scholarly journals COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review

2021 ◽  
Vol 3 (2) ◽  
pp. 122-129
Author(s):  
Maximiliano Gabriel Castro ◽  
◽  
Gisel Cuevas ◽  
Keyword(s):  
Potential Role ◽  
Clinical Evidence ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Narrative Review ◽  
Randomized Controlled ◽  
Prophylactic Dose ◽  
Published Evidence ◽  
Prophylactic Anticoagulation

The COVID-19 pandemic and the limited therapeutic arsenal available strain daily clinical practice. Guidelines have recently recommended routine anticoagulation of hospitalized COVID-19 patients. However, apart from the expert panels’ experience, the provenance of this recommendation is not clear, due to the scarce published evidence. We provide a narrative review with the objective of unraveling the rationale for this practice. First, we analyze the biochemical, histopathological and clinical evidence for a pro-thrombotic profile in COVID-19 patients. Then, we present the clinical data from previous studies and discuss to what extent they aid in clinical decision-making. We conclude that, in the absence of randomized controlled trials, which are of utmost importance, prophylactic-dose anticoagulation should be offered to critically ill patients hospitalized for COVID-19 pneumonia, particularly those with high d-dimer levels, since they are the population most likely to benefit from it.

scholarly journals Empowering Clinical Decision Making in Oligometastatic Colorectal Cancer: The Potential Role of Drug Screening of Patient-Derived Organoids

2021 ◽  
pp. 1192-1199
Author(s):  
Gianluca Mauri ◽  
Erika Durinikova ◽  
Alessio Amatu ◽  
Federica Tosi ◽  
Andrea Cassingena ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Decision Making ◽  
Drug Screening ◽  
Potential Role ◽  
Clinical Decision Making ◽  
Clinical Decision

The Indaba in African Values-Based Practice

2015 ◽  
Author(s):  
C.W. van Staden ◽  
K. W. M. Fulford
Keyword(s):  
Decision Making ◽  
Potential Role ◽  
Clinical Decision Making ◽  
Family Members ◽  
Clinical Decision ◽  
Her Family ◽  
African Context ◽  
Key Features ◽  
Communicative Processes

This chapter shows how a particular kind of meeting, called in isiZulu the indaba, contributes toBatho Pele, an African values-based practice. First, it explores the challenge of values diversity, including what it means to respect diversity of values, and the different responses to the challenge from regulatory ethics and from values-based practice. It then explores the challenge of diversity in an African context through the story of a real (though biographically disguised) person, Ms. Precious Pelo, her family members and clinicians. Ms. Pelo’s story shows the need for substantive (process-focused) rather than merely executive (outcomes-focused) communicative processes in responding to the challenge of values diversity in clinical decision-making. Finally, it describes part of an indaba convened for Ms. Pelo, its opening minutes illustrating many of the key features ofBatho Pele. We conclude with an indication of the potential role of indabas in other areas of values-based practice.

A randomized, controlled trial of the role of weaning predictors in clinical decision making*

2006 ◽  
Vol 34 (10) ◽  
pp. 2530-2535 ◽  
Author(s):  
Maged A. Tanios ◽  
Michael L. Nevins ◽  
Katherine P. Hendra ◽  
Pierre Cardinal ◽  
Jill E. Allan ◽  
...  
Keyword(s):  
Decision Making ◽  
Randomized Controlled Trial ◽  
Clinical Decision Making ◽  
Controlled Trial ◽  
Clinical Decision ◽  
Randomized Controlled ◽  
Weaning Predictors

scholarly journals L’adenocarcinoma prostatico: un nuovo approccio diagnostico integrato finalizzato alla scelta terapeutica

2016 ◽  
Vol 5 (1) ◽  
Author(s):  
A. Delle Fave ◽  
S. Erra
Keyword(s):  
Prostate Cancer ◽  
Needle Biopsy ◽  
Potential Role ◽  
Clinical Decision Making ◽  
Clinical Presentation ◽  
Molecular Targets ◽  
Clinical Decision ◽  
Growth Patterns ◽  
Individual Assessment

Prostate cancer is different in clinical presentation , histopathological tumor growth, patterns and survival than others cancer. Therefore, individual assessment of a tumor’s aggressive potential is crucial for clinical decision-making in men with prostate cancer. Here we discuss the potential role of ERG and CD117 as a prognostic factors and molecular targets in needle biopsy on prostate cancer.

scholarly journals In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Joonho Park ◽  
Hyeyoon Kim ◽  
So Yeon Kim ◽  
Yeonjae Kim ◽  
Jee-Soo Lee ◽  
...  
Keyword(s):  
Clinical Decision Making ◽  
Clinical Decision ◽  
Good Prognosis ◽  
Severe Illness ◽  
Proteome Profiling ◽  
T Cell Suppression ◽  
Cell Suppression ◽  
Profiling Analysis ◽  
Necrosis Factor

AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over forty million patients worldwide. Although most coronavirus disease 2019 (COVID-19) patients have a good prognosis, some develop severe illness. Markers that define disease severity or predict clinical outcome need to be urgently developed as the mortality rate in critical cases is approximately 61.5%. In the present study, we performed in-depth proteome profiling of undepleted plasma from eight COVID-19 patients. Quantitative proteomic analysis using the BoxCar method revealed that 91 out of 1222 quantified proteins were differentially expressed depending on the severity of COVID-19. Importantly, we found 76 proteins, previously not reported, which could be novel prognostic biomarker candidates. Our plasma proteome signatures captured the host response to SARS-CoV-2 infection, thereby highlighting the role of neutrophil activation, complement activation, platelet function, and T cell suppression as well as proinflammatory factors upstream and downstream of interleukin-6, interleukin-1B, and tumor necrosis factor. Consequently, this study supports the development of blood biomarkers and potential therapeutic targets to aid clinical decision-making and subsequently improve prognosis of COVID-19.

scholarly journals A Narrative Review of Early Oral Stepdown Therapy for the Treatment of Uncomplicated Staphylococcus aureus Bacteremia: Yay or Nay?

2020 ◽  
Vol 7 (6) ◽  
Author(s):  
Michael Dagher ◽  
Vance G Fowler ◽  
Patty W Wright ◽  
Milner B Staub
Keyword(s):  
Staphylococcus Aureus ◽  
Hospital Readmission ◽  
Potential Role ◽  
Review Article ◽  
Narrative Review ◽  
Oral Antibiotics ◽  
Staphylococcus Aureus Bacteremia ◽  
Complete Treatment

Abstract Historically, intravenous (IV) antibiotics have been the cornerstone of treatment for uncomplicated Staphylococcus aureus bacteremia (SAB). However, IV antibiotics are expensive, increase the rates of hospital readmission, and can be associated with catheter-related complications. As a result, the potential role of oral antibiotics in the treatment of uncomplicated SAB has become a subject of interest. This narrative review article aims to summarize key arguments for and against the use of oral antibiotics to complete treatment of uncomplicated SAB and evaluates the available evidence for specific oral regimens. We conclude that evidence suggests that oral step-down therapy can be an alternative for select patients who meet the criteria for uncomplicated SAB and will comply with medical treatment and outpatient follow-up. Of the currently studied regimens discussed in this article, linezolid has the most support, followed by fluoroquinolone plus rifampin.

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