Comparison of Impairment of PFT due to Plain Vs Pegylated Interferon Therapy in pts With Ch. Hepatitis C Virus Infection

2021 ◽  
Vol 15 (12) ◽  
pp. 3337-3340
Author(s):  
Umer Sohail ◽  
Zahid Hussain Shah ◽  
Sohaib Haider Zaidi ◽  
Umair Ashfaq ◽  
Salman Kazmi
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Pulmonary Function ◽  
Interferon Therapy ◽  
Pulmonary Function Tests ◽  
Pegylated Interferon ◽  
Function Tests ◽  
Before And After ◽  
Group 2 ◽  
Group 1

Aim: To compare Impairment of pulmonary function tests due to plain versus pegylated interferon therapy in the diagnosed cases of chronic Hepatitis C Methodology: In this comparative study, 71 patients fulfilling inclusion criteria were randomly included in each group. Study consisted; Group 1 (Control Group): Pulmonary Function Tests performed before and after the completion of 24 weeks of treatment with Plain/conventional Interferons and ribavirin. Group 2 (experimental Group): PFTs performed before and after the completion of 24 weeks treatment with Pegylated Interferon Therapy and ribavirin. Referred patients of both groups underwent spirometry (PFTs) at baseline and at the end of 6 months Results: Mean value observed for age was 49.86, for height 1.592 meters, for weight 62.6 kg and for BMI 24.9. Before and after therapy mean for FEV1 was 90.19 and 67.71 and it was 91.34 and 67.83 for FVC respectively. N=71 patients were enrolled in both groups. Male gender showed high prevalence 70%. Group-1 (46 vs 25) & group-2 (45 vs 26) male to female ratio seen. Adult age group hold bulk of disease (30 - 40 years of age). Patients preferred winter season for treatment (Sep to Nov). Low viral load and genotype 3a were common findings (82% and 35%). Constitutional symptoms improved after therapy (86 to 44%) as a whole. Individually, anorexia, body aches, lethargy and fever were like this (39 vs 19%, 66 vs 28%, 54 vs 30%, 19 vs 11%) pre and post therapy. Cough and dyspnea reported in 7% and 20% respectively. Conclusion: According to the present study, treatment with pegylated interferon and ribavirin is associated with impairment of pulmonary function tests similarly as treatment with plain interferon and ribavirin. Long Half-life of pegylated interferon cause more impairment in lung functions as indicated by limited available literature (Foster GR et al). Keywords: Chronic hepatitis C, Pulmonary function tests, plain/Conventional interferon therapy, Pegylated interferon therapy.

scholarly journals Frequency of restrictive pulmonary function tests in patients with chronic Hepatitis C

2021 ◽  
Vol 1 (4) ◽  
pp. e223
Author(s):  
Shahid Hamid ◽  
Khalid Mehmood Khan ◽  
Fawad Ahmed ◽  
Asia Firdous
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Pulmonary Fibrosis ◽  
Pulmonary Function ◽  
Chronic Hepatitis C ◽  
Lung Fibrosis ◽  
Pulmonary Function Tests ◽  
Hepatitis C Infection ◽  
Function Tests ◽  
Restrictive Pattern

Hepatis C infection is a common health problem world wide and is the major cause of chronic liver disease in Pakistan. Common complications of chronic hepatitis c infection are cirrhosis, ascities and hepatocellular carcinoma. Also HCV infection is associated with several extra hepatic manifestations including interstitial lung fibrosis. It has been found that frequency of pulmonary fibrosis is increased in patients with cirrhosis of liver as the stage of cirrhosis advances.This lung fibrosis can cause restrictive pattern of pulmonary function tests. This study was conducted to determine frequency of restrictive pulmonary function in patients with different stages of chronic hepatitis C  infection, based on child pough classification. Study design This is descriptive case study Method 99 patients of age range 20 to 80 year, both males and females having chronic hepatitis C infection and interferon based treatment naïve patients were included from outpatient and inpatient department were selected. Patients were divided into three groups according to child’s criteria i.e. group A, group B, and group C. Pulmonary function tests were performed on patients in all three groups to look for  FEV1/FVC ratio in all patients. FEV1/FVC ratio  more than 80 was considered as restrictive pulmonary function. Results Out of 99 patients 32(35%) were found to have restrictive pattern of pulmonary functions Conclusion Chronic hepatitis C infection is associated with restrictive pattern of pulmonary function, suggestive of pulmonary fibrosis.

scholarly journals Should Routine Pulmonary Function Tests be Performed in Patients with Left Ventricular Dysfunction and/or Congestive Heart Failure undergoing Cardiac Surgery?

2021 ◽  
Author(s):  
Turki Albacker ◽  
Abdulaziz Alhothali ◽  
Amr Arafat ◽  
Khaled Algarni ◽  
Ahmed Eldemerdash ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Cardiac Surgery ◽  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Left Ventricular ◽  
Function Tests ◽  
Severe Reduction ◽  
Group 2 ◽  
Group 1

Background It is controversial whether pulmonary function testing should be performed routinely in cardiac surgery patients. The aim of our study was to focus on patients who have congestive heart failure, caused by left ventricular dysfunction or left-sided heart valve disease, and study the prognostic value of performing preoperative pulmonary function testing on their postoperative outcomes Methods: This is a retrospective propensity score matched study that included 366 patients with congestive heart failure who underwent cardiac surgery and had preoperative pulmonary function test. The patients were divided into two groups: Group 1; who had a normal or mild reduction in pulmonary function tests and group 2; who had moderate to severe reduction in pulmonary function tests. The postoperative outcomes, including pulmonary complications, were compared between the two groups. Results Pulmonary function tests were normal or mildly reduced in 190 patients (group 1) and moderately to severely reduced in 176 patients (group 2). Propensity matching identified 111 matched pairs in each group with balanced preoperative and operative characteristics. Compared to group 1, Group 2 had longer duration of mechanical ventilation [12 (7.5- 16) vs. 9 (6.5- 13) hours, p<0.001], higher postoperative Creatinine [111 (90- 142) vs. 105 (81- 128) µmol/dl, p=0.02] and higher hospital mortality (6.31% vs 0%, p=0.02). Conclusion In congestive heart failure patients undergoing cardiac surgery, moderate to severe reduction of pulmonary function test was associated with longer duration of mechanical ventilation and higher hospital mortality.

scholarly journals Ropeginterferon alfa-2b every 2 weeks as a novel pegylated interferon for patients with chronic hepatitis B

2020 ◽  
Author(s):  
Yi-Wen Huang ◽  
Chao-Wei Hsu ◽  
Sheng-Nan Lu ◽  
Ming-Lung Yu ◽  
Chien-Wei Su ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hbeag Seroconversion ◽  
Pegylated Interferon ◽  
Preliminary Evaluation ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Background Ropeginterferon alfa-2b is a novel mono-pegylated interferon that has only one major form as opposed to 8–14 isomers of other on-market pegylated interferon, allowing injection every two or more weeks with higher tolerability. It received European Medicines Agency and Taiwan marketing authorization in 2019 and 2020, for treatment of polycythemia vera. This phase I/II study aimed to have preliminary evaluation of safety and efficacy in chronic hepatitis B. Methods Thirty-one HBeAg-positive and 31 HBeAg-negative were stratified by HBeAg status and randomized at 1:1:1 ratio to q2w ropeginterferon alfa-2b 350 μg (group 1), q2w 450 μg (group 2) or q1w PEG-IFN alfa-2a 180 μg (group 3). Each patient received 48-week treatment (TW48) and 24-week post-treatment follow-up (FW24). Results The baseline demographics were comparable among the three groups, except for mean HBeAg in HBeAg-positive patients (2.90, 2.23, 2.99 log10 S/CO, respectively). Cumulative HBeAg seroconversion rate at follow-up period was 27.3% (3/11), 36.4% (4/11), and 11.1% (1/9) with time to HBeAg seroconversion starting from TW24, TW16, and TW48 in group 1, 2, and 3, respectively. The rate of HBV DNA < 2000 IU/mL and HBsAg levels < 1500 IU/mL at FW24 were comparable in all groups. Ropeginterferon alfa-2b (group 1 & 2) had numerically lower incidence of rash (9.5% and 4.5%) as compared to PEG-IFN alfa-2a (36.8%). Ropeginterferon alfa-2b 350 μg (group 1) had more ALT elevation (38.1%), however the rate was comparable in group 2 (9.1%) and group 3 (10.5%). Conclusion In this preliminary study, ropeginterferon alfa-2b, although in only half the number of injections, is as safe and effective as pegylated interferon alfa-2a for chronic hepatitis B. Graphic abstract

Serological Markers of Autoimmunity in Renal Transplant Patients before and after Alpha-interferon Therapy for Chronic Hepatitis C

1996 ◽  
Vol 16 (6) ◽  
pp. 478-483 ◽  
Author(s):  
Lionel Rostaing ◽  
Fran&ccedil;oise Oksman ◽  
Jacques Izopet ◽  
Emmanuel Baron ◽  
Jean-Marc Cisterne ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Renal Transplant ◽  
Chronic Hepatitis C ◽  
Interferon Therapy ◽  
Alpha Interferon ◽  
Serological Markers ◽  
Transplant Patients ◽  
Before And After ◽  
Renal Transplant Patients

scholarly journals Air stacking: effects on pulmonary function in patients with spinal muscular atrophy and in patients with congenital muscular dystrophy,

2014 ◽  
Vol 40 (5) ◽  
pp. 528-534 ◽  
Author(s):  
Tanyse Bahia Carvalho Marques ◽  
Juliana de Carvalho Neves ◽  
Leslie Andrews Portes ◽  
João Marcos Salge ◽  
Edmar Zanoteli ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Pulmonary Function ◽  
Spinal Muscular Atrophy ◽  
Muscular Atrophy ◽  
Pulmonary Function Tests ◽  
Congenital Muscular Dystrophy ◽  
Spinal Deformities ◽  
Respiratory Complications ◽  
Function Tests ◽  
Before And After

OBJECTIVE: Respiratory complications are the main causes of morbidity and mortality in patients with neuromuscular disease (NMD). The objectives of this study were to determine the effects that routine daily home air-stacking maneuvers have on pulmonary function in patients with spinal muscular atrophy (SMA) and in patients with congenital muscular dystrophy (CMD), as well as to identify associations between spinal deformities and the effects of the maneuvers. METHODS: Eighteen NMD patients (ten with CMD and eight with SMA) were submitted to routine daily air-stacking maneuvers at home with manual resuscitators for four to six months, undergoing pulmonary function tests before and after that period. The pulmonary function tests included measurements of FVC; PEF; maximum insufflation capacity (MIC); and assisted and unassisted peak cough flow (APCF and UPCF, respectively) with insufflations. RESULTS: After the use of home air-stacking maneuvers, there were improvements in the APCF and UPCF. In the patients without scoliosis, there was also a significant increase in FVC. When comparing patients with and without scoliosis, the increases in APCF and UPCF were more pronounced in those without scoliosis. CONCLUSIONS: Routine daily air-stacking maneuvers with a manual resuscitator appear to increase UPCF and APCF in patients with NMD, especially in those without scoliosis.

Pulmonary Function Tests Before and After Stereotactic Radiation of the Lung

2007 ◽  
Vol 69 (3) ◽  
pp. S510 ◽  
Author(s):  
M. Bucci ◽  
J.Y. Chang ◽  
M. McAleer ◽  
Z. Liao ◽  
T. Guerrero ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Stereotactic Radiation ◽  
Function Tests ◽  
Before And After
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