scholarly journals Rational Design, Synthesis and Cytotoxic Activity of N-(Phenylcarbamoyl)Benzamide on HeLa Cell Lines

2020 ◽  
Vol 52 (2) ◽  
pp. 174
Author(s):  
Bambang Tri Purwanto ◽  
Siswandono Siswandono ◽  
Suko Hardjono ◽  
Dian Triwidiandany
Keyword(s):  
Hela Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Rational Design ◽  
Design Synthesis ◽  
Hela Cell Lines

scholarly journals Novel C-ring Analogs of Ursolic acid: Synthesis and Cytotoxic Evaluation

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901
Author(s):  
Uppuluri V. Mallavadhani ◽  
Banita Pattnaik ◽  
Nitasha Suri ◽  
Ajit K. Saxena
Keyword(s):  
Hela Cell ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Cell Lines ◽  
Ursolic Acid ◽  
Parent Compound ◽  
Acid Synthesis ◽  
Hela Cell Line ◽  
Hela Cell Lines ◽  
Protective Groups

Ursolic acid (1), a natural pentacyclic triterpenic acid, afforded a variety of ring-C transformed products (5–11) when treated with N-bromosuccinimide under the influence of a range of protective groups and solvents. The synthesized compounds have been evaluated for cytotoxic activity against prostate PC 3, leukemia THP 1, cervical Hela and lung A-549 cancer cell lines. Among the tested analogs, compounds 5, 8, 9 and 10 showed potent activity against PC 3, THP 1 and Hela cell lines. Especially, compound 10 showed enhanced activity against the Hela cell line than the parent compound. Compounds 5, 8 and 9 showed comparable activities against PC 3 and THP 1 cell lines.

scholarly journals CYTOTOXIC CONSTITUENTS FROM AERIAL PARTS OF HELICTERES HIRSUTA PLANT, COLLECTED IN BINH PHUOC PROVINCE

2018 ◽  
Vol 127 (1A) ◽  
pp. 111
Author(s):  
Pham Huu Dien
Keyword(s):  
Hela Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Folk Medicine ◽  
Hep G2 ◽  
Aerial Parts ◽  
Hela Cell Lines ◽  
Human Prostate Carcinoma ◽  
Pure Compounds ◽  
Human Lung Carcinoma

<p><em>Helicteres hirsuta</em> plant is a member of <em>Helicteres </em>genus<em> </em>of the plant family Sterculiaceae and widely found in countries of South Asia such as Vietnam, Lao, Thailand etc. In recent years, it is known as a new folk medicine protecting and securing people against human lung carcinoma, hormone - dependent human prostate carcinoma and human liver. In this paper, from aerial parts of <em>Helicteres hirsuta</em> plant, collected in Binhphuoc province (October, 2016) three pure compounds <strong>1</strong>-<strong>3</strong> were isolated and structurally elucidated, such as <em>b</em>-stigmasterol (<strong>1</strong>), protosta-17(20), 24-dien-3<em>b</em>-ol (<strong>2</strong>) and icosanoic acid (<strong>3</strong>). Among them, compound <strong>2</strong> has a remarkable cytotoxic activity against SK-LU-1, Hep-G2, and Hela cell lines with IC<sub>50</sub> values from 32.86 to 77.31 mg/mL, meanwhile compound <strong>3</strong> shows a moderable cytotoxic activity against SK-Mel-2, AGS, SK-LU-1, Hep-G2, and Hela cell lines with IC<sub>50</sub> values from 59.02 to 80.87 mg/mL.  </p>

scholarly journals Synthesis and Antiproliferative Activity of Diethylamine Mannich Base of Asymmetrical Mono-Carbonyl Curcumin Analogs against HeLa Cell Lines

2017 ◽  
Author(s):  
Pekik Wiji Prasetyaningrum ◽  
Anton Bahtiar ◽  
Hayun Hayun
Keyword(s):  
Hela Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Mannich Base ◽  
Parent Compound ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Curcumin Analogs ◽  
Hela Cell Lines

A series of diethylamine Mannich base of asymmetrical mono-carbonyl analogs of curcumin (AMACs) were synthesized and evaluated for cytotoxic activity against Hela Cell lines. The structures of the synthesized compounds were confirmed on the basis of FTIR, 1H-NMR, 13C-NMR and mass spectral data. Preliminary cytotoxic test using BSLT showed that all the synthesized compounds exhibited more potent cytotoxic activity than that of curcumin. While results of MTT assay showed that all the synthesized compounds exhibited more potent antiproliferative activity against HeLa cell lines than that of cisplatin. Compound 2b exhibited as the most potent compound of the series. Compound 2a, 2b, 2c, and 2f had IC50 (&micro;M) less than that of compound 1a, 1b, 1c and 1f indicating that the addition of diethylamine Mannich base improves the antiproliferative activity of the parent compound.

scholarly journals Antiproliferative effects of some medicinal plants on HeLa cells

2013 ◽  
Vol 65 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Desanka Cenic-Milosevic ◽  
Z. Tambur ◽  
D. Bokonjic ◽  
S. Ivancajic ◽  
Tatjana Stanojkovic ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Hela Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Hela Cells ◽  
Melissa Officinalis ◽  
Echinacea Angustifolia ◽  
Antiproliferative Effects ◽  
Hela Cell Lines ◽  
Ic50 Value

Medicinal plants maintain the health and vitality of individuals, and also have potential curative effect on various diseases, including cancer. In this study were investigated the antiproliferative effects of water extracts of previously obtained ethanolic dry extracts of three different medicinal plants (Echinacea angustifolia, Salvia officinalis and Melissa officinalis) on cell lines derived from human cervix adenocarcinoma (HeLa cells). The best cytotoxic activity (IC50 = 43.52 ?g/ml) on HeLa cell lines was exhibited by Echinacea angustifolia. The extract of Salvia officinalis also showed a good cytotoxic activity against HeLa cell lines; the IC50 value was 70.41 ?g/ml. Melissa officinalis manifested a slightly weaker cytotoxic activity and an IC50 value of 122.22 ?g/ml.

scholarly journals Dipterostilbenosides A and B, Oligostilbene Glycosides from Dipterocarpus tuberculatus

2014 ◽  
Vol 9 (9) ◽  
pp. 1934578X1400900
Author(s):  
Serm Surapinit ◽  
Jonkolnee Jong-aramruang ◽  
Pongpun Siripong ◽  
Suttira Khumkratok ◽  
Santi Tip-pyang
Keyword(s):  
Hela Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Spectroscopic Data ◽  
Methanolic Extract ◽  
Chemical Investigation ◽  
Hela Cell Lines

From the chemical investigation of the methanolic extract of the roots of the Thai dipterocarp, Dipterocarpus tuberculatus, two new oligostilbene glycosides, dipterostilbenes A (1) and B (2), were isolated together with four known stilbenes. Their structures and relative configurations were determined on the basis of spectroscopic data. From an evaluation of cytotoxic activity against KB and HeLa cell lines, α-viniferin (5) and (-)-hopeaphenol (6) showed potent activity, but less than that of doxorubicin.

Cytotoxic β-Dihydroagarofuran Sesquiterpenoids from the Fruits of Celastrus orbiculatus

2008 ◽  
Vol 63 (7-8) ◽  
pp. 515-518 ◽  
Author(s):  
Jing Xu ◽  
Yuan-Qiang Guo ◽  
Xian Li ◽  
Kun Wei ◽  
Xiaojun Zhao ◽  
...  
Keyword(s):  
Hela Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cervical Carcinoma ◽  
Human Melanoma ◽  
Activity Relationship ◽  
Celastrus Orbiculatus ◽  
Human Cervical Carcinoma ◽  
Structure Activity ◽  
Hela Cell Lines

Assay-guided fractionation led to the isolation of nine β-dihydroagarofuran sesquiterpenoids from the fruits of Celastrus orbiculatus. All isolated β-dihydroagarofuran sesquiterpenoids were tested for their cytotoxic activity against human melanoma A375-S2 and human cervical carcinoma Hela cell lines. Among them, compounds 1-5 and 7 showed cytotoxic activity. Compound 3 exhibited promising cytotoxicity against both human melanoma A375- S2 and human cervical carcinoma Hela cell lines. The structure-activity relationship was discussed briefly.

Evaluation of Antioxidant, Antimicrobial and Anticancer activity of Thiazole Tagged Isatin Hydrazones

2016 ◽  
Vol 3 (2) ◽  
pp. 4-9 ◽  
Author(s):  
Venkateshwarlu Eggadi ◽  
Umasankar Kulandaivelu ◽  
Sharvana Bhava Bandaru Sheshagiri ◽  
Venkateshwar Rao Jupalli
Keyword(s):  
Antioxidant Activity ◽  
Hela Cell ◽  
Cytotoxic Activity ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Wide Spectrum ◽  
Zone Of Inhibition ◽  
Hela Cell Lines ◽  
Ic50 Values ◽  
Isatin Derivatives

Isatin and its derivatives is versatile lead molecule for potential bioactive agents and shows wide spectrum of activities. In this study, we evaluated antioxidant, antimicrobial and cytotoxic activity of isatin-3-[N2-(2-benzalaminothiazol-4-yl)] hydrazone derivatives using well defined models. Antioxidant activity of the isatin derivatives (Va-Vj) was evaluated by using the 1, 1-diphenyl-2-picryl hydrazine radicals scavenging assay. The antimicrobial activity is evaluated by cup plate method and anticancer activity is evaluated by MTT assay against HBL-100 & HeLa cell lines. Compound Vh (R = 5-Cl, R1 = OH & R2 = OCH3) showed good antioxidant activity with the IC50 of 8.09 M. In addition Ve and Vi have showned most active antibacterial activity against Bacillus subtilis, Staphylococcus aureus and Escherichia coli with a Zone of Inhibition (mm) 20, 16, 18 and 14, 12, 15 on respective organism at 100 g/disc. The compound Vi have produced a good antifungal activity against Aspergillus niger and Clostridium vericulata with the zone of inhibition values of 9 and 8 mm respectively. These isatin derivatives also among the test compounds, compound Vd (R = 5-Cl, R1 = OH & R2 = OCH3) and compound Vh (R = 5-Cl, R1 = OH & R2 = OCH3) have shown nearly equal cytotoxic activity with IC50 values of 246.53 mM and 247.29 mM against HBL-100 cell lines and HeLa cell lines respectively. From the results, isatin derivatives showed powerful antioxidant activity, antimicrobial and anticancer activity may be due to the halogens substituted at 5th position of isatin. The standard drugs used were ampicillin, clotrimazole, cisplatin and ascorbic acid for antibacterial, antifungal, anticancer and antioxidant respectively.

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