Clinical evaluation of ethanolic extract of curcumin (Curcuma longa) on wound healing in Black Bengal goats

ABSTRACT The objective of the present study was to evaluate the effect of a hydrocolloid dressing on second intention wound healing in cats. Two full-thickness skin wounds, measuring 2 × 2 cm, were created on both sides of the dorsal midline of 10 cats; bilaterally, one randomly selected wound was bandaged with a hydrocolloid dressing and the second one (control) with a semiocclusive pad. Subjective clinical evaluation of granulation tissue formation, of the quantity and nature of wound exudate, and planimetry were performed on the right-side wounds, and histological examination on the left. No significant differences in subjective clinical evaluation or in planimetry were observed between the hydrocolloid-treated wounds and controls. Most wounds had serous or absence of exudate (41.25% and 25%, respectively), whereas purulent exudate was observed in 7.5% of wounds. Edema was significantly increased in the hydrocolloid-treated wounds compared with controls on day 7 but no significant differences in the other histological variables were observed.

Download Full-text

Evaluation of Aqueous Creams Containing Ethanolic Extract of Curcuma longa (Turmeric) as Bioactive Ingredient for the Management of Wounds

International Journal of Applied Biology and Pharmaceutical Technology ◽

10.26502/ijabpt.202103 ◽

2021 ◽

Vol 12 (01) ◽

Author(s):

Kenneth Chinedu Ugoeze ◽

Majiroghene Uyoyoumaero Okpa ◽

Nkemakolam Nwachukwu ◽

Bruno Chukwuemeka Chinko ◽

Kennedy Emeka Oluigbo

Keyword(s):

Curcuma Longa ◽

Ethanolic Extract

Download Full-text

WOUND HEALING ACTIVITY OF THE WHOLE PLANT OF MOMORDICA CHARANTIA LINN. IN RATS

INDIAN DRUGS ◽

10.53879/id.55.11.11317 ◽

2018 ◽

Vol 55 (11) ◽

pp. 64-70

Author(s):

M.P Singh ◽

◽

Y.S. Sarangdevot ◽

S.S. Sisodia

Keyword(s):

Wound Healing ◽

Ethyl Acetate ◽

Petroleum Ether ◽

Ethanolic Extract ◽

Momordica Charantia ◽

Alcohol Extract ◽

Whole Plant ◽

Healing Property ◽

Aqueous Ethanolic Extract ◽

Wound Healing Activity

The aim of the present study was to explore the effect of wound healing activity of the whole plant of Momordica charantia Linn. in rats. The effect of aqueous ethanolic extract of Momordica charantia Linn. (Family; Cucurbetaceae) was evaluated on resutured incision, granuloma pouch and excision wound models in rats. The wound healing activity was measured by the rate of wound contraction, skin breaking strength, weight of the granulation tissue, and collagen content. The concentrated ethyl alcohol extract was subject to fractionation by using petroleum ether (40-60o V/V), solvent ether, ethyl acetate, butanol, butanone, ethanol and methanol in succession. All the fractions were screened for wound healing property. The results of pharmacological activity led to the conclusion that the petroleum ether fraction exhibited more significant wound healing promotion property followed by solvent ether and butanone, from all the parameters studied. Ethyl acetate, ethanol and methanol fractions were least effective.

Download Full-text

Wound healing activity of Conyza canadensis (L.) Cronquist

Science and Technology Development Journal - Natural Sciences ◽

10.32508/stdjns.v1it5.533 ◽

2018 ◽

Vol 1 (T5) ◽

pp. 35-40

Author(s):

To Dinh Le ◽

Nga Thi Hoang ◽

Nhan Thi Thanh Nguyen ◽

Thuoc Linh Tran ◽

Thao Thi Phuong Dang

Keyword(s):

Wound Healing ◽

Antibacterial Activity ◽

Ethyl Acetate ◽

National Park ◽

Ethanolic Extract ◽

Ethyl Acetate Fraction ◽

Conyza Canadensis ◽

Keratinocyte Proliferation ◽

Wound Healing Activity ◽

Stimulation Of

Conyza canadensis (L.) Cronquist (CCL) has been used by K’Ho minority in Bidoup Nui Ba national park, Lam Dong province, Vietnam as one of wound healing remedies. However, the scientific proof of treatment is still unclear. This study aimed to evaluate this wound healing potential of CCL. CCL power was extracted by ethanol and then partitioned consecutively with petroleum ether, ethyl acetate and water. Wound healing potential was evaluated by antibacterial activity, stimulation of fibroblast and keratinocyte proliferation. Agar-well diffusion was used in the antibacterial tests and the results showed that CCL had antibacterial activity against 02 dermatitis bacteria (Pseudomonas aeruginosa, Staphylococcus aureus) and 02 opportunistic infection bacteria (Escherichia coli, Enterococcus faecalis). Moreover, our results illustrated that CCL stimulated the fibroblast and keratinocyte proliferation compared to the control. Particularly, the fibroblast division increased 1.6 times at 31.25 µg/mL when treated by ethanolic extract, while ethyl acetate fraction showed 1.7 times increase at 10 µg/mL in keratinocyte proliferation compared to the control. Taken together, our study contributed scientific base of CCL in the wound healing.

Download Full-text