Acute Hepatopathy Associated With Mitotane Administration in a Dog

2006 ◽  
Vol 42 (4) ◽  
pp. 298-301 ◽  
Author(s):  
Craig B. Webb ◽  
David C. Twedt
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Supportive Care ◽  
Prothrombin Time ◽  
Liver Enzyme ◽  
Hepatic Failure ◽  
Enzyme Activities ◽  
Total Bilirubin ◽  
Persistent Elevation ◽  
Phosphatase Enzyme

An adult dog with a persistent elevation in alkaline phosphatase enzyme activity was started on mitotane for suspected hyperadrenocorticism. One month later, the dog was presented for intermittent anorexia and acute icterus. The dog’s liver enzyme activities and total bilirubin were markedly elevated, prothrombin time was prolonged, and blood urea nitrogen and glucose were low. Histopathology revealed marked, centrilobular, hepatocellular loss. After discontinuation of the mitotane, the dog recovered with supportive care and was normal 3 months later, which was consistent with mitotane-associated hepatic failure.

scholarly journals Phosphorylation of purified bovine heart and rat liver 6-phosphofructo-2-kinase by protein kinase C and comparison of the fructose-2,6-bisphosphatase activity of the two enzymes

1986 ◽  
Vol 240 (1) ◽  
pp. 57-61 ◽  
Author(s):  
M H Rider ◽  
L Hue
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Exchange Reaction ◽  
Liver Enzyme ◽  
Rat Liver ◽  
Phosphorylation State ◽  
Bovine Heart ◽  
Kinase C

Purified bovine heart 6-phosphofructo-2-kinase can be phosphorylated in the presence of protein kinase C and dephosphorylated by alkaline phosphatase; changes in phosphorylation state have no effect on enzyme activity. By contrast, the rat liver enzyme is a poor substrate for protein kinase C. Unlike the liver enzyme, which is bifunctional and is phosphorylated by fructose 2,6-[2-32P]bisphosphate, the heart enzyme contains 10 times less fructose 2,6-bisphosphatase activity and is phosphorylated at a slower rate and to a lesser extent than the liver enzyme. Both rat liver and bovine heart enzymes catalyse a similar exchange reaction between [U-14C]ADP and ATP.

Effects of Metal Poisoning on Five Liver Enzymes in the Killifish (Fundulus heteroclitus)

1970 ◽  
Vol 27 (2) ◽  
pp. 383-390 ◽  
Author(s):  
Eugene Jackim ◽  
Janice M. Hamlin ◽  
Stephen Sonis
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Xanthine Oxidase ◽  
Liver Enzyme ◽  
Fundulus Heteroclitus ◽  
Liver Enzymes ◽  
Enzyme Preparations ◽  
Liver Enzyme Activity ◽  
Acid And Alkaline Phosphatase ◽  
Metal Poisoning

Activities of five liver enzymes (acid and alkaline phosphatase, catalase, xanthine oxidase, and ribonuclease) from Fundulus heteroclitus surviving exposure to 96-hr TLm concentrations of salts of six metals (lead, copper, mercury, beryllium, cadmium, and silver) differed markedly from those of unexposed fish. Changes in enzyme activity produced by the exposures were not necessarily the same in magnitude or direction as those observed when the salts were introduced directly into the enzyme preparations. It is proposed that changes in liver enzyme activity may be useful as a kind of biochemical autopsy tool for diagnosing sublethal metal poisoning in fish.

Silicon Deficiency Induces Alkaline Phosphatase Enzyme Activity in Cultures of Four Marine Diatoms

2013 ◽  
Vol 37 (2) ◽  
pp. 312-324 ◽  
Author(s):  
Soledad Fuentes ◽  
Gary H. Wikfors ◽  
Shannon Meseck
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Marine Diatoms ◽  
Phosphatase Enzyme

scholarly journals Detection of Alkaline Phosphatase Enzyme Activity with a CatalyCEST MRI Biosensor

ACS Sensors ◽  
2016 ◽  
Vol 1 (7) ◽  
pp. 857-861 ◽  
Author(s):  
Iman Daryaei ◽  
Mahsa Mohammadebrahim Ghaffari ◽  
Kyle M. Jones ◽  
Mark D. Pagel
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Phosphatase Enzyme

scholarly journals Comparison of deferasirox and deferoxamine effect on liver enzyme activities and ferritin level in patients with beta-thalassemia

2020 ◽  
Vol 24 (3) ◽  
pp. 354-359
Author(s):  
Rasul Ali ◽  
Dler Ali ◽  
Zhyan Ahmed ◽  
Amal Ahmed ◽  
Dilvin Hassen ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Enzyme ◽  
Serum Ferritin ◽  
Enzyme Activities ◽  
Serum Ferritin Level ◽  
Liver Enzymes ◽  
Ferritin Level ◽  
Alanine Transaminase ◽  
Aspartate Transaminase ◽  
Blood Disorder

Background and objective: Patients on blood transfusion may develop complications related to iron overload and the effects of chelating agents (drugs), which adversely affect the liver in thalassemia, which is a genetic blood disorder of hemoglobin synthesis that causes severe anemia. This study aimed to assess the effect of deferasirox and deferoxamine drugs on liver enzyme activities (aspartate transaminase, alanine transaminase, and alkaline phosphatase), and serum ferritin level in β_thalassemic patients. Methods: This study was carried out in Erbil city from October 2017 to February 2018. Blood specimens were collected in Hawler thalassemia center and Raparin hospital. The samples included 105 individuals; 70 β-thalassemic patients (35 treated by deferasirox as group A and 35 treated by deferoxamine as group B), and 35 healthy individuals (control group C). Results: The serum aspartate transaminase and alkaline phosphatase activities in β-thalassemic patients were higher than that of controls. The serum alanine transaminase activity in the patients' groups showed non-significant elevation than that of controls. The serum ferritin level in the patients was significantly higher than that of controls. Conclusion: Our finding showed that both deferasirox and deferoxamine drugs affect liver enzymes and increase ferritin level. Keywords: β-thalassemia; Deferasirox; Deferoxamine; Liver enzymes; Ferritin.

Regulation of Intestinal Alkaline Phosphatase by Dietary Phosphate

1972 ◽  
Vol 50 (12) ◽  
pp. 1152-1156 ◽  
Author(s):  
L. W. McCuaig ◽  
I. Motzok
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Enzyme Activities ◽  
Inorganic Phosphate ◽  
Intestinal Alkaline Phosphatase ◽  
Dietary Phosphate ◽  
Intestinal Enzyme

Day-old chicks were fed practical rations containing varying levels of inorganic phosphate (Pi) in an attempt to study the regulation of intestinal alkaline phosphatase by phosphate. Low dietary Pi (0.16%) increased the enzyme activity by 50% compared to adequate Pi (0.48%). The enzyme activities were significantly reversed 8 days after reversing the diets. In another experiment chicks were fed 0.16 or 0.80%) Pi for 4 weeks and killed when full-fed, or after 3 days' starvation. In the full-fed birds low dietary Pi reduced the intestinal nuclear Pi and doubled the intestinal enzyme activity. Nuclear Pi was found to be inversely correlated with alkaline phosphatase in the fed animals. No such effects were found in the starved birds.

Sign in / Sign up

Export Citation Format

Share Document