scholarly journals A case of multiple pulmonary nodules diagnosed as pulmonary melanoma without extra-pulmonary site

2021 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Yoshihiro Miyashita ◽  
Miyuki Kobayashi ◽  
Yumiko Kakizaki ◽  
Toshiharu Tsutsui ◽  
Takashi Kumagai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Pulmonary Nodules ◽  
Final Diagnosis ◽  
Tumor Biopsy ◽  
Annual Screening ◽  
Nodular Lesions ◽  
Extra Pulmonary ◽  
The Right ◽  
Pulmonary Sarcoma

A 67-year-old patient visited the hospital for the evaluation of pulmonary nodular lesions detected in his chest radiograph duringan annual screening. He was asymptomatic and transbronchial tumor biopsy of the nodule in the right upper lobe revealed features of pulmonary sarcoma, which did not resemble any of the histolopathological categories of primary lung cancer. A positive immunological staining for both HMB-45 and Melan-A resulted in the final diagnosis of melanoma. It is important for a respiratory clinician to remind the possibility of a melanoma, when tumors cannot be histopathologically classified under any of the categories of primary lung cancer.

scholarly journals Pulmonary Nodule in a Patient with Oral and Lung Cancer: Cryptococcus Infection

2019 ◽  
Vol 7 (4) ◽  
pp. 102
Author(s):  
Yamagata ◽  
Hirano ◽  
Kanno ◽  
Uchida ◽  
Fukuzawa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mediastinal Lymph Node ◽  
Left Lung ◽  
Pulmonary Nodules ◽  
Pulmonary Cryptococcosis ◽  
Thoracoscopic Resection ◽  
Inferior Lobe ◽  
Primary Lung Tumors ◽  
Oral Cancer Patients ◽  
The Right

Pulmonary nodules are frequently considered to be a metastatic disease or primary lung tumors in oral cancer patients. We present a case of pulmonary cryptococcosis in a 68-year-old man with oral and lung cancer. This lung cancer was treated with thoracoscopic resection of the right inferior lobe and mediastinal lymph node dissection. Lower gingival cancer was treated with a mandibulectomy, neck dissection, and reconstruction after chemoradiotherapy. A 20 mm cavitary nodule appeared at the left lung S6 one-month after surgery, during post-operative computed tomography. Thoracoscopic partial resection of the left inferior lobe was performed under the suspicion of lung metastasis. Pathology results revealed a pseudo-epithelial granuloma with necrosis and many yeast-shaped fungi with capsules. A pathological diagnosis of Cryptococcus infection was made. The patient was prescribed the antifungal agent fosfluconazole, which was administered intravenously for 1 week and intraoral fluconazole for 12 months. No recurrence of the Cryptococcus infection has been noted after 1.5 years.

scholarly journals Diagnosis and outcome of resected solitary pulmonary nodules after liver transplantation

2019 ◽  
Author(s):  
Mari Tone ◽  
Nobuyasu Awano ◽  
Takehiro Izumo ◽  
Hanako Yoshimura ◽  
Tatsunori Jo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Liver Transplantation ◽  
Early Stage ◽  
Lung Resection ◽  
Invasive Pulmonary Aspergillosis ◽  
Primary Lung Cancer ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Computed Tomography Scans

Abstract Objective Solitary pulmonary nodules after liver transplantation are challenging clinical problems. Herein, we report the causes and clinical courses of resected solitary pulmonary nodules in patients who underwent liver transplantation. Methods We retrospectively obtained medical records of 68 patients who underwent liver transplantation between March 2009 and June 2016. This study mainly focused on patients with solitary pulmonary nodules observed on computed tomography scans during follow-ups that were conducted until their deaths or February 2019. Results Computed tomography scans revealed solitary pulmonary nodules in 7 of the 68 patients. Definitive diagnoses were obtained using video-assisted lung resection in all seven patients. None experienced major postoperative complications. The final pathologic diagnoses were primary lung cancer in three patients, pulmonary metastases from hepatocellular carcinoma in one patient, invasive pulmonary aspergillosis in one patient, post-transplant lymphoproliferative disorder in one patient, and hemorrhagic infarction in one patient. The three patients with lung cancer were subsequently treated with standard curative resection. Conclusions Solitary pulmonary nodules present in several serious but potentially curable diseases, such as early-stage lung cancer. Patients who present with solitary pulmonary nodules after liver transplantation should be evaluated by standard diagnostic procedures, including surgical biopsy if necessary.

scholarly journals Next-generation sequencing facilitates differentiating between multiple primary lung cancer and intrapulmonary metastasis: a case series

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Changjiang Liu ◽  
Chengang Liu ◽  
Xiao Zou ◽  
Lin Shao ◽  
Ying Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Primary Lung Cancer ◽  
Invasive Adenocarcinoma ◽  
Free Survival ◽  
Multiple Primary ◽  
Minimally Invasive Adenocarcinoma ◽  
The Right ◽  
Generation Sequencing

Abstract Background In lung cancer management, differential diagnosis between multiple primary lung cancer (MPLC) and intrapulmonary metastasis (IMP) is a critical point that is of direct therapeutic and clinical importance. However, this process often suffers from absence of a gold standard, resulting in equivocal cases. Herein, we present a series of three cases, in which genomic alteration patterns revealed by next-generation sequencing (NGS) facilitated the differential diagnosis between MPLC and IMP. Case presentation Case 1 was a 57-year-old female with two separate lesions in the upper lobe and the lower lobe of left lung, which were both histopathologically determined as T2aN0M0 adenocarcinomas. NGS identified an EGFR L858R in one lesion and an EGFR 20 exon insertion in the other one, suggestive of double primary malignancies. The patient underwent wedge resections and received an adjuvant treatment of icotinib and chemotherapy. She had a disease-free survival (DFS) of 19 months and counting. Case 2 was a 55-year-old female with multiple small lesions in both lungs. Histopathological examinations of resected lesions from right upper lobe revealed three subtypes: atypical adenomatous hyperplasia of alveolar epithelium, adenocarcinomas in situ and minimally invasive adenocarcinoma. NGS identified two different BRAF driver mutations G466E and V600_K601delinsE in two lesions of adenocarcinoma in situ, and a BRAF K601E in a lesion of minimally invasive adenocarcinoma. Case 3, a 68-year-old male, had the right upper lobe lesion histophathologically classified as a stage T3NxM0 mixed adenoneuroendocrine carcinoma and the left upper lobe lesion as a stage T1aN0M0 adenocarcinoma. NGS performed with different loci of surgical tissues revealed a rare sensitizing EGFR mutation G719A shared by the right upper lobe lesion and lymph node, and two EGFR mutations L861Q and G719S in left upper lobe lesion. The patient received icotinib treatment postoperatively and achieved a stable disease with a progression-free survival of 5 months. Conclusion Our cases provide evidence for utility of NGS in facilitating diagnosis and treatment decisions.

scholarly journals Primary lung cancer of the right middle lobe

1991 ◽  
Vol 5 (5) ◽  
pp. 514-519
Author(s):  
Makoto Nonaka ◽  
Takashi Arai ◽  
Keizou Inagaki ◽  
Takatorno Morita ◽  
Makoto Yana ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Middle Lobe ◽  
Right Middle Lobe ◽  
The Right

Diagnostic procedures in obtaining pathological materials for pulmonary nodules due to primary lung cancer.

1998 ◽  
Author(s):  
M Obara ◽  
H Satoh ◽  
H Ishikawa ◽  
Y T Yamashita ◽  
N Tanaka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Pulmonary Nodules ◽  
Diagnostic Procedures

scholarly journals Coincident detection of lung metastasis of prostate cancer and primary lung cancer: A case report

2015 ◽  
Vol 9 (7-8) ◽  
pp. 524
Author(s):  
Yusuke Muro ◽  
Takeo Kosaka ◽  
Tai Hato ◽  
Shuji Mikami ◽  
Mototsugu Oya
Keyword(s):  
Prostate Cancer ◽  
Lung Cancer ◽  
Lung Metastasis ◽  
Needle Biopsy ◽  
Rare Case ◽  
External Beam Radiotherapy ◽  
Primary Lung Cancer ◽  
Lower Lobe ◽  
Lung Lesion ◽  
The Right

We report an extremely rare case of 79-year-old man, who was discovered with coincidental lung metastasis of prostate cancer and primary lung cancer. The patient presented with low prostatespecific antigen and two lung lesions: one in the right lower lobe, and one in the right upper lobe, 3 years after, he was treated with external beam radiotherapy for Gleason score 4+3=7, cT3aN0M0 prostate cancer. A computed tomography-guided needle biopsy of a nodule in the right lower lobe revealed suspicious metastasis of prostate cancer. Thoracoscopic excisions of both lesions were performed, and each lung lesion was diagnosed as being metastatic prostate cancer and primary lung cancer.

scholarly journals Multiple primary lung cancer versus intrapulmonary metastatic cancer: A case of multiple pulmonary nodules

2018 ◽  
Vol 10 (2) ◽  
pp. 352-358
Author(s):  
Chunquan Liu ◽  
Huawei Li ◽  
Kaikai Xu ◽  
Shuai Song ◽  
Ying He ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Metastatic Cancer ◽  
Primary Lung Cancer ◽  
Pulmonary Nodules ◽  
Multiple Pulmonary Nodules ◽  
Multiple Primary

scholarly journals Lobectomy with bronchoplasty and pulmonary arterial angioplasty for lung cancer after correction of contralateral partial anomalous pulmonary venous connection

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Koichi Fukumoto ◽  
Madoka Goto ◽  
Yasuhisa Ichikawa ◽  
Yuta Kawasumi ◽  
Mika Uchiyama ◽  
...  
Keyword(s):  
Heart Failure ◽  
Lung Cancer ◽  
Pulmonary Resection ◽  
Lung Tumor ◽  
Primary Lung Cancer ◽  
Right Heart Failure ◽  
Contralateral Side ◽  
Pulmonary Arterial ◽  
The Right ◽  
Anomalous Pulmonary Venous Connection

Abstract Background There have been few reports on surgically treated primary lung cancer accompanied by contralateral partial anomalous pulmonary venous connection (PAPVC). In such cases, repair of the PAPVC might be necessary to avoid postoperative right-heart failure due to the increased flow of the left-to-right shunt. Case presentation We herein report a case of lung adenocarcinoma treated by left-upper lobectomy with bronchoplasty and pulmonary arterial angioplasty after induction chemoradiation therapy followed by surgical correction of the PAPVC in the right-upper lobe. The patient is alive without recurrence of lung cancer or any symptoms of heart failure 17 months after pulmonary resection. Conclusion When considering performing major pulmonary resection for lung tumor, thoracic surgeons should pay close attention to the presence of a PAPVC not only on the ipsilateral side of the lung tumor, but also the contralateral side, although it is a rare phenomenon.

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