome (PCOS) & Pituitary Macroadenoma, which warrant surgical management (major causes of Infertility) selected cases like ours can be managed medically successfully.

scholarly journals Healthbot for Polycystic Ovarian Syndrome

2021 ◽  
Vol 13 (2) ◽  
pp. 1-08
Author(s):  
Jeyshree Krishnaswamy Sundararajan ◽  
Yanyan Li ◽  
Ahmad Hadaegh
Keyword(s):  
Blood Pressure ◽  
Polycystic Ovarian Syndrome ◽  
Reproductive Age ◽  
High Cholesterol ◽  
Women Of Reproductive Age ◽  
Endocrine Disorder ◽  
Cholesterol Levels ◽  
The People ◽  
And Control ◽  
Ovarian Syndrome

Polycystic ovarian syndrome(PCOS) is one of the predominant hormonal imbalances present in women of reproductive age. It needs to be diagnosed and treated at an earlier stage as it's inter-related to diabetes, high cholesterol levels, and obesity. This paper presents an application specially designed for women to help them keep track of their Body Mass Index, Blood Sugar, and Blood Pressure based on their age. The people diagnosed with PCOS(an endocrine disorder) can use this application to make their life easy since it helps follow certain exercises, diets, and timely reminders for water and medicines. It has features like the period tracker to track the user’s menstrual cycle, find dieticians nearby, links to various PCOS supplements, users can track their moods during different menstrual phases and control their mood swings. Finally, the application has games to add that interactive touch.

scholarly journals A Detailed Research on Detection of Polycystic Ovary Syndrome from Ultrasound Images of Ovaries

2019 ◽  
Vol 8 (2S11) ◽  
pp. 467-472
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Ultrasound Images ◽  
Time Analysis ◽  
Ovary Syndrome ◽  
Endocrine Disorder ◽  
Real Time Analysis ◽  
Ovarian Syndrome ◽  
Biochemical Abnormalities

A common endocrine disorder named polycystic ovarian syndrome (PCOS) usually occurs to several women’s during their reproductive age. This type of disease leads to infertility which represent with amenorrhea and hirsutism. The combination of clinical, endocrinological, and biochemical abnormalities are known to be PCOS which particularly related with the metabolism of estrogen and androgens. The periphery of ovaries is identified with the most common immature follicles which are less than 10mm. Analyzing this kind of situations in women is a major challenge which now doctors used ultrasound images which have the necessary details like number of follicles, size, and position. For real-time analysis of PCOS is a major task as follicles contains different sizes and highly connected with tissues and blood vessels which results in error prone. Several researchers have proposed different techniques for analyzing the PCOS using the ultrasound images of ovaries. In this study, we analyze the important factors and techniques used in detection of PCOS by using the ultrasound images taken from the women’s ovary and compared the results of existing works.

scholarly journals Emerging Topics in Cardiometabolic and Psychologic Sequelae, Pathogenesis, and Treatment of Polycystic Ovarian Syndrome: A Review

Children ◽  
2019 ◽  
Vol 6 (8) ◽  
pp. 89 ◽  
Author(s):  
Shah
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Treatment Options ◽  
Reproductive Age ◽  
Endocrine Disorder ◽  
Diagnostic Parameters ◽  
Reproductive Age Women ◽  
Therapeutic Considerations ◽  
Emerging Topics ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder, affecting 6–10% of reproductive age women and influences the reproductive, metabolic, dermatologic, and psychiatric health of affected girls and women. Despite its prevalence, the pathogenesis of the disease is largely unknown, and treatment options are limited. Thus, PCOS has been a ripe area for research in recent years, and novel etiologic pathways, diagnostic parameters, and treatment options are being explored. This review focuses on recent data suggesting pathogenic and therapeutic considerations, as well as the psychiatric and metabolic sequelae of PCOS.

scholarly journals Polycystic ovarian syndrome: pathogenesis and management

2021 ◽  
Vol 10 (2) ◽  
pp. 803
Author(s):  
Coumba Aicha Thiam ◽  
Malyn M. L. K. Antoine ◽  
Chrystal D. Antoine-Frank
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Clinical Presentation ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Surgical Interventions ◽  
Psychological Issues ◽  
Endocrine Disorder ◽  
And Control ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is an endocrine disorder that commonly affects women of reproductive age. Its prevalence varies quite significantly and its clinical presentation includes: reproductive, metabolic and psychological issues.  PCOS develops due to a variety of factors some of which are not yet fully understood. Due to the complexity in the development and presentation of this condition, the management of PCOS in most instances is complicated and involves the combination of pharmacological, non-pharmacological and surgical interventions. This review discusses the pathogenesis and management of PCOS as means of providing information that would enhance understanding and control of this disease.

The Role of Vitamin B6 in Reducing Serum Prolactin in Comparison to Cabergoline

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Suha J. Witwit
Keyword(s):  
Prolactin Level ◽  
Vitamin B6 ◽  
Reproductive Age ◽  
Serum Prolactin ◽  
Polycystic Ovaries ◽  
Endocrine Disorder ◽  
Hypothalamic Pituitary Axis

Hyperprolactinemia is a common endocrine disorder of hypothalamic-pituitary axis. It affect about 4-17% of women in reproductive age and about 3-10% of patients with polycystic ovaries. Vitamin B6 is an effective prolactin inhibitor that is extremely cheap and safe.it exerts hypothalamic dopaminergic effect which causes a significant reduction in prolactin level. The aim of the study is To evaluate the effectiveness of vitamin B6 in reducing serum prolactin in Hyperprolactinemic patient. Compare this effect to that of cabergoline.

Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations

2018 ◽  
Vol 25 (15) ◽  
pp. 1792-1804 ◽  
Author(s):  
Silvana R. Ferreira ◽  
Alicia B. Motta
Keyword(s):  
Endometrial Cancer ◽  
Adhesion Molecules ◽  
Polycystic Ovarian Syndrome ◽  
Cellular Proliferation ◽  
Steroid Receptors ◽  
Reproductive Age ◽  
Present Review ◽  
Implantation Failure ◽  
Uterine Function ◽  
Ovarian Syndrome

Background: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations. Methods: We conducted a search at the http://www.ncbi.nlm.nhi.gov/pubmed/electronic database using the following key words: endometrial steroid receptors, endometrium, uterine function, endometrium and PCOS, implantation window, implantation and PCOS, implantation markers, inflammation, oxidative stress. We selected the articles based on their titles and abstracts, then we analyzed the full text and classified the articles depending on the information provided according to the sections of the present review. Results: The endocrine and metabolic abnormalities displayed in women with PCOS promote complex effects on the endometrium, leading to a low rate of implantation and even infertility. Women with PCOS show alterations in the Hypothalamic-Pituitary- Ovarian axis, which results in constant circulating levels of estrogen, similar to those at the early follicular phase, and a deficiency in the withdrawal of estrogen and progesterone. Besides this deficiency in the withdrawal of estrogen and progesterone, the insulin/ glucose pathway, adhesion molecules, cytokines and the inflammatory cascade, together with the establishment of a pro-oxidative status, lead to an imbalance in the uterine function, which in turn leads to implantation failure or even endometrial cancer. Conclusion: Women with PCOS display a dysregulation of the Hypothalamic-Pituitary- Ovarian axis, which alters the steroid pathway. In addition, the deficiency in the withdrawal of estrogen and progesterone in the endometrium results in abnormal endometrial cellular proliferation. The imbalance in adipose tissue observed in PCOS patients reinforces the increase in circulating hormones. The present review describes the role of hormones, metabolites, cytokines, adhesion molecules and the insulin/glucose pathway related to the uterine endometrium in women with PCOS and their role in implantation failure and development of endometrial cancer.

scholarly journals To Study the Effect on Fertility Outcome by Gonadotropins vs Laparoscopic Ovarian Drilling in Clomiphene-resistant Cases of Polycystic Ovarian Syndrome

2017 ◽  
Vol 9 (4) ◽  
pp. 336-340 ◽  
Author(s):  
Richa Singh ◽  
Meenal Jain ◽  
Poonam Yadav ◽  
Sarvesh Awasthi ◽  
Pallavi Raj
Keyword(s):  
Statistical Analysis ◽  
Ovulation Induction ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Clomiphene Citrate ◽  
Reproductive Age ◽  
Multiple Pregnancies ◽  
Laparoscopic Ovarian Drilling ◽  
Ovarian Drilling ◽  
Ovarian Syndrome

ABSTRACT Introduction The polycystic ovary syndrome (PCOS) is the most common condition associated with chronic anovulation affecting 4 to 6% of reproductive age women. Aim To compare the effectiveness of laparoscopic ovarian drilling (LOD) for ovulation induction with gonadotropins in clomiphene-resistant PCOS in terms of ovulation, pregnancy, live birth, abortion, multiple pregnancies, and complication like ovarian hyperstimulation syndrome (OHSS). Setting and design A prospective hospital-based randomized trial. Materials and methods It was a prospective study, which was carried out from January 2012 to May 2015. Totally, 89 women were evaluated in the study, out of which 44 women were in gonadotropin group and 45 were in LOD group. Statistical analysis Standard statistical analysis was done and significance of difference in results was tested by chi-square test. Results Ovulation rate in gonadotropin group was 75.0% at 6 months, whereas in LOD group, it was 20% at 3 months and was increased up to 66.66% after addition of clomiphene citrate and gonadotropin. The primary outcome in terms of pregnancy in gonadotropin group was 45.45% after 6 cycles and in LOD group was 11.11% after 3 cycles and 40.00% after 6 cycles with supplementation of clomiphene citrate and gonadotropin. Conclusion The ongoing pregnancy rate from ovulation induction with LOD alone was significantly less but if supplemented by clomiphene citrate and gonadotropin, it seems equivalent to ovulation induction with gonadotropin, but the former procedure carries a lower risk of multiple pregnancies. How to cite this article Yadav P, Singh S, Singh R, Jain M, Awasthi S, Raj P. To Study the Effect on Fertility Outcome by Gonadotropins vs Laparoscopic Ovarian Drilling in Clomiphene-resistant Cases of Polycystic Ovarian Syndrome. J South Asian Feder Obst Gynae 2017;9(4):336-340.

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