Efficacy of Ilex paraguariensis versus Placebo on Lipid Profile in Randomized Clinical Trial: A Systematic Review and Meta-analysis

Objectives: to perfom analysis of the clinical efficacy and safety of using monofocal IOLs in the surgical treatment of cataracts in adult patients. Material and methods. In available sources (databases of the Cochrane Library and Medline) a search was conducted to evaluate the effectiveness and safety of using monofocal IOLs in cataract surgery in adult patients according to the PICO(S) regimen. A literature review was conducted in July 2018 for the keywords “intraocular lenses” and “cataract” using the following filters: clinical trial, randomized clinical trial, meta-analysis, systematic review (clinical trial, randomized clinical trial, meta-analysis, systematic review). Posting languages: English. Depth of search — 5 years. Last search date is July 27, 2018. Results. An initial search in the Medline database found 21,737 publications and 2157 in the Cochrane Library database. A total of 17,894 links were found. In a meta-analysis Zhao Y. et al., 2017, a comparison of the incidence of opacities of the posterior capsule (secondary cataract) after surgical treatment with the implantation of hydrophobic and hydrophilic IOLs was made. In multicenter retrospective cohort study Ursell P., et al, 2018 assessed the frequency of the Nd: YAG-laser capsulotomy for the treatment of secondary cataract which developed after the implantation of the IOL within the first 3 years after surgery. Conclusion. During the systematic review, the relationship between the incidence of complications (secondary cataracts) and the properties of the IOL material was found. The implantation of lenses from a hydrophobic material is associated with a lower incidence of secondary cataracts than the implantation of lenses from a hydrophilic material.

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Efficacy of Hydroxychloroquine in Hand Osteoarthritis: a Protocol for Systematic Review and Meta-analysis of Randomized Clinical Trial

10.37766/inplasy2020.11.0005 ◽

2020 ◽

Author(s):

Qiangqiang Li ◽

Ya-Dong Xie ◽

Wen-Qiang Liang ◽

Guo-Qing Yang ◽

Huai-Bin Zhang ◽

...

Keyword(s):

Systematic Review ◽

Clinical Trial ◽

Randomized Clinical Trial ◽

Meta Analysis ◽

Hand Osteoarthritis

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Effects of n-3 EPA and DHA supplementation on fat free mass and physical performance in elderly. A systematic review and meta-analysis of randomized clinical trial

Mechanisms of Ageing and Development ◽

10.1016/j.mad.2021.111476 ◽

2021 ◽

pp. 111476

Author(s):

Mariangela Rondanelli ◽

Simone Perna ◽

Antonella Riva ◽

Giovanna Petrangolini ◽

Enrica Di Paolo ◽

...

Keyword(s):

Systematic Review ◽

Clinical Trial ◽

Randomized Clinical Trial ◽

Physical Performance ◽

Meta Analysis ◽

Fat Free Mass ◽

Epa And Dha

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Faculty Opinions recommendation of Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727695764.793533264 ◽

2017 ◽

Author(s):

Sunit Singhi

Keyword(s):

Systematic Review ◽

Randomized Controlled Trials ◽

Lipid Profile ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled ◽

Probiotic Lactobacillus

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The Effects of Coenzyme Q10 Supplementation on Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Current Pharmaceutical Design ◽

10.2174/1381612824666180406104516 ◽

2018 ◽

Vol 24 (23) ◽

pp. 2729-2742 ◽

Cited By ~ 6

Author(s):

Nasrin Sharifi ◽

Reza Tabrizi ◽

Mahmood Moosazadeh ◽

Naghmeh Mirhosseini ◽

Kamran B. Lankarani ◽

...

Keyword(s):

Systematic Review ◽

Lipid Profile ◽

Coenzyme Q10 ◽

Metabolic Disorders ◽

Metabolic Diseases ◽

Meta Analysis ◽

Lipid Profiles ◽

Controlled Trials ◽

Serum Triglycerides ◽

Coq10 Supplementation

Background and objective: Oxidative stress and inflammation are key parameters in developing metabolic disorders. Hence, antioxidant intake might be an appropriate approach. Several studies have evaluated the effect of coenzyme Q10 (CoQ10) supplementation on lipid profile among patients with metabolic diseases, though findings are controversial. The aim of this systematic review and meta-analysis was to determine the effects of CoQ10 supplementation on lipid profile in patients with metabolic disorders. Methods: We searched PubMed, EMBASE, Web of Science and Cochrane Library databases until July 2017. Prospective clinical trials were selected assessing the effect of CoQ10 supplementation on different biomarkers. Two reviewers independently assessed the eligibility of studies, extracted data, and evaluated the risk of bias of included studies. A fixed- or random-effects model was used to pool the data, which expressed as a standardized mean difference with 95% confidence interval. Heterogeneity was measured using a Q-test and with I2 statistics. Results: A total of twenty-one controlled trials (514 patients and 525 controls) were included. The meta-analysis indicated a significant reduction in serum triglycerides levels (SMD -0.28; 95% CI, -0.56, -0.005). CoQ10 supplementation also decreased total-cholesterol (SMD -0.07; 95% CI, -0.45, 0.31), increased LDL- (SMD 0.04; 95% CI, -0.27, 0.36), and HDL-cholesterol levels (SMD 0.10; 95% CI, -0.32, 0.51), not statistically significant. Conclusion: CoQ10 supplementation may significantly reduce serum triglycerides levels, and help to improve lipid profiles in patients with metabolic disorders. Additional prospective studies are recommended using higher supplementation doses and longer intervention period.

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