IN VIVO AND IN VITRO EVALUATION OF ANTI-CANCER ACTIVITY OF NEWLY SYNTHESIZED COBALT COMPLEX OF COUMARIN SCHIFF BASES

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (04) ◽  
pp. 61-69
Author(s):  
A. Rayaji ◽  
A. H. M. Viswanatha Swamy ◽  

Hepatocarcinogenesis is a multistep process involving different genetic alterations that ultimately lead to malignant transformation of the hepatocytes. Modern treatment of cancer includes chemotherapy, hormone therapy, radiotherapy and surgery but they are associated with several adverse effects such as alopecia, fatigue and general weakening of the body’s immune system due to bone marrow suppression. However, there is a continual need to look out for newer drugs to overcome the menace of cancer. In view of this we synthesized the new Coumarin-Cobalt complex derivatives. Structures of all the newly synthesized metal complexes are supported by Spectral data such as IR, NMR, and mass spectrometry. Coumarin-Cobalt complex of vanillin exhibited significant anti-cancer activity by in vivo anticancer activity (BrdU estimation). Immunohistochemical analysis has been done by BrdU and the synthesized compounds were screened for anti-oxidant activity and in vitro HepG2 cell lines. The IC50 values of the HepG2 cell lines as compared with that of standard Cisplatin and compounds IIIb, IIId, IIIe, IIIh and IIIj showed appreciable activity at a concentration less than 10 μG. Coumarin-Cobalt complex of vanillin exhibited significant anti-cancer activity. Anti-oxidant activity performed by Nitric oxide reducing ability, Superoxide dismutase and reducing activity:Compounds IIIc, IIIe and IIIg showed appreciable activity at 400μg/mL and 800 μg/mL screened by nitric oxide reducing ability, superoxide anion was effectively scavenged by compound IIIg at 400μg/mL and 800 μg/mL and reducing power of compounds IIIc and IIIj is comparable with standard ascorbic acid at concentrations 400μg/mL and 800 μg/mL.

2014 ◽  
Vol 12 (4) ◽  
pp. 304-310 ◽  
Author(s):  
Moon-Hee Choi ◽  
Hyo-Kyung Han ◽  
Yong-Jo Lee ◽  
Han-Gyo Jo ◽  
Hyun-Jae Shin

RSC Advances ◽  
2017 ◽  
Vol 7 (6) ◽  
pp. 3408-3412 ◽  
Author(s):  
Long Ma ◽  
Haiyan Liu ◽  
Lingpei Meng ◽  
Ping Qin ◽  
Botao Zhang ◽  
...  

Triterpenoidal saponins fraction isolated from a traditional Chinese medicine Conyza blinii H. Lév. demonstrates anti-cancer activity both in vitro and in vivo.


2021 ◽  
Vol 25 (11) ◽  
pp. 104-109
Author(s):  
Gullapelli Kumaraswamy ◽  
Ravichandar Maroju ◽  
Srinivas Bandari ◽  
Gouthami Dasari ◽  
Gullapelli Sadanandam

A novel series of 2-(1-((1-substitutedphenyl-1H-1,2,3- triazol-4-yl)methoxy)ethyl)-1-((1-substituted phenyl- 1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazole (3a-j)derivatives was synthesized in moderate to high yields. The structures of all the synthesized compounds were characterized by 1HNMR, 13CNMR and Mass spectroscopic methods. The title compounds were screened for their anti-oxidant activity and anti-cancer activity. The cancer activity results reveal that the compounds 3j, 3b and 3f are showing promising activity and remaining compounds exhibited moderate activity against all the tested cancer cell lines. The anti-oxidant activity also shows that the compounds 3c and 3d have shown excellent activity and remaining compounds were also found to exhibit moderate activity against the test organisms employed.


2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Alexander J. Stevenson ◽  
Eleanor I. Ager ◽  
Martina A. Proctor ◽  
Dubravka Škalamera ◽  
Andrew Heaton ◽  
...  

2012 ◽  
Vol 166 (3) ◽  
pp. 991-1001 ◽  
Author(s):  
T Nie ◽  
CC Wong ◽  
N Alston ◽  
P Aro ◽  
PP Constantinides ◽  
...  
Keyword(s):  

2015 ◽  
Vol 15 ◽  
pp. 264-273 ◽  
Author(s):  
Yuwen Ting ◽  
Yi-Shiou Chiou ◽  
Min-Hsiung Pan ◽  
Chi-Tang Ho ◽  
Qingrong Huang

2018 ◽  
Vol 19 (3) ◽  
pp. 903 ◽  
Author(s):  
Se Byeon ◽  
Young-Su Yi ◽  
Jongsung Lee ◽  
Woo Yang ◽  
Ji Kim ◽  
...  

2019 ◽  
Vol 7 (40) ◽  
pp. 6247-6256
Author(s):  
Binbin Chu ◽  
Sicong Wu ◽  
Xiaoyuan Ji ◽  
Runzhi Chen ◽  
Bin Song ◽  
...  

A facile microwave-assisted synthetic approach enables the fabrication of different-dimensional Si nanostructures with unique optical merits for cancer therapy.


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