Cytochrome P450 genetic variants and hypertension risk in South Indian population

2014 ◽  
Vol 6 (1) ◽  
pp. 22-26
Author(s):  
Annan Sudarsan Arun Kumar ◽  
Srinivasamurthy Suresh Kumar ◽  
Gurusamy Umamaheswaran ◽  
Jayaraman Balachandar ◽  
Chandrasekaran Adithan
Keyword(s):  
Cytochrome P450 ◽  
Genetic Variants ◽  
Indian Population ◽  
South Indian Population ◽  
Hypertension Risk ◽  
South Indian

scholarly journals Genetic variants in leptin: Determinants of obesity and leptin levels in South Indian population

Adipocyte ◽  
2014 ◽  
Vol 4 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Shruti Dasgupta ◽  
Mohammed Salman ◽  
Lokesh B Siddalingaiah ◽  
GL Lakshmi ◽  
D Xaviour ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian

scholarly journals Role of eNOS and TGFβ1 gene polymorphisms in the development of diabetic nephropathy in type 2 diabetic patients in South Indian population

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Sindhu Varghese ◽  
Subbaraj Gowtham Kumar
Keyword(s):  
Diabetic Nephropathy ◽  
Genetic Variants ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Diabetic Patients ◽  
South Indian Population ◽  
Type 2 Diabetic Patients ◽  
South Indian ◽  
Type 2 Diabetic

Abstract Background Diabetic nephropathy is known to be a leading complication of diabetes mellitus, characterized by diverse aspects such as high urinary albumin level, elevated blood pressure, and genetic susceptibility leading to end-stage renal disease. The current study was carried out to investigate the association of eNOS and TGFβ1 gene polymorphisms in the progression of diabetic nephropathy among type 2 diabetic patients in the South Indian population. The eNOS and TGFβ1 genetic variants were genotyped in 280 T2DM patients, 140 with DN, 140 without DN, and 140 controls. Genotyping was performed using ARMS PCR and the genomic variants were confirmed by the Sanger sequencing method. Results A significant (p < 0.05) association was observed in the genotypic frequencies of eNOS (G > T) polymorphism in the T2DM patients with diabetic nephropathy when compared to controls. The frequency of TT (heterozygous) genotype was observed to increase in patients with type 2 diabetes and DN when compared to the diabetic patients without DN and controls. This indicates that diabetic patients with TT genotype are at an increased risk to develop DN. However, TGFβ1 (G > C) polymorphism did not show any association in the allele and genotypic frequencies with DN when compared with T2DM and controls. Conclusion The results of the study propose a strong influence of TT genotype of eNOS gene be significantly linked with diabetic nephropathy in T2DM patients. Whereas no association was examined concerning TGFβ1 gene polymorphism and DN. Nevertheless, large sample size studies are required to confirm the part of these genetic variants in the development of DN.

Estrogen receptor α genetic variants and the risk of stroke in a South Indian population from Andhra Pradesh

2010 ◽  
Vol 411 (21-22) ◽  
pp. 1817-1821 ◽  
Author(s):  
Anjana Munshi ◽  
Vandana Sharma ◽  
Subhash Kaul ◽  
Amal Al-Hazzani ◽  
Ali A. Alshatwi ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Genetic Variants ◽  
Andhra Pradesh ◽  
Indian Population ◽  
Estrogen Receptor Α ◽  
South Indian Population ◽  
South Indian

scholarly journals Inter and intra ethnic variation of vitamin K epoxide reductase complex and cytochrome P450 4F2 genetic polymorphisms and their prevalence in South Indian population

2013 ◽  
Vol 19 (3) ◽  
pp. 301 ◽  
Author(s):  
DhakchinamoorthiKrishna Kumar ◽  
Sajjanavar Manjunath ◽  
Chandrasekaran Adithan ◽  
DeepakGopal Shewade ◽  
Prayaga Ushakiran ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Genetic Polymorphisms ◽  
Vitamin K ◽  
Indian Population ◽  
South Indian Population ◽  
Ethnic Variation ◽  
Vitamin K Epoxide Reductase ◽  
South Indian ◽  
Epoxide Reductase

mRNA expression profile in peripheral blood mononuclear cells based on ADRB1 Ser49Gly and Arg389Gly polymorphisms in essential hypertension — a case-control pilot investigation in South Indian population

2018 ◽  
Vol 56 (8) ◽  
pp. 1230-1237 ◽  
Author(s):  
Varsha Varakantham ◽  
Ashok Kumar Kurakula Sailoo ◽  
Balakrishna Nagalla ◽  
Dinesh Kumar Bharatraj
Keyword(s):  
Essential Hypertension ◽  
Mrna Expression ◽  
Genetic Variants ◽  
Indian Population ◽  
Mononuclear Cells ◽  
Case Control ◽  
South Indian Population ◽  
Mrna Levels ◽  
Peripheral Blood Mononuclear ◽  
South Indian

AbstractBackground:β1-Adrenoreceptor (ADRB1) genetic polymorphisms are widely studied for susceptibility to many cardiovascular diseases such as essential hypertension. However, the mRNA expression ofADRB1is rarely studied.Methods:A case-control pilot study with 292 hypertensives and 324 controls was designed to evaluate the role of the Ser49Gly and Arg389Gly, which are commonly studied single nucleotide polymorphisms (SNP), in the mRNA levels ofADRB1, in conjunction with its genetic predisposition to essential hypertension.Results:Differential expression ofADRB1mRNA was seen between hypertensives and controls (p<0.01) based on genetic variants of Ser49Gly. Among hypertensive subjects, Ser49Ser and Gly49Gly were highly expressed in comparison to Ser49Gly (p<0.05 and p<0.01, respectively), whereas genetic variants of Arg389Gly did not demonstrate any such variations. We found no association between theADRB1SNPs viz., Ser49Gly and Arg389Gly and essential hypertension.Conclusions:The increased mRNA levels of Gly49Gly may indicate a plausible role in the interindividual variations in drug response. Further,ADRB1polymorphisms did not contribute to the genetic risk of essential hypertension. Studies with larger sample size are warranted to confirm these observations in the South Indian population.

scholarly journals Vitamin D Receptor Genetic Variants among CKD Patients of South Indian Population

2018 ◽  
Vol 06 (02) ◽  
Author(s):  
Selvaraman Nagamani ◽  
Shanmuga Perumal M ◽  
Ankit Srivastava ◽  
kh. Dhanachandra Singh ◽  
Ritushree Kukreti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Genetic Variants ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian

Variants in XPC, Noxa and TLR4 genes are not associated with bleomycin-induced lung injury in Hodgkin lymphoma patients

2020 ◽  
Vol 17 (3) ◽  
pp. 203-212
Author(s):  
Dimpal N Thakkar ◽  
Indumathi Prapath ◽  
Subathra Adithan ◽  
Kesavan Ramasamy ◽  
Sandhiya Selvarajan ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Lung Injury ◽  
Hodgkin Lymphoma ◽  
Genetic Polymorphisms ◽  
Real Time Pcr ◽  
Genetic Variants ◽  
Pulmonary Toxicity ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian

Aim: Pulmonary toxicity is a well-known adverse reaction of bleomycin. In this study, we investigated the influence of XPC, PMAIP1/Noxa and TLR4 genetic variants on the development of bleomycin-induced lung injury (BILI) in south Indian patients with Hodgkin lymphoma. Materials & methods: Hodgkin lymphoma patients receiving adriamycin, bleomycin, vinblastine and dacarbazine regimen were recruited for the study and BILI was diagnosed based on symptoms and/or radiological signs. DNA samples were genotyped using real-time PCR. Results: A total of 78 patients were recruited in the study and BILI was observed in 17 (21.8%) patients. Polymorphisms in XPC, PMAIP1/Noxa and TLR4 genes were not associated with the development of BILI. Conclusion: The selected genetic polymorphisms do not predict the risk of BILI in south Indian population.

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