CYTOTOXIC CONSTITUENTS FROM AERIAL PARTS OF HELICTERES HIRSUTA PLANT, COLLECTED IN BINH PHUOC PROVINCE
<p><em>Helicteres hirsuta</em> plant is a member of <em>Helicteres </em>genus<em> </em>of the plant family Sterculiaceae and widely found in countries of South Asia such as Vietnam, Lao, Thailand etc. In recent years, it is known as a new folk medicine protecting and securing people against human lung carcinoma, hormone - dependent human prostate carcinoma and human liver. In this paper, from aerial parts of <em>Helicteres hirsuta</em> plant, collected in Binhphuoc province (October, 2016) three pure compounds <strong>1</strong>-<strong>3</strong> were isolated and structurally elucidated, such as <em>b</em>-stigmasterol (<strong>1</strong>), protosta-17(20), 24-dien-3<em>b</em>-ol (<strong>2</strong>) and icosanoic acid (<strong>3</strong>). Among them, compound <strong>2</strong> has a remarkable cytotoxic activity against SK-LU-1, Hep-G2, and Hela cell lines with IC<sub>50</sub> values from 32.86 to 77.31 mg/mL, meanwhile compound <strong>3</strong> shows a moderable cytotoxic activity against SK-Mel-2, AGS, SK-LU-1, Hep-G2, and Hela cell lines with IC<sub>50</sub> values from 59.02 to 80.87 mg/mL. </p>