Malignant tumor of the peripheral nerve sheaths in the parotid gland - a case report

2019 ◽  
Vol 8 (4) ◽  
pp. 1-5
Author(s):  
Andrei Movila ◽  
Viktoriya Didora ◽  
Dawid Zagacki ◽  
Marcin Braun ◽  
Alina Morawiec-Sztandera ◽  
...  
Keyword(s):  
Case Report ◽  
Parotid Gland ◽  
Peripheral Nerve ◽  
Facial Nerve ◽  
Head And Neck ◽  
Soft Tissue Sarcomas ◽  
Malignant Schwannoma ◽  
Nerve Sheath ◽  
Superficial Lobe ◽  
S 100

Abstract Neoplasms of the parotid glands constitute about 6% of head and neck tumours, the most common of which are: adenoma multiforme and Warthin’s tumor. Schwannoma is benign, encapsulated tumor of the nerve cells (lemocytes, Schwann cells), most often it occurs in the trunk, head, extremely rarely observed in the parotid gland. 9% Schwannomas derives from the facial nerve sheath, constituting from 0.5% -1.2% of all salivary gland tumors. The literature describes 80 cases of intraparotid Schwannoma. Malignant Schwannoma (MPNST) account for 5% to 10% of all soft tissue sarcomas. High-grade MPNST tumors are aggressive, with a tendency to relapse and metastasis. We present a case report of a 84-year-old female patient presented to the Head and Neck Oncology Clinic of the Medical University of Lodz, due to the painful tumor of the left parotid region. The tumor appeared six months before hospitalization. During the physical examination, there was a polycyclic tumor with reduced mobility, the skin on the tumor was slightly red, lymph nodes uninvolved, facial nerve function preserved. BACC revealed tumour tissue composed of sheets and spindle-shaped cells. The patient was qualified for surgical treatment. Under the general anesthesia the superficial lobe of the parotid gland along with the tumor was removed. After the procedure, no facial nerve palsy was found. The patient did well post-operatively and was discharged home on the 8th day after surgery. Immunohistochemical staining showed the tumour cells to be diffusely and strongly immunoreactive for S-100 protein and Ki67 40-50%. Strong and diffuse staining for S-100 protein were consistent with the malignant peripheral nerve sheath tumour (MPNST). The patient was referred for radiotherapy, due to the postoperative outcome and advanced age, no adjuvant treatment was proposed. The patient has been in observation for 1 year. No relapse was found in the follow-up studies.

Cerebral Metastasis from an Epithelioid Malignant Schwannoma: Case Report

Neurosurgery ◽  
1991 ◽  
Vol 29 (6) ◽  
pp. 906-909 ◽  
Author(s):  
Vincenzo D'Angelo ◽  
Gianpiero Casadei ◽  
Luigi Bizzozero
Keyword(s):  
Case Report ◽  
Brain Metastasis ◽  
Peripheral Nerve ◽  
Spindle Cell ◽  
S100 Protein ◽  
Neuron Specific Enolase ◽  
Cerebral Metastasis ◽  
Malignant Schwannoma ◽  
Nerve Sheath ◽  
The Right

Abstract The authors present a case of brain metastasis from an epithelioid malignant schwannoma. The patient previously had undergone a surgical resection of the primary tumor in the right forearm. The neoplasm was composed of nests of cells with an entirely epithelioid appearance without spindle cell areas. Immunohistochemically, the tumor cells stained positive for S100 protein and negative for cytokeratin, neuron-specific enolase, and anti-melanoma antiserum. To our knowledge, this is the first reported case of cerebral metastasis from an epithelioid malignant tumor of the peripheral nerve sheath.

scholarly journals RECURRENCE OF MALIGNANT PERIPHERAL NERVE SHEATH TUMOR

2021 ◽  
Vol 7 (4) ◽  
pp. 145-148
Author(s):  
Alin Istodor ◽  
Ovidiu Ardelean ◽  
Carmen Rădulescu ◽  
Octavian Mazilu
Keyword(s):  
Case Report ◽  
Peripheral Nerve ◽  
Ct Scan ◽  
Pelvic Pain ◽  
Malignant Schwannoma ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Pelvic Region ◽  
Nerve Sheath ◽  
Short Period

Peripheral nerve sheath tumor (PNST) is known as a benign tumor called Schwannomas, developed from the Schwann cells that produce myelin and collagen, and can occur in a wide variety of locations. In some cases, it can take a malignant turn and grow as a pelvic mass known as malignant peripheral nerve sheath tumor (MPNST), malignant schwannoma, malignant neurofibroma, malignant mesenchynoma and neurogenic sarcoma. Our case report presents a female patient presenting dysuria and pelvic pain. The clinical examination revealed a palpable mass in the lower abdomen. The computer tomography (CT) scan of the abdomen and pelvic region showed a tumor mass that was in contact with the nearby organs, but not infiltrating them. After the surgery, histopathology confirmed the MPNST proliferation. A month after, the patient returned for a follow-up and presenting pelvic pain. The CT scan of the abdomen and pelvic region showed a tumoral mass compressing the nearby organs, but not infiltrating them. The patient was referred to oncology board for palliative treatment. The particularity of this case report is the short period of time recurrence of the MPNST, rather than metastases. The most important treatment for MPNSTs remains surgery, trying to achieve negative margins. However, there have been reported two cases of unresectable MPSNT with partial remission to chemo- and radiotherapy.  

scholarly journals Case report of malignant peripheral nerve sheath tumor of parotid in a patient with neurofibromatosis type 1

2021 ◽  
Vol 7 (12) ◽  
pp. 1927
Author(s):  
Anuradha P. ◽  
Bathi Reddy ◽  
Suhail Gaur
Keyword(s):  
Parotid Gland ◽  
Peripheral Nerve ◽  
Protein A ◽  
Soft Tissue Sarcomas ◽  
Neurofibromatosis Type ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Parotid Swelling ◽  
The Right

<p>Malignant peripheral nerve sheath tumor (MPNST) refers to spindle cell sarcomas arising from or separating in the direction of cells of the peripheral nerve sheath. The MPNST of the parotid gland is an extremely rare tumor, accounts for &lt;5% of all soft tissue sarcomas, and carries a poor prognosis. Diagnosis of MPNSTs is usually based on histopathology aided by IHC, which reflects the Schwann cell differentiation in this neoplasm. Approximately 50-90% of MPNSTs are positive for S-100 protein. A 56-year-old male presented with right parotid swelling for 3 months and incomplete right eye closure. The patient was diagnosed with neurofibromatosis 1 (NF-1) and pulmonary tuberculosis in the past. On Examination, a hard, tender swelling measuring 5×4 cm involving the right parotid gland and right grade 2 LMN facial palsy was noted. Histopathology was suggestive of a MPNST.</p><p><strong> </strong></p>

scholarly journals Case report and immunohistochemical study of a malignant peripheral nerve sheath tumor in a dog

2017 ◽  
Vol 54 (4) ◽  
pp. 420
Author(s):  
Thaís De Almeida Moreira ◽  
Leandro Willian Borges ◽  
Talita Lopes Serra ◽  
Diego Petrocino Caetano ◽  
Marcelo Carrijo da Costa ◽  
...  
Keyword(s):  
Case Report ◽  
Peripheral Nerve ◽  
Immunohistochemical Study ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
S 100

O tumor maligno da bainha do nervo periférico é raro e pouco descrito em cães. Classicamente, o termo “neurofibroma/sarcoma” é empregado quando o tumor é composto por células de Schwann e células perineurais. Neste relato são descritos os achados clínicos, histopatológicos e imuno-histoquímicos de um caso de tumor maligno da bainha do nervo periférico, provavelmente neurofibrossarcoma, localizado no subcutâneo do membro pélvico de um cão da raça Rottweiler. Os achados histopatológicos associados às observações imuno-histoquímicas contribuíram para o diagnóstico, sendo observada positividade para proteína S-100, vimentina e CD57, permitindo a diferenciação da neoplasia em questão de outros tumores malignos com características morfológicas similares.

Intranodal neurilemmoma presenting as parotid mass

2009 ◽  
Vol 123 (8) ◽  
pp. 912-914 ◽  
Author(s):  
D G Grant ◽  
N Breitenfeldt ◽  
N A Shepherd ◽  
D M Thomas
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Parotid Gland ◽  
Histopathological Analysis ◽  
Rare Tumour ◽  
Histological Features ◽  
First Report ◽  
Nerve Sheath ◽  
Superficial Lobe

AbstractObjective:We report a case of benign intranodal neurilemmoma, an extremely rare tumour arising from a nerve sheath within a lymph node.Case report:A 67-year-old woman underwent surgery for a left-sided parotid mass. Histopathological analysis revealed a tumour arising from a lymph node within the superficial lobe of the parotid gland. The tumour demonstrated histological features of an intranodal neurilemmoma.Conclusions:This case represents the first report of an intranodal neurilemmoma arising within a parotid lymph node, and supports the proposal that intranodal neurilemmoma be recognised as a distinct histological entity.

scholarly journals Reclassification of 21 Presumptive Canine Peripheral Nerve Sheath Tumors (PNST) Using a Literature-Based Immunohistochemical Panel

2016 ◽  
Vol 66 (4) ◽  
pp. 455-465 ◽  
Author(s):  
Rubina Sirri ◽  
Silvia Sabattini ◽  
Giuliano Bettini ◽  
Luciana Mandrioli
Keyword(s):  
Peripheral Nerve ◽  
Soft Tissue Sarcomas ◽  
Therapeutic Implications ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath ◽  
Archived Samples ◽  
Histological Appearance ◽  
S 100 ◽  
Poorly Differentiated

Abstract The aim of this study was to re-evaluate archived samples of canine soft tissue sarcomas (STSs) morphologically consistent with peripheral nerve sheath tumors (PNSTs). In each case, an immunohistochemical panel was applied, including α-SMA, calponin, desmin, S-100, GFAP, NSE and Olig2, in order to assess whether the phenotype was consistent with the tumor histological appearance. Additionally, the expression of EGFR, a marker with potential therapeutic implications in malignant PNSTs, was evaluated. Twenty-one tumors were included. Fourteen cases (66.7%) were positive for one or more muscular markers and were reclassified as perivascular tumors (PWTs). A positive labeling for S-100 was observed in one tumor (4.8%), thus classifi ed as PNST. The other 6 tumors were generically classified as poorly differentiated STSs. No unique histopathological feature was observed within the three groups. NSE and Olig2 labeling was aspecific and not useful for diagnostic purposes. GFAP was negative in all cases. Six cases (28.6%) were positive for EGFR, including the PNST. Even after the application of a wide immunohistochemical panel, distinguishing between PNSTs and PWTs remains a challenge. Finally, a subgroup of cases cannot be classified based on light microscopy alone.

Malignant Triton Tumor without Von Recklinghausen’s Neurofibromatosis in a 16 year-old Indonesian Girl: A Case Report

2017 ◽  
Vol 43 (1) ◽  
pp. 3
Author(s):  
Neni Anggraini ◽  
Nurjati Chairani Siregar
Keyword(s):  
Visual Acuity ◽  
Case Report ◽  
Early Detection ◽  
Peripheral Nerve ◽  
Correct Diagnosis ◽  
Nerve Sheath Tumor ◽  
Malignant Triton Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
S 100

Background: To diagnose malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation in malignant triton tumor which has a rare incidence. Case Illustration: We reported a case in a 16 year-old girl who presented with progressively painless proptosis of the left eye and decreased visual acuity. There was no evidence of Recklinghausen’s disease. She underwent surgery and radiotherapy. The histopatologic findings showed malignant peripheral nerve sheath tumor (MPNST). Four years later, she suffered recurrence proptosis and decreased visual acuity. Histomorphology supported by immunostaining with S-100 protein confirmed the diagnosis of malignant triton tumor. She underwent chemotherapy and enucleation. Conclusion: This case highlights the prudent use of immunohistochemistry that is essential in making an early detection and a correct diagnosis.

scholarly journals Malignant peripheral nerve sheath tumors

2007 ◽  
Vol 22 (6) ◽  
pp. 1-8 ◽  
Author(s):  
Gaurav Gupta ◽  
Allen Maniker
Keyword(s):  
Peripheral Nerve ◽  
Soft Tissue Sarcomas ◽  
Nerve Fibers ◽  
World Health ◽  
Malignant Schwannoma ◽  
Malignant Neoplasms ◽  
Cell Of Origin ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath

Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue sarcomas of ectomesenchymal origin. The World Health Organization coined the term MPNST to replace previous heterogeneous and often confusing terminology, such as “malignant schwannoma,” “malignant neurilemmoma,” “neurogenic sarcoma,” and “neurofibrosarcoma.” Malignant peripheral nerve sheath tumors arise from major or minor peripheral nerve branches or sheaths of peripheral nerve fibers, and are derived from Schwann cells or pluripotent cells of neural crest origin. The Schwann cell is thought to be the major contributor to the formation of benign as well as malignant neoplasms of the nerve sheath. While this fact remains essentially true, the identity of cell of origin of the MPNST remains elusive, and has not yet been conclusively identified. It has been suggested that these tumors may have multiple cell line origins. In this review, the authors discuss the epidemiology, diagnosis, management, and treatment of MPNSTs.

Malignant Peripheral Nerve Sheath Tumor of the Parotid Gland

2003 ◽  
Vol 112 (7) ◽  
pp. 637-643 ◽  
Author(s):  
Shun-Ichi Imamura ◽  
Haruko Suzuki ◽  
Shin-Ichi Usami ◽  
Eiki Koda ◽  
Akihiko Yoshizawa
Keyword(s):  
Parotid Gland ◽  
Peripheral Nerve ◽  
Head And Neck ◽  
English Language ◽  
Immunohistochemical Analysis ◽  
Radical Resection ◽  
Nerve Sheath Tumor ◽  
Histologic Diagnosis ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath

Malignant peripheral nerve sheath tumor (MPNST) has been defined as any malignant tumor arising from or differentiating toward cells of the peripheral nerve sheath. We treated a case of MPNST arising from the right parotid gland that showed a highly aggressive course. We reviewed the English-language literature published since 1990 and found 142 cases of head and neck MPNST reported within the past 13 years. The results of the review suggested that MPNSTs may arise from any organs of the head and neck. Immunohistochemical analysis of various neural markers plays a significant role in the evaluation of the histologic diagnosis. Curative treatment based on radical resection of MPNSTs of head and neck origin is more difficult than treatment of MPNSTs of other origins.

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