HIF2α Upregulates the Migration Factor ODZ1 under Hypoxia in Glioblastoma Stem Cells

Background: Glioblastoma (GBM) remains a major clinical challenge due to its invasive capacity, resistance to treatment, and recurrence. We have previously shown that ODZ1 contributes to glioblastoma invasion and that ODZ1 mRNA levels can be upregulated by epigenetic mechanisms in response to hypoxia. Herein, we have further studied the transcriptional regulation of ODZ1 in GBM stem cells (GSCs) under hypoxic conditions and analyzed whether HIF2α has any role in this regulation. Methods: We performed the experiments in three primary GSC cell lines established from tumor specimens. GSCs were cultured under hypoxia, treated with HIF regulators (DMOG, chetomin), or transfected with specific siRNAs, and the expression levels of ODZ1 and HIF2α were analyzed. In addition, the response of the ODZ1 promoter cloned into a luciferase reporter plasmid to the activation of HIF was also studied. Results: The upregulation of both mRNA and protein levels of HIF2α under hypoxia conditions correlated with the expression of ODZ1 mRNA. Moreover, the knockdown of HIF2α by siRNAs downregulated the expression of ODZ1. We found, in the ODZ1 promoter, a HIF consensus binding site (GCGTG) 1358 bp from the transcription start site (TSS) and a HIF-like site (CCGTG) 826 bp from the TSS. Luciferase assays revealed that the stabilization of HIF by DMOG resulted in the increased activity of the ODZ1 promoter. Conclusions: Our data indicate that the HIF2α-mediated upregulation of ODZ1 helps strengthen the transcriptional control of this migration factor under hypoxia in glioblastoma stem cells. The discovery of this novel transcriptional pathway identifies new targets to develop strategies that may avoid GBM tumor invasion and recurrence.

Digitalization of the migration sphere in the Russian Federation: state and prospects

This article is dedicated to the analysis of the current state of digitalization of the migration sphere in the Russian Federation. It is demonstrated that the implementation of modern digital technologies, as well as information technology tools into the mechanisms of migration governance (in a broader sense, digital transformation of the system of relations between migrants and accepting country) is objectively inevitable in the context of global digital transition and growing role of the migration factor for the economy. The goal of this research is to determine the political-legal factors and problems that impact digital transition in the migration sphere of the Russian Federation. For achieving the set tasks, the article employs general scientific methods and approaches, including comparative methods. The author provides a brief overview of coevolution of the migration situation and migration regulation in the Russian Federation for the period 2012–2021. It is noted that the goals, tasks and instruments of migration governance change along with the transformation of perception of the importance of migration factor for the Russian Federation and its role in solution of economic development objective. Based on the parallel consideration of political-legal decisions and practices of digitalization of the migration sphere, the author summarizes the current results and challenges. It is indicated that the project approach and advanced legal regulation contribute to the digital reforms in the migration sphere; however, in practice we can observe deceleration of the pace of reforms due to lack of coherence in actions and conceptual approaches. The key reason is that the basic acts that regulate modernization of the migration sphere in the Russian Federation are not the strategic planning documents.

Verification of the neo-Marxist concept of global semi-periphery (on the example of the role of the migration factor)

Neo-Marxism world-system analysis was an effective means of the understanding of the postcolonial global order. The concepts of «core», «periphery» and «semi-periphery» reflected the dependent development of states in the global capitalist system. Capitalism structured the global order in the classical Marxist dichotomy of exploiters and exploited which can be represented with various subjects (states, groups of states, territories) and which according to neo-Marxism can’t disappear, because it reflects the essence of global antagonism. However, the realities of global development at the end of the 20th century demanded that neo-Marxism should reconsider the rigid link between the core-peripheral approach and the horizontal vision of the world: globalisation caused massive flows of migrants to highly developed countries and the gradual blurring of the boundaries between the core and periphery. There was the question in neo-Marxism which was about the ability of capitalism to preserve the core-peripheral organisation of the global division of labour. There was the idea that capitalism was able to reproduce core-periphery relations within the core states by including immigrants in the super-exploitation of labour through a covert policy of neo-racism. Such a vertical organisation of the core-peripheral model around the world, which was called dual society in neo-Marxism, would mean the formation of the global semi-periphery. The purpose of the article is to verify the neo-Marxist concept of the global semi-periphery using the example of the role of the migration factor in its formation. The study is based on UN data, as well as studies with a pronounced statistical component. According to the results of the study, it was concluded that the neo-Marxist concept of the global semi-periphery had not been verified by actual empirical material (on the example of the role of the migration factor). The available statistical and analytical data do not allow to totally confirm the neo-Marxist position that the global order under the influence of migration has been transformed and that it works in the conceptual model of a dual society. Globally, migration is not a determining factor in the widespread formation and unification of the dual method of labour exploitation within states. The quantitative data on the flow of migrants, comparative data on salaries in the countries of the core and the degree of concentration of income among certain groups of the population in the countries of the capitalist system state that the world is still largely reproduced in the horizontal core-peripheral model. Thus, there are no empirical grounds for stating the presence of a global dual society under the influence of the migration factor and consequently the presence of a global semi-periphery within the neo-Marxist approach of E. Balibar, I. Wallerstein, M. Hardt and A. Negri.

Effect of the Migration Option on Rural Microenterprise Establishment Decisions in the Mfantsiman Municipality of Ghana

The role of microenterprise in providing economic opportunities and employment options to the poor due to their ease of entry is recognised across the world. To enhance rural job creation through microenterprise development interventions, it is essential to understand how microenterprise establishment decisions are made among rural dwellers. The study examined how the option to migrate to other localities affects microenterprise establishment decisions among rural dwellers in the Mfantsiman Municipality of Ghana. A mixed method design was used in the study. This involved a cross-sectional survey of 20 rural communities, during which data was collected from 800 respondents. Data were also collected from one focus group in each of the 20 communities. A conjoint decision analysis was carried out from interactions of the attributes of each respondent with the migration factor and other socio-economic factors. The migration option reduced the probability of local microenterprise establishment, with the most significant effect among people aged between 15 and 30 years. Furthermore, rural microenterprise establishment decisions are least influenced by the interactive effect of personal attributes and the migration factor as compared to interaction with other factors including access to electricity, institutional support services, market for outputs and returns on investment.

[Disagreement of Scholars' Views on The Biography of Imam Al-Shatibi] Perselisihan Pandangan Ulama Tentang Biografi Imam Al-Shatibi

This article aims to discuss about the differences between scholar's views on Imam al-Shatibi. These differences are divided into four parts: the origin of names, titles, sight defects, and migration to Egypt. These differences have led to misunderstanding among people about the real facts on Imam al-Shatibi. One of the factors that lead to this misunderstanding is attributed to some of the members of the al - Qur'an and al - Qiraat who are ignorant of this matter. This study will also present the answers to the differences so as to provide a complete explanation for this problem. This study is a qualitative study. Therefore, the findings are based on the documentation and investigation that has been analyzed using the text and content analysis methods. The findings suggest that the origin of the name of Imam al-Shatibi is closely related to heredity, language and marriage factors. The differences over his title were derived from several factors in the field of writing. The dispute over sight defects involves a period of time, while his migration factor to Egypt is not merely due to the pilgrimage.Keywords: Imam al-Shatibi, Qiraat Science, Qurra Biography, Imam Qiraat Artikel ini bertujuan membincangkan tentang perselisihan pandangan ulama tentang Imam al-Shatibi. Perselisihan tersebut dibahagikan kepada empat bahagian, iaitu asal usul nama, gelaran, kecacatan penglihatan, dan penghijrahan ke Mesir. Perselisihan ini telah menimbulkan salah faham dalam kalangan masyarakat tentang perkara sebenar berkenaan Imam al-Shatibi. Antara faktor berlaku salah faham adalah berpunca daripada sebahagian ahli al-Quran dan al-Qiraat sendiri yang tidak arif tentang perkara tersebut. Kajian juga akan mengemukakan jawapan kepada perselisihan terbabit seterusnya memberi penjelasan yang tuntas bagi permasalahan ini. Kajian ini adalah merupakan kajian kualitatif. Dapatan kajian adalah bersumberkan dokumentasi dan persejarahan yang dianalisis menggunakan metode analisis teks dan kandungan. Hasil kajian mendapati asal usul nama Imam al-Shatibi ini berkait rapat dengan faktor keturunan, bahasa dan perkahwinan. Perselisihan tentang gelaran beliau pula didapati berpunca daripada beberapa faktor antaranya dalam bidang penulisan. Perselisihan berkenaan kecacatan penglihatan adalah melibatkan tempoh umur, manakala faktor penghijrahan beliau ke Mesir bukan semata-mata kerana ingin menunaikan haji. Kata kunci: Imam al-Shatibi, Ilmu Qiraat, Biografi Qurra, Imam Qiraat

Population prediction of purwanegara village, Indonesia using modified logistic model with migration factor

Population growth model is a widely been used model to do an estimation and forecasting towards the population of peoples, animals, bac-teria and even in economics growth. Many studies have been carried out on population growth model concerning the factors of birth, death and carrying capacity in order to predict the number of population at certain area. From these studies there is only one study involved the constant value factor of migration as an input in the logistic model. Therefore contradicting with the above modified logistic model, in this study logistic model is modified by adding a migration factor as a function of population. This function takes into account the migration and the interaction between peoples that is limited to the carrying capacity of the environment. This model can be solved qualitatively using the analysis of equilibrium point and quantitatively using the separable variables method. This modified logistic model with migration factor has been applied in the population prediction of Purwanegara village in Central Java Province, Indonesia. Throughout the results, the modified logistic model with migration factor as a function of population gives a better result for population prediction of Purwanegara village in Central Java Province, Indonesia compared with logistic model.