scholarly journals New therapeutic modalities in drug discovery and development: Insights & opportunities

ADMET & DMPK ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 227-230
Author(s):  
Manfred Kansy ◽  
Giulia Caron
Keyword(s):  
Drug Discovery ◽  
Special Issue ◽  
Drug Discovery And Development ◽  
Therapeutic Modalities

New Therapeutic Modalities in Drug Discovery and Development: Insights & Opportunities (Editorial for the special issue of ADMET and DMPK)

scholarly journals Editorial on Special Issue “Tuberculosis Drug Discovery and Development 2019”

2020 ◽  
Vol 10 (17) ◽  
pp. 6069
Author(s):  
Claudia Sala ◽  
Laurent Roberto Chiarelli ◽  
Giovanna Riccardi
Keyword(s):  
Infectious Disease ◽  
Mycobacterium Tuberculosis ◽  
Drug Discovery ◽  
Human Health ◽  
Cause Of Death ◽  
Etiological Agent ◽  
Special Issue ◽  
Drug Discovery And Development ◽  
Global Challenge

Mycobacterium tuberculosis, the etiological agent of human tuberculosis (TB), represents a global challenge to human health since it is the main cause of death by an infectious disease worldwide [...]

scholarly journals Editorial for the Special Issue on Micro/Nanofluidic Devices for Single Cell Analysis, Volume II

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 875
Author(s):  
Tuhin Subhra Santra ◽  
Fan-Gang Tseng
Keyword(s):  
Drug Discovery ◽  
Single Cell ◽  
Single Cell Analysis ◽  
Compositional Heterogeneity ◽  
Cell Analysis ◽  
Special Issue ◽  
Drug Discovery And Development ◽  
Nanofluidic Devices

The functional, genetic, or compositional heterogeneity of healthy and diseased tissues promotes significant challenges to drug discovery and development [...]

Drug Discovery and Development Strategies for COVID-19

2020 ◽  
Vol 2 (2) ◽  
pp. 1-5
Author(s):  
Aarajana Shrestha ◽  
Tara Man Kadayat
Keyword(s):  
Drug Discovery ◽  
Drug Development ◽  
Development Strategies ◽  
Special Issue ◽  
Medical Sciences ◽  
Drug Discovery And Development ◽  
Current Drug ◽  
The World ◽  
Global Threat ◽  
Effective Drugs

COVID-19 Special Issue: Coronavirus Disease 2019 (COVID-19) has emerged as a global threat. Scientists and clinicians are endeavoring to find effective drugs and vaccines for this disease. This special issue of the Europasian Journal of Medical Sciences (EJMS) aims to cover the problems, solutions, and challenges of COVID-19 around the world. In this Editorial, EJMS Editors Aarajana Shrestha and Tara Man Kadayat highlight the processes of drug discovery and development and a brief overview of the current drug development strategies against COVID-19.

Sitagliptin: a potential drug for the treatment of SARS-CoV-2?

2020 ◽  
Author(s):  
Sanaa Bardaweel
Keyword(s):  
Clinical Trials ◽  
Drug Discovery ◽  
Antimalarial Drug ◽  
Drug Repurposing ◽  
Spike Protein ◽  
Diabetic Patients ◽  
Potential Drug ◽  
Chemokine Production ◽  
Drug Discovery And Development ◽  
Sequence Identity

Recently, an outbreak of fatal coronavirus, SARS-CoV-2, has emerged from China and is rapidly spreading worldwide. As the coronavirus pandemic rages, drug discovery and development become even more challenging. Drug repurposing of the antimalarial drug chloroquine and its hydroxylated form had demonstrated apparent effectiveness in the treatment of COVID-19 associated pneumonia in clinical trials. SARS-CoV-2 spike protein shares 31.9% sequence identity with the spike protein presents in the Middle East Respiratory Syndrome Corona Virus (MERS-CoV), which infects cells through the interaction of its spike protein with the DPP4 receptor found on macrophages. Sitagliptin, a DPP4 inhibitor, that is known for its antidiabetic, immunoregulatory, anti-inflammatory, and beneficial cardiometabolic effects has been shown to reverse macrophage responses in MERS-CoV infection and reduce CXCL10 chemokine production in AIDS patients. We suggest that Sitagliptin may be beneficial alternative for the treatment of COVID-19 disease especially in diabetic patients and patients with preexisting cardiovascular conditions who are already at higher risk of COVID-19 infection.

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