Magnesium homeostasis and therapy in hypertension

2020 ◽  
Author(s):  
Klaus Kisters ◽  
Hans-Georg Classen ◽  
Jürgen Vormann ◽  
Tanja Werner ◽  
Ronald Smetana ◽  
...  
Keyword(s):  
Magnesium Homeostasis

Role of kidney in maintaining calcium and magnesium homeostasis and its disorders (Part I)

2018 ◽  
Vol 20 (2) ◽  
pp. 150-169
Author(s):  
Ja.F. Zverev ◽  
◽  
V.M. Bryukhanov ◽  
A.Ya. Rykunova ◽  
◽  
...  
Keyword(s):  
Magnesium Homeostasis ◽  
Calcium And Magnesium

scholarly journals Magnesium Deficiency Alters Expression of Genes Critical for Muscle Magnesium Homeostasis and Physiology in Mice

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2169
Author(s):  
Dominique Bayle ◽  
Cécile Coudy-Gandilhon ◽  
Marine Gueugneau ◽  
Sara Castiglioni ◽  
Monica Zocchi ◽  
...  
Keyword(s):  
Gastrocnemius Muscle ◽  
Magnesium Deficiency ◽  
Mitochondrial Dynamics ◽  
Body Weight Gain ◽  
Whole Body ◽  
Muscle Physiology ◽  
Deficient Diet ◽  
Muscle Weight ◽  
Magnesium Homeostasis ◽  
Expression Of Genes

Chronic Mg2+ deficiency is the underlying cause of a broad range of health dysfunctions. As 25% of body Mg2+ is located in the skeletal muscle, Mg2+ transport and homeostasis systems (MgTHs) in the muscle are critical for whole-body Mg2+ homeostasis. In the present study, we assessed whether Mg2+ deficiency alters muscle fiber characteristics and major pathways regulating muscle physiology. C57BL/6J mice received either a control, mildly, or severely Mg2+-deficient diet (0.1%; 0.01%; and 0.003% Mg2+ wt/wt, respectively) for 14 days. Mg2+ deficiency slightly decreased body weight gain and muscle Mg2+ concentrations but was not associated with detectable variations in gastrocnemius muscle weight, fiber morphometry, and capillarization. Nonetheless, muscles exhibited decreased expression of several MgTHs (MagT1, CNNM2, CNNM4, and TRPM6). Moreover, TaqMan low-density array (TLDA) analyses further revealed that, before the emergence of major muscle dysfunctions, even a mild Mg2+ deficiency was sufficient to alter the expression of genes critical for muscle physiology, including energy metabolism, muscle regeneration, proteostasis, mitochondrial dynamics, and excitation–contraction coupling.

Magnesium Homeostasis in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis: Role of the Dialysate Magnesium Concentration

2003 ◽  
Vol 27 (9) ◽  
pp. 853-857 ◽  
Author(s):  
Kostas P. Katopodis ◽  
Elli L. Koliousi ◽  
Emilios K. Andrikos ◽  
Michael V. Pappas ◽  
Moses S. Elisaf ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Magnesium Concentration ◽  
Magnesium Homeostasis

Disorders of calcium and magnesium homeostasis

1982 ◽  
Vol 72 (3) ◽  
pp. 473-488 ◽  
Author(s):  
Zalman S. Agus ◽  
Alan Wasserstein ◽  
Stanley Goldfarb
Keyword(s):  
Magnesium Homeostasis ◽  
Calcium And Magnesium

The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis

2012 ◽  
pp. 127-139
Author(s):  
Vladimir Chubanov ◽  
Jonathan T. Eggenschwiler ◽  
Lillia V. Ryazanova ◽  
Thomas Gudermann ◽  
Alexey G. Ryazanov
Keyword(s):  
Magnesium Homeostasis

Fluid and electrolyte problems in neurosurgery

2010 ◽  
pp. 110-124
Author(s):  
George Samandouras
Keyword(s):  
Calcium Homeostasis ◽  
Acid Base ◽  
Sodium Homeostasis ◽  
Potassium Homeostasis ◽  
Fluid Homeostasis ◽  
Magnesium Homeostasis

Chapter 3.2 discusses fluid and electrolyte problems in neurosurgery, including fluid homeostasis disorders, sodium homeostasis disorders, potassium homeostasis disorders, calcium homeostasis disorders, magnesium homeostasis disorders, and acid-base disorders.

scholarly journals Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism

2019 ◽  
Vol 116 (8) ◽  
pp. 2925-2934 ◽  
Author(s):  
Serge Hardy ◽  
Elie Kostantin ◽  
Shan Jin Wang ◽  
Tzvetena Hristova ◽  
Gabriela Galicia-Vázquez ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Rapid Change ◽  
Metabolic Reprogramming ◽  
Regenerating Liver ◽  
Energy Status ◽  
Intracellular Magnesium ◽  
Cellular Energy ◽  
Magnesium Homeostasis ◽  
Upstream Orf ◽  
Cellular Bioenergetics

Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. Although high PRL levels have been linked to cancer progression, regulation of their expression is poorly understood. Here we show that modulating intracellular magnesium levels correlates with a rapid change of PRL expression by a mechanism involving its 5′UTR mRNA region. Mutations or CRISPR-Cas9 targeting of the conserved upstream ORF present in the mRNA leader derepress PRL protein synthesis and attenuate the translational response to magnesium levels. Mechanistically, magnesium depletion reduces intracellular ATP but up-regulates PRL protein expression via activation of the AMPK/mTORC2 pathway, which controls cellular energy status. Hence, altered PRL-2 expression leads to metabolic reprogramming of the cells. These findings uncover a magnesium-sensitive mechanism controlling PRL expression, which plays a role in cellular bioenergetics.

scholarly journals Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus

PLoS Genetics ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. e1008336 ◽  
Author(s):  
Emilie Trachsel ◽  
Peter Redder ◽  
Patrick Linder ◽  
Joshua Armitano
Keyword(s):  
Staphylococcus Aureus ◽  
Genetic Screens ◽  
Magnesium Homeostasis

Phosphatase of regenerating liver maintains cellular magnesium homeostasis

2018 ◽  
Vol 475 (6) ◽  
pp. 1129-1139 ◽  
Author(s):  
Atsushi Yoshida ◽  
Yosuke Funato ◽  
Hiroaki Miki
Keyword(s):  
Cancer Progression ◽  
Functional Relationship ◽  
Cultured Cells ◽  
Culture Conditions ◽  
Signal Transducer ◽  
Regenerating Liver ◽  
Mrna Transcription ◽  
Protein Levels ◽  
Magnesium Homeostasis ◽  
Phosphatase Of Regenerating Liver

Phosphatase of regenerating liver (PRL) is highly expressed in malignant cancers and promotes cancer progression. Recent studies have suggested its functional relationship with Mg2+, but the importance and molecular details of this relationship remain unknown. Here, we report that PRL expression is regulated by Mg2+ and PRL protects cells from apoptosis under Mg2+-depleted conditions. When cultured cells were subjected to Mg2+ depletion, endogenous PRL protein levels increased significantly. siRNA-mediated knockdown of endogenous PRL did not significantly affect cell proliferation under normal culture conditions, but it increased cell death after Mg2+ depletion. Imaging analyses with a fluorescent probe for Mg2+ showed that PRL knockdown severely reduced intracellular Mg2+ levels, indicating a role for PRL in maintaining intracellular Mg2+. We also examined the mechanism of augmented expression of PRL proteins and found that PRL mRNA transcription was stimulated by Mg2+ depletion. A series of analyses revealed the activation and the crucial importance of signal transducer and activator of transcription 1 in this process. Collectively, these results implicate PRL in maintaining cellular Mg2+ homeostasis.

Magnesium Regulates the Circadian Oscillator in Cyanobacteria

2019 ◽  
Vol 34 (4) ◽  
pp. 380-390 ◽  
Author(s):  
Young M. Jeong ◽  
Cristiano Dias ◽  
Casey Diekman ◽  
Helene Brochon ◽  
Pyonghwa Kim ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Circadian Clock ◽  
Biological Rhythms ◽  
Circadian Oscillator ◽  
Magnesium Concentration ◽  
Circadian Oscillation ◽  
Magnesium Homeostasis ◽  
Low Magnesium

The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylation. KaiA activates KaiC phosphorylation by binding the A-loop of KaiC, while KaiB attenuates the phosphorylation by sequestering KaiA from the A-loop. Structural analysis revealed that magnesium regulates the phosphorylation and dephosphorylation of KaiC by dissociating from and associating with catalytic Glu residues that activate phosphorylation and dephosphorylation, respectively. High magnesium causes KaiC to dephosphorylate, whereas low magnesium causes KaiC to phosphorylate. KaiC alone behaves as an hourglass timekeeper when the magnesium concentration is alternated between low and high levels in vitro. We suggest that a magnesium-based hourglass timekeeping system may have been used by ancient cyanobacteria before magnesium homeostasis was established.

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