DOSE DEPENDENT ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF MENTHA ARVENSIS LEAVES IN TRITON AND HIGH CHOLESTEROL DIET INDUCED RATS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (01) ◽  
pp. 71-80
Author(s):  
S Ugare ◽  
A. D. Tarnalli ◽  
N. A. Khatib ◽  
Keyword(s):  
Ethanolic Extract ◽  
Post Treatment ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Mentha Arvensis ◽  
Antihyperlipidemic Activity ◽  
Triton Wr 1339 ◽  
Chronic Models ◽  
Dose Dependent

A study was undertaken to evaluate antihyperlipidemic activity of ethanolic extract of leaves of Mentha arvensis in Triton and high cholesterol diet induced hyperlipidemic male albino Wstar rats. Acute hyperlipidemia was induced by administration of Triton WR-1339 (100 mg / kg i.v.) to the male albino Wstar rats. In chronic models; the animals were fed with high cholesterol diet for a period of 10 days. EEMA leaves at a dose of 200 and 400 mg/kg of body weight were administered at a single dose per day to the hyperlipidemic induced rats for a period of 14 days. In hyperlipidemic rats there is significant increase in TC, TG, LDL, VLDL level and significant decrease in HDL level, but after post treatment with EEMA, there was a significant decrease in TC, TG, LDL, VLDL and increase in HDL level. Post treatment with EEMA leaves lowered levels of total protein and triglycerides.

Antihyperlipidemic Activity of Gymenma sylvestre R. Br. Leaf Extract on Rats Fed with High Cholesterol Diet

2010 ◽  
Vol 6 (2) ◽  
pp. 138-141 ◽  
Author(s):  
P.R. Rachh ◽  
M.R. Rachh ◽  
N.R. Ghadiya ◽  
D.C. Modi ◽  
K.P. Modi ◽  
...  
Keyword(s):  
Leaf Extract ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Antihyperlipidemic Activity

scholarly journals PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL

Biomedika ◽  
2013 ◽  
Vol 5 (2) ◽  
Author(s):  
. Muhtadi ◽  
. Haryoto ◽  
Tanti Azizah Sujono ◽  
Peni Indaryudha ◽  
Andi Suhendi
Keyword(s):  
Ethanolic Extract ◽  
Male Rats ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Control Group Design ◽  
Group I ◽  
Nephelium Lappaceum

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains  avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet

scholarly journals ANTI-ATHEROSCLEROTIC AND LIPID LOWERING EFFECTS OF CINNAMOMUM VERUM IN CHOLESTEROL-FED RABBITS

2016 ◽  
Vol 9 (1) ◽  
pp. 75 ◽  
Author(s):  
Suresh C. Joshi ◽  
Pratibha K. Jain ◽  
Priyanka Sharma
Keyword(s):  
Atherogenic Index ◽  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
Phytochemical Analysis ◽  
Dependent Manner ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Histological Changes ◽  
Marked Decline ◽  
Dose Dependent

Objective: The present study was designed to investigate the antihyperlipidemic and anti-atherosclerotic activity of 70% methanolic crude extract of Cinnamomum verum bark in high cholesterol-fed diet rabbits.Methods: C. verum extract was administered at a dose level of 200 mg/kg and 300 mg/kg (p. o) daily for 120 d to cholesterol-fed rabbits. Lipid profile in serum and histological changes in heart and aorta were investigated. The statistical analysis was carried out by student’s ‘t’test.Results: Plant extract showed a significant decrease in the levels of serum total cholesterol, triglycerides, phospholipids, LDL, VLDL (P ≤ 0.001) in a dose-dependent manner in treated animals. HDL ratio improved overwhelmingly as well as the marked decline was also noticed in the atherogenic index after administration with C. verum extract. Histopathological examinations demonstrated less cholesterol deposits in the aorta and significant increase in lumen size of coronary arteries of high cholesterol diet animals given C. verum compared to the high cholesterol diet animals not given C. verum supplement.Conclusion: The phytochemical analysis of methanol extracts indicated a strong presence of alkaloids, flavonoids, tannins, phenols, saponins and fatty acids may be responsible for the significant hypolipidaemic as well as antiatherosclerotic activity. Our study exhibited that the methanol extract of C. verum bark is a potent hypolipidaemic agent and decreased cholesterol deposition in the aorta and plaque formation process in the coronary artery of high cholesterol diet animals.

Anti-hyperlipidemic activity of an extract from roots and rhizomes of Panicum repens L. on high cholesterol diet-induced hyperlipidemia in rats

2015 ◽  
Vol 70 (5-6) ◽  
pp. 139-144 ◽  
Author(s):  
Walid Hamdy El-Tantawy ◽  
Abeer Temraz ◽  
Hoda E. Hozaien ◽  
Omayma D. El-Gindi ◽  
Kamilia F. Taha
Keyword(s):  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
High Cholesterol Diet ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
Total Lipids ◽  
High Cholesterol ◽  
Panicum Repens

Abstract The hypolipidemic effect of an ethanolic extract from the roots and rhizomes of Panicum repens L. was investigated in rats suffering from high-cholesterol, diet-induced hyperlipidemia, and the phytochemicals in the extract were analyzed. The extract was administered p.o. in doses of 250 mg/kg/day together with cholesterol at a dose of 100 mg/kg/day for 7 weeks. The high-cholesterol diet caused a significant increase in total lipids, total cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and the atherogenic index, whereas the level of high-density lipoprotein cholesterol (HDL-C) was significantly decreased. Administration of the P. repens extract (p<0.05) significantly reduced the rise of the serum levels of total lipids, TC, TG, and LDL-C, as well as the atherogenic index, whereas it significantly increased (p<0.05) the level of HDL-C. HPLC analysis of the phenolics and flavonoids in the extract revealed the presence of gallic acid, chlorogenic acid, chicoric acid, primulic acid, rutin, apigenin-7-glucoside, and quercetin. In conclusion, the P. repens extract was found to possess hypolipidemic activity in high-fat, diet-induced hyperlipidemic rats.

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