The role of gonadotrophin releasing hormone agonist for the treatment of scar endometriosis

Endometriosis is an oestrogen sensitive condition, leading to reluctance to prescribe hormone replacement therapy. Treatment of endometriosis either medically with gonadotrophin releasing hormone analogues or with surgery involving bilateral oophorectomy leads to oestrogen deficiency. While this may lead to vasomotor symptoms, the consequence which has been of most concern is a reduction in bone mass. Repeated courses of gonadotrophin releasing hormone analogues may mean that women with endometriosis enter the menopause with a below average bone density. Thus, there is a place for hormone replacement therapy both as add-back therapy in premenopausal women receiving gonadotrophin releasing hormone analogues, and in postmenopausal women with a past history of endometriosis. Addback therapy with continuous combined regimes and tibolone do not prevent disease resolution in the hypogonadal patient. The evidence regarding the use of hormone replacement therapy in patients with a history of endometriosis is poor, but suggests that we could be less conservative than we have been.

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Expression of isg15 and conjugating enzyme during peri-implanation period in sheep

Biotechnology in Animal Husbandry ◽

10.2298/bah2002215k ◽

2020 ◽

Vol 36 (2) ◽

pp. 215-223

Author(s):

Shahin Khan ◽

Haidar Ali ◽

Sher Hayat ◽

Sohail Ahmad ◽

Muhammad Ibrahim ◽

...

Keyword(s):

Early Pregnancy ◽

Recovery Rate ◽

Housekeeping Gene ◽

Differentially Expressed ◽

Releasing Hormone ◽

Gonadotrophin Releasing Hormone ◽

Pregnancy Recognition ◽

Conjugating Enzyme

Pregnancy recognition in ruminant affects numerous genes regulation. Interferon-stimulatory gene (ISG15), an ubiquitin-like protein that mediates theconjugation of different proteins through its ISGylation enzymes UBE1L and UBCH8, is also differentially expressed during early pregnancy. The purpose of this study was to investigate the role of ISG-15 in the establishment of pregnancy and conceptus elongation during early post conception periods and to ascertain the presence of ISGylation enzymes UBE1L and UBCH8. Therefore, sheep were synchronized through cloprostenol sodium and gonadotrophin releasing hormone-1 and serviced by rams. The blood was collected on the post-mating days 6, 11, 12, 13, 14, 16, 17, 21, 23 and 25. The ISG-15, UBE1L and UBCH8 primers were used to amplify the corresponding transcriptomic region using PCR. Recovery rate of each transcriptomic fragment was compared with the housekeeping gene GAPDH. ISG-15 expression was higher on day 12, contrary to UBE1L were higher on day 6 and UBCH8 on day 21. Furthermore, the ISG-15 is ubiquitin-like protein, mediates UBE1L and UBCH8 enzymes to guard the conceptus against viral pathogenicity during early pregnancy.

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Premenstrual Exacerbation of Life-Threatening Asthma: Effect of Gonadotrophin Releasing Hormone Analogue Therapy

Canadian Respiratory Journal ◽

10.1155/1996/691249 ◽

1996 ◽

Vol 3 (3) ◽

pp. 203-206 ◽

Cited By ~ 2

Author(s):

Alun L Edwards ◽

M Sarah Rose ◽

Lois E Donovan ◽

Gordon T Ford

Keyword(s):

Menstrual Cycle ◽

Gnrh Analogue ◽

Hormonal Changes ◽

Gnrh Analogues ◽

Releasing Hormone ◽

Life Threatening ◽

Gonadotrophin Releasing Hormone ◽

Premenstrual Exacerbation ◽

Insight Into

Variability in the severity of asthma during various phases of the menstrual cycle has been frequently suspected. However, the hormonal changes that might affect mediators of bronchospasm have yet to be elucidated. The case of a 41-year-old woman suffering from longstanding asthma with life-threatening exacerbations is reported. The patient was treated with buserelin, a gonadotropin releasing hormone (GnRH) analogue, which created a temporary chemical menopause and thus permitted diagnosis of a premenstrual exacerbation of asthma and offered insight into potential therapy. GnRH analogues may therefore be of value in assessing women with severe asthma suspected to vary with the menstrual cycle. The addition of estrogens and progestins at the same time as treatment with GnRH analogue may be of value in determining the role of these hormones in the pathogenesis of menstrually related exacerbations of asthma.

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Role of gonadotrophin releasing hormone secretory dynamics in the control of the human menstrual cycle

Human Reproduction ◽

10.1093/humrep/8.suppl_2.62 ◽

1993 ◽

Vol 8 (suppl 2) ◽

pp. 62-65 ◽

Cited By ~ 14

Author(s):

M. Filicori ◽

G. Cognigni ◽

P. Dellai ◽

R. Arnone ◽

M. Sambataro ◽

...

Keyword(s):

Menstrual Cycle ◽

Releasing Hormone ◽

Gonadotrophin Releasing Hormone ◽

Human Menstrual Cycle

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Lipopolysaccharide reduces gonadotrophin-releasing hormone (GnRH) gene expression: role of RFamide-related peptide-3 and kisspeptin

Reproduction Fertility and Development ◽

10.1071/rd18277 ◽

2019 ◽

Vol 31 (6) ◽

pp. 1134 ◽

Cited By ~ 5

Author(s):

Chooi Yeng Lee ◽

ShengYun Li ◽

Xiao Feng Li ◽

Daniel A. E. Stalker ◽

Claire Cooke ◽

...

Keyword(s):

Gene Expression ◽

In Situ Hybridisation ◽

Releasing Hormone ◽

Related Peptide ◽

Concomitant Reduction ◽

Intracerebroventricular Injections ◽

Gonadotrophin Releasing Hormone ◽

Lh Secretion

RFamide-related peptide (RFRP)-3 reduces luteinising hormone (LH) secretion in rodents. Stress has been shown to upregulate the expression of the RFRP gene (Rfrp) with a concomitant reduction in LH secretion, but an effect on expression of the gonadotrophin-releasing hormone (GnRH) gene (Gnrh1) has not been shown. We hypothesised that lipopolysaccharide (LPS)-induced stress affects expression of Rfrp, the gene for kisspeptin (Kiss1) and/or Gnrh1, leading to suppression of LH levels in rats. Intracerebroventricular injections of RFRP-3 (0.1, 1, 5 nmol) or i.v. LPS (15μgkg−1) reduced LH levels. Doses of 1 and 5 nmol RFRP-3 were then administered to analyse gene expression by in situ hybridisation. RFRP-3 (5 nmol) had no effect on Gnrh1 or Kiss1 expression. LPS stress reduced GnRH and Kiss1 expression, without affecting Rfrp1 expression. These data indicate that LPS stress directly or indirectly reduces Gnrh1 expression, but this is unlikely to be due to a change in Rfrp1 expression.

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