scholarly journals Histopathological span of diseases in patients going through hysterectomies: an audit of 190 consecutive hysterectomy specimens in Multan

2021 ◽  
Vol 15 (7) ◽  
pp. 1729-1732
Author(s):  
Zertaj Kashif ◽  
Sonia Zafar W. ◽  
Sehar Shamshad Ali ◽  
M. Bilal Pasha ◽  
Kanwar Sajid Ali ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Histopathological Examination ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Therapeutic Modality ◽  
Gynecological Disorders ◽  
Track Record ◽  
Women's Lives ◽  
Microscopic Diagnosis ◽  
Chronic Cervicitis

Introduction: Gynecological diseases affect women’s lives in numerous manners. They are frequent in all communities but the types of disorders and their presentations differ substantially in various regions and races. However, the studies and researches specifying these disorders in particular regions and communities are very low in number. Hysterectomy is one of the most frequently opted operations worldwide particularly in developing countries and hardly any studies are done about its epidemiology and prevalence in Multan region of Pakistan. Objective: The objective of this study is to assess the variety of histopathological diseases in patients undergoing hysterectomies in Multan region Design: Retrospective study including 190 hysterectomy specimens. Place and duration: Department of Histopathology Bakhtawar Amin Medical & Dental College, Multan from January 2019 to December 2020. Methodology: Histopathology reports of all hysterectomy specimens removed due to gynecological disorders were included. All the relevant data like age, parity, clinical manifestations, indication and type of hysterectomy were recorded along with histopathological microscopic diagnosis of cervix, endometrium, myometrium, fallopian tubes and ovaries. The data was collected from medical track record, histopathological request form and histopathology report files. Results: A total of 190 hysterectomies were received in histopathology department. The mean age was 47.8 years (ranging from 25-75 years). Majority of the ladies were between age groups 41-50 years. The major presenting complaint was menstrual irregularity followed by abdominal pain. Out of 190 specimen, 170 (89.5%) of hysterectomies were done because of non neoplastic/ benign conditions. Chronic cervicitis, adenomyosis and leiomyomata were the most commonly noticed incidental findings. Conclusion: Hysterectomy is an extensively used therapeutic modality, largely for benign non neoplastic disorders to relieve the clinical symptoms and to enhance the living conditions. Presence of incidental diseases in majority of hysterectomy specimens indicates that for conclusive opinion, histopathological examination is must. Key words: Histopathology, hysterectomy, benign gynecological disorders, leiomyoma, adenomyosis

scholarly journals Study of correlation of ultrasonography with surgical evaluation of adnexal masses: a prospective study

2018 ◽  
Vol 7 (10) ◽  
pp. 4218
Author(s):  
Urmila Tripathi ◽  
Geetanjali Munda
Keyword(s):  
Prospective Study ◽  
Clinical Symptoms ◽  
Histopathological Examination ◽  
Abdominal Mass ◽  
Age Groups ◽  
Serous Cystadenoma ◽  
Ovarian Tumors ◽  
Adnexal Masses ◽  
Malignant Changes ◽  
A Prospective Study

Background: Adnexal masses are one of the most common pathologies among women of all age groups. Ovarian tumors, alone, represent two thirds of these cases. Malignant ovarian tumors are the fourth most common cause of death in women. Accurate diagnosis is required foremost for proper treatment and management of the patients.Methods: A prospective study done on 100 patients with adnexal masses presenting to Department of Obstetrics and Gynecology at Kamla Raja Hospital, G.R.M.C, Gwalior from February 2015 to August 2016. Firstly, the cases were studied by ultrasonography then intraoperatively and simultaneous sampling for HPE done. The study included women with clinical symptoms of pain abdomen/ discomfort, bleeding per vaginum, abdominal mass was subjected to ultrasonography, diagnosed with adnexal mass. 100 indicated patients were taken for surgery and intraoperative tissue and fluid samples were taken and sent for HPE.Results: No discordance found regarding laterality of adnexal masses between ultrasonographical findings and surgical findings. 69% cases were devoid of any septation/locules/nodules. Most common pathology found to be ectopic pregnancy. Most common benign ovarian mass encountered was serous cystadenoma (31.1%) and malignant mass was serous adenocarcinoma (12.7%). Apart from 13 malignant adnexal masses, 2 adnexal masses had malignant changes found on histopathological examination. 11 cases were found to be of advanced stage on surgical findings, which then confirmed by HPE.Conclusions: There is positive correlation between ultrasonographical and surgerical evaluation of adnexal masses. Correlation of the lesion’s location and appearance at imaging with the surgical findings will aid in the detection of potential pathology reporting errors.

scholarly journals FEATURES OF CLINICAL SYMPTOMS AND THE INFLUENCE OF RISK FACTORS ON THE OCCURRENCE OF BRONCHIAL ASTHMA IN CHILDREN OF LVIV REGION OF DIFFERENT AGES

2021 ◽  
pp. 96-101
Author(s):  
O. R. Trutiak ◽  
O. L. Lychkovska ◽  
R. R. Holovyn ◽  
M. I. Dats-Opoka
Keyword(s):  
Risk Factors ◽  
Preschool Children ◽  
Bronchial Asthma ◽  
Clinical Symptoms ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Physical Development ◽  
Shortness Of Breath ◽  
Different Ages ◽  
Asthma In Children

Bronchial asthma (BA) is a common chronic pathology of the lower respiratory tract in children. The first manifestations of the disease can begin at any age, but the clinical features, of the course, are different in different periods of childhood. Manifestations and course of asthma may disappear or progress with age. Therefore, it is likely that there are differences in the pathophysiology, inflammatory response of the body and the features of the clinic of asthma in children of different ages, which affects the diagnosis and treatment. The aim of the study was to determine the features of clinical symptoms and the influence of risk factors for asthma on its occurrence in children of different ages. Materials and methods. We analyzed the anamnesis and clinical symptoms of 57 children aged 3 to 18 years, who were treated from September 2020 to June 2021 in the Lviv Regional Children's Clinical Hospital “OHMATDYT” and in the Lviv Municipal City Children's Clinical Hospital. The age groups did not differ statistically in the severity of asthma (P> 0.05). Thus, in group 1 was 1 patient (9.09%) with mild form, 1 patient (9.09%) - moderate persistent form, 8 patients (72.73%) - with severe persistent form. Among patients of age group 2 was 1 patient (3.85%) with mild persistent form, 3 children (11.54%) - moderate and 21 children (80.77%) - with severe persistent form. In group 3 was 1 patient (5%) with a mild persistent form, 6 patients (30%) - moderate and 12 children (80%) - with a severe persistent form. The vast majority of patients were boys (84.21 ± 4.83%). All patients underwent general clinical examinations, spirometry, and allergy tests. We used the clinical-anamnestic method to perform the tasks of the work, which consisted in collecting a detailed somatic and genealogical anamnesis during the parents` questionnaire. Physical development of children was assessed using centile tables. Statistics were evaluated by calculating Student's t-test and Pearson's consistency test. Preschool children with asthma were more likely to experience shortness of breath during exercise and a wet low-yielding cough, and children of primary and secondary school age were more characterized by concomitant allergic rhinitis. Autumn was more unfavorable period for the exacerbation of clinical manifestations of asthma in children of Lviv region was period. We did not find correlation of birth weight on the timing of asthma. However, a burdensome obstetric history contributed to the early development of clinical manifestations of asthma. Preschool children were more likely to be exposed to nicotine during the antenatal period and had a shorter duration of breastfeeding, which may be a probable risk factor for asthma in preschool children. In 77% of children from different age groups were burdened with a history of allergies, with 66% of cases more pronounced in the maternal line. An analysis of physical development revealed that most preschool children were overweight. Conclusions. Asthma has features of clinical symptoms in children of different ages - shortness of breath during exercise and whooping cough are characteristic of preschool children, and concomitant chronic persistent rhinitis - for older age groups. Seasonal exacerbations are characteristic of asthma in children; in particular, the autumn period is more unfavorable, common for asthmatics in children of all ages among patients in Lviv region. Maternal smoking during pregnancy has a significant effect on the risk of developing asthma in children. Also, a burdened maternal allergy history and overweight child contributes to the development of asthma in children.

scholarly journals Pattern of Histopathologically Confirmed Uterine and Ovarian Anomeli Among 98 Hysterectomies Attending a Private Medical College Hospital, Dhaka

2017 ◽  
Vol 8 (1) ◽  
pp. 6-9
Author(s):  
Tabassum Tahmin Sajani ◽  
Tanjila Tahmin Sarnali ◽  
Md Atiqur Rahman ◽  
Shoib Ahmed
Keyword(s):  
Histopathological Examination ◽  
Developed Countries ◽  
Age Group ◽  
Pathological Findings ◽  
Carcinoma Cervix ◽  
College Hospital ◽  
Medical College ◽  
Total Hysterectomy ◽  
Gynecological Disorders ◽  
Chronic Cervicitis

Background: Endometrial diseases ranked among the most common gynecological disorders that affect women globally. This study was undertaken to identify the most common pathologies identified in hysterectomy specimens.Materials & Methods: The present study was conducted in the Department of Pathology, Anwer Khan Modern Medical College, Dhaka over a period of 6 months from July to December 2013. Ninety eight (98) hysterectomy specimens were received by the pathology department during this period. On receiving the hysterectomy specimens, the gross features were noted. A detailed microscopic examination was done to arrive at an accurate diagnosis.Result: Most of the women 54% were 40-49 years age group followed by 25% in 30-39 years age group. Chronic cervicitis and adenomyosis were the commonest pathological findings in (80.6%) and (32.7%) respectively. Other pathologies identified include Leiomyoma (23.5%), endometrial hyperplasia (17.4%), endometrial polyp (4.1%) and PID with hemorrhagic infection (1.0%). Two cases of carcinoma cervix (2.0%), two local invasion of tumors (2.0%) and one adenocarcima (1.0%) was found. Type of operation most common is total hysterectomy with oophorectomy (51.0%).Conclusion: Hysterectomy still remains the widely used treatment modality even in developed countries. The ultimate diagnosis is only on histology, so every hysterectomy specimen should be subjected to histopathological examination. Benign pathologies are more common than their malignant counterparts and the most common pathologies identified in hysterectomy specimens are chronic cervicitis, adenomyosis and leiomyoma.Anwer Khan Modern Medical College Journal Vol. 8, No. 1: Jan 2017, P 6-9

scholarly journals COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes

2020 ◽  
Author(s):  
Mohammad Ali Ashraf ◽  
Nasim Shokouhi ◽  
Elham Shirali ◽  
Fateme Davari-tanha ◽  
Omeed Memar ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Treatment Options ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Ground Glass Opacity ◽  
Post Discharge ◽  
Reactive Protein ◽  
Presenting Symptoms ◽  
Discharged Patients ◽  
Symptom Relapse

Abstract Background There is a growing need for information regarding the recent coronavirus disease of 2019 (Covid-19). We present a comprehensive report of Covid-19 patients in Iran.Methods One hundred hospitalized patients with Covid-19 were studied. Data on potential source of exposure, demographic, clinical, and paraclinical features, therapy outcome, and post-discharge follow-up were analyzed.Results The median age of the patients was 58 years, and the majority of the patients (72.7%) were above 50 years of age. Fever was present in 45.2% of the patients on admission. The most common clinical symptoms were shortness of breath (74%) and cough (68%). Most patients had elevated C-reactive protein (92.3%), elevated erythrocyte sedimentation rate (82.9%), lymphocytopenia (74.2 %) on admission. Lower lobes of the lung were most commonly involved, and ground-glass opacity (81.8%) was the most frequent finding in CT scans. The administration of hydroxychloroquine improved the clinical outcome of the patients. Lopinavir/ritonavir was efficacious at younger ages. Of the 70 discharged patients, 40% had symptom relapse, (8.6%) were readmitted to the hospital, and 3 patients (4.3%) died.Conclusions This report demonstrates a heterogeneous nature of clinical manifestations in patients affected with Covid-19. The most common presenting symptoms are non-specific, so attention should be made on broader testing, especially in age groups with the greatest risk and younger individuals who can serve as carriers of the disease. Hydroxychloroquine and lopinavir/ritonavir (in younger age group) can be potential treatment options. Finally, patients discharged from the hospital should be followed up because of potential symptom relapse.

scholarly journals COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes

2020 ◽  
Author(s):  
Mohammad Ali Ashraf ◽  
Nasim Shokouhi ◽  
Elham Shirali ◽  
Fateme Davari-tanha ◽  
Omeed Memar ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Treatment Options ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Ground Glass Opacity ◽  
Post Discharge ◽  
Reactive Protein ◽  
Presenting Symptoms ◽  
Discharged Patients ◽  
Symptom Relapse

AbstractPurposeThere is a growing need for information regarding the recent coronavirus disease of 2019 (Covid-19). We present a comprehensive report of Covid-19 patients in Iran.MethodsOne hundred hospitalized patients with Covid-19 were studied. Data on potential source of exposure, demographic, clinical, and paraclinical features, therapy outcome, and post-discharge follow-up were analyzed.ResultsThe median age of the patients was 58 years, and the majority of the patients (72.7%) were above 50 years of age. Fever was present in 45.2% of the patients on admission. The most common clinical symptoms were shortness of breath (74%) and cough (68%). Most patients had elevated C-reactive protein (92.3%), elevated erythrocyte sedimentation rate (82.9%), lymphocytopenia (74.2 %) on admission. Lower lobes of the lung were most commonly involved, and ground-glass opacity (81.8%) was the most frequent finding in CT scans. The administration of hydroxychloroquine improved the clinical outcome of the patients. Lopinavir/ritonavir was efficacious at younger ages. Of the 70 discharged patients, 40% had symptom relapse, (8.6%) were readmitted to the hospital, and 3 patients (4.3%) died.ConclusionThis report demonstrates a heterogeneous nature of clinical manifestations in patients affected with Covid-19. The most common presenting symptoms are non-specific, so attention should be made on broader testing, especially in age groups with the greatest risk and younger individuals who can serve as carriers of the disease. Hydroxychloroquine and lopinavir/ritonavir (in younger age group) can be potential treatment options. Finally, patients discharged from the hospital should be followed up because of potential symptom relapse.

scholarly journals Comparison of the clinical manifestations between different age groups of patients with overseas imported COVID-19

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243347
Author(s):  
Yujuan Han ◽  
Zujin Luo ◽  
Wenliang Zhai ◽  
Yue Zheng ◽  
Huan Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Symptoms ◽  
Demographic Data ◽  
Disease Onset ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Symptom Improvement ◽  
Group A ◽  
Group B

The current study investigated the clinical manifestations and outcomes of different age groups of patients with overseas imported COVID-19. In total, 53 COVID-19 patients admitted to the designated Beijing Xiaotangshan Hospital between March 16 and April 15 of 2020 were included. Based on the percentage of disease aggravation during hospital stay according to CT, the patients were divided into two groups: ≤40 years (group A; n = 41) and >40 years (group B; n = 12). The demographic data, epidemiological history, disease courses, potential complications, clinical symptoms, lab indices, chest CT outcomes, treatment protocols and turnovers of the two groups were compared. According to clinical typing, compared with group A, group B had a significantly greater proportion of the common type of COVID-19 (P<0.05) and greater comorbidity of type 2 diabetes (P<0.001). The two groups presented significantly different lab indices. Group B showed significantly more frequent CT abnormalities, with greater proportions of multiple lesions and bilateral lung involvement (P<0.05). During hospitalization, group B had a greater proportion of disease aggravation according to CT (P<0.01). Compared with group A, group B received a significantly greater proportion of antiviral therapy and presented a significantly greater occurrence of adverse drug reactions (P<0.05). The two groups did not significantly differ in time from admission to clinical symptom improvement or from disease onset to negative outcomes according to nucleic acid testing, the appearance of IgG or the appearance of IgM. They also did not significantly differ in length of stay. Older imported COVID-19 patients, particularly those with type 2 diabetes, showed a broader pulmonary extent and faster development of the disease, more severe pathogenetic conditions and a greater risk of developing a critically severe type. Increased attention should be given to this population in clinical practice.

scholarly journals Clinical manifestations in primary ciliary dyskinesia: systematic review and meta-analysis

2016 ◽  
Vol 48 (4) ◽  
pp. 1081-1095 ◽  
Author(s):  
Myrofora Goutaki ◽  
Anna Bettina Meier ◽  
Florian S. Halbeisen ◽  
Jane S. Lucas ◽  
Sharon D. Dell ◽  
...  
Keyword(s):  
Systematic Review ◽  
Primary Ciliary Dyskinesia ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Explanatory Factors ◽  
Symptom Prevalence ◽  
Meta Analyses ◽  
Ciliary Dyskinesia

Few original studies have described the prevalence and severity of clinical symptoms of primary ciliary dyskinesia (PCD). This systematic review and meta-analysis aimed to identify all published studies on clinical manifestations of PCD patients, and to describe their prevalence and severity stratified by age and sex.We searched PubMed, Embase and Scopus for studies describing clinical symptoms of ≥10 patients with PCD. We performed meta-analyses and meta-regression to explain heterogeneity.We included 52 studies describing a total of 1970 patients (range 10–168 per study). We found a prevalence of 5% for congenital heart disease. For the rest of reported characteristics, we found considerable heterogeneity (I2 range 68–93.8%) when calculating the weighted mean prevalence. Even after taking into account the explanatory factors, the largest part of the between-studies variance in symptom prevalence remained unexplained for all symptoms. Sensitivity analysis including only studies with test-proven diagnosis showed similar results in prevalence and heterogeneity.Large differences in study design, selection of study populations and definition of symptoms could explain the heterogeneity in symptom prevalence. To better characterise the disease, we need larger, multicentre, multidisciplinary, prospective studies that include all age groups, use uniform diagnostics and report on all symptoms.

scholarly journals Histopathological spectrum of nonneoplastic lesions of large intestine- A three year study

2021 ◽  
Vol 6 (4) ◽  
pp. 253-258
Author(s):  
Arti Rameshrao Anvikar ◽  
Leena Shrikant Salunke ◽  
Alka Vikas Gosavi ◽  
Priyanka Santosh Palve
Keyword(s):  
Large Intestine ◽  
Histopathological Examination ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Duplication Cyst ◽  
Endoscopic Biopsy ◽  
Histopathological Findings ◽  
Neoplastic Lesions ◽  
Amoebic Colitis ◽  
A Site

Large intestine is a site for an array of different nonneoplastic and neoplastic lesions. Clinical manifestations may overlap, thus making the diagnosis difficult and creating the need for tissue diagnosis. Our study aims at detail histopathological examination of the different non neoplastic lesions of large intestine. A total of 30 nonneoplastic lesions of large intestine were studied over a period of 3 years. Both resected specimens and endoscopic biopsy specimens were included. Histopathological findings were studied along with analysis of the distribution of lesions and correlation of the histopathological findings with clinical parameters. The lesions were distributed in all age groups, with maximum frequency in 5 to 8 decades. The frequency was significantly higher in males (23 cases- 76.7%) as compared to females (7 cases- 23.3%). The most common lesion was perforation (10 cases), followed by gangrene (4 cases). Two cases had gangrene with perforation. Other lesions included Hirschprung’s disease (5 cases), Crohn’s disease (two cases) and one case each of Enteric duplication cyst, tuberculosis, amoebic colitis with perforation and Peutz-Jeghers polyp. Three cases had nonspecific inflammation. Our study emphasizes the importance of histopathological examination in the management of colonic lesions

scholarly journals The etiology of viral gastroenteritis in patients requiring hospitalization: Differences between rotavirus and norovirus infections - practical or only academic significance?

2017 ◽  
Vol 145 (9-10) ◽  
pp. 498-502
Author(s):  
Radoslava Doder ◽  
Dajana Lendak ◽  
Svetlana Ilic ◽  
Nadica Kovacevic ◽  
Slavica Tomic ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Age Groups ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Polymerase Chain Reaction Method ◽  
Hospitalized Patients ◽  
Hospital Treatment ◽  
Viral Gastroenteritis ◽  
Clinical Center ◽  
Novi Sad

Introduction/Objective. Viral gastroenteritides (VGEs) have great infectious potential and may occur in all age groups. Loss of fluid due to vomiting and diarrhea represent a special risk, and may result in a more severe clinical presentation in children, the elderly, and people with chronic diseases. The aim of the study was to explore the causes of VGEs among hospitalized patients, as well as to evaluate the severity of clinical symptoms in rotavirus and norovirus infections. Methods. The observational prospective study included 191 patients aged 2?88 years who were treated at the Clinic for Infectious Diseases, Clinical Center of Vojvodina, Novi Sad, over a two-year period. Testing of stool samples for viral agents was done by the reverse-transcription polymerase chain reaction method. Positive findings were found in 59 patients. Results. Of 59 patients with confirmed viral gastroenteritis, in 31 (52.5%) it was caused by rotavirus, in 17 (28.8%) by norovirus, three patients (5.1%) had other viral causes, while co-infection with two viruses was found in eight (13.5%) patients. The severity of clinical manifestations as expressed with Vesikari score did not differ with regard to infectious agents (p = 0.353). However, patients with rotavirus infection had a higher incidence of fever (p = 0.043), longer duration of diarrhea (p = 0.015) and dehydration (p = 0.014), and longer need for hospital treatment (p = 0.030). Conclusion. The most common cause of VGEs in our hospitalized patients was rotavirus. There was no difference in the severity of clinical symptoms between rotavirus and norovirus infections.

scholarly journals DYNAMICS OF PHENOTYPIC MANIFESTATIONS OF CONNECTIVE TISSUE DYSPLASIA IN CHILDREN WITH UROANDROLOGICAL PATHOLOGY IN THE AGE ASPECT

2019 ◽  
Vol 23 (4) ◽  
pp. 188-192
Author(s):  
I. G. Vasilyeva ◽  
S. M. Sharkov ◽  
B. G. Safronov ◽  
I. E. Volkov ◽  
I. S. Burov ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Oral Cavity ◽  
Clinical Symptoms ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Preschool Age ◽  
Urogenital System ◽  
Age Group ◽  
Older Children ◽  
Connective Tissue Dysplasia

Introduction. The article includes a comparative study of phenotypic manifestations of undifferentiated connective tissue dysplasia in children of different age groups with urological and andrological pathology. Material and methods. The trial performed included 214 children aged from 1 month to 17 years with clinical manifestations of undifferentiated connective tissue dysplasia who were treated in the children’s uroandrological department for congenital malformations of the urogenital system. The generally accepted table of external phenotypic markers in scores was used in establishing undifferentiated connective tissue dysplasia . Results. In infants, the most frequent disorders were in ears and skin. In the preschool age, in the majority of cases, craniocephalic abnormalities, pathology of osteo-articular system and ears were met. The trail has revealed that the rate of ocular abnormalities increases with age. Moreover, two or more ocular problems were most common in older children. Anomalies of the oral cavity were diagnosed only in a quarter of infants and were manifested in them by a single sign. In older age groups, oral cavity anomalies were in more than half of the patients, and often they were not isolated. During the survey of senior schoolchildren, it was noted that all children of this age group had this or that disorder in their osteo-articular system, and almost always they were multiple. Conclusion. Somatic manifestations of undifferentiated connective tissue dysplasia are often multiorganic and often have non-specific clinical symptoms. Identification of patterns of formation of uroandrological pathology in patients of different age groups with connective tissue insufficiency will ensure timely prevention and correction of visceral manifestations of dysplasia in children.

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