USE OF EFFERENT THERAPY METHODS IN THE TREATMENT OF DESTRUCTIVE PANCREATITIS

Vestnik ◽  
2021 ◽  
pp. 206-209
Author(s):  
А.Т. Джумабеков ◽  
А.Ж. Артыкбаев ◽  
Р.Е. Каштаев ◽  
С.С. Калиева ◽  
С.Ж. Жанбырбаев ◽  
...  

Своевременное включение методов эфферентной терапии (гемодиафильтрация, плазмаферез) в комплексную интенсивную терапию сепсиса и септического шока у больных с острым деструктивным панкреатитом, находящихся на стационарном лечении в ЦГКБ г. Алматы, позволило быстро стабилизировать гемодинамику, респираторные нарушения и отказаться от применения адреномиметиков, а также значительно уменьшить клинические проявления тяжелой интоксикации, гипоксии и эндотоксикоза. Timely inclusion of efferent therapy methods (hemodiafiltration, plasmapheresis) in the complex intensive therapy of sepsis and septic shock in patients with acute destructive pancreatitis who are inpatient treatment at the Central city clinical hospital in Almaty, made it possible to quickly stabilize hemodynamics, respiratory disorders and abandon the use of adrenomimetics, as well as significantly reduce the clinical manifestations of severe intoxication, hypoxia and endotoxicosis.

1992 ◽  
Vol 7 (2) ◽  
pp. 90-100 ◽  
Author(s):  
Margaret M. Parker ◽  
Mitchell P. Fink

The incidence of sepsis and septic shock has been increasing dramatically over the past 10 years. Despite advances in antimicrobial therapy, the mortality of septic shock remains very high. We review the clinical manifestations of sepsis and septic shock and describe the cardiovascular manifestations. Pathophysiology of the cardiovascular changes is discussed, and mediators believed to be involved in the pathogenesis are reviewed. Management of septic shock is also discussed, including antimicrobial therapy, supportive care, and adjunctive treatment aimed at affecting the mediators involved in producing the sepsis syndrome.


2022 ◽  
Vol 75 (1) ◽  
Author(s):  
Miriam Maria Mota Silva ◽  
Danielle Samara Tavares de Oliveira-Figueiredo ◽  
Adilma da Cunha Cavalcanti

ABSTRACT Objectives: to analyze factors associated with sepsis and septic shock in cancer patients in the Intensive Care Unit. Methods: cross-sectional, retrospective study with a quantitative approach, with a sample of 239 patients in an oncology hospital. Secondary data from medical records were used. The outcome variable was “presence of sepsis and/or septic shock”; and exposures: sex, length of stay, origin, use of invasive procedures and primary tumor site. Descriptive, bivariate analyzes and multiple logistic regression models were performed. Results: the prevalence of sepsis was 95% CI: 14.7-24.7 and septic shock of 95% CI: 37.7-50.3. In the multiple analysis, sepsis and/or septic shock were associated with hospital stay longer than seven days, being from the Emergency Department, presence of invasive procedures and hematological site. Conclusions: sepsis and/or septic shock in cancer patients were associated with clinical characteristics and health care factors.


Vestnik ◽  
2021 ◽  
pp. 215-223
Author(s):  
А.Т. Джумабеков ◽  
Р.Е. Каштаев ◽  
С.М. Жарменов ◽  
С.Ж. Жанбырбаев ◽  
А.Ж. Артыкбаев ◽  
...  

Применение принципов комплексного использования эндоскопического гемостаза и использование эрадикационной, антисекреторной терапии у больных с гастродуоденальным кровотечением, находящихся на стационарном лечении в ЦГКБ г. Алматы, позволило улучшить результаты лечения больных, значительно снизить количество осложнений после операций, сократить частоту как общей, так и послеоперационной летальности. The application of the principles of the integrated use of endoscopic hemostasis and the use of eradication, antisecretory therapy in patients with gastroduodenal bleeding who are inpatient treatment at the Central City Clinical Hospital of Almaty, made it possible to improve the results of treatment of patients, significantly reduce the number of complications after surgery, and reduce the incidence of both general and postoperative mortality.


Vestnik ◽  
2021 ◽  
pp. 252-255
Author(s):  
К.Х. Мухамеджанов

В данной статье представлены результаты клинических проявлений и рентгенологических исследований, перестройки костной ткани. Результаты наших исследований показали, что обычная рентгенография не решает всей проблемы диагностики стрессовых переломов напряжения. Мы в данной публикации выделяем те случаи, когда обычная рентгенография не в силах решить проблему диагностики и требует использования дополнительных методов лучевой диагностики. Исследование проведено на базе ЦГКБ г. Алматы. Под нашим наблюдением находились 11 (100%) больных, у которых заподозрено наличие перестройки костей. У 6 (54.5%) больных данные рентгенологического исследования указывали, на наличие стрессовой перестройки кости у 5 (45,5%) больных признаки были сомнительными. Применение компьютерной томографии (КТ) и динамическое рентгенологическое исследование позволило установить диагноз стрессовой перегрузки костей. This article presents the results of clinical manifestations and X-ray studies of the bone remodeling. The results of our research have shown that conventional radiography does not solve the entire problem of diagnosing stress fractures of tension. In this publication, we highlight those cases when conventional radiography is unable to solve the diagnostic problem and requires the use of additional methods of radiation diagnostics. The research was carried out on the basis of the Central City Clinical Hospital of Almaty. We observed 11 (100%) patients in whom the presence of bone remodeling was suspected. In 6 (54.5%) patients, X-ray examination data indicated that the presence of stress bone remodeling in 5 (45.5%) patients were dubious. The use of computed tomography analysis (CT) and dynamic X-ray examination made it possible to establish the diagnosis of bone stress overload.


Vestnik ◽  
2021 ◽  
pp. 175-181
Author(s):  
М.Е. Рамазанов ◽  
М.Р. Рысулы ◽  
Н.Р. Рахметов ◽  
Б.К. Жанбырбай ◽  
В.Н. Сон ◽  
...  

Сепсис и септический шок являются одной из основных проблем здравоохранения. Ежегодно, по всему миру, он является причиной смерти более миллиона людей, при этом частота летальных исходов составляет примерно один случай из четырех. Летальность при тяжелом сепсисе и септическом шоке может достигать 30-90 процентов. На базе «ГКБ №7» УОЗ г. Алматы нами была разработана и внедрена алгоритм ранней диагностики и лечения сепсиса и современные методы применения биомаркеров диагностики и мониторинга сепсиса (акт внедрения от 01.06.2019г.), где основными показателями были сортировка по «Triage» системе на основе шкалы SOFA 3, определение современных биомаркеров как прокальцитонин и пресепсин. Так же определение гемокультуры, нейтрофильного лейкоцитоза, лактата, C-реактивного белка, и раннее применение эффективных антимикробных препаратов (в первый час) с момента постановки диагноза «септический шок» или «тяжелый сепсис», которые в свою очередь дали возможность своевременной фиксации признаков генерализации гнойного процесса и ранней диагностике осложнений. Упущение времени на этапе диагностики являются причиной возникновения в дальнейшем ошибок постановки окончательного диагноза и проведения соответствующего лечения. Многих ошибок можно избежать, если лечащие врачи будут точно следовать рекомендациям по ранней диагностике сепсиса и обоснованного выбора антимикробной терапии в каждом конкретном случае. На основании вышеизложенного, алгоритм разработанное и утвержденное руководством клиники «ГКБ №7», выполнение диагностических процедур адаптированную под диагностические возможности клиники, лечебную тактику пациентов с диагнозом «Сепсис» и налаженное система контроля над ее выполнением, - дало возможность к раннему выявлению генерализации гнойного процесса и развития тяжелого сепсиса или септического шока и соответственно привели к снижению летальности. Sepsis and septic shock are a major health problem. Globally, it causes more than a million deaths annually, with a death rate of about one in four. Mortality in severe sepsis and septic shock can be as high as 30-90 percent.On the basis of "City Clinical Hospital № 7" of the UOZ in Almaty, we have developed and implemented an algorithm for early diagnosis and treatment of sepsis and modern methods of using biomarkers for diagnosis and monitoring of sepsis (act of implementation dated 01.06.2019), where the main indicators were sorting according to "Triage" system based on the SOFA 3 scale, the definition of modern biomarkers such as procalcitonin and presepsin. Also, the determination of blood culture, neutrophilic leukocytosis, lactate, C-reactive protein, and the early use of effective antimicrobial drugs (in the first hour) from the moment of diagnosis of "septic shock" or "severe sepsis", which in turn made it possible to timely fix signs of generalization purulent process and early diagnosis of complications.Loss of time at the diagnostic stage is the reason for the subsequent occurrence of errors in the final diagnosis and appropriate treatment. Many mistakes can be avoided if the treating physicians strictly follow the recommendations for the early diagnosis of sepsis and the informed choice of antimicrobial therapy on a case-by-case basis.Based on the above, the algorithm developed and approved by the management of the clinic "City Clinical Hospital № 7", the implementation of diagnostic procedures adapted to the diagnostic capabilities of the clinic, the treatment tactics of patients diagnosed with "Sepsis" and an established monitoring system for its implementation, - made it possible to early detection of generalization of the purulent process and the development of severe sepsis or septic shock and, accordingly, led to a decrease in mortality.


2021 ◽  
Vol 40 (9) ◽  
pp. 567-575
Author(s):  
Sara Crestani ◽  
Erica Passini ◽  
valentina Spaggiari ◽  
Carlotta Toffoli ◽  
Alessandra Boncompagni ◽  
...  

Shock is a generalized tissue hypoperfusion that leads to severe cellular distress and complicates some cases of paediatric and neonatal sepsis. Although a reduction in associated sepsis mortality has been observed in the last decades, it remains one of the most important causes of death or long-term neurodevelopmental disabilities in children. Prompt recognition of this condition is therefore essential to improve survival and long-term outcome. The paediatrician and the neonatologist must therefore be able to promptly recognize the signs and symptoms of sepsis and septic shock to set up an adequate treatment according to the most recent international guidelines. This article provides epidemiological data from Italian and international studies, describes the pathophysiology and clinical manifestations of sepsis and septic shock, as well as the therapeutic indications according to very recent recommendations.


MedPharmRes ◽  
2018 ◽  
Vol 2 (3) ◽  
pp. 27-32
Author(s):  
Bien Le ◽  
Dai Huynh ◽  
Mai Tuan ◽  
Minh Phan ◽  
Thao Pham ◽  
...  

Objectives: to evaluate the fluid responsiveness according to fluid bolus triggers and their combination in severe sepsis and septic shock. Design: observational study. Patients and Methods: patients with severe sepsis and septic shock who already received fluid after rescue phase of resuscitation. Fluid bolus (FB) was prescribed upon perceived hypovolemic manifestations: low central venous pressure (CVP), low blood pressure, tachycardia, low urine output (UOP), hyperlactatemia. FB was performed by Ringer lactate 500 ml/30 min and responsiveness was defined by increasing in stroke volume (SV) ≥15%. Results: 84 patients were enrolled, among them 30 responded to FB (35.7%). Demographic and hemodynamic profile before fluid bolus were similar between responders and non-responders, except CVP was lower in responders (7.3 ± 3.4 mmHg vs 9.2 ± 3.6 mmHg) (p 0.018). Fluid response in low CVP, low blood pressure, tachycardia, low UOP, hyperlactatemia were 48.6%, 47.4%, 38.5%, 37.0%, 36.8% making the odd ratio (OR) of these triggers were 2.81 (1.09-7.27), 1.60 (0.54-4.78), 1.89 (0.58-6.18), 1.15 (0.41-3.27) and 1.27 (0.46-3.53) respectively. Although CVP < 8 mmHg had a higher response rate, the association was not consistent at lower cut-offs. The combination of these triggers appeared to raise fluid response but did not reach statistical significance: 26.7% (1 trigger), 31.0% (2 triggers), 35.7% (3 triggers), 55.6% (4 triggers), 100% (5 triggers). Conclusions: fluid responsiveness was low in optimization phase of resuscitation. No fluid bolus trigger was superior to the others in term of providing a higher responsiveness, their combination did not improve fluid responsiveness as well.


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