scholarly journals Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors

2016 ◽  
Vol 25 (6) ◽  
pp. 307-317 ◽  
Author(s):  
Tae-Kyung Kim ◽  
Pyung-Lim Han
Keyword(s):  
Functional Connectivity ◽  
Basolateral Amygdala ◽  
Hormone Receptors ◽  
Orexin Receptors ◽  
Melanin Concentrating Hormone

Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis

2015 ◽  
Vol 212 ◽  
pp. 114-123 ◽  
Author(s):  
Yuki Kobayashi ◽  
Akie Hamamoto ◽  
Tomo Hirayama ◽  
Yumiko Saito
Keyword(s):  
Molecular Cloning ◽  
Signaling Pathway ◽  
Hormone Receptors ◽  
Xenopus Tropicalis ◽  
Melanin Concentrating Hormone

scholarly journals Changes in Functional Connectivity in Orbitofrontal Cortex and Basolateral Amygdala during Learning and Reversal Training

2000 ◽  
Vol 20 (13) ◽  
pp. 5179-5189 ◽  
Author(s):  
Geoffrey Schoenbaum ◽  
Andrea A. Chiba ◽  
Michela Gallagher
Keyword(s):  
Functional Connectivity ◽  
Orbitofrontal Cortex ◽  
Basolateral Amygdala ◽  
Reversal Training

scholarly journals Paired-Pulse Inhibition and Disinhibition of the Dentate Gyrus Following Orexin Receptors Inactivation in the Basolateral Amygdala

2021 ◽  
Vol 0 (0) ◽  
pp. 1-16
Author(s):  
Esmaeil Akbari ◽  
◽  
Narges Hosseinmardi ◽  
Motahareh Rouhi Ardeshiri ◽  
◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Dentate Gyrus ◽  
Dimethyl Sulfoxide ◽  
Rat Brain ◽  
Learning And Memory ◽  
Basolateral Amygdala ◽  
Local Interneuron ◽  
Paired Pulse ◽  
Orexin Receptors ◽  
Neuronal Transmission

The basolateral amygdala (BLA) has substantial effects on the neuronal transmission and synaptic plasticity processes through the dentate gyrus. Orexin neuropeptides play different roles in the sleep/wakefulness cycle, feeding, learning, and memory. The present study was conducted to investigate the function of the orexin receptors of the BLA in the hippocampal local interneuron circuits. For this, paired-pulse responses from dentate gyrus (DG) region were recorded. Within the procedure, SB-334867-A (12μg/0.5μl), and, TCS-OX2-29 (10μg/0.5μl (orexin 1 and 2 receptors antagonists, respectively), were administered into the both side of the BLA areas of the rat brain. Dimethyl sulfoxide (DMSO) was used as the solvent in the control animals with the volume of 0.5μl. Our data indicated that the paired-pulse (PP) responses were not affected by the inactivation of the orexin receptors of the BLA.

scholarly journals Oxytocin enhances basolateral amygdala activation and functional connectivity in autistic women while processing emotional faces

2021 ◽  
Author(s):  
Tanya Procyshyn ◽  
MIchael Lombardo ◽  
Meng-Chuan Lai ◽  
Bonnie Auyeung ◽  
Sarah Crockford ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Basolateral Amygdala ◽  
Brain Regions ◽  
Placebo Condition ◽  
Emotional Faces ◽  
Amygdala Activation ◽  
Within Subjects ◽  
Emotional Information Processing ◽  
Face Stimuli ◽  
The Right

Background: Oxytocin is hypothesized to promote positive social interactions by enhancing the salience of social stimuli, which may be reflected by altered amygdala activation. While previous neuroimaging studies have reported that oxytocin enhances amygdala activation to emotional face stimuli in autistic men, effects in autistic women remain unclear. Methods: The influence of intranasal oxytocin on neural response to emotional faces vs. shapes were tested in 16 autistic and 21 non-autistic women by fMRI in a placebo-controlled, within-subjects, cross-over design. Effects of group (autistic vs. non-autistic) and drug condition (oxytocin vs. placebo) on the activation and functional connectivity of the basolateral amygdala, the brain’s “salience detector”, were assessed. Relationships between individual differences in autistic-like traits, social anxiety, salivary oxytocin levels, and amygdala activation were also explored.Results: Autistic and non-autistic women showed minimal activation differences in the placebo condition. Significant drug × group interactions were observed for both amygdala activation and functional connectivity. Oxytocin increased left basolateral amygdala activation among autistic women (35 voxel cluster, MNI coordinates of peak voxel = -22 -10 -28; mean change=+0.079%, t=3.159, ptukey=0.0166), but not non-autistic women (mean change =+0.003%, t=0.153, ptukey=0.999). Furthermore, oxytocin increased functional connectivity of the right basolateral amygdala with brain regions associated with socio-emotional information processing in autistic women, but not non-autistic women, thereby attenuating group connectivity differences observed in the placebo condition. Conclusions: This work demonstrates that intranasal oxytocin increases basolateral amygdala activation and connectivity in autistic women while processing emotional faces, which extends and specifies previous findings in autistic men.

Reduced resting-state functional connectivity of the basolateral amygdala to the medial prefrontal cortex in preweaning rats exposed to chronic early-life stress

2018 ◽  
Vol 223 (8) ◽  
pp. 3711-3729 ◽  
Author(s):  
Angela Guadagno ◽  
Min Su Kang ◽  
Gabriel A. Devenyi ◽  
Axel P. Mathieu ◽  
Pedro Rosa-Neto ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Medial Prefrontal Cortex ◽  
Resting State ◽  
Life Stress ◽  
Early Life ◽  
Basolateral Amygdala ◽  
Early Life Stress ◽  
Resting State Functional Connectivity

scholarly journals Progressively Disrupted Intrinsic Functional Connectivity of Basolateral Amygdala in Very Early Alzheimer’s Disease

2016 ◽  
Vol 7 ◽  
Author(s):  
Marion Ortner ◽  
Lorenzo Pasquini ◽  
Martina Barat ◽  
Panagiotis Alexopoulos ◽  
Timo Grimmer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Basolateral Amygdala ◽  
Intrinsic Functional Connectivity ◽  
Early Alzheimer’S Disease

Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2

2011 ◽  
Vol 169 (1-3) ◽  
pp. 6-12 ◽  
Author(s):  
Akie Hamamoto ◽  
Kanta Mizusawa ◽  
Akiyoshi Takahashi ◽  
Yumiko Saito
Keyword(s):  
Hormone Receptors ◽  
Signalling Pathway ◽  
Melanin Concentrating Hormone

Cellular models for the study of the pharmacology and signaling of melanin-concentrating hormone receptors

2010 ◽  
Vol 30 (6) ◽  
pp. 385-402 ◽  
Author(s):  
Alex N. Eberle ◽  
Gabriele Mild ◽  
Urs Zumsteg
Keyword(s):  
Hormone Receptors ◽  
Cellular Models ◽  
Melanin Concentrating Hormone

scholarly journals Functional and directed connectivity of the cortico-limbic network in mice in vivo

2021 ◽  
Author(s):  
Zeinab Khastkhodaei ◽  
Muthuraman Muthuraman ◽  
Jenq-Wei Yang ◽  
Sergiu Groppa ◽  
Heiko J. Luhmann
Keyword(s):  
Functional Connectivity ◽  
Psychiatric Disorders ◽  
Emotional Regulation ◽  
Animal Studies ◽  
Basolateral Amygdala ◽  
Brain Regions ◽  
Therapeutic Interventions ◽  
Distinct Frequency ◽  
Feedback Connections

AbstractHigher cognitive processes and emotional regulation depend on densely interconnected telencephalic and limbic areas. Central structures of this cortico-limbic network are ventral hippocampus (vHC), medial prefrontal cortex (PFC), basolateral amygdala (BLA) and nucleus accumbens (NAC). Human and animal studies have revealed both anatomical and functional alterations in specific connections of this network in several psychiatric disorders. However, it is often not clear whether functional alterations within these densely interconnected brain areas are caused by modifications in the direct pathways, or alternatively through indirect interactions. We performed multi-site extracellular recordings of spontaneous activity in three different brain regions to study the functional connectivity in the BLA–NAC–PFC–vHC network of the lightly anesthetized mouse in vivo. We show that BLA, NAC, PFC and vHC are functionally connected in distinct frequency bands and determined the influence of a third brain region on this connectivity. In addition to describing mutual synchronicity, we determined the strength of functional connectivity for each region in the BLA–NAC–PFC–vHC network. We find a region-specificity in the strength of feedforward and feedback connections for each region in its interaction with other areas in the network. Our results provide insights into functional and directed connectivity in the cortico-limbic network of adult wild-type mice, which may be helpful to further elucidate the pathophysiological changes of this network in psychiatric disorders and to develop target-specific therapeutic interventions.

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