Evaluation Of Antiulcer Activity Of Ocimum Sanctum And Its Mechanism In Animal Models

10.5580/2c61 ◽  
2012 ◽  
Vol 10 (1) ◽  
Keyword(s):  
Animal Models ◽  
Ocimum Sanctum ◽  
Antiulcer Activity

scholarly journals Actions Underlying Antidiabetic Effects of Ocimum sanctum Leaf Extracts in Animal Models of Type 1 and Type 2 Diabetes

2015 ◽  
Vol 5 (1) ◽  
pp. 1-12 ◽  
Author(s):  
J. Hannan ◽  
O. Ojo ◽  
L. Rokeya ◽  
J. Khaleque ◽  
M. Akhter ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Animal Models ◽  
Ocimum Sanctum ◽  
Leaf Extracts ◽  
Antidiabetic Effects

Cytoprotective, antioxidant and anti-inflammatory mechanism related to antiulcer activity of Cissampelos sympodialis Eichl. in animal models

2018 ◽  
Vol 222 ◽  
pp. 190-200 ◽  
Author(s):  
Igor Rafael Praxedes De Sales ◽  
Rodrigo De Oliveira Formiga ◽  
Flávia Danniele Frota Machado ◽  
Raphaela Francelino Nascimento ◽  
Matheus Marley Bezerra Pessoa ◽  
...  
Keyword(s):  
Animal Models ◽  
Antiulcer Activity ◽  
Inflammatory Mechanism ◽  
Anti Inflammatory

Antiulcer activity of methanol fraction ofBarleria lupulina Lindl. in animal models

2004 ◽  
Vol 18 (11) ◽  
pp. 925-929 ◽  
Author(s):  
V. Suba ◽  
T. Murugesan ◽  
M. Pal ◽  
Subhash C. Mandal ◽  
B. P. Saha
Keyword(s):  
Animal Models ◽  
Antiulcer Activity ◽  
Methanol Fraction

Evaluation of the role of nitric oxide and antioxidation in the antiulcer activity of Ocimum sanctum leaves: an experimental study

2015 ◽  
Vol 15 (4) ◽  
pp. 313-317 ◽  
Author(s):  
Pranjit Santonu Bhajoni ◽  
Girish Gulab Meshram ◽  
Mangala Lahkar ◽  
Manik Shankarrao Ghadlinge ◽  
Harmeet Singh Rehan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Experimental Study ◽  
Ocimum Sanctum ◽  
Antiulcer Activity

scholarly journals Antiulcer activity of ethanolic extract of Sesamum Indicum on experimental animal models

2019 ◽  
Vol 5 (6) ◽  
pp. 1144-1151
Author(s):  
Arun Kumar ◽  
Nitin Kumar ◽  
Rahul Shukla ◽  
Anurag Chaudhary
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Ethanolic Extract ◽  
Sesamum Indicum ◽  
Antiulcer Activity ◽  
Experimental Animal Models

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

Inflammational Animal Models for Schizophrenia

2015 ◽  
Vol 223 (3) ◽  
pp. 157-164 ◽  
Author(s):  
Georg Juckel
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Immune Activation ◽  
Microglial Activation ◽  
Treatment Options ◽  
Early Adulthood ◽  
Brain Regions ◽  
Synaptic Connections ◽  
Preventive Interventions ◽  
Immunological System

Abstract. Inflammational-immunological processes within the pathophysiology of schizophrenia seem to play an important role. Early signals of neurobiological changes in the embryonal phase of brain in later patients with schizophrenia might lead to activation of the immunological system, for example, of cytokines and microglial cells. Microglia then induces – via the neurotoxic activities of these cells as an overreaction – a rarification of synaptic connections in frontal and temporal brain regions, that is, reduction of the neuropil. Promising inflammational animal models for schizophrenia with high validity can be used today to mimic behavioral as well as neurobiological findings in patients, for example, the well-known neurochemical alterations of dopaminergic, glutamatergic, serotonergic, and other neurotransmitter systems. Also the microglial activation can be modeled well within one of this models, that is, the inflammational PolyI:C animal model of schizophrenia, showing a time peak in late adolescence/early adulthood. The exact mechanism, by which activated microglia cells then triggers further neurodegeneration, must now be investigated in broader detail. Thus, these animal models can be used to understand the pathophysiology of schizophrenia better especially concerning the interaction of immune activation, inflammation, and neurodegeneration. This could also lead to the development of anti-inflammational treatment options and of preventive interventions.

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