scholarly journals Analysis of the Distribution and Temporal Trends of Grade and Stage in Urothelial Bladder Cancer in Northern New England from 1994 to 2004

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Alan R. Schned ◽  
Petra Lenz ◽  
Lee E. Moore ◽  
Alison Johnson ◽  
Michael Jones ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
New England ◽  
New Hampshire ◽  
Large Population ◽  
Case Control ◽  
Low Grade ◽  
Short Term ◽  
Non Invasive ◽  
Urothelial Carcinomas ◽  
Northern New England

We investigate the distribution of bladder tumor category and stage in Northern New England by geographic region, smoking status, and over time. 1091 incident bladder cancer cases from the New England Bladder Cancer Study (NEBCS), a large population-based case-control study carried out in Maine, New Hampshire, and Vermont (2001–2004) and 680 bladder cancer cases from previous case-control studies in New Hampshire (1994–2000) were used in the analysis. Of 1091 incident bladder cancer cases from the NEBCS, 26.7% of tumors were papillary urothelial neoplasms of low malignant potential (PUNLMP), 26.8% low-grade papillary urothelial carcinomas (PUC-LG), 31.3% high-grade papillary urothelial carcinomas (PUC-HG), 9.1% nonpapillary urothelial carcinomas (non-PUC), and 4.3% carcinoma in situ (CIS). Approximately 70% of cases were noninvasive (Tis/Ta), and all PUNLMP cases were of the Ta category. By contrast, half of all PUC-HG carcinomas were invasive. Short-term time trend analysis within the NEBCS (2001–2004) indicated an increase in the percentage of PUNLMP (P-trend <0.0001) paralleled by a decrease in PUC-LG (P-trend = 0.02) and for PUC-LG an increase in the percentage of non-invasive tumors (P-trend 0.04). Our findings suggest possible short-term trends with an increase in the percentage of PUNLMP and a change in the percentage of PUC-LG towards non-invasive disease.

Occupation and Bladder Cancer in a Population-Based Case-Control Study in Northern New England

Epidemiology ◽  
2009 ◽  
Vol 20 ◽  
pp. S128
Author(s):  
Joanne Colt ◽  
Margaret Karagas ◽  
Molly Schwenn ◽  
Dalsu Baris ◽  
Alison Johnson ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
New England ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Northern New England ◽  
Control Study

scholarly journals Occupation and bladder cancer in a population-based case-control study in Northern New England

2010 ◽  
Vol 68 (4) ◽  
pp. 239-249 ◽  
Author(s):  
J. S. Colt ◽  
M. R. Karagas ◽  
M. Schwenn ◽  
D. Baris ◽  
A. Johnson ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
New England ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Northern New England ◽  
Control Study

scholarly journals Diagnostic Performance of Oncuria™, a Urinalysis Test for Bladder Cancer

2021 ◽  
Author(s):  
Yosuke Hirasawa ◽  
Ian Pagano ◽  
Runpu Chen ◽  
Yijun Sun ◽  
Yunfeng Dai ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Diagnostic Performance ◽  
Clinical Laboratory ◽  
Demographic Data ◽  
Roc Curves ◽  
Low Grade ◽  
Linear Discriminant ◽  
Non Invasive ◽  
Diagnostic Panel ◽  
Parallel Measurement

Abstract Background: Due to insufficient accuracy, urine-based assays currently have a limited role in the management of patients with bladder cancer. The identification of multiplex molecular signatures associated with disease has the potential to address this deficiency and to assist with accurate, non-invasive diagnosis and monitoring. Methods: To evaluate the performance of Oncuria™, a multiplex immunoassay for bladder detection in voided urine samples. The test was evaluated in a multi-institutional cohort of 362 prospectively collected subjects presenting for bladder cancer evaluation. The parallel measurement of 10 biomarkers (A1AT, APOE, ANG, CA9, IL8, MMP9, MMP10, PAI1, SDC1 and VEGFA) was performed in an independent clinical laboratory. The ability of the test to identify patients harboring bladder cancer was assessed. Bladder cancer status was confirmed by cystoscopy and tissue biopsy. The association of biomarkers and demographic factors was evaluated using linear discriminant analysis (LDA) and predictive models were derived using supervised learning and cross-validation analyses. Diagnostic performance was assessed using ROC curves.Results: The combination of the 10 biomarkers provided an AUROC 0.93 [95% CI: 0.87 – 0.98], outperforming any single biomarker. The addition of demographic data (age, sex, and race) into a hybrid signature improved the diagnostic performance AUROC 0.95 [95% CI: 0.90 – 1.00]. The hybrid signature achieved an overall sensitivity of 0.93, specificity of 0.93, PPV of 0.65 and NPV of 0.99 for bladder cancer classification. Sensitivity values of the diagnostic panel for high-grade bladder cancer, low-grade bladder cancer, MIBC and NMIBC were 0.94, 0.89, 0.97 and 0.93, respectively. Conclusions: Urinary levels of a biomarker panel enabled the accurate discrimination of bladder cancer patients and controls. The multiplex Oncuria™ test can achieve the efficient and accurate detection and monitoring of bladder cancer in a non-invasive patient setting.

scholarly journals Non-invasive detection of bladder cancer through the analysis of driver gene mutations and aneuploidy

2017 ◽  
Author(s):  
Simeon Springer ◽  
Maria Del Carmen Rodriguez Pena ◽  
Lu Li ◽  
Christopher Douville ◽  
Yuxuan Wang ◽  
...  
Keyword(s):  
At Risk ◽  
Bladder Cancer ◽  
Gene Mutations ◽  
Urine Samples ◽  
Driver Gene ◽  
Low Grade ◽  
Invasive Approach ◽  
Non Invasive ◽  
Patients At Risk ◽  
Copy Number Changes

AbstractCurrent non-invasive approaches for bladder cancer (BC) detection are suboptimal. We report the development of non-invasive molecular test for BC using DNA recovered from cells shed into urine. This “UroSEEK” test incorporates assays for mutations in 11 genes and copy number changes on 39 chromosome arms. We first evaluated 570 urine samples from patients at risk for BC (microscopic hematuria or dysuria). UroSEEK was positive in 83% of patients that developed BC, but in only 7% of patients who did not develop BC. Combined with cytology, 95% of patients that developed BC were positive. We then evaluated 322 urine samples from patients soon after their BCs had been surgically resected. UroSEEK detected abnormalities in 66% of the urine samples from these patients, sometimes up to 4 years prior to clinical evidence of residual neoplasia, while cytology was positive in only 25% of such urine samples. The advantages of UroSEEK over cytology were particularly evident in low-grade tumors, wherein cytology detected none while UroSEEK detected 67% of 49 cases. These results establish the foundation for a new, non-invasive approach to the detection of BC in patients at risk for initial or recurrent disease.

scholarly journals Ingested nitrate and nitrite and bladder cancer in Northern New England

2019 ◽  
Vol 3 ◽  
pp. 427-428
Author(s):  
Ward M ◽  
Barry K ◽  
Jones R ◽  
Cantor K ◽  
Beane Freeman L ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
New England ◽  
Northern New England ◽  
Nitrate And Nitrite

scholarly journals Impact of Farmers Home Administration's Future Policies on Northern New England Dairymen

1972 ◽  
Vol 1 (01) ◽  
pp. 139-147
Author(s):  
Sherrill B. Nott ◽  
Laura Calub
Keyword(s):  
New England ◽  
New Hampshire ◽  
Dairy Farms ◽  
Business Sector ◽  
Policy Alternatives ◽  
Northern New England ◽  
Farmers Home Administration ◽  
Future Policy ◽  
The Impact ◽  
Home Administration

Individuals working with farmers in the Northern New England States of Maine, New Hampshire and Vermont have claimed that the Farmers Home Administration has increased non-farm loans, while deliberately curtailing new farm loan activities and reducing the service on existing farm loans. If these allegations are true, it is important for the Northern New England agri-business sector to consider the future implications. The objective of this paper is to analyze the impact of future policy alternatives available to the Farmers Home Administration on the region's dairy farms.

scholarly journals The Copenhagen case-control study of bladder cancer: role of smoking in invasive and non-invasive bladder tumours.

1987 ◽  
Vol 41 (1) ◽  
pp. 30-36 ◽  
Author(s):  
O M Jensen ◽  
J Wahrendorf ◽  
M Blettner ◽  
J B Knudsen ◽  
B L Sorensen
Keyword(s):  
Bladder Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Non Invasive ◽  
Control Study ◽  
Bladder Tumours

1779 SURVEILLANCE GUIDELINES FOR LOW GRADE NON-INVASIVE BLADDER CANCER: A COST COMPARISON

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Ian Udell ◽  
Raj Kurpad ◽  
Angela Smith ◽  
Michael Woods ◽  
Eric Wallen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cost Comparison ◽  
Invasive Bladder Cancer ◽  
Low Grade ◽  
Non Invasive

scholarly journals Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case–Control Study (New England, USA)

10.1289/ehp89 ◽  
2017 ◽  
Vol 125 (6) ◽  
pp. 067010 ◽  
Author(s):  
Laura E. Beane Freeman ◽  
Kenneth P. Cantor ◽  
Dalsu Baris ◽  
John R. Nuckols ◽  
Alison Johnson ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
New England ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Water Disinfection ◽  
Multiple Routes ◽  
Control Study
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