FEATURES OF THE CLINICAL COURSE AND CHOICE OF THERAPY IN PERSONS OVER 70 YEARS OF AGE WITH NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS: A LITERARY REVIEW

2021 ◽  
pp. 39-43
Author(s):  
А.Р. КАЗБЕКОВА ◽  
Ж.К. БУРИБАЕВА ◽  
А. АБИЕВА

Сахарный диабет - это эндокринное заболевание, при котором происходит нарушение выработки инсулина или понижение чувствительности клеточных рецепторов к нему, что в результате ведет к увеличению сахара в крови. Диабет 2 типа часто называют "болезнью цивилизации". Около четверти населения в возрасте старше 65 лет имеют сахарный диабет, а половина - предиабет, причем отмечается тенденция к усугублению данной ситуации в ближайшие десятилетия. В связи с улучшением социальнодемократической ситуации, старением населения, развитием гериатрии как самостоятельный раздел медицины, появилась возможность раннего выявления сахарного диабета. Но лечение данной группы пациентов имеет ряд проблем, связанных с когнитивными нарушениями, которые препятствуют обучению и приверженности пациентов к лечению; коморбидными состояниями, при которых невозможно адекватно оценивать тяжесть заболевания. Diabetes mellitus is an endocrine disorder in which the production of insulin is impaired or the sensitivity of cell receptors to it is impaired, which results in an increase in blood sugar. Type 2 diabetes is often referred to as the "disease of civilization". About a quarter of the population over the age of 65 has diabetes mellitus, and half have prediabetes, and this situation tends to worsen in the coming decades. In connection with the improvement of the social and democratic situation, the aging of the population, the development of geriatrics as an independent branch of medicine, it became possible to detect diabetes mellitus early. But the treatment of this group of patients has a number of problems associated with cognitive impairment that hinder the learning and adherence of patients to treatment; comorbid conditions in which it is impossible to adequately assess the severity of the disease

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1535-P ◽  
Author(s):  
HYE-IN JUNG ◽  
JAEHYUN BAE ◽  
EUGENE HAN ◽  
GYURI KIM ◽  
JI-YEON LEE ◽  
...  

2021 ◽  
Vol 12 (4) ◽  
pp. 1029-1039
Author(s):  
Qiu Wang ◽  
Lirong Ma ◽  
Yuanying Zhang ◽  
Lin Zhang ◽  
Yu An ◽  
...  

Author(s):  
Yangyang Cheng ◽  
Xiaohui Du ◽  
Bilin Zhang ◽  
Junxia Zhang

Abstract Background Serum wnt1-induced signaling pathway protein 1 (WISP1) levels are increased with obesity, which is a common complication associated with lower extremity atherosclerotic disease (LEAD). However, to date, the relationship between elevated WISP1 levels and the incidence of lower extremity atherosclerotic disease (LEAD) in type 2 diabetes mellitus (T2DM) remains unclear. Methods 174 newly diagnosed type 2 diabetic patients were enrolled in our study. Patients were divided into two groups, LEAD group (n=100) and control group (n=74). Anthropometric parameters, blood pressure and some biochemical parameters were obtained. Body composition was detected by bioelectrical impedance analysis (BIA). Levels of serum insulin were determined by radioimmunoassay. Serum WISP1 and interleukin 6 (IL-6) levels were determined using an enzyme-linked immunosorbent assay. Results It was shown that serum WISP1 levels in diabetic patients with LEAD were higher than those without LEAD (P<0.001). Serum WISP1 levels were positively related with waist circumference (r=0.237, P=0.003), waist-hip ratio (r=0.22, P=0.006), visceral fat area (r=0.354, P<0.001), serum creatinine (r=0.192, P=0.012), interleukin 6 (r=0.182, P=0.032), c-reactive protein (r=0.681, P<0.001), triglycerides (r=0.119, P<0.001), fasting glucose (r=0.196, P=0.011), glycated hemoglobin (r=0.284, P<0.001), and HOMA-IR (r=0.285, P<0.026). Compared with the lowest tertile, the odds ratio of the middle tertile for LEAD incidence was 3.27 (95% CI, 1.24–8.64) and 4.46 (95% CI, 1.62–12.29) for the highest tertile after adjusting confounding factors. Conclusion The results suggest that increased serum WISP1 levels independently contribute to the incidence of LEAD in patients with newly diagnosed T2DM.


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