Effects of n-3 EPA and DHA supplementation on fat free mass and physical performance in elderly. A systematic review and meta-analysis of randomized clinical trial

Objectives: to perfom analysis of the clinical efficacy and safety of using monofocal IOLs in the surgical treatment of cataracts in adult patients. Material and methods. In available sources (databases of the Cochrane Library and Medline) a search was conducted to evaluate the effectiveness and safety of using monofocal IOLs in cataract surgery in adult patients according to the PICO(S) regimen. A literature review was conducted in July 2018 for the keywords “intraocular lenses” and “cataract” using the following filters: clinical trial, randomized clinical trial, meta-analysis, systematic review (clinical trial, randomized clinical trial, meta-analysis, systematic review). Posting languages: English. Depth of search — 5 years. Last search date is July 27, 2018. Results. An initial search in the Medline database found 21,737 publications and 2157 in the Cochrane Library database. A total of 17,894 links were found. In a meta-analysis Zhao Y. et al., 2017, a comparison of the incidence of opacities of the posterior capsule (secondary cataract) after surgical treatment with the implantation of hydrophobic and hydrophilic IOLs was made. In multicenter retrospective cohort study Ursell P., et al, 2018 assessed the frequency of the Nd: YAG-laser capsulotomy for the treatment of secondary cataract which developed after the implantation of the IOL within the first 3 years after surgery. Conclusion. During the systematic review, the relationship between the incidence of complications (secondary cataracts) and the properties of the IOL material was found. The implantation of lenses from a hydrophobic material is associated with a lower incidence of secondary cataracts than the implantation of lenses from a hydrophilic material.

Download Full-text

Efficacy of Hydroxychloroquine in Hand Osteoarthritis: a Protocol for Systematic Review and Meta-analysis of Randomized Clinical Trial

10.37766/inplasy2020.11.0005 ◽

2020 ◽

Author(s):

Qiangqiang Li ◽

Ya-Dong Xie ◽

Wen-Qiang Liang ◽

Guo-Qing Yang ◽

Huai-Bin Zhang ◽

...

Keyword(s):

Systematic Review ◽

Clinical Trial ◽

Randomized Clinical Trial ◽

Meta Analysis ◽

Hand Osteoarthritis

Download Full-text

Vitamin D in Basketball Players: Current Evidence and Future Directions

Sports Health A Multidisciplinary Approach ◽

10.1177/19417381211019343 ◽

2021 ◽

pp. 194173812110193

Author(s):

Emilija Stojanović ◽

Dragan Radovanović ◽

Tamara Hew-Butler ◽

Dušan Hamar ◽

Vladimir Jakovljević

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Body Composition ◽

Physical Performance ◽

Bone Health ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Current Evidence ◽

Basketball Players ◽

Level Of Evidence

Context: Despite growing interest in quantifying and correcting vitamin D inadequacy in basketball players, a critical synthesis of these data is yet to be performed to overcome the low generalizability of findings from individual studies. Objective: To provide a comprehensive analysis of data in basketball pertaining to (1) the prevalence of vitamin D inadequacy; (2) the effects of vitamin D supplementation on 25-hydroxyvitamin D [25(OH)D] concentration (and its association with body composition), bone health, and performance; and (3) crucial aspects that warrant further investigation. Data Sources: PubMed, MEDLINE, ERIC, Google Scholar, SCIndex, and ScienceDirect databases were searched. Study Selection: After screening, 15 studies were included in the systematic review and meta-analysis. Study Design: Systematic review and meta-analysis. Level of Evidence: Level 3. Data Extraction: The prevalence of vitamin D inadequacy, serum 25(OH)D, body composition, stress fractures, and physical performance were extracted. Results: The pooled prevalence of vitamin D inadequacy for 527 basketball players in 14 studies was 77% ( P < 0.001; 95% CI, 0.70-0.84). Supplementation with 4000 IU/d and 4000 IU/wk (absolute mean difference [AMD]: 25.39 nmol/L; P < 0.001; 95% CI, 13.44-37.33), as well as 10,000 IU/d (AMD: 100.01; P < 0.001; 95% CI, 70.39-129.63) vitamin D restored 25(OH)D to normal concentrations. Body composition data revealed inverse correlations between changes in serum 25(OH)D (from pre- to postsupplementation) and body fat ( r = −0.80; very large). Data concerning positive impacts of vitamin D supplementation on bone health and physical performance remain sparse. Conclusion: The high proportion of vitamin D inadequacy underscores the need to screen for serum 25(OH)D in basketball players. Although supplementation restored vitamin D sufficiency, the beneficial effects on bone health and physical performance remain sparse. Adiposity can modulate 25(OH)D response to supplementation.

Download Full-text