scholarly journals Dosimetric feasibility and clinical outcome of image guided interstitial brachytherapy using two different fractionation schedule in carcinoma cervix

2021 ◽  
Author(s):  
Bidyut Mandal ◽  
Abhishek Basu ◽  
Janmenjoy Mondal ◽  
Debjit Ghosh
Keyword(s):  
Clinical Outcome ◽  
Interstitial Brachytherapy ◽  
Carcinoma Cervix ◽  
Image Guided ◽  
Fractionation Schedule

PO-1982 Dosimetric and clinical outcome in image guided interstitial brachytherapy for cervical stump cancer

2021 ◽  
Vol 161 ◽  
pp. S1685-S1686
Author(s):  
F. GUILLEMIN ◽  
P. POMMIER ◽  
A. SERRE ◽  
F. GASSA ◽  
N. SANDT ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Interstitial Brachytherapy ◽  
Image Guided ◽  
Cervical Stump

scholarly journals Role of interstitial brachytherpy using template (mupit) in locally advanced carcinoma cervix

2016 ◽  
Author(s):  
Ashish Bhange ◽  
Abhishek Gulia ◽  
Anirudh Punnakal ◽  
Anil Kumar Anand ◽  
Anil Kumar Bansal ◽  
...  
Keyword(s):  
Local Control ◽  
Residual Disease ◽  
Locally Advanced ◽  
Concurrent Chemotherapy ◽  
Interstitial Brachytherapy ◽  
Carcinoma Cervix ◽  
Advanced Carcinoma ◽  
Needle Position ◽  
Grade 3

Introduction: Locally advanced carcinoma cervix includes stages IIB, IIIA, IIIB and IVA. Interstitial brachytherapy has the potential to deliver adequate dose to lateral parametrium and to vagina. Hence, it is preferable in cases with distorted anatomy, extensive (lower) vaginal wall involvement, bulky residual disease post EBRT and parametrium involvement upto lateral pelvic wall. Aim and Objective: To determine clinical outcome and complications (acute and chronic) in locally advanced carcinoma cervix, treated with interstitial brachytherapy using template (MUPIT - Martinez universal perineal interstitial template). Materials and Methods: This study is a retrospective analysis of 37 cases of locally advanced carcinoma cervix (stage IIB-2, IIIB-30, IVA-5), treated with EBRT (dose-median 45Gy/25#) ± concurrent chemotherapy (CCT) - Inj. Cisplatin/Inj Carboplatin, followed by interstitial brachytherapy using MUPIT from December 2009 to June 2015. Initial treatment with EBRT ± CCT was followed by intertstitial brachytherapy. Under spinal anaesthesia and epidural analgesia, MUPIT application was done. Straight and divergent needles (median 26, range 19-29) were inserted to cover parametrium adequately. Needle position was verified with planning CT scan and Brachytherapy planning was done. Dose was normalized to 5 mm box surface from outermost needle with optimization of dose to OAR (Bladder, Rectum and Sigmoid colon). Prescription dose –25Gy in 5#. Treatment was delivered by Microselectron HDR using Ir192 source. Treatment fractions were delivered twice daily with min 6 Hrs. gap in-between fractions. Results: The median duration of follow-up was 25 months. Local control was achieved in 28 patients with residual disease in 7 patients and local recurrence in 2 patients. 10 patients had acute lower GI toxicity {Grade1 (n=6), Grade 2 (n=4)}, 2 patients had acute Grade 1 bladder toxicity. 1 patient had grade 3 and 1 patient had grade 4 chronic bladder toxicity. Chronic rectal toxicity was seen in 10 patients {Grade 2 (n=4), Grade 3 (n=4), Grade 4 (n=2)}. Conclusion: Local control was achieved in 28/37 patients (75.6%) and overall survival rate of 81.1% at median follow up of 25 months in patients with locally advanced carcinoma cervix and unfavorable prognostic factors.

scholarly journals Clinical outcome of image-guided adaptive radiotherapy in the treatment of lung cancer patients

2015 ◽  
Vol 54 (9) ◽  
pp. 1430-1437 ◽  
Author(s):  
Marie Tvilum ◽  
Azza A. Khalil ◽  
Ditte S. Møller ◽  
Lone Hoffmann ◽  
Marianne M. Knap
Keyword(s):  
Lung Cancer ◽  
Clinical Outcome ◽  
Cancer Patients ◽  
Adaptive Radiotherapy ◽  
Lung Cancer Patients ◽  
Image Guided

scholarly journals Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx

2020 ◽  
Vol 6 (4) ◽  
pp. 20200005
Author(s):  
Naoya Murakami ◽  
Seiichi Yoshimoto ◽  
Masakazu Uematsu ◽  
Tairo Kashihara ◽  
Kana Takahashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumour ◽  
Interstitial Brachytherapy ◽  
High Dose ◽  
Inferior Wall ◽  
Residual Tumour ◽  
Image Guided ◽  
Keratinizing Squamous Cell Carcinoma

High-dose-rate interstitial brachytherapy (HDR-ISBT) is relatively rarely applied for the head and neck cancer because of its anatomical complexity and difficulty of applicator placement. However, its dose distribution is more confined even better than intensity-modulated radiation therapy (IMRT) and can deliver a higher dose while sparing surrounding normal tissues. In this case report, the effectiveness of HDR-ISBT as a boost following IMRT for keratinizing squamous cell carcinoma of nasopharynx was presented. A 76-year-old female who suffered from cT3N0M0 keratinizing squamous cell carcinoma of the nasopharynx was treated with definitive concurrent chemoradiation therapy involving IMRT. However, physical examination and laryngoscope fibre finding showed evident residual tumour at 60 Gy of IMRT, then, boost HDR-ISBT was proposed. After delivering 66 Gy of IMRT, CT image-guided HDR-ISBT 4 Gy in a single fraction was performed under local anaesthesia and sedation. MRI taken 5 months after HDR-ISBT showed remarkable shrinkage of the primary tumour. After HDR-ISBT, the remaining session of IMRT was delivered from the next day until 70 Gy in 35 fractions. It was demonstrated that boost HDR-ISBT combined with IMRT for keratinizing squamous cell carcinoma of the nasopharynx was performed safely and showed favourable efficacy.

Image-Guided Hypofractionated Small Volume Radiotherapy of Non-Small Cell Lung Cancer – Feasibility and Clinical Outcome

Onkologie ◽  
2012 ◽  
Vol 35 (7-8) ◽  
pp. 408-412 ◽  
Author(s):  
Stefan Janssen ◽  
Nicolas J. Dickgreber ◽  
Carolin Koenig ◽  
Michael Bremer ◽  
Martin Werner ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Outcome ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Volume ◽  
Small Cell ◽  
Small Cell Lung ◽  
Image Guided

TU-FF-A2-03: Image-Guided Helical Tomotherapy to Treat Advanced Cancers of the Scalp: Prospects for Dose Conformity and Clinical Outcome

2007 ◽  
Vol 34 (6Part19) ◽  
pp. 2576-2576
Author(s):  
K Kainz ◽  
J F Wilson ◽  
C Schultz ◽  
P Jursinic ◽  
X A Li
Keyword(s):  
Clinical Outcome ◽  
Helical Tomotherapy ◽  
Image Guided
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