scholarly journals Impact of bariatric surgery on non-alcoholic fatty liver disease

2017 ◽  
Vol 89 (2) ◽  
pp. 1-4 ◽  
Author(s):  
Piotr Major ◽  
Michał Pędziwiatr ◽  
Mateusz Rubinkiewicz ◽  
Maciej Stanek ◽  
Anna Głuszewska ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Weight Loss ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Liver Enzymes ◽  
Alcoholic Fatty Liver ◽  
The Impact ◽  
Alcoholic Fatty Liver Disease

Introduction; p to 300 million people have the body mass index (BMI) greater than 30 kg/m2. Obesity is the cause of many serious diseases, such as type 2 diabetes, hypertension, and non-alcoholic fatty liver disease (NAFLD). Bariatric surgery is the only effective method of achieving weight loss in patients with morbid obesity. Objectives: The aim of the study was to assess the impact of bariatric surgery on non-alcoholic fatty liver disease in patients operated on due to morbid obesity. Material and Methods: We included 20 patients who were qualified for bariatric procedures based on BMI > 40 kg/ m2 or BMI > 35kg/m2 with the presence of comorbidities. The average body weight in the group was 143.85kg, with an average BMI of 49.16kg/m2. Before the procedure, we evaluated the severity of non-alcoholic fatty liver disease in each patient using the Sheriff-Saadeh ultrasound scale. We also evaluated the levels of liver enzymes. Follow-up evaluation was performed twelve months after surgery. Results: Twelve months after surgery, the average weight was 102.34 kg. The mean %WL was 33.01%, %EWL was 58.8%, and %EBMIL was 61.37%. All patients showed remission of fatty liver disease. Liver damage, evaluated with ultrasound imaging, decreased from an average of 1.85 on the Sheriff-Saadeh scale, before surgery, to 0.15 twelve months after surgery (p < 0.001). As regards liver enzymes, the level of alanine aminotransferase decreased from 64.5 (U/l) to 27.95 (U/l) (p < 0.001), and the level of aspartate aminotransferase decreased from 54.4 (U/l) to 27.2 (U/l). Conclusions: Bariatric procedures not only lead to a significant and lasting weight loss, but they also contribute to the reduction of fatty liver disease and improve liver function.

scholarly journals Non-Alcoholic Fatty Liver Disease (NAFLD) and Bariatric/Metabolic Surgery as Its Treatment Option: A Review

2021 ◽  
Vol 10 (24) ◽  
pp. 5721
Author(s):  
Paulina Głuszyńska ◽  
Dorota Lemancewicz ◽  
Janusz Bogdan Dzięcioł ◽  
Hady Razak Hady
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Liver Disease ◽  
Fatty Liver ◽  
Metabolic Surgery ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Bariatric Metabolic Surgery ◽  
Alcoholic Fatty Liver Disease

The prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) has considerably increased over the last years. NAFLD is currently the most common cause of chronic liver disease in the developing world. The diagnosis of NAFLD/NASH is often incidental, as the early-stage of disease is frequently free of symptoms. Most patients recognized with NAFLD have severe obesity and other obesity-related disease such as type 2 diabetes mellitus (T2DM), insulin-resistance, dyslipidemia and hypertension. The only proven method for NAFLD improvement and resolution is weight loss. Bariatric surgery leads to significant and long-term weight loss as well as improvement of coexisting diseases. There is a lot of evidence suggesting that metabolic/bariatric surgery is an effective method of NAFLD treatment that leads to reduction in steatosis, hepatic inflammation and fibrosis. However, there is still a need to perform long-term studies in order to determine the role of bariatric surgery as a treatment option for NAFLD and NASH. This review discusses current evidence about epidemiology, pathogenesis and treatment options for NAFLD including bariatric/metabolic surgery and its effect on improvement and resolution of NAFLD.

scholarly journals Impact of bariatric surgery on non-alcoholic fatty liver disease: an integrative review

2021 ◽  
Vol 10 (13) ◽  
pp. e397101321437
Author(s):  
Antônio Alves Júnior ◽  
Tereza Virgínia Silva Bezerra do Nascimento ◽  
João Augusto Cegarra Quintiliano ◽  
Julia Maria Salgado Carvalho ◽  
Roberta Kayane Silva Leal ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Liver Disease ◽  
Fatty Liver ◽  
Latin American ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Secondary Sources ◽  
Type Studies ◽  
The Impact ◽  
Alcoholic Fatty Liver Disease

The present study aims to demonstrate the results of the impact of bariatric surgery on non-alcoholic fatty liver disease through secondary sources available in the literature. A literature review was carried out with the descriptors "Non-alcoholic Fatty Liver Disease" OR "NAFLD" AND "Bariatric Surgery"; “Doença Hepática Gordurosa não Alcoólica” OR “DHGNA” AND “Cirurgia Bariátrica” in the databases: Latin American and Caribbean Health Sciences Literature, through the Virtual Health Library, and Medical Literature Analysis and Retrieval System Online (Medline), through PubMed. Cohort-type studies addressing the effects of bariatric surgery on non-alcoholic fatty liver disease published in the last 5 years were included in the review. Thirty-one studies were identified, of which 10 were excluded for not performing postoperative evaluation and 8 were excluded for not containing the methodological criteria, totaling 13 studies. The current literature presents data suggestive of the association between bariatric surgery and the regression of non-alcoholic fatty liver disease, however, the studies observed present wide variations in methodological applications and samples with heterogeneous profiles, which makes it difficult to generalize the results. More studies are needed so that it is possible to document with greater evidence and reproducibility the action of different types of bariatric surgery on the rate of this liver disease regression.

The impact of a dedicated metabolic hepatology clinic for the treatment of non-alcoholic fatty liver disease

2017 ◽  
Author(s):  
Kenzo Motohashi ◽  
Ahmad Moolla ◽  
Tom Marjot ◽  
Mark Ainsworth ◽  
Jeremy Tomlinson ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
The Impact ◽  
Alcoholic Fatty Liver Disease
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