The Role of Vitamin B6 in Reducing Serum Prolactin in Comparison to Cabergoline

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Suha J. Witwit
Keyword(s):  
Prolactin Level ◽  
Vitamin B6 ◽  
Reproductive Age ◽  
Serum Prolactin ◽  
Polycystic Ovaries ◽  
Endocrine Disorder ◽  
Hypothalamic Pituitary Axis

Hyperprolactinemia is a common endocrine disorder of hypothalamic-pituitary axis. It affect about 4-17% of women in reproductive age and about 3-10% of patients with polycystic ovaries. Vitamin B6 is an effective prolactin inhibitor that is extremely cheap and safe.it exerts hypothalamic dopaminergic effect which causes a significant reduction in prolactin level. The aim of the study is To evaluate the effectiveness of vitamin B6 in reducing serum prolactin in Hyperprolactinemic patient. Compare this effect to that of cabergoline.

Case 11.1

2014 ◽  
pp. 531-532
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Polycystic Ovaries ◽  
Endocrine Disorder ◽  
Secondary Amenorrhea ◽  
Increased Risk

28-year-old woman with secondary amenorrhea and hirsutism Axial fat-suppressed 2D SSFP images (Figure 11.1.1) demonstrate multiple follicles arranged in the periphery of the ovaries bilaterally. Polycystic ovary syndrome PCOS is the most common endocrine disorder in women of reproductive age, affecting between 6% and 15%, depending on the criteria used for diagnosis. It typically presents with anovulatory or oligo-ovulatory menstrual cycles leading to oligomenorrhea, polycystic ovaries, and clinical and biochemical hyperandrogenism. PCOS is also associated with increased risk of obesity, insulin resistance, diabetes mellitus, metabolic syndrome, and infertility....

scholarly journals Polycystic ovarian syndrome and pituitary macroadenoma a deadly combination with good outcome

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Ansari Sumayya Shamim ◽  
◽  
Reena Jatin Wani ◽  
Hema Prakash Relwani ◽  
Kruti Doshi ◽  
...  
Keyword(s):  
Prolactin Level ◽  
Polycystic Ovarian Syndrome ◽  
Reproductive Age ◽  
Pituitary Macroadenoma ◽  
Management Options ◽  
Endocrine Disorder ◽  
Good Outcome ◽  
Compliant Patient ◽  
Ovarian Syndrome

We are presenting here a case of polycystic ovarian syndrome, an endocrine disorder, afflicting 5-13% females of reproductive age, causing 70-80% infertility associated with pituitary macroadenoma i.e. size >10mm& prolactin level >250 ng/mI. PCOS has a higher relationship with metabolic disturbance and hypothalamic-pituitary-ovarian axis function disorder. Prolactinoma is present in about 50% women with hyperprolactinemia and 33% present with galactorrhea. Our patient was a 22 yrs nulligravida married since 3 yrs first presenting 5 yrs back with complaints of secondary amenorrhea with galactorrhea and infertility. On evaluation she was diagnosed as PCOS and pituitary macroadenoma on MRI. We medically treated her with tab. cabergoline in consultation with endocrinologist and neurosurgeons opinion. Being a compliant patient with regular follow up she conceived twice with good outcome and breastfed her babies on medical management only. Now she has 2 children (male child of 3 yrs and 1 month). Dilemma in management options will be discussed. Summary: Inspite of having both Polycystic Ovarian Syndrome (PCOS) & Pituitary Macroadenoma, which warrant surgical management (major causes of Infertility) selected cases like ours can be managed medically successfully.

scholarly journals Role of diagnostic hystero-laparoscopy in the evaluation of female infertility

2019 ◽  
Vol 8 (8) ◽  
pp. 3156
Author(s):  
Deepa Shanmugham ◽  
Nambala Divya Sahitya ◽  
Sindhu Natarajan ◽  
Deepak Kannan Saravanany
Keyword(s):  
Tertiary Care ◽  
Reproductive Age ◽  
Polycystic Ovaries ◽  
Tertiary Care Centre ◽  
Male Factor ◽  
Acute Pelvic Inflammatory Disease ◽  
Tubal Factor ◽  
The Mean ◽  
A Prospective Study

Background: Infertility affects about 10-15% of reproductive age couples. The main causes of infertility include male factor, ovulatory disorders, tubal factor and endometriosis. This study was conducted to determine the role of Diagnostic hystero-laparoscopy (DHL) in the evaluation of female infertility.Methods: This study was a prospective study done in a tertiary care centre over a period of 1 year on all infertile couples. The exclusion criteria: male factor infertility, hypothyroidism, hyperprolactinemia, acute pelvic inflammatory disease. Diagnostic hysterolaparoscopy was performed in all study patients in pre ovulatory phase, under general anaesthesia. The findings were then documented and analysed.Results: A total number of 90 patients were recruited for the study. The mean age of the patients was 28±3 years. The mean BMI of the study patients was 25±4 kg/m2. The mean duration of infertility was 5.4 years. On laparoscopy, 28 patients had polycystic ovaries (31.1%), 4 patients had pelvic adhesions (4.4%), 2 patients had endometriosis (2.2%) and tubal block was identified in 10 patients (11.11%). 10 patients had abnormal findings on hysteroscopy.Conclusions: Hystero laparoscopy is an effective diagnostic tool in the evaluation of infertility and has to be included in basic diagnostic workup.

scholarly journals Cardiometabolic Features of Polycystic Ovary Syndrome: Role of Androgens

Physiology ◽  
2017 ◽  
Vol 32 (5) ◽  
pp. 357-366 ◽  
Author(s):  
Licy L. Yanes Cardozo ◽  
Damian G. Romero ◽  
Jane F. Reckelhoff
Keyword(s):  
Risk Factors ◽  
Polycystic Ovary Syndrome ◽  
Cardiometabolic Risk ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Endocrine Disorder ◽  
Reproductive Age Women ◽  
Cardiometabolic Profile

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects reproductive-age women. Hyperandrogenemia is present in a significant fraction (~80%) of women with PCOS. Increased prevalence of cardiometabolic risk factors is frequently observed in PCOS women. The present review aims to highlight the key role of androgens in mediating the negative cardiometabolic profile observed in PCOS women.

scholarly journals Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Manal Abudawood ◽  
Hajera Tabassum ◽  
Atheer H. Alanazi ◽  
Fatmah Almusallam ◽  
Feda Aljaser ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Health Concern ◽  
Control Group ◽  
Polycystic Ovaries ◽  
Strong Negative Correlation ◽  
Pcos Group

AbstractPolycystic ovary syndrome (PCOS) is a global health concern for women of reproductive age, as 6.5% of women worldwide are affected by this syndrome. PCOS is marked by hyperandrogenism, anovulation, menstrual abnormalities, and polycystic ovaries. Metals such as arsenic, cadmium, lead and mercury are considered to be systemic toxicants/human carcinogens and seem to have devastating effects on humans, even at minimal exposures. One of the probable aetiological factors for PCOS has been identified as oxidative stress. In view of the probable associations among oxidative stress, metal toxicity and PCOS, the present study examined the role of heavy metals in the generation of oxidative stress among females. This prospective study included 106 women (56 women diagnosed with PCOS and 50 women who were not diagnosed with PCOS as control women). There were no significant differences in the sociodemographic characteristics between the two groups except for the irregularity of menses and the presence of acne. The serum As, Cd, Pb, and Hg levels increased and the serum glutathione (GSH) and superoxide dismutase (SOD) levels diminished significantly in the PCOS group compared to the control group at P < 0.001. The SOD levels were negatively correlated with the As and Pb levels at P < 0.05. Additionally, the PCOS group exhibited a strong negative correlation between the GSH and As levels (P < 0.01), GSH and Pb levels (P < 0.05) and GSH and Hg levels (P < 0.01). Furthermore, the As levels were positively correlated with increased levels of Cd, Pb and Hg among PCOS women. Significant positive correlations were observed between Pb and Cd and between Cd and Hg at P < 0.001. The outcome of the study provides clear insight into the role of metal-induced oxidative stress, which plays a vital role in the pathophysiology underlying PCOS and suggests the use of these markers as prognostic tools to reduce the consequences of high-risk exposure to these metals among females.

scholarly journals Reproductive Endocrinologic Pattern in Infertile Black Women with Polycystic Ovarian Syndrome

2021 ◽  
pp. 230-236
Author(s):  
Tawaqualit Abimbola Ottun ◽  
Faosat Olayiwola Jinadu ◽  
Ayokunle Moses Olumodeji ◽  
Adeniyi Abiodun Adewunmi ◽  
Fatimat Motunrayo Akinlusi ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
High Serum ◽  
Reproductive Hormones ◽  
Reproductive Age ◽  
Serum Prolactin ◽  
Polycystic Ovaries ◽  
Nigerian Women ◽  
Infertile Women ◽  
Ovarian Syndrome ◽  
Stimulating Hormone

Background: Polycystic ovarian syndrome (PCOS) is a very common endocrine cause of infertility affecting about 10% of women of reproductive age. We evaluated the pattern of reproductive hormones in infertile Nigerian women with PCOS. Methods: This was a prospective cross-sectional study at the Lagos State University Teaching Hospital over a 6-month period in which One hundred and fifty infertile women, with diagnosis of PCOS using the Rotterdam’s criteria, had quantitative assessment of their reproductive hormones like Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Progesterone, Testosterone, Prolactin and Thyroid Stimulating Hormone (TSH), with relevant socio-demographic and clinical data noted in the study proforma. Z test, chi-square and correlation tests were used as appropriate to analyse the data with p<0.05 significance level. Results: The mean age of infertile women with PCOS was 26.50±4.4years; all the women had either oligomenorrhea (62%) or secondary amenorrhea (38%), 56.5% were obese and 33.3% had hirsutism. While 37.7% of the women had abnormally elevated serum LH, 16.4% had high serum FSH, 39% had LH:FSH ratio> 2.5, 96% had low serum progesterone, 29% had high serum prolactin, 17.4% had high serum TSH values and 92% had features of polycystic ovaries on trans-vaginal ultrasound. Correlation of age and BMI with serum FSH, LH and prolactin values were weak and insignificant. Conclusion: PCOS is common among young Nigerian women presenting for infertility treatment; with dominant features of oligomenorrhea and polycystic ovaries. Hormonal abnormalities are common, varied and not associated with other clinical characteristics.

scholarly journals Polycystic ovarian syndrome and pituitary macroadenoma a deadly combination with good outcome

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Ansari Sumayya Shamim ◽  
◽  
Reena Jatin Wani ◽  
Hema Prakash Relwani ◽  
Kruti Doshi ◽  
...  
Keyword(s):  
Prolactin Level ◽  
Polycystic Ovarian Syndrome ◽  
Reproductive Age ◽  
Pituitary Macroadenoma ◽  
Management Options ◽  
Endocrine Disorder ◽  
Good Outcome ◽  
Compliant Patient ◽  
Ovarian Syndrome

We are presenting here a case of polycystic ovarian syndrome, an endocrine disorder, afflicting 5-13% females of reproductive age, causing 70-80% infertility associated with pituitary macroadenoma i.e. size >10 mm & prolactin level >250 ng/mI. PCOS has a higher relationship with metabolic disturbance and hypothalamic-pituitary-ovarian axis function disorder. Prolactinoma is present in about 50% women with hyperprolactinemia and 33% present with galactorrhea. Our patient was a 22 yrs nulligravida married since 3 yrs first presenting 5 yrs back with complaints of secondary amenorrhea with galactorrhea and infertility. On evaluation she was diagnosed as PCOS and pituitary macroadenoma on MRI. We medically treated her with tab. cabergoline in consultation with endocrinologist and neurosurgeons opinion. Being a compliant patient with regular follow up she conceived twice with good outcome and breastfed her babies on medical management only. Now she has 2 children (male child of 3 yrs and 1 month). Dilemma in management options will be discussed.

scholarly journals Role of Fetal Serum Prolactin in Pregnancy

2015 ◽  
Vol 3 (2) ◽  
Author(s):  
DR. SAYESHA VIRK ◽  
DR SHIKHA JOSHI ◽  
DR AMRITA BHADAURIA ◽  
DR. C. HARIHARAN
Keyword(s):  
Prolactin Level ◽  
Serum Prolactin ◽  
Medical Sciences ◽  
Serum Prolactin Level ◽  
Cord Serum ◽  
Fetal Serum ◽  
Group A ◽  
Group B ◽  
A Prospective Study

<p>In our study we have tried to to study the comparison of fetal cord serum prolactin level in normal and abnormal pregnancies and correlate the cord serum prolactin level with occurrence of HMD and to establish the fact that If cord serum prolactin is less, then there might be the chances of neonate developing HMD .study was conducted in Department of Obstetrics and Gynaecology, Datta Meghe Institute Of Medical Sciences, Sawangi (Meghe), Wardha (1st September 2005 to 31st August 2007: on 160 randomly selected booked and unbooked women GROUP A 80 women with normal pregnancies GROUP B 80 women with abnormal pregnancies.</p><p><br />In a prospective study umbilical cord serum prolactin level was found to be lower in women with abnormal pregnancy.</p>

SERUM PROLACTINE LEVEL IN PATIENTS OF PSORIASIS VULGARIS AND ITS CORRELATION WITH DISEASE SEVERITY: A CASE-CONTROL STUDY

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Pawan Kumar Saini ◽  
Devendra Yadav ◽  
Rozy Badyal ◽  
Suresh Jain ◽  
Arti Singh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Prolactin Level ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Serum Prolactin ◽  
P Value ◽  
Serum Prolactin Level ◽  
R Value ◽  
Control Study

Background: Psoriasis is an autoimmune chronic inflammatory disorder affecting the skin mediated by T-lymphocytes resulting in production of cytokines which cause hyperproliferation of keratinocytes.  Several factors and hormones like Prolactin have an action similar to these cytokines in promoting the multiplication of keratinocytes and other cells like lymphocytes and epithelial cells may have a role on the etiopathogenesis of psoriasis. Aim:-The aim of study is to compare the serum Prolactin levels in patients of psoriasis with a control group. Setting and study design: This is a case-control study conducted in the department of Dermatology, Venereology and Leprosy GMC, Kota over a period of 1year from July 2017 to June 2018 Material and method: The study included 100 cases of psoriasis (60 males and 40 females) and 100 controls similar for age and sex. Serum Prolactin levels were measured by ECLIA and results were obtained. Statistical analysis: Mean and standard deviation were calculated for each variable. Statistical significance of the results was analyzed using correlation analysis (Pearson correlation coefficient) and independent samples t-test. Statistical significance was assumed at p value<0.05. Result: Serum Prolactin level was significantly higher in cases of psoriasis compared to controls (p-value <0.001). PASI score and serum Prolactin levels were found to have a positive correlation (r value = 0.337; p-value: 0.001). No significant  correlation was found between serum levels of Prolactin and duration of disease r value= -0.034, P value =0.733). Serum Prolactin level was higher in male patients compared to females patients. Conclusion:- High serum Prolactin may be a biological marker of disease severity in psoriasis and may have a role in the pathogenesis of psoriasis. Further studies with large sample size are required to confirm this hypothesis.

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