Pregnancy outcomes after exposure to phendimetrazine in first trimester of pregnancy

2012 ◽  
Vol 55 (1) ◽  
pp. 1
Author(s):  
Min-Young Lee ◽  
June-Seek Choi ◽  
Jung-Yeol Han ◽  
Hyun-Kyeong Ahn ◽  
Jae-Hyug Yang ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
First Trimester ◽  
First Trimester Of Pregnancy

scholarly journals Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon

2021 ◽  
Vol 15 (4) ◽  
pp. e0009390
Author(s):  
Jamille Gregório Dombrowski ◽  
André Barateiro ◽  
Erika Paula Machado Peixoto ◽  
André Boler Cláudio da Silva Barros ◽  
Rodrigo Medeiros de Souza ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Multivariate Logistic Regression Analysis ◽  
Brazilian Amazon ◽  
First Trimester ◽  
Inflammatory Factors ◽  
Anthropometric Measures ◽  
First Trimester Of Pregnancy ◽  
Adverse Pregnancy ◽  
Angiopoietin 2

Background Malaria in Brazil represents one of the highest percentages of Latin America cases, where approximately 84% of infections are attributed to Plasmodium (P.) vivax. Despite the high incidence, many aspects of gestational malaria resulting from P. vivax infections remain poorly studied. As such, we aimed to evaluate the consequences of P. vivax infections during gestation on the health of mothers and their neonates in an endemic area of the Amazon. Methods and findings We have conducted an observational cohort study in Brazilian Amazon between January 2013 and April 2015. 600 pregnant women were enrolled and followed until delivery. After applying exclusion criteria, 329 mother-child pairs were included in the analysis. Clinical data regarding maternal infection, newborn’s anthropometric measures, placental histopathological characteristics, and angiogenic and inflammatory factors were evaluated. The presence of plasma IgG against the P. vivax (Pv) MSP119 protein was used as marker of exposure and possible associations with pregnancy outcomes were analyzed. Multivariate logistic regression analysis revealed that P. vivax infections during the first trimester of pregnancy are associated with adverse gestational outcomes such as premature birth (adjusted odds ratio [aOR] 8.12, 95% confidence interval [95%CI] 2.69–24.54, p < 0.0001) and reduced head circumference (aOR 3.58, 95%CI 1.29–9.97, p = 0.01). Histopathology analysis showed marked differences between placentas from P. vivax-infected and non-infected pregnant women, especially regarding placental monocytes infiltrate. Placental levels of vasomodulatory factors such as angiopoietin-2 (ANG-2) and complement proteins such as C5a were also altered at delivery. Plasma levels of anti-PvMSP119 IgG in infected pregnant women were shown to be a reliable exposure marker; yet, with no association with improved pregnancy outcomes. Conclusions This study indicates that P. vivax malaria during the first trimester of pregnancy represents a higher likelihood of subsequent poor pregnancy outcomes associated with marked placental histologic modification and angiogenic/inflammatory imbalance. Additionally, our findings support the idea that antibodies against PvMSP119 are not protective against poor pregnancy outcomes induced by P. vivax infections.

scholarly journals High starchy food intake may increase the risk of adverse pregnancy outcomes: a nested case-control study in the Shaanxi province of Northwestern China

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Liyan Huang ◽  
Li Shang ◽  
Wenfang Yang ◽  
Danyang Li ◽  
Cuifang Qi ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Pregnancy Outcomes ◽  
Case Control Study ◽  
First Trimester ◽  
Adverse Pregnancy Outcomes ◽  
Starchy Food ◽  
First Trimester Of Pregnancy ◽  
Adverse Pregnancy ◽  
Nested Case Control ◽  
Control Study

Abstract Background There was a wider disparity in the diet characterization among most studies on diet and pregnancy outcomes in different countries, and the research in northern China is limited. Therefore, the purpose of the present study that was conducted in northwest China was to understand the dietary characteristics of periconceptional women and to explore the relationship between and specific dietary patterns with adverse pregnancy outcomes. Methods A nested case-control study was conducted from October 2017 to November 2018 in Shaanxi, China. Based on a prospective cohort of 368 women who were pregnant or prepared for pregnancy, 63 participants who developed the outcomes of gestational hypertension, gestational diabetes, preterm birth, low birth weight, and birth defects were included in the case group. A total of 237 healthy pregnant women were included during the same period in the control group. Dietary intake was assessed using a validated food frequency questionnaire for the three months before pregnancy and the first trimester. Information on delivery details and antenatal pregnancy complications was obtained from the hospital maternity records. Dietary patterns were derived using factor analysis. Stratified analysis was performed on the overall, single and multiple adverse pregnancy outcomes categories. Adjustment was made for sociodemographic characteristics and nutritional supplement status. Results Six major dietary patterns were identified. The ‘starchy’ dietary pattern, composed of high intake in noodle and flour products and/or rice and its products, was associated with the odds of developing of adverse pregnancy outcomes (OR: 2.324, 95% CI: 1.293–4.178). This risk remained significant following adjustment for potential confounders of maternal demographic characteristics and nutritional status (aOR: 2.337, 95% CI:1.253–4.331). Strong association were found during the first trimester of pregnancy, but showed no association during the three months before pregnancy (aOR:1.473, 95% CI: 0.682–3.234). Conclusions High starchy food intake was associated with adverse pregnancy outcomes, particularly during the first trimester of pregnancy. Health education focusing on periconceptional dietary patterns could be a practical strategy for preventing adverse pregnancy outcomes.

scholarly journals Angiopoietin 1 and 2 serum concentrations in first trimester of pregnancy as biomarkers of adverse pregnancy outcomes

2014 ◽  
Vol 210 (4) ◽  
pp. 345.e1-345.e9 ◽  
Author(s):  
Francisco J. Schneuer ◽  
Christine L. Roberts ◽  
Anthony W. Ashton ◽  
Cyrille Guilbert ◽  
Vitomir Tasevski ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
First Trimester ◽  
Adverse Pregnancy Outcomes ◽  
Serum Concentrations ◽  
First Trimester Of Pregnancy ◽  
Adverse Pregnancy ◽  
Angiopoietin 1

scholarly journals The Association between Maternal Dietary Iron Intake during the First Trimester of Pregnancy with Pregnancy Outcomes and Pregnancy-Related Complications

2020 ◽  
Vol 9 (1) ◽  
pp. 52 ◽  
Author(s):  
Hossein Hajianfar ◽  
Khadijeh Abbasi ◽  
Leila Azadbakht ◽  
Ahmad Esmaeilzadeh ◽  
Negar Mollaghasemi ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
First Trimester ◽  
Dietary Iron ◽  
Iron Intake ◽  
First Trimester Of Pregnancy

scholarly journals Household Air Pollution, Levels of Micronutrients and Heavy Metals in Cord and Maternal Blood, and Pregnancy Outcomes

2018 ◽  
Vol 15 (12) ◽  
pp. 2891 ◽  
Author(s):  
Ganiyu Arinola ◽  
Anindita Dutta ◽  
Oluwafemi Oluwole ◽  
Christopher Olopade
Keyword(s):  
Heavy Metals ◽  
Folic Acid ◽  
Birth Weight ◽  
Cord Blood ◽  
Pregnancy Outcomes ◽  
First Trimester ◽  
Maternal Blood ◽  
Blood Levels ◽  
Pollution Levels ◽  
First Trimester Of Pregnancy

Cooking with kerosene emits toxic pollutants that may impact pregnancy outcomes. Sixty-eight women in their first trimester of pregnancy, kerosene users (n = 42) and liquefied natural gas (LNG) users (n = 26), were followed until birth. Maternal and cord blood were collected immediately after birth. Levels of micronutrients and heavy metals were quantified. Pregnancy outcomes (gestation age (GA), birth weight (BW), and chest and head circumference) were also measured. Mean (± standard deviation (SD)) age of mothers in kerosene and LNG groups were similar (p = 0.734). Mean (±SD) BW of newborns of LNG users was significantly higher compared to newborns of kerosene users (3.43 ± 0.32 vs. 3.02 ± 0.43, p < 0.001). Mean GA (in weeks) was similar between the two groups (p = 0.532). Women in the kerosene group had significantly higher cord blood levels of zinc, lead, mercury, iodine and vitamin B6 and lower levels of folic acid compared to LNG users (p < 0.05). Newborns of kerosene users had reduced levels of zinc, lead, mercury, iodine, vitamins B6 and B12, folic acid, and homocysteine compared with LNG users (p < 0.05). Also, cooking with kerosene was significantly associated with reduced birth weight after adjusting for potential confounders (β ± standard error (SE) = −0.326 ± 0.155; p = 0.040). Smoke from kerosene stove was associated with reduced birth weight and micronutrients imbalance in mothers and newborns.

Low maternal pregnancy-associated plasma protein A during the first trimester of pregnancy and pregnancy outcomes

2016 ◽  
Vol 136 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Marja Kaijomaa ◽  
Leena Rahkonen ◽  
Veli-Matti Ulander ◽  
Esa Hämäläinen ◽  
Henrik Alfthan ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Pregnancy Outcomes ◽  
Protein A ◽  
First Trimester ◽  
First Trimester Of Pregnancy

scholarly journals Thyroid Antibody Positivity in the First Trimester of Pregnancy Is Associated with Negative Pregnancy Outcomes

2011 ◽  
Vol 96 (6) ◽  
pp. E920-E924 ◽  
Author(s):  
Roberto Negro ◽  
Alan Schwartz ◽  
Riccardo Gismondi ◽  
Andrea Tinelli ◽  
Tiziana Mangieri ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
First Trimester ◽  
Thyroid Antibody ◽  
Antibody Positivity ◽  
First Trimester Of Pregnancy

scholarly journals Perceived Barriers to Exercise in the First Trimester of Pregnancy

2018 ◽  
Vol 27 (4) ◽  
pp. 198-206 ◽  
Author(s):  
Terin T. Sytsma ◽  
Kate P. Zimmerman ◽  
Jennifer B. Manning ◽  
Sarah M. Jenkins ◽  
Nancy C. Nelson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
First Trimester ◽  
Regular Physical Activity ◽  
Perceived Barriers ◽  
Barriers To Exercise ◽  
First Trimester Of Pregnancy

Regular physical activity has been shown to improve pregnancy outcomes. We sought to identify barriers to exercise during the first trimester of pregnancy. Five hundred forty-nine pregnant women in their first trimester rated barriers to exercise on a scale of 1 (not a barrier) to 5 (a huge barrier) and recorded physical activity (minutes/week). Women were placed into one of three classifications, nonexercisers (zero exercise), infrequent exercisers (<150 minutes/week), or exercisers (≥150 minutes/week). The greatest barriers (mean) were nausea/fatigue (3.0) and lack of time (2.6). Exercisers reported significantly lower barrier levels. Nausea/fatigue was a greater barrier for nonexercisers compared to exercisers (3.6 vs 2.8, p < .001). Focusing education and interventions on these barriers may help pregnant women achieve healthy exercise levels.

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