Purple sweet potato ethanolic extract reduces aortic VCAM expression in rabbit with high-cholesterol diet

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains  avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet

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DOSE DEPENDENT ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF MENTHA ARVENSIS LEAVES IN TRITON AND HIGH CHOLESTEROL DIET INDUCED RATS

INDIAN DRUGS ◽

10.53879/id.56.01.11274 ◽

2019 ◽

Vol 56 (01) ◽

pp. 71-80

Author(s):

S Ugare ◽

A. D. Tarnalli ◽

N. A. Khatib ◽

Keyword(s):

Ethanolic Extract ◽

Post Treatment ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

Mentha Arvensis ◽

Antihyperlipidemic Activity ◽

Triton Wr 1339 ◽

Chronic Models ◽

Dose Dependent

A study was undertaken to evaluate antihyperlipidemic activity of ethanolic extract of leaves of Mentha arvensis in Triton and high cholesterol diet induced hyperlipidemic male albino Wstar rats. Acute hyperlipidemia was induced by administration of Triton WR-1339 (100 mg / kg i.v.) to the male albino Wstar rats. In chronic models; the animals were fed with high cholesterol diet for a period of 10 days. EEMA leaves at a dose of 200 and 400 mg/kg of body weight were administered at a single dose per day to the hyperlipidemic induced rats for a period of 14 days. In hyperlipidemic rats there is significant increase in TC, TG, LDL, VLDL level and significant decrease in HDL level, but after post treatment with EEMA, there was a significant decrease in TC, TG, LDL, VLDL and increase in HDL level. Post treatment with EEMA leaves lowered levels of total protein and triglycerides.

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Anti-hyperlipidemic activity of an extract from roots and rhizomes of Panicum repens L. on high cholesterol diet-induced hyperlipidemia in rats

Zeitschrift für Naturforschung C ◽

10.1515/znc-2014-4147 ◽

2015 ◽

Vol 70 (5-6) ◽

pp. 139-144 ◽

Cited By ~ 1

Author(s):

Walid Hamdy El-Tantawy ◽

Abeer Temraz ◽

Hoda E. Hozaien ◽

Omayma D. El-Gindi ◽

Kamilia F. Taha

Keyword(s):

Density Lipoprotein ◽

Ethanolic Extract ◽

Lipoprotein Cholesterol ◽

Atherogenic Index ◽

High Cholesterol Diet ◽

Hypolipidemic Effect ◽

Cholesterol Diet ◽

Total Lipids ◽

High Cholesterol ◽

Panicum Repens

Abstract The hypolipidemic effect of an ethanolic extract from the roots and rhizomes of Panicum repens L. was investigated in rats suffering from high-cholesterol, diet-induced hyperlipidemia, and the phytochemicals in the extract were analyzed. The extract was administered p.o. in doses of 250 mg/kg/day together with cholesterol at a dose of 100 mg/kg/day for 7 weeks. The high-cholesterol diet caused a significant increase in total lipids, total cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and the atherogenic index, whereas the level of high-density lipoprotein cholesterol (HDL-C) was significantly decreased. Administration of the P. repens extract (p<0.05) significantly reduced the rise of the serum levels of total lipids, TC, TG, and LDL-C, as well as the atherogenic index, whereas it significantly increased (p<0.05) the level of HDL-C. HPLC analysis of the phenolics and flavonoids in the extract revealed the presence of gallic acid, chlorogenic acid, chicoric acid, primulic acid, rutin, apigenin-7-glucoside, and quercetin. In conclusion, the P. repens extract was found to possess hypolipidemic activity in high-fat, diet-induced hyperlipidemic rats.

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Sweet Potato Leaf Feeding Decreases Cholesterol, Oxidative Stress and Thrombosis Formation in Syrian Hamsters with a High-Cholesterol Diet

Life ◽

10.3390/life11080802 ◽

2021 ◽

Vol 11 (8) ◽

pp. 802

Author(s):

Hao-Hsiang Chang ◽

Yi-Chan Lan ◽

Shiu-Dong Chung ◽

Chiang-Ting Chien

Keyword(s):

Total Cholesterol ◽

Sweet Potato ◽

Control Diet ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Atherogenic Index ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

Potato Leaf

Nutritional strategies to reduce hyperlipidemia and the risk of cardiovascular disease are gaining more public favor and medical professionals’ attention. The authors of this study explored the effect of sweet potato leaf powder (SPLP) feeding on the parameters of plasma lipids, reactive oxygen species, and time to thrombosis formation in Syrian hamsters fed with high-cholesterol diets. The animals were separated into six groups: a feeding control diet, a control diet containing 0.1% cholesterol, a control diet containing 0.2% cholesterol, a control diet containing 0.1% cholesterol plus 2.5% SPLP, a control diet containing 0.1% cholesterol plus 5% SPLP, and a control diet containing 0.2% cholesterol plus 5% SPLP for six weeks. The levels of serum total cholesterol (51% increase), low-density lipoprotein cholesterol (70.6% increase), very-low-density lipoprotein cholesterol (51.3% increase), and the triglyceride and atherogenic index (LDL-C/HDL-C) significantly increased in the high-cholesterol diet groups. Concomitant 5% sweet potato leaf powder ingestion significantly decreased the lipid profiles, with a 20.6% total cholesterol reduction in the 0.1% cholesterol diet groups, a 17.2% reduction in the 0.2% group, a 48.7% LDL reduction in the 0.1% cholesterol group, and a 30.3% reduction in the 0.2% group, with a consequent decrease in the atherogenic index. SPLP feeding was found to be associated with increased fecal sterol contents, with a 188.6% increase in the 0.1% cholesterol-fed group and a 177.3% increase in the 0.2% group. The SPLP-fed groups had depressed ROS levels, elongated FeCl3-induced times to thrombosis formation, and increased liver superoxide dismutase contents and SREBP-1 protein expression. Sweet potato leaf intake could reduce plasma total cholesterol, LDL, and oxidative stress. We suggest sweet potato leaf intake as a choice of nutritional strategy for hyperlipidemia and cardiovascular disease prevention.

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