scholarly journals EARLY PREGNANCY MATERNAL VITAMIN D DEFICIENCY AND RISK OF GESTATIONAL DIABETES MELLITUS IN LIBYAN PREGNANT WOMEN

2020 ◽  
pp. 1-4
Author(s):  
Omaima H. Getlawi ◽  
Vellanki. Lakshmi narasamma ◽  
Salima M. Hawda ◽  
Musa O. Busarira ◽  
Eman E. Fadeel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Risk Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Vitamin D3 ◽  
First Trimester ◽  
Vitamin D Levels

Background Vitamin D deficiency is a common occurrence, which affects maternal health during pregnancy. Evidence is accumulating for a role of a low level of vitamin D during the early pregnancy as a risk factor for the development of gestational diabetes mellitus (GDM). Our objectives are to describe the patterns of vitamin D levels in early pregnancy in mothers attending main antenatal services in Ajdabiya city, during the first quarter of the year 2017 and to examine the relationship between vitamin D levels and glucose metabolic derangements in pregnant women among the above-described population. Methods A cohort study was conducted in healthy pregnant women attending routine antenatal care in Ajdabiya city in 2017. All mothers were screened for serum 25 (OH) D level and glycated hemoglobin (HbA1c) and anthropometric by the time of booking during the first trimester (gestational age "GA" 7-15th week of pregnancy). All women with low 25 (OH) D level were screened for GDM with non-fasting post-challenge blood glucose and confirmed by OGTT according to the American Diabetes Association (ADA) classification of GDM criteria in their 2nd trimester. Data was analyzed by using SPSS, IBM 20.0. Results All mothers in the study population were Libyan, their ages ranged from 18-43 years. Parity ranged from nulliparous to P10. More than 60% of mothers were housewives while others were either working or students and considered as having an outdoor lifestyle. In the first trimester, we detected 412 mothers had serum vitamin D3 below normal, the majority of cases had deficient serum 25 (OH) D (391, 94.9%) while 21 (5.1%) women had an insufficient serum 25 (OH) D. Serum 25 (OH) D ranged from 5.9-30.0 ng/ml. In the 2nd trimester, we confirmed 43 (10.43%) pregnant women with GDM out of 391 women with deficient serum 25 (OH) D level. 25 (OH) D deficiency was statistically significant (p = 0.035, OR = 0.963, 95% CI = 0.881-0.996) and associated with all GDM cases. Conclusion We conclude that 25 (OH) D deficiency was significantly correlated with GDM, as a consequence, the deficiency of 25 (OH) D could act as a risk factor for GDM. This result implies the necessity of focusing on vitamin D3 supplementation for women of childbearing age.

scholarly journals Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland

2021 ◽  
Author(s):  
Kristin S. Magnusdottir ◽  
Ellen A. Tryggvadottir ◽  
Ola K. Magnusdottir ◽  
Laufey Hrolfsdottir ◽  
Thorhallur I. Halldorsson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
First Trimester ◽  
Vitamin D Status ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
25Ohd Concentration

Background: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications. The vitamin D status has never previously been studied in pregnant women in Iceland. Objective: The aim of this research study was to evaluate the vitamin D status of an Icelandic cohort of pregnant women and the association between the vitamin D status and the GDM incidence. Design: Subjects included pregnant women (n = 938) who attended their first ultrasound appointment, during gestational weeks 11–14, between October 2017 and March 2018. The use of supplements containing vitamin D over the previous 3 months, height, pre-pregnancy weight, and social status were assessed using a questionnaire, and blood samples were drawn for analyzing the serum 25‑hydroxyvitamin D (25OHD) concentration. Information regarding the incidence of GDM later in pregnancy was collected from medical records. Results: The mean ± standard deviation of the serum 25OHD (S-25OHD) concentration in this cohort was 63±24 nmol/L. The proportion of women with an S-25OHD concentration of ≥ 50 nmol/L (which is considered adequate) was 70%, whereas 25% had concentrations between 30 and 49.9 nmol/L (insufficient) and 5% had concentrations < 30 nmol/L (deficient). The majority of women (n = 766, 82%) used supplements containing vitamin D on a daily basis. A gradual decrease in the proportion of women diagnosed with GDM was reported with increasing S-25OHD concentrations, going from 17.8% in the group with S-25OHD concentrations < 30 nmol/L to 12.8% in the group with S-25OHD concentrations ≥75 nmol/L; however, the association was not significant (P for trend = 0.11). Conclusion: Approximately one-third of this cohort had S-25OHD concentrations below adequate levels (< 50 nmol/L) during the first trimester of pregnancy, which may suggest that necessary action must be taken to increase their vitamin D levels. No clear association was observed between the vitamin D status and GDM in this study.

scholarly journals Assessment of Polymorphism of the VDR Gene and Serum Vitamin D Values in Gestational Diabetes Mellitus

2019 ◽  
Vol 41 (07) ◽  
pp. 425-431
Author(s):  
Thais Walverde Siqueira ◽  
Edward Araujo Júnior ◽  
Rosiane Mattar ◽  
Silvia Daher
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Vitamin ◽  
Vdr Gene ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Objective To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM). Methods A prospective case-control study that recruited healthy pregnant women (control group) (n = 78) and women with GDM (GDM group) (n = 79), with no other comorbidities. Peripheral blood samples were collected in the 3rd trimester of gestation, and all of the pregnant women were followed-up until the end of the pregnancy and the postpartum period. Serum vitamin D concentrations were measured by high-performance liquid chromatography (HPLC). For genomic polymorphism analysis, the genomic DNA was extracted by the dodecyltrimethylammonium bromide/cetyltrimethylammonium bromide (DTAB/CTAB) method, and genotyping was performed by the polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) technique, using the restriction enzyme FokI. The Student-t, Mann-Whitney, chi-squared, and Fischer exact tests were used for the analysis of the results. Results There was no significant difference between the pregnant women in the control and GDM groups regarding serum vitamin D levels (17.60 ± 8.89 ng/mL versus 23.60 ± 10.68 ng/mL; p = 0.1). Also, no significant difference was detected between the FokI genotypic frequency when the 2 groups were compared with each other (p = 0.41). Conclusion There was no association between the FokI polymorphism and the development of GDM, nor was there any change in serum vitamin D levels in patients with GDM.

Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus

2014 ◽  
Vol 51 (4) ◽  
pp. 609-616 ◽  
Author(s):  
Marilyn Lacroix ◽  
Marie-Claude Battista ◽  
Myriam Doyon ◽  
Ghislaine Houde ◽  
Julie Ménard ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
First Trimester ◽  
Vitamin D Levels ◽  
Lower Vitamin

scholarly journals Serum Vitamine D3 Level in Women with Gestational Diabetes Mellitus

2021 ◽  
pp. 90-98
Author(s):  
Riham M. Enab ◽  
Amal A. El Sokary ◽  
Heba A. Mourad ◽  
Amal E. Mahfouz
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Control Group ◽  
Study Group ◽  
Significant Difference

Background: Vitamin D3 is synthesized in skin and sequentially metabolized in liver and kidney in humans. It is well known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. The primary objective of this study was to evaluate vitamin D3 level in pregnant women who were suffering from gestational diabetes mellitus and comparing it with the control groups. Materials and Methods: This case control study was conducted on 100 pregnant women who were attending the inpatient and outpatient clinics of Obstetrics department, Tanta University Hospital, who were divided into two equal groups.Group A (control group): Fifty apparently healthy pregnant women at 24th-28th weeks of gestation. Group B (study group): Fifty pregnant women had gestational diabetes. Results: There is significant increase between the two studied groups according to HbA1c, also there is decrease between the two groups as regards VIT D. Mean HbA1c % was statistically significant higher in the study group versus control group. There was statistical significant difference noted between mean serum level of vitamin D among the two studied groups. A statistically significant negative correlation was observed between serum 25 OH vitamin D and HbA1c among our cases (r=- 0.745) (p ≤ 0.001). Mean serum vitamin D was significantly lower in cases with complications than those with normal outcome. Conclusion: Vitamin D deficiency may have a positive relationship with gestational diabetes mellitus.

scholarly journals Relationship Between Vitamin D Levels of Women with Gestational Diabetes Mellitus and Birthweight of Their Newborns: Preliminary Results (P11-020-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Patricia Padilha ◽  
Claudia Saunders ◽  
Elisabete Queiroz ◽  
Barbara Nascimento ◽  
Thaissa Lima ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Birth Weight ◽  
Gestational Diabetes ◽  
Nutritional Status ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Rio De Janeiro ◽  
Vitamin D Levels ◽  
The Mean

Abstract Objectives To evaluate the relationship between vitamin D levels in women with gestational diabetes and the birth weight of their newborns. Methods This is a cross-sectional study nested in a controlled clinical trial performed in a public maternity hospital in Rio de Janeiro, with a sample composed of adult pregnant women diagnosed with gestational diabetes mellitus, without other chronic morbidities. The nutritional status of vitamin D was classified as 25(OH)D, being classified as: sufficient between 30 and 100 ng/mL; insufficient: between 20 and 29 ng/mL; and deficient below 20 ng/mL. In this analysis, the data regarding the vitamin D levels at the beginning of the study (T0) of the research were considered, and the dependent variable was the birth weight. Pearson's correlation was performed to evaluate the degree of correlation between two continuous variables, being considered as a level of statistical significance the value of P < 0.05. Results The mean maternal age was 35.4 (± 5.9) years (N = 11), and among these, 18.2% (n = 2) had adequate nutritional status, 27.3% (n = 3), overweight and 54, 5% (n = 6), obesity, according to pre-gestational BMI. Among the factors admitted as a risk for hypovitaminosis D (BMI > 25kg/m², brown/black skin color, marital status (married) and occupation), 45.5% (n = 5) presented 3 or more of them. As for nutritional status of vitamin D, 63.6% (n = 7) had insufficiency, 27.3% (n = 3), deficiency and 9.1% (n = 1), sufficiency. The initial mean concentration of 25(OH)D was 21.2 n/mL. It was observed that 72.7% (n = 8) of the pregnant women presented no gestational intercurrences at delivery or in the puerperium, while 18.4% (n = 2) presented unfavorable outcomes. The mean birth weight was 2842.5 (± 1251.1) grams and the mean gestational age at birth was 36.2 (± 6.5) weeks. With respect to neonatal outcomes was observed a significant positive correlation (r = 0, 900; P = 0.037) between serum levels of 25(OH)D at baseline and birthweight. Conclusions Preliminary data indicated that best status of vitamin D is related to higher birthweight values. Funding Sources FAPERJ (FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIRO).

scholarly journals Gestational diabetes mellitus, Vitamin D status and fetomaternal outcome

2019 ◽  
Vol 8 (8) ◽  
pp. 3300
Author(s):  
Rekha T. ◽  
Shazia Parveen ◽  
Nasreen Noor ◽  
Seema Hakim ◽  
Shagufta Moin
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Wide Spectrum ◽  
Medical Complication ◽  
Increased Risk ◽  
Vitamin D Levels

Background: Diabetes is the most common medical complication of pregnancy. Vitamin D deficiency which was initially considered only to influence bone metabolism, is now known to exert a wide spectrum of extra-skeletal effects. Vitamin D deficiency is closely associated with gestational diabetes mellitus, it also leads to adverse maternal and child outcome. Objective of this study was to compare the vitamin D levels in healthy pregnant women and women with gestational diabetes mellitus and to observe the feto-maternal outcome.Methods: This prospective study was carried out on 160 pregnant women between the age group 20-40 years attending the Obstetrics and Gynaecology department of JNMC, AMU, Aligarh from October 2016 to October 2018. Women were divided into group A- normal pregnant women and group B- women with GDM. Estimation of vitamin D was done in both the groups.Results: Mean vitamin D levels were lower in women with GDM as compared to normal pregnant women.Conclusions: Women with vitamin D deficiency have an increased risk of developing GDM and adverse feto maternal outcome as compared to those who had normal level of vitamin.

86-LB: Elevated First-Trimester Neutrophil Count Is Associated with the Development of Gestational Diabetes Mellitus in Pregnant Women

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 86-LB
Author(s):  
TIANGE SUN ◽  
FANHUA MENG ◽  
RUI ZHANG ◽  
ZHIYAN YU ◽  
SHUFEI ZANG ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Neutrophil Count ◽  
First Trimester
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