scholarly journals 18F-FDG-PET/CT in staging, recurrence detection and response evaluation of primary splenic lymphoma with eight years follow up

2015 ◽  
Vol 18 (1) ◽  
pp. 37-38 ◽  
Author(s):  
Sellam Karunanithi ◽  
Shambo Guha Roy ◽  
Vijaya Murugan ◽  
Chandrasekhar Bal ◽  
Rakesh Kumar
Keyword(s):  
Fdg Pet ◽  
Response Evaluation ◽  
Pet Ct ◽  
Splenic Lymphoma ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Primary Splenic Lymphoma

Use of 18F-FDG PET/CT Imaging for Evaluation of Patients With Primary Splenic Lymphoma

2014 ◽  
Vol 39 (9) ◽  
pp. 772-776 ◽  
Author(s):  
Sellam Karunanithi ◽  
Punit Sharma ◽  
Shambo Guha Roy ◽  
Beth Vettiyil ◽  
Atul Sharma ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Pet Ct ◽  
Splenic Lymphoma ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Primary Splenic Lymphoma

18F-FDG-PET/CT response assessment in patients with advanced melanoma treated with combination of low-dose ipilimumab and anti-PD1: A real-world experience.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e21533-e21533
Author(s):  
Caio Dabbous Liz ◽  
Marcos Rezende Teixeira ◽  
Luciana Beatriz Mendes Gomes Siqueira ◽  
Jose A. Rinck ◽  
Joao Paulo S. N. Lima ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Low Dose ◽  
Stage Iv ◽  
Complete Response ◽  
Advanced Melanoma ◽  
Response Evaluation ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

e21533 Background: Combination therapy with anti-PD1 and low-dose ipilimumab has shown reduced rate of immune-related adverse effects compared with standard dose used in the Checkmates studies 067 and 204. However, the discussion whether low-dose ipilimumab may hamper the response rate in advanced melanoma is still open. Methods: We conducted a retrospective analysis of response evaluation based on 18F-FDG PET/CT for patients with advanced melanoma treated with combination of nivolumab 3mg/kg plus ipilimumab 1mg/kg for 4 cycles (N3+I1) followed by anti-PD1 maintenance therapy and compared the results to RECIST 1.1 response criteria in the same population. Results: Between December 2017 and August 2020, 45 patients with advanced melanoma treated with N3+I1 in first-line setting were identified. Unresectable stage III/stage IV were 2/43 patients, respectively. Among stage IV patients, 60.5% were M1c, 23.3% had elevated LDH and 28% had brain metastasis (3 or more brain lesions: 58%). At a median follow-up of 16.7 months, 11 patients (24.4%) had G3/G4 toxicity. During induction phase, three patients (6.6%) discontinued all drugs and 2 other patients (4.4%) interrupted only ipilimumab. Review of response evaluation by RECIST was possible in 36 patients and showed an objective response of 50%. Complete response (CR): 11% and partial response (PR): 39%. Eight percent presented progressive disease (PD). In 37 patients, review of response evaluation using 18F-FDG PET/CT was possible. Twenty-four patients (65%) achieved metabolic CR, 5 (13.5%) PD and 8 (21.5%) were classified as non-CR non-PD. Median progression-free survival (PFS) and overall survival(OS) were not reached. 12-month PFS and OS were: 72.5 and 89%, respectively. During the study follow-up, only 1 patient with metabolic complete response relapsed and 3 out of 8 with non-CR non-PD progressed. Conclusions: Using low-dose ipilimumab combination does not hamper the response rates and, possibly due to fewer protocol interruptions, these patients may achieve more complete responses as showed by 18F-FDG PET/CT evaluation.

FRI0262 The Role of 18F-FDG-PET/CT in the Diagnosis and Follow-Up of Large Vessel Vasculitis

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 519.2-519
Author(s):  
G. Pazzola ◽  
M. Casali ◽  
F. Muratore ◽  
N. Pipitone ◽  
L. Boiardi ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Large Vessel Vasculitis ◽  
Large Vessel ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Value of fourth and subsequent post-therapy follow-up 18F-FDG PET/CT scans in patients with breast cancer

2016 ◽  
Vol 37 (6) ◽  
pp. 602-608
Author(s):  
Mehdi Taghipour ◽  
Sara Sheikhbahaei ◽  
Tyler J. Trahan ◽  
Rathan M. Subramaniam
Keyword(s):  
Breast Cancer ◽  
Fdg Pet ◽  
Ct Scans ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Post Therapy

18F-FDG PET/CT in the Initial Assessment and for Follow-up in Patients With Tuberculosis

2016 ◽  
Vol 41 (4) ◽  
pp. e187-e194 ◽  
Author(s):  
Ingrid Stelzmueller ◽  
Helmut Huber ◽  
Rainer Wunn ◽  
Marina Hodolic ◽  
Michael Mandl ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Initial Assessment ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

333018F-Fluorodeoxyglucose Positron Emission Tomography Computed Tomography (PET/CT) for the diagnosis of prosthetic valve infective endocarditis (PVIE): a prospective multicenter study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Philip ◽  
L Tessonnier ◽  
J Mancini ◽  
J L Mainardi ◽  
D Lussato ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Predictive Value ◽  
Fdg Pet ◽  
Prosthetic Valve ◽  
Cardiac Uptake ◽  
Pet Ct ◽  
Major Criterion ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract Background and objectives 18F-FDG PET/CT has recently been added as a major criterion in the ESC 2015 infective endocarditis (IE) guidelines, but the value of this new diagnostic algorithm has never been prospectively assessed. Purposes 1. Primary objective: to assess the value of the new ESC criteria including 18F-FDG PET/CT in prosthetic valve infective endocarditis (PVIE). 2. Secondary objectives: to determine the reproducibility of 18F-FDG PET/CT; to assess its ability to predict embolic events. Methods Between 2014 and 2017, 175 patients with suspected PVIE were prospectively included in 3 French centers. After exclusion of patients with uninterpretable or not feasible PET/CT,115 patients were finally included in the analysis, including 91 definite IE and 24 rejected IE, as defined by an expert Consensus of Endocarditis Team after 3-month follow-up as Gold Standard Nuclear data were blindly analyzed by two independent nuclear medicine physicians. Patients follow-up was scheduled at one and three months after hospitalization Results Significant cardiac uptake by PET/CT (major criterion) was observed in 67 among 91 patients with definite PVIE and 6 patients with rejected IE (sensitivity 73.6%, specificity 75%, positive predictive value 91%, negative predictive value 42%). Considering cardiac uptake as a major criterion, the ESC 2015 classification increased the sensitivity of Duke criteria from 57 to 84% (p<0.001) but decreased its specificity from 84 to 70% (p<0.001). Intraobserver reproducibility of cardiac uptake evaluation was good (kappa = 0.84) but inter observer reproductibility was less satisfactory (kappa = 0.63). Embolic events occurred in 31 patients (27%) and were correlated with vegetation size by ECHO (p<0.001), Staphylococcus infection (p=0.003), and PET/CT cardiac uptake (p=0.02). Conclusion 1. the value of PET CT and ESC criteria is confirmed and may allow earlier diagnosis of PVIE 2. PET CT is associated with an increased risk of false positive results probably related to the technical improvements 3. Reproducibility of nuclear measurements seems unsatisfactory, justifying efforts to standardize PET studies interpretation 4. Our study describes for the first time a positive correlation between a positive PET/Ct and occurrence of embolic events, warranting additional studies.

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