scholarly journals Celiac disease with acute cerebellar stroke as first presentation: A case report

2021 ◽  
Vol 26 (3) ◽  
pp. 591-594
Author(s):  
Maria Maddalena Sirufo ◽  
Enrica Maria Bassino ◽  
Francesca De Pietro ◽  
Lia Ginaldi ◽  
Massimo De Martinis
Keyword(s):  
Celiac Disease ◽  
Gastrointestinal Symptoms ◽  
Cerebellar Hemisphere ◽  
Neurological Involvement ◽  
Positive Serology ◽  
Immune Disorder ◽  
Brain Ct Scan ◽  
Serology Test ◽  
The Right

Celiac disease is an immune disorder occurring in response to ingestion of gluten in genetically predisposed individuals. It is a complex multiorgan disease with possible neurological involvement. Thrombotic events can occur but rarely as presenting symptom. We describe the case of a young man admitted to the Stroke Unit for worsening headache, nausea, vomiting, unsteadiness, dysarthria, and dysmetria. Brain CT scan showed an ischemic hypodense lesion of the right cerebellar hemisphere with compression of the adjacent IV ventricle. Studies to determine the etiology of stroke showed positive serology for celiac disease. On follow up he has completely recovered clinically. He is on gluten-free diet and the serology is now negative. Our case demonstrated that in young stroke, even without gastrointestinal symptoms, celiac disease should be considered a possible differential diagnosis and the appropriate serology test performed.

scholarly journals Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 156 ◽  
Author(s):  
Mónica Villanueva ◽  
Amaya Oyarzún ◽  
Bárbara Leyton ◽  
Mónica González ◽  
Elizabeth Navarro ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Nutritional Status ◽  
Gastrointestinal Symptoms ◽  
Failure To Thrive ◽  
Age At Diagnosis ◽  
Pediatric Hospitals ◽  
Geographical Variations ◽  
Number Of Patients ◽  
Antiendomysial Antibodies

The frequency of celiac disease (CD) has increased along time, with relevant changes reported in geographical variations, clinical presentation and nutritional repercussions. In recent years, some celiac patients are presenting overweight/obesity, but it is unclear how frequent this is and to what extent undernutrition remains a concern. This is relevant because CD tends to be overlooked in overweight patients. With this in mind, we assessed age at diagnosis, clinical characteristics and nutritional status of 155 celiac patients diagnosed between 1994–2017 in four pediatric hospitals in Santiago, Chile. Since 2003, the number of patients diagnosed has increased (p < 0.0033), coinciding with antitransglutaminase and antiendomysial antibodies becoming available to public health systems. In 2000, 4.5% of patients were asymptomatic at diagnosis, suggesting that active search is not routinely applied. Gastrointestinal symptoms plus failure to thrive were significantly more frequent under 2 years (p = 0.0001). Nutritional status has improved at diagnosis and during follow up, but undernutrition remains more frequent in children <2 and <5 years (p < 0.002 and p < 0.0036, respectively). Overweight at diagnosis was reported in 2002 and obesity in 2010. After initiating treatment, since 2010, patients changing from undernourishment to overweight has sometimes been observed after only 6 months on a gluten-free diet.

scholarly journals Recurrent Pneumonia due to Fibrosing Mediastinitis in a Teenage Girl: A Case Report with Long-Term Follow-Up

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Avigdor Hevroni ◽  
Chaim Springer ◽  
Oren Wasser ◽  
Avraham Avital ◽  
Benjamin Z. Koplewitz
Keyword(s):  
Fibrous Tissue ◽  
Rare Condition ◽  
High Morbidity ◽  
Healthy Children ◽  
Teenage Girl ◽  
Positive Serology ◽  
Recurrent Pneumonia ◽  
Fibrosing Mediastinitis ◽  
The Right

A teenage girl was evaluated for recurrent right pneumonia. The evaluation revealed a calcified mediastinal mass that compressed the right intermediate and middle lobar bronchi, as well as the right pulmonary artery and veins. The clinical picture together with imaging studies and borderline positive serology testing suggested a diagnosis of fibrosing mediastinitis associated with histoplasmosis. This rare condition is characterized by the local proliferation of invasive fibrous tissue within the mediastinum due to a hyperimmune reaction to Histoplasma capsulatum. Antifungal and anti-inflammatory therapies are usually ineffective, and surgical intervention contains a high morbidity risk. Palliative surgery and stenting of the compressed airway have been suggested. In the past, the prognosis was thought to be poor, but recent studies demonstrate a more positive outcome. Our patient had been radiologically and functionally stable under follow-up for over thirteen years and has married and delivered two healthy children, both following an uneventful pregnancy.

scholarly journals Evaluation of adult celiac disease from a tertiary reference center: a retrospective analysis

2020 ◽  
Vol 66 (1) ◽  
pp. 55-60
Author(s):  
Omer Burcak Binicier ◽  
Ferahnaz Tosun
Keyword(s):  
Celiac Disease ◽  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Gastrointestinal Symptoms ◽  
Single Type ◽  
Adult Celiac Disease ◽  
Antibody Positivity ◽  
The Mean ◽  
Time Of Admission

SUMMARY OBJECTIVE It has been observed that celiac disease (CD) is not restricted to a single type characterized by diarrhea but also has atypical, asymptomatic (silent), and latent forms. The prevalence of this autoimmune disease, which affects approximately 1% of the world, is estimated to be around 3%, including atypical and asymptomatic cases. In our study, we aimed to evaluate adult celiac patients. METHODS Between December 2008-2015, patients diagnosed with CD over the age of 18 years old were included in the study. Patients’ symptoms at admission, frequency and type of anemia, transaminase levels, and celiac antibody positivity, and autoimmune diseases diagnosed at follow up were evaluated retrospectively. RESULTS Of 195 patients, 151 (77.4%) were female. The mean age of the patients was 35.73 ± 12.19 years (range, 18-71 years). A hundred patients (51.3%) had gastrointestinal symptoms. At the time of admission, 118 patients (60.5%) had anemia, and 52 (26.7%) had hypertransaminasemia. During the mean follow-up period of 58 months (36-120 months), 84 (43.1%) of the patients presented at least one autoimmune disease, and this rate was 96.6% in individuals diagnosed above the age of 50 years. CONCLUSION In adult CD, resistant anemia, dyspepsia, and hypertransaminasemia are very common findings at the time of diagnosis, and the association with other autoimmune diseases, especially Hashimoto’s thyroiditis, is high.

IDIOPATHIC CELIAC DISEASE

PEDIATRICS ◽  
1953 ◽  
Vol 11 (3) ◽  
pp. 224-237
Author(s):  
PAUL A. DI SANT'AGNESE
Keyword(s):  
Celiac Disease ◽  
Clinical Symptoms ◽  
Respiratory Infections ◽  
Gastrointestinal Symptoms ◽  
Adult Life ◽  
Early Years ◽  
Clinical Recovery ◽  
Upper Respiratory ◽  
Latent Phase

The mortality and course of the illness of 58 patients with celiac disease, previously reported, are described. Three patients died; the remaining 55 went on to clinical recovery. The greatest clinical gains were made by these cases in the 6 to 24 months following initiation of treatment, but the abnormal character of the stools persisted for months or years. Relapses were not uncommon during the early years of improvement following upper respiratory infections or dietary indiscretions. The results of the follow-up study of 23 patients, 3 to 11 years after the original admission to Babies Hospital, are reported. It was found that despite remission of clinical symptoms, many abnormal laboratory and roentgenographic findings persisted (termed "latent phase of celiac disease"). It is reasonable to expect that some patients who have had severe celiac disease during infancy or early childhood may experience a recurrence of gastrointestinal symptoms in adult life.

Population screening for celiac disease: Follow up of patients identified by positive serology

2007 ◽  
Vol 22 (4) ◽  
pp. 532-535 ◽  
Author(s):  
Raanan Shamir ◽  
Vered Yehezkely-Schildkraut ◽  
Corina Hartman ◽  
Rami Eliakim
Keyword(s):  
Celiac Disease ◽  
Population Screening ◽  
Positive Serology

scholarly journals Pernio as the clinical presentation of celiac disease: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2094044
Author(s):  
Alexandre Lemieux ◽  
Natasha Emily Sanchez Vivas ◽  
Julie Powell ◽  
Prévost Jantchou ◽  
Marie-Paule Morin
Keyword(s):  
Celiac Disease ◽  
Case Report ◽  
Pharmacological Treatment ◽  
Clinical Remission ◽  
Clinical Presentation ◽  
Gastrointestinal Symptoms ◽  
Skin Lesions ◽  
Gluten Free Diet ◽  
Gluten Free

We present the case of a 12-year-old girl with severe pernio as the sole clinical presentation of celiac disease (CD), without associated gastrointestinal symptoms. Lesions greatly improved once a gluten free diet was initiated. At 5-year follow-up, she remains in clinical remission throughout the year with no pharmacological treatment, without skin lesions flare-up in the winter months.

scholarly journals A 12-Week Pilot Exercise Program for Inactive Adults With Celiac Disease: Study Protocol

2019 ◽  
Vol 8 ◽  
pp. 216495611985377 ◽  
Author(s):  
A Justine Dowd ◽  
Liam Kronlund ◽  
Candice Parmar ◽  
Julia T Daun ◽  
Kathryn Wytsma-Fisher ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Negative Symptoms ◽  
Gastrointestinal Symptoms ◽  
Exercise Program ◽  
Interval Training ◽  
Maximal Heart Rate ◽  
Physical And Mental Health ◽  
Self Compassion ◽  
Lifestyle Education

Background Individuals with celiac disease must follow a strict gluten-free diet (GFD) in order to avoid negative short- and long-term health consequences. Unfortunately, many people with celiac disease report poor quality of life (QoL) despite following a strict GFD, and up to 30% still report negative symptoms (eg, gastrointestinal upset). Purpose The purpose of the MOVE-C (understanding the relationship between the Microbi Ome, Vitality, and Exercise in Celiac disease) pilot study is to explore the effects of a 12-week supervised progressive high-intensity interval training (HIIT) and lifestyle intervention on physiological, behavioral, and psychosocial outcomes among inactive adults with celiac disease. Methods/Design: Sixty inactive adults diagnosed with celiac disease will be randomized to HIIT+ or waitlist control (WLC). Participants in the HIIT+ will engage in a 12-week HIIT + lifestyle education program. HIIT sessions will be comprised of 2 workouts per week, working up to 14 × 30-second intervals at 90% maximal heart rate (HRmax) followed by 2 minutes recovery at 50% HRmax. The 6 biweekly lifestyle sessions will involve education on the promotion of a whole foods GFD, sleep hygiene, psychosocial coping skills (eg, self-compassion), and self-regulatory skills to master changes in behaviors. Assessments will occur at pre and post 12-week intervention and 3-month follow-up. WLC participants will be offered a 12-week HIIT program + online lifestyle education sessions after completing the final assessment. The primary outcomes are QoL and gut microbiota composition assessed with 16S rRNA sequencing. The secondary outcomes are markers of metabolic syndrome (waist circumference, fasting glucose, serum lipids, blood pressure, and body composition), gastrointestinal symptoms, sleep quality, adherence to a GFD, exercise behavior, self-regulatory efficacy, and self-compassion. It is hypothesized that participants in the HIIT+ will experience improvements in all outcomes when compared to those in the WLC. These improvements are expected to be maintained at the 3-month follow-up. Discussion The findings from this study will advance the knowledge regarding the effects of HIIT and lifestyle education on key outcomes for an at-risk chronic disease population. Furthermore, the findings can be used to inform future programs to improve fitness and physical and mental health outcomes for people with celiac disease.

scholarly journals The Changing Frequency of Celiac Disease Diagnosed at the Stollery Children’s Hospital

2010 ◽  
Vol 24 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Seema Rajani ◽  
Hien Q Huynh ◽  
Justine Turner
Keyword(s):  
Celiac Disease ◽  
Gastrointestinal Symptoms ◽  
Retrospective Chart Review ◽  
Children's Hospital ◽  
Number Of Children ◽  
Atypical Symptoms ◽  
Wide Range ◽  
Children’S Hospital ◽  
Atypical Presentations

BACKGROUND: Celiac disease (CD) is recognized as one of the most common and important autoimmune gastrointestinal disorders affecting children. There is evidence that a diagnosis of CD during childhood improves health outcomes. The increasing prevalence of CD is due to increased awareness of the wide range of extraintestinal symptoms associated with CD.OBJECTIVE: To determine whether there has been a temporal increase in the diagnosis of CD associated with an increased diagnosis of children without typical gastrointestinal symptoms at the Stollery Children’s Hospital (Edmonton, Alberta).METHODS: Patients with biopsy-proven CD diagnosed at the Stollery Children’s Hospital from 1998 to 2007, were identified by retrospective chart review. Baseline and follow-up data, including demographics, symptoms, risk factors, anthropometrics and laboratory investigations, were collected.RESULTS: An increase in the frequency of diagnosis of CD was noted during the study period, particularly from January 2003 onward. Before January 2003, nine children were diagnosed with CD – all with typical symptoms. Between January 2003 and January 2007, inclusive, 149 children were diagnosed with CD, of whom 46% had absent or atypical symptoms. At follow-up, 96% of patients reported improved symptoms, including 53% of individuals who reported being asymptomatic before diagnosis.CONCLUSIONS: In the last four years of the period studied, the number of children diagnosed with CD at Stollery Children’s Hospital increased 11-fold. Screening children at risk for CD, and those with atypical presentations, contributed to the increased number of diagnoses. Identification of CD and establishment of lifelong, dietary gluten avoidance during childhood has important health benefits and should be encouraged.

scholarly journals Intestinal anti-tissue transglutaminase IgA deposits as a complementary method for the diagnostic evaluation of celiac disease in patients with low-grade histological lesions

2021 ◽  
Author(s):  
María Roca ◽  
Ester Donat ◽  
Etna Masip ◽  
Verónica Ballester ◽  
Isabel Gómez ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Pediatric Population ◽  
Histological Study ◽  
Final Diagnosis ◽  
Low Grade ◽  
Positive Serology ◽  
Histological Lesion ◽  
Complementary Method

Summary Evaluating the usefulness of intestinal anti-transglutaminase IgA (anti-TG2 IgA) deposits detection as a complementary or decision-supporting tool in the diagnosis of celiac disease (CD) in patients with low degree of enteropathy. Small intestinal biopsies (SIB) were performed from 2008 to 2017 in patients on suspicion of CD (positive CD serology and/or symptoms) referred to our Pediatric Gastroenterology Unit. We determined anti-TG2 IgA deposits by using double immunofluorescence in all the patients in whom Marsh 0 or Marsh1 was detected in the conventional histological study and in a random selection of patients with clearly positive serology and histological Marsh 2-3 lesion. 75 pediatric patients were split into 3 groups according to the final diagnosis: 1) 13 children with a Marsh 0 or 1, negative CD serology and final non-CD diagnosis;none presented intestinal anti-TG2 IgA deposits; 2) 15 potential CD cases (Marsh 0 or 1 and CD-associated antibodies), detecting anti-TG2 IgA deposits in 12; on follow-up, another biopsy performed in 11/15 showed villi atrophy in 7 and a Marsh 2 lesion in two of them, patients being finally diagnosed as CD cases; and 3) 47 children with Marsh 2-3 histological lesion and final CD diagnosis; all of them had intestinal anti-TG2 IgA deposits. Anti-TG2 deposits are a useful complementary tool for CD diagnosis in pediatric population with digestive pathologies suggestive of CD. It is especially helpful in those with low grade lesion, in which anti-TG2 deposits are predictive of the development of more severe lesions on follow-up.

Sign in / Sign up

Export Citation Format

Share Document