scholarly journals Development and Applications of Varieties of Bioactive Glass Compositions in Dental Surgery, Third Generation Tissue Engineering, Orthopaedic Surgery and as Drug Delivery System

10.5772/24942 ◽  
2011 ◽  
Author(s):  
Samit Kumar ◽  
Biswanath Kundu ◽  
Someswar Datt
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Bioactive Glass ◽  
Drug Delivery System ◽  
Delivery System ◽  
Orthopaedic Surgery ◽  
Third Generation ◽  
Dental Surgery ◽  
Glass Compositions

scholarly journals Bioactive Glass as a Nanoporous Drug Delivery System for Teicoplanin

2020 ◽  
Vol 10 (7) ◽  
pp. 2595 ◽  
Author(s):  
Chih-Ling Huang ◽  
Wei Fang ◽  
Bo-Rui Huang ◽  
Yan-Hsiung Wang ◽  
Guo-Chung Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inductively Coupled Plasma ◽  
High Performance ◽  
Ph Value ◽  
Sol Gel ◽  
Phase Identification ◽  
Bet Analysis

Bioactive glass (BG) was made by the sol–gel method and doped with boron (B) to increase its bioactivity. Microstructures of BG and B-doped BG were observed by scanning electron microscopy, and phase identification was performed using an X-ray diffraction diffractometer. The ion concentrations released after soaking in simulated body fluid (SBF) for 1, 4, and 7 days were measured by inductively coupled plasma mass spectrometry, and the pH value of the SBF was measured after soaking samples to determine the variation in the environment. Brunauer–Emmett–Teller (BET) analysis was performed to further verify the characteristics of mesoporous structures. High performance liquid chromatography was used to evaluate the drug delivery ability of teicoplanin. Results demonstrated that B-doped BG performed significantly better than BG in parameters assessed by the BET analysis. B-doped BG has nanopores and more rough structures, which is advantageous for drug delivery as there are more porous structures available for drug adsorption. Moreover, B-doped BG was shown to be effective for keeping pH values stable and releasing B ions during soaking in SBF. The cumulative release of teicoplanin from BG and B-doped BG reached 20.09% and 3.17% on the first day, respectively. The drug release gradually slowed, reaching 29.43% and 4.83% after 7 days, respectively. The results demonstrate that the proposed bioactive glass has potential as a drug delivery system.

Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with β-cyclodextrin

Biomaterials ◽  
2004 ◽  
Vol 25 (2) ◽  
pp. 327-333 ◽  
Author(s):  
Z.R. Domingues ◽  
M.E. Cortés ◽  
T.A. Gomes ◽  
H.F. Diniz ◽  
C.S. Freitas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Drug Delivery System ◽  
Delivery System

scholarly journals New skeletal drug delivery system containing antibiotics using self-setting bioactive glass cement.

1992 ◽  
Vol 40 (12) ◽  
pp. 3346-3348 ◽  
Author(s):  
Makoto OTSUKA ◽  
Yoshihisa MATSUDA ◽  
Tadashi KOKUBO ◽  
Satoru YOSHIHARA ◽  
Takashi NAKAMURA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Drug Delivery System ◽  
Delivery System

scholarly journals Levodopa-Loaded 3D-Printed Poly (lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson’s Disease

2021 ◽  
Vol 11 (22) ◽  
pp. 10727
Author(s):  
Ezgi Saylam ◽  
Yigit Akkaya ◽  
Elif Ilhan ◽  
Sumeyye Cesur ◽  
Ece Guler ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Parkinson's Disease ◽  
Drug Delivery System ◽  
Delivery System ◽  
Neural Tissue ◽  
Fickian Diffusion ◽  
Pore Sizes ◽  
3D Printed

Parkinson’s disease, the second most common neurodegenerative disease in the world, develops due to decreased dopamine levels in the basal ganglia. Levodopa, a dopamine precursor used in the treatment of Parkinson’s disease, can be used as a drug delivery system. This study presents an approach to the use of 3D-printed levodopa-loaded neural tissue scaffolds produced with polylactic acid (PLA) and chitosan (CS) for the treatment of Parkinson’s disease. Surface morphology and pore sizes were examined by scanning electron microscopy (SEM). Average pore sizes of 100–200 µm were found to be ideal for tissue engineering scaffolds, allowing cell penetration but not drastically altering the mechanical properties. It was observed that the swelling and weight loss behaviors of the scaffolds increased after the addition of CS to the PLA. Levodopa was released from the 3D-printed scaffolds in a controlled manner for 14 days, according to a Fickian diffusion mechanism. Mesenchymal stem cells (hAD-MSCs) derived from human adipose tissue were used in MTT analysis, fluorescence microscopy and SEM studies and confirmed adequate biocompatibility. Overall, the obtained results show that PLA/CS 3D-printed scaffolds have an alternative use for the levodopa delivery system for Parkinson’s disease in neural tissue engineering applications.

scholarly journals Fabrication of Injectable Chitosan-Chondroitin Sulfate Hydrogel Embedding Kartogenin-Loaded Microspheres as an Ultrasound-Triggered Drug Delivery System for Cartilage Tissue Engineering

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1487
Author(s):  
Fu-Zhen Yuan ◽  
Hu-Fei Wang ◽  
Jian Guan ◽  
Jiang-Nan Fu ◽  
Meng Yang ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Chondroitin Sulfate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
In Vitro Degradation

Ultrasound-responsive microspheres (MPs) derived from natural polysaccharides and injectable hydrogels have been widely investigated as a biocompatible, biodegradable, and controllable drug delivery system and cell scaffolds for tissue engineering. In this study, kartogenin (KGN) loaded poly (lactide-co-glycolic acid) (PLGA) MPs (MPs@KGN) were fabricated by premix membrane emulsification (PME) method which were sonicated by an ultrasound transducer. Furthermore, carboxymethyl chitosan-oxidized chondroitin sulfate (CMC-OCS) hydrogel were prepared via the Schiff’ base reaction-embedded MPs to produce a CMC-OCS/MPs scaffold. In the current work, morphology, mechanical property, porosity determination, swelling property, in vitro degradation, KGN release from scaffolds, cytotoxicity, and cell bioactivity were investigated. The results showed that MPs presented an obvious collapse after ultrasound treatment. The embedded PLGA MPs could enhance the compressive elastic modulus of soft CMC-OCS hydrogel. The cumulative release KGN from MPs exhibited a slow rate which would display an appropriate collapse after ultrasound, allowing KGN to maintain a continuous concentration for at least 28 days. Moreover, the composite CMC-OCS@MPs scaffolds exhibited faster gelation, lower swelling ratio, and lower in vitro degradation. CCK-8 and LIVE/DEAD staining showed these scaffolds did not influence rabbit bone marrow mesenchymal stem cells (rBMMSCs) proliferation. Then these scaffolds were cultured with rBMMSCs for 2 weeks, and the immunofluorescent staining of collagen II (COL-2) showed that CMC-OCS hydrogel embedded with MPs@KGN (CMC-OCS@MPs@KGN) with ultrasound had the ability to increase the COL-2 synthesis. Overall, due to the improved mechanical property and the ability of sustained KGN release, this injectable hydrogel with ultrasound-responsive property is a promising system for cartilage tissue engineering.

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