scholarly journals The effectiveness of using thiamine in the Wernicke-Korsakoff syndrome

2021 ◽  
Author(s):  
Virgínia Madureira Costa ◽  
Iris Maria de Miranda Correia ◽  
Laís Michela Rodrigues Sales Arruda ◽  
José Leandro da Silva Menezes Diniz ◽  
Maria Tereza Corrêa de Araújo ◽  
...  
Keyword(s):  
Scientific Evidence ◽  
Vitamin B1 ◽  
Ocular Manifestations ◽  
Korsakoff Syndrome ◽  
Vitamin B1 Deficiency ◽  
Thiamine Therapy ◽  
Higher Doses ◽  
The Brain ◽  
Made In ◽  
The Ideal

Introduction: The Wernicke-Korsakoff syndrome is a condition caused by thiamine (vitamin B1) deficiency in the brain, being a debilitating and potentially fatal factor. It is characterized by a classic triad: delirium, ophthalmoparesis and ataxia. Objectives: Analyze the possible effectiveness of using thiamine in the prognostic change of patients with the syndrome, as well as the ideal dose and identification of possible secondary outcomes of the use of thiamine. Methods: A systematic review made in March 2021, included studies published between 2011-2021. The descriptors selected according to the MeSH platform, were inserted in the SCIELO, Lilacs and PubMed databases, resulting in a total of 323 studies, of which only 8 were selected. Results: Among the 8 evaluated articles, 5 reinforce the effectiveness of thiamine therapy, with prognostic changes in those patients, and only 4 of these studies describe their clinical evolution, showing mostly a gradual regression of the ocular manifestations and ataxia, while neurological symptoms tend to develop later. Thus 62,5% of the articles show improvement of patients with these therapeutics. Other studies do not refer to the prognosis after the institution of the treatment. About the dose, it was observed that the therapeutic effectiveness was related to higher doses of thiamine. Conclusion: Most of the analyzed studies were favorable to the hypothesis of the early use of thiamine in regression of the symptoms. Regarding the most effective dose, the topic still needs studies with high scientific evidence, as it hasn’t yet been thoroughly discussed in the literature.

scholarly journals Potassium in the Brain in Vitamin B1 Deficiency

Nature ◽  
1936 ◽  
Vol 138 (3487) ◽  
pp. 368-368
Author(s):  
HENRY W. KINNERSLEY
Keyword(s):  
Vitamin B1 ◽  
Vitamin B1 Deficiency ◽  
The Brain

scholarly journals CONFABULATIONS IN A CHRONIC ALCOHOLIC- A SUBTLE PRESENTATION OF KORSAKOFF SYNDROME

2019 ◽  
Vol 7 (7) ◽  
pp. 58-60
Author(s):  
Yan Leyfman
Keyword(s):  
Case Report ◽  
Alcohol Abuse ◽  
Retrograde Amnesia ◽  
Vitamin B1 ◽  
Wernicke Encephalopathy ◽  
Chronic Alcoholic ◽  
Present Case Report ◽  
Personality Changes ◽  
Korsakoff Syndrome ◽  
Vitamin B1 Deficiency

Wernicke Encephalopathy is an acute neuropsychiatric condition, characterized by confusion, nystagmus, ataxia, and ophthalmoplegia, resulting from thiamine (Vitamin B1) deficiency, typically secondary to alcohol abuse. Failure to properly diagnose, which occurs in 80% of the time, can result in gradual progression to irreversible Korsakoff Syndrome, characterized by irreversible personality changes, and anterograde and retrograde amnesia. The present case report seeks to highlight this patient’s chronology to Korsakoff Syndrome and our attempted interventions.

Lessons Learned From Coaching Postsecondary Students With Traumatic Brain Injury

2020 ◽  
Vol 5 (1) ◽  
pp. 88-96
Author(s):  
Mary R. T. Kennedy
Keyword(s):  
College Students ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Sense Of Self ◽  
Scientific Evidence ◽  
Sudden Onset ◽  
Lessons Learned ◽  
Speech Language Pathologists ◽  
The Brain ◽  
Exhaustive List

Purpose The purpose of this clinical focus article is to provide speech-language pathologists with a brief update of the evidence that provides possible explanations for our experiences while coaching college students with traumatic brain injury (TBI). Method The narrative text provides readers with lessons we learned as speech-language pathologists functioning as cognitive coaches to college students with TBI. This is not meant to be an exhaustive list, but rather to consider the recent scientific evidence that will help our understanding of how best to coach these college students. Conclusion Four lessons are described. Lesson 1 focuses on the value of self-reported responses to surveys, questionnaires, and interviews. Lesson 2 addresses the use of immediate/proximal goals as leverage for students to update their sense of self and how their abilities and disabilities may alter their more distal goals. Lesson 3 reminds us that teamwork is necessary to address the complex issues facing these students, which include their developmental stage, the sudden onset of trauma to the brain, and having to navigate going to college with a TBI. Lesson 4 focuses on the need for college students with TBI to learn how to self-advocate with instructors, family, and peers.

Aetiologies and anatomy of confabulation

2017 ◽  
Author(s):  
Armin Schnider
Keyword(s):  
Brain Damage ◽  
Limbic Encephalitis ◽  
Artery Aneurysm ◽  
Anterior Communicating Artery ◽  
Brain Areas ◽  
Anatomical Basis ◽  
Korsakoff Syndrome ◽  
Hypoxic Brain ◽  
Degenerative Dementia ◽  
The Brain

What diseases cause confabulations and which are the brain areas whose damage is responsible? This chapter reviews the causes, both historic and present, of confabulations and deduces the anatomo-clinical relationships for the four forms of confabulation in the following disorders: alcoholic Korsakoff syndrome, traumatic brain injury, rupture of an anterior communicating artery aneurysm, posterior circulation stroke, herpes and limbic encephalitis, hypoxic brain damage, degenerative dementia, tumours, schizophrenia, and syphilis. Overall, clinically relevant confabulation is rare. Some aetiologies have become more important over time, others have virtually disappeared. While confabulations seem to be more frequent after anterior brain damage, only one form has a distinct anatomical basis.

scholarly journals Molecular Mechanisms of Drug Resistance in Glioblastoma

2021 ◽  
Vol 22 (12) ◽  
pp. 6385
Author(s):  
Maya A. Dymova ◽  
Elena V. Kuligina ◽  
Vladimir A. Richter
Keyword(s):  
Drug Resistance ◽  
Brain Tumor ◽  
Molecular Mechanisms ◽  
Primary Brain Tumor ◽  
Therapeutic Resistance ◽  
Molecular Characteristics ◽  
Blood Brain ◽  
Conventional Radiation ◽  
The Brain ◽  
Made In

Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly resistant to conventional radiation and chemotherapy, and is not amenable to effective surgical resection. The present review summarizes recent advances in our understanding of the molecular mechanisms of therapeutic resistance of GBM to already known drugs, the molecular characteristics of glioblastoma cells, and the barriers in the brain that underlie drug resistance. We also discuss the progress that has been made in the development of new targeted drugs for glioblastoma, as well as advances in drug delivery across the blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB).

Comparative studies on vitamin B1 deficiency in whole blood of chronically haemodialysed patients: chromatographic, fluorimetric and PCA study

2021 ◽  
pp. 122880
Author(s):  
Paweł B. Rudnicki-Velasquez ◽  
Hanna Storoniak ◽  
Karolina Jagiełło ◽  
Joanna Kreczko–Kurzawa ◽  
Magdalena Jankowska ◽  
...  
Keyword(s):  
Whole Blood ◽  
Comparative Studies ◽  
Vitamin B1 ◽  
Vitamin B1 Deficiency

Thiamine (Vitamin B1)

2011 ◽  
Vol 16 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Aviva Fattal-Valevski
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Metabolism ◽  
Oxidant Stress ◽  
Vitamin B1 ◽  
Vitamin B ◽  
Deficient Diet ◽  
Common Cause ◽  
Korsakoff Syndrome ◽  
Reducing Substances ◽  
B Vitamin

Thiamine (vitamin B1) was the first B vitamin to have been identified. It serves as a cofactor for several enzymes involved in energy metabolism. The thiamine-dependent enzymes are important for the biosynthesis of neurotransmitters and for the production of reducing substances used in oxidant stress defenses, as well as for the synthesis of pentoses used as nucleic acid precursors. Thiamine plays a central role in cerebral metabolism. Its deficiency results in dry beriberi, a peripheral neuropathy, wet beriberi, a cardiomyopathy with edema and lactic acidosis, and Wernicke—Korsakoff syndrome, whose manifestations consist of nystagmus, ophthalmoplegia, and ataxia evolving into confusion, retrograde amnesia, cognitive impairment, and confabulation. Patients on a strict thiamine-deficient diet display a state of severe depletion within 18 days. The most common cause of thiamine deficiency in affluent countries is either alcoholism or malnutrition in nonalcoholic patients. Treatment by thiamine supplementation is beneficial for diagnostic and therapeutic purposes.

scholarly journals Effects Of Combinations Of Patternmaking Methods And Dress Forms On Garment Appearance

2017 ◽  
Vol 17 (3) ◽  
pp. 277-286 ◽  
Author(s):  
Chinami Fujii ◽  
Masayuki Takatera ◽  
KyoungOk Kim
Keyword(s):  
Sensory Evaluation ◽  
Body Shape ◽  
Front Side ◽  
Calculation Methods ◽  
Ideal Body ◽  
Sensory Evaluations ◽  
Body Shapes ◽  
Made In ◽  
The Ideal

AbstractWe investigated the effects of the combinations of patternmaking methods and dress forms on the appearance of a garment. Six upper garments were made using three patternmaking methods used in France, Italy, and Japan, and two dress forms made in Japan and France. The patterns and the appearances of the garments were compared using geometrical measurements. Sensory evaluations of the differences in garment appearance and fit on each dress form were also carried out. In the patterns, the positions of bust and waist darts were different. The waist dart length, bust dart length, and positions of the bust top were different depending on the patternmaking method, even when the same dress form was used. This was a result of differences in the measurements used and the calculation methods employed for other dimensions. This was because the ideal body shape was different for each patternmaking method. Even for garments produced for the same dress form, the appearances of the shoulder, bust, and waist from the front, side, and back views were different depending on the patternmaking method. As a result of the sensory evaluation, it was also found that the bust and waist shapes of the garments were different depending on the combination of patternmaking method and dress form. Therefore, to obtain a garment with better appearance, it is necessary to understand the effects of the combinations of patternmaking methods and body shapes.

ADULT SCURVY ASSOCIATED WITH VITAMIN-B1 DEFICIENCY

The Lancet ◽  
1938 ◽  
Vol 231 (5990) ◽  
pp. 1385-1387 ◽  
Author(s):  
J. Bruce Young
Keyword(s):  
Vitamin B1 ◽  
Vitamin B1 Deficiency
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