scholarly journals HIPPOCAMPAL CONNECTIVITY IN ILLITERATE ADULTS FROM BRAZIL

2021 ◽  
Author(s):  
Elisa Resende ◽  
Vivian Lara ◽  
Ana Luisa Santiago ◽  
Clarisse Friedlaender ◽  
Howard Rosen ◽  
...  
Keyword(s):  
Free Recall ◽  
Episodic Memory ◽  
Memory Performance ◽  
High Educational Level ◽  
Ventral Medial Prefrontal Cortex ◽  
Selective Reminding ◽  
The Mean ◽  
Selective Reminding Test ◽  
Illiterate Adults

Background: The role of hippocampal connectivity for good memory performance is well known in persons with high educational level. However, it is understudied the role of hippocampal connectivity in illiterate populations. Objectives: To determine whether the hippocampal connectivity correlate with episodic memory in illiterate adults. Methods: Thirty-nine illiterate adults underwent resting state functional MRI and an episodic memory test (Free and Cued Selective Reminding Test). We correlated the hippocampal connectivity at rest with the free recall scores. Analyzes were corrected for head motion and physiological BOLD signal. Results: Participants were most female (66%) and black (79%) and the mean age was 49 years-old (±13.9). The mean score on free recall was 27.2 (±10.7) out of 48 points. We found a significant correlation between both hippocampi and the posterior cingulate and ventral medial prefrontal cortex. However, we did not find an association between the hippocampal connectivity and the memory scores. Conclusions: The lack of association with memory scores might be associated with low brain reserve in this group of individuals.

P3-305: Exploring the Anatomical Substrate of Episodic Memory: the Structural Mri Correlates of the Free and Cued Selective Reminding Test in ihe Memento Cohort

2016 ◽  
Vol 12 ◽  
pp. P958-P958
Author(s):  
Stephane Epelbaum ◽  
Vincent Bouteloup ◽  
Jean-Francois Mangin ◽  
Bruno Vellas ◽  
Florence Pasquier ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Structural Mri ◽  
Selective Reminding ◽  
Selective Reminding Test

scholarly journals The relationship between eye movements and autobiographical recollection is mediated by individual differences in autobiographical capacity

2019 ◽  
Author(s):  
Michael Armson ◽  
Nicholas Diamond ◽  
Laryssa Levesque ◽  
Jennifer Ryan ◽  
Brian Levine
Keyword(s):  
Individual Differences ◽  
Eye Movements ◽  
Free Recall ◽  
Memory Performance ◽  
Fixation Rate ◽  
Blank Screen ◽  
Autobiographical Recall ◽  
The Relationship ◽  
Precise Role

The precise role of visual mechanisms in recollection of personal past events is unknown. The present study addresses this question from the oculomotor perspective. Participants freely recalled past episodes while viewing a blank screen under free and fixed viewing conditions. Memory performance was quantified with the Autobiographical Interview, which separates internal (episodic) and external (non-episodic) details. In Study 1, fixation rate was predictive of the number of internal (but not external) details recalled across both free and fixed viewing. In Study 2, using an experimenter-controlled staged event, we again observed the effect of fixations on free recall of internal (but not external) details, but this was modulated by individual differences in AM, such that the coupling between fixations and internal details was greater for those endorsing higher than lower episodic AM. These results suggest that eye movements promote richness in autobiographical recall, particularly for those with strong AM.

scholarly journals Associative memory and in vivo brain pathology in asymptomatic presenilin-1 E280A carriers

Neurology ◽  
2020 ◽  
Vol 95 (10) ◽  
pp. e1312-e1321
Author(s):  
Edmarie Guzmán-Vélez ◽  
Jairo Martínez ◽  
Kate Papp ◽  
Ana Baena ◽  
Clara Vila-Castelar ◽  
...  
Keyword(s):  
Free Recall ◽  
Cued Recall ◽  
Cognitive Testing ◽  
Presenilin 1 ◽  
Brain Pathology ◽  
Total Recall ◽  
Disease Trajectory ◽  
Selective Reminding ◽  
Selective Reminding Test

ObjectiveTo determine whether performance on the Free and Cued Selective Reminding Test (FCSRT) is associated with PET in vivo markers of brain pathology and whether it can distinguish those who will develop dementia later in life due to autosomal-dominant Alzheimer disease (AD) from age-matched controls.MethodsTwenty-four cognitively unimpaired Presenilin-1 E280A carriers (mean age 36 years) and 28 noncarriers (mean age 37 years) underwent Pittsburg compound B-PET (amyloid), flortaucipir-PET (tau), and cognitive testing, including the FCSRT (immediate and delayed free and cued recall scores). Linear regressions were used to examine the relationships among FCSRT scores, age, mean cortical amyloid, and regional tau burden.ResultsFree and total recall scores did not differ between cognitively unimpaired mutation carriers and noncarriers. Greater age predicted lower free recall and delayed free and total recall scores in carriers. In cognitively impaired carriers, delayed free recall predicted greater amyloid burden and entorhinal tau, while worse immediate free recall scores predicted greater tau in the inferior temporal and entorhinal cortices. In turn, in all carriers, lower free and total recall scores predicted greater amyloid and regional tau pathology.ConclusionsFCSRT scores were associated with in vivo markers of AD–related pathology in cognitively unimpaired individuals genetically determined to develop dementia. Difficulties on free recall, particularly delayed recall, were evident earlier in the disease trajectory, while difficulties on cued recall were seen only as carriers neared the onset of dementia, consistent with the pathologic progression of the disease. Findings suggest that the FCSRT can be a useful measure to track disease progression in AD.

The Involvement of the Thalamus in Semantic Retrieval: A Clinical Group Study

2013 ◽  
Vol 25 (6) ◽  
pp. 872-886 ◽  
Author(s):  
Giulio Pergola ◽  
Christian Bellebaum ◽  
Britta Gehlhaar ◽  
Benno Koch ◽  
Michael Schwarz ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Memory Performance ◽  
Striking Difference ◽  
Clinical Group ◽  
Healthy Controls ◽  
Semantic Retrieval ◽  
Retrieval Task ◽  
Phonological Representations

There is increasing attention about the role of the thalamus in high cognitive functions, including memory. Although the bulk of the evidence refers to episodic memory, it was recently proposed that the mediodorsal (MD) and the centromedian–parafascicular (CM–Pf) nuclei of the thalamus may process general operations supporting memory performance, not only episodic memory. This perspective agrees with other recent fMRI findings on semantic retrieval in healthy participants. It can therefore be hypothesized that lesions to the MD and the CM–Pf impair semantic retrieval. In this study, 10 patients with focal ischemic lesions in the medial thalamus and 10 healthy controls matched for age, education, and verbal IQ performed a verbal semantic retrieval task. Patients were assigned to a target clinical group and a control clinical group based on lesion localization. Patients did not suffer from aphasia and performed in the range of controls in a categorization and a semantic association task. However, target patients performed poorer than healthy controls on semantic retrieval. The deficit was not because of higher distractibility but of an increased rate of false recall and, in some patients, of a considerably increased rate of misses. The latter deficit yielded a striking difference between the target and the control clinical groups and is consistent with anomia. Follow-up high-resolution structural scanning session in a subsample of patients revealed that lesions in the CM–Pf and MD were primarily associated with semantic retrieval deficits. We conclude that integrity of the MD and the CM–Pf is required for semantic retrieval, possibly because of their role in the activation of phonological representations.

scholarly journals Prognostic Value of Learning and Retention Measures from the Free and Cued Selective Reminding Test to Identify Incident Mild Cognitive Impairment

2021 ◽  
pp. 1-8
Author(s):  
Ellen Grober ◽  
Cuiling Wang ◽  
Melissa Kitner-Triolo ◽  
Richard B. Lipton ◽  
Claudia Kawas ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Free Recall ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Standard Deviation Increase ◽  
Immediate Recall ◽  
Cox Proportional Hazards Models ◽  
Selective Reminding ◽  
Selective Reminding Test

Abstract Objective: To compare the predictive validity of learning and retention measures from the picture version of the Free and Cued Selective Reminding Test with Immediate Recall (pFCSRT + IR) for identifying incident mild cognitive impairment (MCI). Methods: Learning was defined by the sum of free recall (FR) and retention by delayed free recall (DFR) tested 15–20 min later. Totally, 1422 Baltimore Longitudinal Study of Aging (BLSA) participants (mean age 69.6 years, 54% male, mean 16.7 years of education) without dementia or MCI received the pFCSRT + IR at baseline and were followed longitudinally. Cox proportional hazards models were used to evaluate the effect of baseline learning and retention on risk of MCI. Results: In total, 187 participants developed MCI over a median of 8.1 years of follow-up. FR and DFR each predicted incident MCI adjusting for age, sex, and education. Also, each independently predicted incident MCI in the presence of the other with similar effect sizes: around 20% decrease in the hazard of MCI corresponding to one standard deviation increase in FR or DFR. Conclusion: The practice of preferring retention over learning to predict incident MCI should be reconsidered. The decision to include retention should be guided by time constraints and patient burden.

The Role of Free and Cued Selective Reminding Test in Predicting [18F]Florbetaben PET Results in Mild Cognitive Impairment and Mild Dementia

2020 ◽  
Vol 73 (4) ◽  
pp. 1647-1659
Author(s):  
Marco Spallazzi ◽  
Giovanni Michelini ◽  
Federica Barocco ◽  
Francesca Dieci ◽  
Sandra Copelli ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mild Dementia ◽  
Selective Reminding ◽  
Selective Reminding Test

[P2-359]: EDUCATION CAN STRENGTHEN THE ROLE OF THE LEFT HIPPOCAMPUS IN EPISODIC MEMORY PERFORMANCE

2017 ◽  
Vol 13 (7S_Part_15) ◽  
pp. P761-P762 ◽  
Author(s):  
Elisa de Paula França Resende ◽  
Kevin Chiang ◽  
Isabel Allen ◽  
Henrique Cerqueira Guimaraes ◽  
Maira Tonidandel Barbosa ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Memory Performance ◽  
Left Hippocampus

scholarly journals Encoding process in delayed recall impairment and rate of forgetting in Alzheimer's disease

2001 ◽  
Vol 59 (2A) ◽  
pp. 171-174 ◽  
Author(s):  
Jairo Degenszajn ◽  
Paulo Caramelli ◽  
Leonardo Caixeta ◽  
Ricardo Nitrini
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Learning Phase ◽  
Delayed Recall ◽  
Selective Reminding ◽  
Moderate Dementia ◽  
Selective Reminding Test

OBJECTIVE: To assess the role of impaired encoding in learning and in delayed recall disturbances, and to evaluate the rate of forgetting in AD. METHOD: Fifteen AD patients with mild or moderate dementia and 15 normal matched controls were assessed with the Buschke Selective Reminding Test. Delayed recall was evaluated after 30 minutes and after 24 hours. RESULTS: AD patients had a poorer performance across the six trials of the learning phase as well as in both delayed recall evaluations, with no difference between recall at 30 minutes and at 24 hours. CONCLUSION: Performance in the learning phase was as specific and almost as sensitive as the performance in delayed recall for AD diagnosis. Encoding impairment was responsible for poorer learning and rapid displacement of previous learned material in the AD group. Finally, we did not find a higher rate of forgetting in AD patients.

scholarly journals Free Recall Episodic Memory Performance Predicts Dementia Ten Years prior to Clinical Diagnosis: Findings from the Betula Longitudinal Study

2015 ◽  
Vol 5 (2) ◽  
pp. 191-202 ◽  
Author(s):  
Carl-Johan Boraxbekk ◽  
Anders Lundquist ◽  
Annelie Nordin ◽  
Lars Nyberg ◽  
Lars-Göran Nilsson ◽  
...  
Keyword(s):  
Free Recall ◽  
Episodic Memory ◽  
Cognitive Performance ◽  
Clinical Diagnosis ◽  
Predictive Value ◽  
Late Onset ◽  
Multinomial Logistic Regression ◽  
Recall Performance ◽  
Memory Performance ◽  
Population Sample

Background/Aims: Early dementia diagnosis is a considerable challenge. The present study examined the predictive value of cognitive performance for a future clinical diagnosis of late-onset Alzheimer's disease or vascular dementia in a random population sample. Methods: Cognitive performance was retrospectively compared between three groups of participants from the Betula longitudinal cohort. Group 1 developed dementia 11-22 years after baseline testing (n = 111) and group 2 after 1-10 years (n = 280); group 3 showed no deterioration towards dementia during the study period (n = 2,855). Multinomial logistic regression analysis was used to investigate the predictive value of tests reflecting episodic memory performance, semantic memory performance, visuospatial ability, and prospective memory performance. Results: Age- and education-corrected performance on two free recall episodic memory tests significantly predicted dementia 10 years prior to clinical diagnosis. Free recall performance also predicted dementia 11-22 years prior to diagnosis when controlling for education, but not when age was added to the model. Conclusion: The present results support the suggestion that two free recall-based tests of episodic memory function may be useful for detecting individuals at risk of developing dementia 10 years prior to clinical diagnosis.

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