scholarly journals Increased Risk for Excessive Weight Gain Infants Who Sleep Less Than 12 Hours Per 24: Response to Yu et al.; Insufficient sleep during infancy is correlated with excessive weight gain in childhood: a longitudinal twin cohort study (JC-20-00773).

2021 ◽  
Author(s):  
Madeleine Grigg-Damberger
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Insufficient Sleep ◽  
Excessive Weight Gain ◽  
Excessive Weight ◽  
Increased Risk

Molecular pathway analysis associates alterations in obesity-related genes and antipsychotic-induced weight gain

2019 ◽  
Vol 32 (2) ◽  
pp. 72-83 ◽  
Author(s):  
Henrik Thyge Corfitsen ◽  
Betina Krantz ◽  
Agnete Larsen ◽  
Antonio Drago
Keyword(s):  
Weight Gain ◽  
Genome Wide Association Study ◽  
Permutation Test ◽  
Nucleotide Polymorphisms ◽  
Data Set ◽  
Excessive Weight Gain ◽  
Molecular Pathway ◽  
Gwas Analysis ◽  
Excessive Weight ◽  
Increased Risk

AbstractObjective:Antipsychotics often induce excessive weight gain. We hypothesised that individuals with genetic variations related to known obesity-risk genes have an increased risk of excessive antipsychotic-induced weight gain (AIWG). This hypothesis was tested in a subset of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial data set.Methods:The CATIE trial compared effects and side effects of five different antipsychotics through an 18-month period. Based on the maximum weight gain recorded, excessive weight gain was defined as >7% weight gain. Cytoscape and GeneMANIA were instrumental in composing a molecular pathway from eight selected genes linked to obesity. Genetic information on a total of 495.172 single-nucleotide polymorphisms (SNPs) were available from 765 (556 males) individuals. Enrichment test was conducted through ReactomePA and Bioconductor. A permutation test was performed, testing the generated pathway against 105 permutated pathways (p ≤ 0.05). In addition, a standard genome-wide association study (GWAS) analysis was performed.Result:GWAS analysis did not detect significant differences related to excessive weight gain. The pathway generated contained 28 genes. A total of 2067 SNPs were significantly expressed (p < 0.01) within this pathway when comparing excessive weight gainers to the rest of the sample. Affected genes including PPARG and PCSK1 were not previously related to treatment-induced weight gain.Conclusions:The molecular pathway composed from high-risk obesity genes was shown to overlap with genetics of patients who gained >7% weight gain during the CATIE trial. This suggests that genes related to obesity compose a pathway of increased risk of excessive AIWG. Further independent analyses are warranted that may confirm or clarify the possible reasoning behind.

scholarly journals The Effects of Pre-Pregnancy Body Mass Index and Gestational Weight Gain on the Risk of Preeclampsia at a Tertiary Referral Hospital, Northern Tanzania

2020 ◽  
Author(s):  
Nelago Tukondjeni Amagulu ◽  
Bariki Mchome ◽  
Julius Pius Alloyce ◽  
Kingsly Tobi ◽  
Eusebius Maro
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Multinomial Logistic Regression ◽  
Normal Weight ◽  
Excessive Weight Gain ◽  
Gestational Weight ◽  
Excessive Weight ◽  
Northern Tanzania ◽  
Increased Risk ◽  
In Pregnancy

Abstract Background: Pre/eclampsia and other hypertensive disorders of pregnancy contributed to 18% of the maternal mortality reported in Northern Tanzanian. There is increasing prevalence of obesity in Tanzania which is related to excessive weight gain in pregnancy. Both high BMI and excessive gestation weight gain are identified to increase risk of PE and subtypes, however this is still inconclusive and little is known about the joint effect of pre-pregnancy BMI and GWG on risk of PE and its subtypes in Africa. We evaluated the independent and joint effects of pre-pregnancy BMI and GWG on the risk of pre-eclampsia and its subtypes among women who delivered at Kilimanjaro Christian Medical Center (KCMC) from October 2018 to May 2019, Northern Tanzania.Methods: We performed a retrospective birth cohort study from October 2018 to May 2019 at KCMC, Tanzania. Pre-pregnancy BMI was categorized using WHO categories into Underweight (˂ 18.5kg/m²), Normal weight (18.5-24.9kg/m²), Overweight (25-29.9kg/m²) and Obese (≥ 30kg/m²). Gestational Weight Gain (GWG) was categorized using the 2009 Institute of Medicine (IOM) guidelines into Inadequate, Adequate and Excessive weight gain in pregnancy. Multinomial logistic regression analysis was used to adjust for confounders using relative risk, 95% confidence interval for the risk ratios (RR) that did not cross 1 and p<0.05 were regarded statistically significant.Results: Among the 1309 women analysed, 5.3% were Underweight, 51.1% Normal weight, 26.9% Overweight and 16.7% were Obese. About 43.5% had excessive GWG. Women with PE were 9.5%. Both obesity and excessive GWG independently increased risk of PE with adjusted RR=2.42, 95%CI: 1.48-3.96 and RR=1.77, 95%CI: 1.16-2.69 when compared to normal BMI and adequate GWG respectively. Jointly, Obesity and Excessive GWG had the highest risk of PE (ARR=4.95, 95%CI: 2.21-11.10). The increased risk was similar for Mild PE (MPE), Severe PE or eclampsia (SP/E) and Late Onset PE (LOPE). No association was found for Early Onset PE (EOPE).Conclusion: Pre-pregnancy Obesity and Excessive GWG independently and jointly increases risk for PE and the risk varies by PE subtype.

scholarly journals Socioeconomic, demographic and nutritional factors associated with maternal weight gain in general practices in Southern Brazil

2010 ◽  
Vol 26 (5) ◽  
pp. 1024-1034 ◽  
Author(s):  
Michele Drehmer ◽  
Suzi Camey ◽  
Maria Inês Schmidt ◽  
Maria Teresa Anselmo Olinto ◽  
Andressa Giacomello ◽  
...  
Keyword(s):  
Weight Gain ◽  
Prenatal Care ◽  
Public Health Problem ◽  
Institute Of Medicine ◽  
Maternal Weight ◽  
Excessive Weight Gain ◽  
Care Services ◽  
Excessive Weight ◽  
Increased Risk ◽  
Prenatal Care Visit

In order to describe adequacy of weight gain during pregnancy and its association with pre-pregnancy nutritional status and other factors, a cohort study of pregnant women enrolled at 16-36 weeks of gestation and followed up until delivery was carried out in prenatal care in primary care services in Rio Grande do Sul State, Brazil. Maternal weight was recorded at each prenatal care visit. Weight gain was classified as "adequate," "insufficient" or "excessive" (Institute of Medicine). Poisson regression was used to measure the associations. The sample was comprised of 667 women, and insufficient and excessive weight gain incidences were 25.8% and 44.8%, respectively. Overweight and obese before pregnancy had a significant increased risk of excessive weight gain in pregnancy (RR: 1.75; 95%CI: 1.48-2.07, RR: 1.55; 95%CI: 1.23-1.96, respectively). Women with fewer than six prenatal visits had a 52% increased risk for weight gain below recommended values. Although insufficient weight gain may still be a public health problem, excessive gain is becoming a concern that needs immediate attention in prenatal care.

The role of antenatal education for the prevention of excessive weight gain during pregnancy

2020 ◽  
Vol 71 (6) ◽  
Author(s):  
Roberta Amadori ◽  
Carmela Melluzza ◽  
Alessia Motta ◽  
Alberto De Pedrini ◽  
Daniela Surico
Keyword(s):  
Weight Gain ◽  
Excessive Weight Gain ◽  
Antenatal Education ◽  
Excessive Weight ◽  
Weight Gain During Pregnancy

Screening for celiac disease among children with overweight and obesity: toward exploring celiac iceberg

2020 ◽  
Vol 33 (8) ◽  
pp. 995-1002
Author(s):  
Valeria Calcaterra ◽  
Corrado Regalbuto ◽  
Matteo Manuelli ◽  
Catherine Klersy ◽  
Gloria Pelizzo ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Weight Gain ◽  
Autoimmune Diseases ◽  
Medical History ◽  
Unknown Origin ◽  
Overweight And Obesity ◽  
Excessive Weight Gain ◽  
Familial Predisposition ◽  
Excessive Weight ◽  
Hla Dq2

AbstractObjectivesThe coexistence of celiac disease (CD) and obesity/overweight is not unusual. We investigate the prevalence and clinical presentation of CD, detected by screening, among children with excessive weight gain.MethodsWe enrolled 200 children referred for overweight/obesity to our outpatient clinic. Medical history during pregnancy and childhood and lifestyle variables were recorded. Patients were screened for CD with total immunoglobulin A (IgA), IgA anti-transglutaminase (tTG-IgA) and IgA anti-endomysial antibodies (EMA-IgA). In subjects with positive autoantibodies, esophagogastroduodenoscopy (EGDS) was performed and genetic testing for HLA DQ2 and/or DQ8 haplotypes was tested.ResultsCD positive antibodies (tTg-IgA and EMA-IgA) were detected in eight patients (4%); in all subjects CD diagnosis was confirmed by HLA-DQ2 and/or DQ8 compatibility and EGDS. No association between CD and medical history during pregnancy and childhood or lifestyle variables was noted; however, a dietary difference was identified with those testing positive for CD also reporting a lower weekly consumption of fruits and vegetables (p=0.04). Headache was reported more frequently in patients with than without CD (p=0.04). Familiar positivity for autoimmune diseases was revealed in CD patients (p=0.01).ConclusionCD should be considered in children with excessive weight gain. Familial predisposition to other autoimmune diseases may represent a risk factor for development of CD. Even though the relationship between headache and CD is not well defined, the patients with headache of unknown origin should be screened for CD.

scholarly journals Family sociodemographic characteristics as correlates of children’s breakfast habits and weight status in eight European countries. The ENERGY (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) project

2014 ◽  
Vol 18 (5) ◽  
pp. 774-783 ◽  
Author(s):  
Yannis Manios ◽  
George Moschonis ◽  
Odysseas Androutsos ◽  
Christina Filippou ◽  
Wendy Van Lippevelde ◽  
...  
Keyword(s):  
Weight Gain ◽  
Energy Balance ◽  
Weight Status ◽  
Educational Status ◽  
European Countries ◽  
Sociodemographic Characteristics ◽  
Excessive Weight Gain ◽  
Breakfast Consumption ◽  
Mediation Analyses ◽  
Excessive Weight

AbstractObjectiveThe purpose of the present study was to investigate the associations of family sociodemographic characteristics with children’s weight status and whether these potential associations are mediated by children’s breakfast habits.DesignA school-based survey among 10–12-year-old children was conducted in eight European countries. Children’s weight and height were measured and breakfast habits and family sociodemographic characteristics were self-reported by 5444 children and their parents. International Obesity Task Force cut-off points were used to categorize children as overweight/obese or normal weight. Mediation analyses were used to test the potential mediating effect of children’s breakfast consumption on the associations between family sociodemographic characteristics and children’s overweight/obesity.SettingSchools in eight European countries participating in the ENERGY (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) project.SubjectsChildren aged 10–12 years and their parents (n 5444).ResultsChildren’s reported daily breakfast consumption varied from 56 % in Slovenia to 92 % in Spain on weekdays and from 79 % in Greece to 93 % in Norway on weekends. Children of native parents, with both parents employed and with at least one parent having more than 14 years of education were more likely to consume breakfast daily and less likely to be overweight/obese. Finally, mediation analyses revealed that the association of parental nationality and parental educational status with children’s overweight/obesity was partially mediated by children’s daily breakfast consumption.ConclusionsThe study shows that the lower likelihood of being overweight/obese among 10–12-year-old children of native background and higher parental educational status was partially mediated by children’s daily breakfast consumption.

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