scholarly journals PREVALÊNCIA DE NEOPLASIAS E MODALIDADES DE TRATAMENTOS EM CÃES, ATENDIDOS NO HOSPITAL VETERINÁRIO DA UNIVERSIDADE FEDERAL DO PARANÁ

2002 ◽  
Vol 7 (2) ◽  
Author(s):  
A. B. DE NARDI ◽  
S. RODASKI ◽  
R. S. SOUSA ◽  
T. A. COSTA ◽  
T. R. MACEDO ◽  
...  
Keyword(s):  
Mast Cell ◽  
Veterinary Medicine ◽  
Professional Practice ◽  
Retrospective Survey ◽  
Mast Cell Tumors ◽  
Important Field ◽  
The University ◽  
Veterinary Hospital ◽  
Prevalence Of Cancer ◽  
Mammary Neoplasia

Tendo em vista a grande incidência das afecções oncológicas este trabalho realizou um estudo retrospectivo em 333 cães acometidos por neoplasias e atendidos no Hospital Veterinário da Universidade Federal do Paraná, Campus de Curitiba, no período de janeiro de 1998 e junho de 2002. Os animais tratados no decorrer destes anos foram catalogados e avaliados no que diz respeito ao diagnóstico, etiologia, tratamento e evolução dos tumores. As neoplasias mais freqüentes foram correlacionadas com o sexo, idade, raça e abordagem terapêutica. A alta prevalência de tumores nas fêmeas (232 casos) em relação aos machos foi correlacionada com o elevado número de neoplasias mamárias (152 casos), representando (45,64%) de todos os tumores pesquisados neste estudo. O segundo tumor mais diagnosticado foi o mastocitoma (11,7%), sendo que 46,15% destes comprometeram cães da raça Boxer. Na seqüência prevaleceram os tumores venéreos transmissíveis (3,3%), seguido dos linfossarcomas (3,3%). A forma principal de diagnóstico constou de citologia (81%) e histopatologia (93,7%). Quanto à terapêutica, 84,68% dos pacientes foram submetidos à cirurgia, 10,51% à cirurgia e quimioterapia e 4,8% foram tratados apenas com fármacos citostáticos. Como conclusão, o elevado número de cães acometidos pelas afecções oncóticas diagnosticadas demonstra a necessidade do médico veterinário dedicar-se intensivamente ao estudo da oncologia veterinária, pois o domínio desta especialidade tornou-se uma exigência do mercado de trabalho atual. Prevalence of neoplasias and kind of treatments in dogs seen in Veterinary Hospital at University Federal of Paraná Abstract A retrospective survey has been carried out at the Oncology Section of the Federal University of Paraná Veterinary Hospital on the prevalence of cancer in dogs. From 333 cases of neoplasia diagnosed during the period of 1998 to 2002 232 cases - 72.7 % - were found in female dogs. From this total about 45.6 % of them were affected with mammary neoplasia. The second more frequent tumor found were mast cell tumors (11.7%) from which 46.15% affected dogs of Boxer breed, followed by transmissible venereal tumors (3.3 %) and lymphoma (3.3%). Diagnostics were carried out mainly by cytology (81 %) and hystopathology (93.7%) procedures. Treatment of the cancer forms diagnosed was performed mainly by surgery (84.6%) followed by surgery and chemotherapy (19.51%) and chemotherapy by means of cytotoxic drugs (10.51%). In conclusion, the increasing number of cancer cases found during these period of time at the University of Paraná Veterinary Hospital has shown the need of veterinarians and of Veterinary Medicine students to intensively dedicate themselves to the field of oncology, a fact that has become imperative in the professional practice as well as in this important field of medical research.

scholarly journals Cartography of neoplasms in dogs from different regions of the city of São Paulo, SP, Brazil: a survey (2002-2003) of data from the Veterinary Hospital of the School of Veterinary Medicine and Animal Science of the University of São Paulo, Brazil

2015 ◽  
Vol 52 (3) ◽  
pp. 257 ◽  
Author(s):  
Kátia Cristina Kimura ◽  
Carolina Scarpa Carneiro ◽  
Renata Moris Domenico ◽  
Ricardo Augusto Dias ◽  
Jucelia Pereira ◽  
...  
Keyword(s):  
Veterinary Medicine ◽  
Sao Paulo ◽  
São Paulo ◽  
Animal Science ◽  
The University ◽  
The City ◽  
Veterinary Hospital ◽  
De Medicina

<p>Avanços na medicina veterinária resultaram em benefícios significativos na vida de animais de estimação nos últimos 20 anos, e o aumento da expectativa de vida para animais levou a uma maior prevalência de neoplasias em cães. A Epidemiologia do Câncer e as ferramentas de análise espacial, embora bem desenvolvidas na pesquisa oncológica humana, estão começando a serem exploradas na Oncologia Veterinária. A cidade de São Paulo, capital do estado de São Paulo, Brasil, é dividida em cinco regiões: Norte, Sul, Leste, Oeste e centro. O Hospital Veterinário da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (HOVET-SVMAS-USP) está localizado na região Oeste de São Paulo, Brasil, e admite casos de pequenos e grandes animais. Tumores mamários caninos são tão numerosos que não são tratados na rotina do HOVET. O objetivo deste trabalho foi realizar um estudo cartográfico para descrever a distribuição espacial dos casos prevalentes de neoplasias em cães a partir do HOVET. Dos 3.620 casos atendidos em 2002 e 2003, 380 (10,5%) casos eram de cães acometidos por tumores benignos e malignos. Não foi encontrada diferença estatística entre a distribuição dos 380 endereços entre as cinco regiões da cidade. Os resultados mostraram que o HOVET atende pacientes caninos de todas as regiões de São Paulo e que há uma distribuição espacial homogênea das neoplasias. Os autores incentivam estudos mais amplos, envolvendo vários hospitais veterinários, clínicas e laboratórios, a fim de obter dados mais precisos sobre a distribuição das neoplasias caninas em São Paulo, SP, Brasil.</p>

Masitinib and Its Role in Inhibiting SARS-CoV-2 Infection

2021 ◽  
Author(s):  
Dr. Stefan Bittmann
Keyword(s):  
Mast Cell ◽  
Veterinary Medicine ◽  
Laboratory Experiments ◽  
Viral Diseases ◽  
Preclinical Studies ◽  
Mast Cell Tumors ◽  
Main Protease

A drug used successfully in veterinary medicine to treat mast cell tumors in dogs may be effective against COVID-19 and some other viral diseases in humans, according to laboratory experiments and preclinical studies published in Science 2021 [1]. Coronaviruses also require such enzymes. After entering the cells, their genome is first converted into 2 polyproteins, which must be broken down into smaller units. This task is performed by 2 proteases. This is once the main protease 3CL (also called Mpro or nsp5). The 2nd enzyme is the "papain-like" protease, abbreviated PLpro. Drugs that block one of these enzymes could prevent the viruses from replicating in the cells and thus stop the progression of the infection.

scholarly journals Empirical Evidence for Professional Practice and Public Policies: An Exploratory Study on Social Exclusion in Users of Primary Care Social Services in Spain

2019 ◽  
Vol 16 (23) ◽  
pp. 4600 ◽  
Author(s):  
Giménez‐Bertomeu ◽  
Domenech‐López ◽  
Mateo‐Pérez ◽  
de‐Alfonseti‐Hartmann
Keyword(s):  
Primary Care ◽  
Social Exclusion ◽  
Social Services ◽  
Professional Practice ◽  
Social Inclusion ◽  
Social Acceptance ◽  
Life Trajectories ◽  
The Social ◽  
Study Population ◽  
The University

This study examines the social exclusion characteristics of a sample of users of primary care social services in two local entities in Spain. The objective of this study was to identify the intensity and scope of social exclusion in an exploratory way and to look at the typology of existing exclusionary situations to inform policy making and professional practice. Data from 1009 users were collected by primary care social services professionals, completing the Social Exclusion Scale of the University of Alicante (SES-UA). The dimensions with the greatest levels of social exclusion in the study population were those related to work/employment, income and education and training. The dimensions with an intermediate level of exclusion were those related to housing and social isolation. Social acceptance, family and social conflict and health were the dimensions with the lowest levels of exclusion. The analysis also showed the existence of five significantly different groups, that showed five different life trajectories along the continuum between social exclusion and social inclusion. The results show the importance and utility of developing professional and policy intervention protocols based on research evidence, with the objective of improving the quality of life of the users.

scholarly journals Industry-Practice-Based Engineering Hydrology Education at USQ, Australia

2019 ◽  
Vol 9 (3) ◽  
pp. 213
Author(s):  
Rezaul Chowdhury
Keyword(s):  
Online Education ◽  
Student Satisfaction ◽  
Learning Outcomes ◽  
Professional Practice ◽  
Assessment Tools ◽  
Discussion Forums ◽  
Self Assessment ◽  
Industry Practice ◽  
The University ◽  
Engineering Hydrology

Engineering education must embrace several challenges, such as increased numbers of work-based students, increased demand for online education, mismatches in employability skills and industry requirements, and lack of student engagement. The hydrology course at the University of Southern Queensland attracts more than 100 students every year, where more than 70% of students are off-campus and most of them are work-based. This study explored how an online hydrology course can embrace industry practice and engage students in order to achieve learning outcomes. Industrial careers in hydrology involve extensive use of hydroclimatological data and modeling applications. The course modules, learning objectives and outcomes, and assessment tools have been designed to align with industry practices. Active participation of students was observed in self-assessment quizzes and discussion forums. The course was rated very well in achieving learning outcomes and in overall student satisfaction. Students appreciated the well-structured real-world and professional practice in the course.

Immunohistochemical Expression of Vascular Endothelial Growth Factor as a Prognostic Marker for Canine Mast Cell Tumors

2021 ◽  
Vol 42 ◽  
pp. 100506
Author(s):  
Samanta Rios Melo ◽  
Eric Vieira Januário ◽  
Erika Zanuto ◽  
Bruna de Castro Miranda ◽  
Thais Rodrigues Macedo ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Mast Cell ◽  
Growth Factor ◽  
Prognostic Marker ◽  
Vascular Endothelial ◽  
Immunohistochemical Expression ◽  
Mast Cell Tumors ◽  
Endothelial Growth Factor

scholarly journals Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors

2021 ◽  
pp. 030098582098513
Author(s):  
Mafalda Casanova ◽  
Sandra Branco ◽  
Inês Berenguer Veiga ◽  
André Barros ◽  
Pedro Faísca
Keyword(s):  
Mast Cell ◽  
Clinical Outcome ◽  
Prognostic Value ◽  
Histological Grade ◽  
Intraobserver Variability ◽  
Low Grade ◽  
High Grade ◽  
Mast Cell Tumors ◽  
Cutaneous Mast Cell ◽  
Grade Iii

Canine cutaneous mast cell tumors (ccMCTs) are currently graded according to Patnaik and Kiupel grading schemes. The qualitative and semiquantitative parameters applied in these schemes may lead to inter- and intraobserver variability. This study investigates the prognostic value of volume-weighted mean nuclear volume ([Formula: see text]), a stereological estimation that provides information about nuclear size and its variability. [Formula: see text] of 55 ccMCTs was estimated using the “point-sampled intercept” method and compared with histological grade and clinical outcome. The clinical history of dogs treated with surgical excision alone was available for 30 ccMCTs. Statistical differences in [Formula: see text] were found between grade II ([Formula: see text]= 115 ± 29 µm3) and grade III ccMCTs ([Formula: see text]= 197 ± 63 µm3), as well as between low-grade ([Formula: see text]= 113 ± 28 µm3) and high-grade ccMCTs ([Formula: see text]= 184 ± 63 µm3). An optimal cutoff value of [Formula: see text] ≥ 150 µm3 and [Formula: see text] ≥ 140 µm3 was determined for grade III and high-grade ccMCTs, respectively. In terms of prognosis, [Formula: see text] was not able to predict the clinical outcome in 42% of the cases; however, cases with [Formula: see text]<125 µm3 had a favorable outcome. These results indicate that, despite having limited prognostic value when used as a solitary parameter, [Formula: see text] is highly reproducible and is associated with histological grade as well as with benign behavior.

Correlation of histologic grading of canine mast cell tumors with Ki67/PCNA/AgNOR/c-Kit scores: 38 cases (2002-2003)

2004 ◽  
Vol 2 (2) ◽  
pp. 98-98 ◽  
Author(s):  
P. J. Bergman ◽  
D. M. Craft ◽  
S. J. Newman ◽  
K. Baer ◽  
M. A. Camps-Palau ◽  
...  
Keyword(s):  
Mast Cell ◽  
Histologic Grading ◽  
Mast Cell Tumors

scholarly journals A Retrospective Study of Eyelid Tumors from 43 Cats

2009 ◽  
Vol 46 (5) ◽  
pp. 916-927 ◽  
Author(s):  
K. M. Newkirk ◽  
B. W. Rohrbach
Keyword(s):  
Surgical Excision ◽  
Average Survival Time ◽  
University Of Tennessee ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Mast Cell Tumors ◽  
Eyelid Tumors ◽  
Average Survival ◽  
Tumor Types ◽  
The University

Submissions to the University of Tennessee pathology service from June 1999 to June 2008 were searched for feline cases of tumors involving the eyelids or nictitans. Forty-three tumors were identified. The average age at diagnosis was 10.4 years. Significantly more males than females had eyelid tumors. There were 12 squamous cell carcinomas (SCCs), 11 mast cell tumors (MCTs), 6 hemangiosarcomas (HSAs), 4 adenocarcinomas (ACAs), 3 peripheral nerve sheath tumors (PNSTs), 3 lymphomas, 3 apocrine hidrocystomas (AHCs), and 2 hemangiomas. Cats with MCTs were significantly younger than cats with all other tumor types combined. In contrast, cats with SCCs were significantly older than cats with other tumor types. The HSAs and SCCs were significantly more likely than other tumors to occur in nonpigmented areas. The MCTs, HSAs, AHCs, and hemangiomas did not recur after surgical excision. In contrast, the lymphomas, ACAs, SCCs, and PNSTs frequently recurred and/or resulted in death or euthanasia of the cat. The SCCs were significantly more likely to recur than the MCTs. The average survival time for cats with SCCs was 7.4 months. Although eyelid MCTs have been reported in cats, the prevalence in this study is much higher than previously described.

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