scholarly journals First-trimester maternal vitamin D levels and risk for gestational diabetes mellitus

2021 ◽  
Vol 21 (3) ◽  
pp. 339-349
Author(s):  
Kağan Güngör ◽  
Nur Dokuzeylül Güngör
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
First Trimester ◽  
Maternal Vitamin ◽  
Vitamin D Levels

Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus

2014 ◽  
Vol 51 (4) ◽  
pp. 609-616 ◽  
Author(s):  
Marilyn Lacroix ◽  
Marie-Claude Battista ◽  
Myriam Doyon ◽  
Ghislaine Houde ◽  
Julie Ménard ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
First Trimester ◽  
Vitamin D Levels ◽  
Lower Vitamin

scholarly journals Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland

2021 ◽  
Author(s):  
Kristin S. Magnusdottir ◽  
Ellen A. Tryggvadottir ◽  
Ola K. Magnusdottir ◽  
Laufey Hrolfsdottir ◽  
Thorhallur I. Halldorsson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
First Trimester ◽  
Vitamin D Status ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
25Ohd Concentration

Background: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications. The vitamin D status has never previously been studied in pregnant women in Iceland. Objective: The aim of this research study was to evaluate the vitamin D status of an Icelandic cohort of pregnant women and the association between the vitamin D status and the GDM incidence. Design: Subjects included pregnant women (n = 938) who attended their first ultrasound appointment, during gestational weeks 11–14, between October 2017 and March 2018. The use of supplements containing vitamin D over the previous 3 months, height, pre-pregnancy weight, and social status were assessed using a questionnaire, and blood samples were drawn for analyzing the serum 25‑hydroxyvitamin D (25OHD) concentration. Information regarding the incidence of GDM later in pregnancy was collected from medical records. Results: The mean ± standard deviation of the serum 25OHD (S-25OHD) concentration in this cohort was 63±24 nmol/L. The proportion of women with an S-25OHD concentration of ≥ 50 nmol/L (which is considered adequate) was 70%, whereas 25% had concentrations between 30 and 49.9 nmol/L (insufficient) and 5% had concentrations < 30 nmol/L (deficient). The majority of women (n = 766, 82%) used supplements containing vitamin D on a daily basis. A gradual decrease in the proportion of women diagnosed with GDM was reported with increasing S-25OHD concentrations, going from 17.8% in the group with S-25OHD concentrations < 30 nmol/L to 12.8% in the group with S-25OHD concentrations ≥75 nmol/L; however, the association was not significant (P for trend = 0.11). Conclusion: Approximately one-third of this cohort had S-25OHD concentrations below adequate levels (< 50 nmol/L) during the first trimester of pregnancy, which may suggest that necessary action must be taken to increase their vitamin D levels. No clear association was observed between the vitamin D status and GDM in this study.

scholarly journals EARLY PREGNANCY MATERNAL VITAMIN D DEFICIENCY AND RISK OF GESTATIONAL DIABETES MELLITUS IN LIBYAN PREGNANT WOMEN

2020 ◽  
pp. 1-4
Author(s):  
Omaima H. Getlawi ◽  
Vellanki. Lakshmi narasamma ◽  
Salima M. Hawda ◽  
Musa O. Busarira ◽  
Eman E. Fadeel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Risk Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Vitamin D3 ◽  
First Trimester ◽  
Vitamin D Levels

Background Vitamin D deficiency is a common occurrence, which affects maternal health during pregnancy. Evidence is accumulating for a role of a low level of vitamin D during the early pregnancy as a risk factor for the development of gestational diabetes mellitus (GDM). Our objectives are to describe the patterns of vitamin D levels in early pregnancy in mothers attending main antenatal services in Ajdabiya city, during the first quarter of the year 2017 and to examine the relationship between vitamin D levels and glucose metabolic derangements in pregnant women among the above-described population. Methods A cohort study was conducted in healthy pregnant women attending routine antenatal care in Ajdabiya city in 2017. All mothers were screened for serum 25 (OH) D level and glycated hemoglobin (HbA1c) and anthropometric by the time of booking during the first trimester (gestational age "GA" 7-15th week of pregnancy). All women with low 25 (OH) D level were screened for GDM with non-fasting post-challenge blood glucose and confirmed by OGTT according to the American Diabetes Association (ADA) classification of GDM criteria in their 2nd trimester. Data was analyzed by using SPSS, IBM 20.0. Results All mothers in the study population were Libyan, their ages ranged from 18-43 years. Parity ranged from nulliparous to P10. More than 60% of mothers were housewives while others were either working or students and considered as having an outdoor lifestyle. In the first trimester, we detected 412 mothers had serum vitamin D3 below normal, the majority of cases had deficient serum 25 (OH) D (391, 94.9%) while 21 (5.1%) women had an insufficient serum 25 (OH) D. Serum 25 (OH) D ranged from 5.9-30.0 ng/ml. In the 2nd trimester, we confirmed 43 (10.43%) pregnant women with GDM out of 391 women with deficient serum 25 (OH) D level. 25 (OH) D deficiency was statistically significant (p = 0.035, OR = 0.963, 95% CI = 0.881-0.996) and associated with all GDM cases. Conclusion We conclude that 25 (OH) D deficiency was significantly correlated with GDM, as a consequence, the deficiency of 25 (OH) D could act as a risk factor for GDM. This result implies the necessity of focusing on vitamin D3 supplementation for women of childbearing age.

scholarly journals Assessment of Polymorphism of the VDR Gene and Serum Vitamin D Values in Gestational Diabetes Mellitus

2019 ◽  
Vol 41 (07) ◽  
pp. 425-431
Author(s):  
Thais Walverde Siqueira ◽  
Edward Araujo Júnior ◽  
Rosiane Mattar ◽  
Silvia Daher
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Vitamin ◽  
Vdr Gene ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Objective To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM). Methods A prospective case-control study that recruited healthy pregnant women (control group) (n = 78) and women with GDM (GDM group) (n = 79), with no other comorbidities. Peripheral blood samples were collected in the 3rd trimester of gestation, and all of the pregnant women were followed-up until the end of the pregnancy and the postpartum period. Serum vitamin D concentrations were measured by high-performance liquid chromatography (HPLC). For genomic polymorphism analysis, the genomic DNA was extracted by the dodecyltrimethylammonium bromide/cetyltrimethylammonium bromide (DTAB/CTAB) method, and genotyping was performed by the polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) technique, using the restriction enzyme FokI. The Student-t, Mann-Whitney, chi-squared, and Fischer exact tests were used for the analysis of the results. Results There was no significant difference between the pregnant women in the control and GDM groups regarding serum vitamin D levels (17.60 ± 8.89 ng/mL versus 23.60 ± 10.68 ng/mL; p = 0.1). Also, no significant difference was detected between the FokI genotypic frequency when the 2 groups were compared with each other (p = 0.41). Conclusion There was no association between the FokI polymorphism and the development of GDM, nor was there any change in serum vitamin D levels in patients with GDM.

scholarly journals The Association of Gene Variants in the Vitamin D Metabolic Pathway and Its Interaction with Vitamin D on Gestational Diabetes Mellitus: A Prospective Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4220
Author(s):  
Minjia Mo ◽  
Bule Shao ◽  
Xing Xin ◽  
Wenliang Luo ◽  
Shuting Si ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
First Trimester ◽  
Postprandial Glucose ◽  
Gene Variants ◽  
Fasting Plasma

The present prospective study included 2156 women and investigated the effect of gene variants in the vitamin D (VitD) metabolic and glucose pathways and their interaction with VitD levels during pregnancy on gestational diabetes mellitus (GDM). Plasma 25(OH)D concentrations were measured at the first and second trimesters. GDM subtype 1 was defined as those with isolated elevated fasting plasma glucose; GDM subtype 2 were those with isolated elevated postprandial glucose at 1 h and/or 2 h; and GDM subtype 3 were those with both elevated fasting plasma glucose and postprandial glucose. Six Gc isoforms were categorized based on two GC gene variants rs4588 and rs7041, including 1s/1s, 1s/2, 1s/1f, 2/2, 1f/2 and 1f/1f. VDR-rs10783219 and MTNR1B-rs10830962 were associated with increased risks of GDM and GDM subtype 2; interactions between each other as well as with CDKAL1-rs7754840 were observed (Pinteraction < 0.05). Compared with the 1f/1f isoform, the risk of GDM subtype 2 among women with 1f/2, 2/2, 1s/1f, 1s/2 and 1s/1s isoforms and with prepregnancy body mass index ≥24 kg/m2 increased by 5.11, 10.01, 10, 14.23, 19.45 times, respectively. Gene variants in VitD pathway interacts with VitD deficiency at the first trimester on the risk of GDM and GDM subtype 2.

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