scholarly journals Metal Complexes as Antimicrobial Agents

10.5772/45651 ◽  
2012 ◽  
Author(s):  
Marcela Rizzotto
Keyword(s):  
Metal Complexes ◽  
Antimicrobial Agents

scholarly journals Metal Complexes as DNA Synthesis and/or Repair Inhibitors: Anticancer and Antimicrobial Agents

2021 ◽  
Vol 03 (04) ◽  
pp. e164-e182
Author(s):  
Mpho Phehello Ngoepe ◽  
Hadley S. Clayton
Keyword(s):  
Dna Synthesis ◽  
Metal Complexes ◽  
Density Functional ◽  
Antimicrobial Agents ◽  
Human Life ◽  
Protein Docking ◽  
Microbial Infection ◽  
Preclinical Development ◽  
In Silico Studies

AbstractMedicinal inorganic chemistry involving the utilization of metal-based compounds as therapeutics has become a field showing distinct promise. DNA and RNA are ideal drug targets for therapeutic intervention in the case of various diseases, such as cancer and microbial infection. Metals play a vital role in medicine, with at least 10 metals known to be essential for human life and a further 46 nonessential metals having been involved in drug therapies and diagnosis. These metal-based complexes interact with DNA in various ways, and are often delivered as prodrugs which undergo activation in vivo. Metal complexes cause DNA crosslinking, leading to the inhibition of DNA synthesis and repair. In this review, the various interactions of metal complexes with DNA nucleic acids, as well as the underlying mechanism of action, were highlighted. Furthermore, we also discussed various tools used to investigate the interaction between metal complexes and the DNA. The tools included in vitro techniques such as spectroscopy and electrophoresis, and in silico studies such as protein docking and density-functional theory that are highlighted for preclinical development.

scholarly journals Synthesis, Characterization and Antibacterial Study of Co (II) and Cu (II) Complexes of Sulfamethoxazole

2020 ◽  
pp. 38-43
Author(s):  
Usman Abubakar Adamu ◽  
Buhari Magaji ◽  
Adamu Baba Mohammad ◽  
Mukhtar Muhammad Sani ◽  
Nitte Adoram
Keyword(s):  
Electrical Conductivity ◽  
Elevated Temperature ◽  
Metal Complexes ◽  
Antimicrobial Agents ◽  
Polar Solvent ◽  
Free Ligand ◽  
Decomposition Temperature ◽  
Molar Ratio ◽  
Tetrahedral Geometry ◽  
E Coli

Complexes of Co and Cu with SMZ were successfully synthesized (1:2 molar ratio) in good yield and characterized by using UV-vis, FTIR, melting point/decomposition temperature, electrical conductivity and solubility in different solvents of varying polarity and proticity. All the prepared complexes were coloured. From the IR results, 529, 631, 528 and 779 cm-1 bands were observed in the spectra of the complexes which were absent in the free ligand spectrum thus, showing the presence of metal-ligand bond (coordination) in the complexes. The electronic spectral data of the complexes suggest an octahedral and tetrahedral geometry for all the complexes. The ligand and the Co (II) complex were found to be soluble polar protic solvents at both room and elevated temperature while, Cu (II) complex was found to be insoluble in polar protic solvent (ethanol) at room temperature but soluble at elevated temperature. The metal complexes are insoluble in non-polar solvent at both temperatures. More so, the ligand was found to be soluble in non-polar solvent at both temperatures. The electrical conductivity measurements indicated that the synthesized complexes are non-electrolytes. The synthesized metal complexes showed improved broad-spectrum antimicrobial activity against E. coli and S. aureus as compared to the ligand.  Thus, the complexes [Co(C10H11N3O3S)] and [Cu(C10H11N3O3S)] are good leads to be developed into antibiotics against the tested antimicrobial agents (E. coli and S. aureus).

scholarly journals Synthesis and Characterization of Bioactive Acylpyrazolone Sulfanilamides and Their Transition Metal Complexes: Single Crystal Structure of 4-Benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one Sulfanilamide

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Omoruyi G. Idemudia ◽  
Alexander P. Sadimenko ◽  
Anthony J. Afolayan ◽  
Eric C. Hosten
Keyword(s):  
Crystal Structure ◽  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Single Crystal ◽  
Transition Metal Complexes ◽  
Antimicrobial Agents ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Single Crystal Structure

Two Schiff base ligands Ampp-Sn1and Bmpp-Sn2, afforded by a condensation reaction between sulfanilamide and the respective acylpyrazolone carbonyl precursors, their Mn(II), Co(II), Ni(II), and Cu(II) complexes prepared by the reaction of ligands and corresponding metal salts in aqueous solutions, were synthesized and then characterized by both analytical and spectroscopic methods, in a view to developing new improved bioactive materials with novel properties. On the basis of elemental analysis, spectroscopic and TGA results, transition metal complexes, with octahedral geometry having two molecules of the bidentate keto-imine ligand each, have been proposed. The single crystal structure of Bmpp-Sn according to X-ray crystallography showed a keto-imine tautomer type of Schiff base, having three intramolecular bonds, one short N2⋯H2⋯O3 hydrogen bond of 1.90 Å and two long C13⋯H13⋯O2 and C32⋯H32⋯O3 hydrogen bonds of 2.48 Å. A moderate to low biological activities have been exhibited by synthesized compounds when compared with standard antimicrobial agents on screening the synthesized compounds againstStaphylococcus aureus,Bacillus pumilus,Proteus vulgaris, andAeromonas hydrophilafor antibacterial activity and against free radical 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) for antioxidant activity.

scholarly journals Synthesis, Spectral and Antimicrobial Studies of Some Co(II), Ni(II) and Cu(II) Complexes Containing 2-Thiophenecarboxaldehyde Moiety

2012 ◽  
Vol 9 (3) ◽  
pp. 1113-1121 ◽  
Author(s):  
A. P. Mishra ◽  
A. Tiwari ◽  
S. K. Gupta ◽  
Rajendra Jain
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Antimicrobial Agents ◽  
Analytical Data ◽  
Molar Conductance ◽  
E Coli ◽  
Antimicrobial Studies ◽  
Degradation Pattern ◽  
Ft Ir ◽  
Schiff Base Metal Complexes

Some new Schiff base metal complexes of Co(II), Ni(II) and Cu(II) derived from 3-chloro-4-fluoroaniline (HL1) and 4-fluoroaniline (HL2) with 2-thiophenecarboxaldehyde have been synthesized and characterized by elemental analysis, FT-IR, FAB-mass, molar conductance, electronic spectra, ESR and magnetic susceptibility. The complexes exhibit coordination number 4 or 6. The complexes are colored and stable in air. Analytical data revealed that all the complexes exhibited 1:2 (metal: ligand) ratio. FAB-mass data show degradation pattern of the complexes. The Schiff base and metal complexes show a good activity against the bacteria;B. subtilis,E. coliandS. aureusand fungiA. niger,A. flavusandC. albicans. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases.

scholarly journals Metal-Based Biologically Active Compounds: Synthesis, Spectral, and Antimicrobial Studies of Cobalt, Nickel, Copper, and Zinc Complexes of Triazole-Derived Schiff Bases

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Kiran Singh ◽  
Yogender Kumar ◽  
Parvesh Puri ◽  
Chetan Sharma ◽  
Kamal Rai Aneja
Keyword(s):  
Metal Complexes ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Condensation Reaction ◽  
Zinc Complexes ◽  
Biologically Active ◽  
Planar Geometry ◽  
Cobalt Nickel ◽  
Copper And Zinc ◽  
Nickel Copper

A series of cobalt, nickel, copper, and zinc complexes of bidentate Schiff bases derived from the condensation reaction of 4-amino-5-mercapto-3-methyl/ethyl-1,2,4-triazole with 2,4-dichlorobenzaldehyde were synthesized and tested as antimicrobial agents. The synthesized Schiff bases and their metal complexes were characterized with the aid of elemental analyses, magnetic moment measurements, spectroscopic and thermogravimetric techniques. The presence of coordinated water in metal complexes was supported by infrared and thermal gravimetric studies. A square planar geometry was suggested for Cu(II) and octahedral geometry proposed for Co(II), Ni(II), and Zn(II) complexes. The Schiff bases and their metal complexes have been screened for antibacterial (Pseudomonas aeruginosa, Bacillus subtilis) and antifungal activities (Aspergillus niger, A. flavus). The metal complexes exhibited significantly enhanced antibacterial and antifungal activity as compared to their simple Schiff bases.

scholarly journals Ultraviolet Radiation and Salinity-Induced Physiological Changes and Scytonemin Induction in Cyanobacteria Isolated from Diverse Habitats

2021 ◽  
Vol 12 (3) ◽  
pp. 3590-3606
Keyword(s):  
Antimicrobial Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Antimicrobial Agents ◽  
Free Ligand ◽  
The Novel ◽  
Bacterial Strains ◽  
Resistant Strains ◽  
Antimicrobial And Antifungal Activity

A novel series of transition metal (II) complexes (5a-h) were conveniently synthesized via reaction of important transition metals (Co, Cu, Zn, Ni) with (E)-N-(4-methylbenzylidene)-2-((Z)-(4-methylbenzylidene)amino)benzamide Schiff base (3) which was previously synthesized by reacting 2- aminobenzohydrazide (1) with 4-methylbenzaldehyde (2). The synthesized metal complexes' structure was elucidated by IR, NMR, mass, and elemental analysis. Additionally, we also evaluated the antioxidant, antimicrobial and antifungal activity of the synthesized metal complexes. The bioassay of the novel transition metal complexes envisioned that compounds5eand5c showed better antimicrobial activity than the free ligand, and compounds5g and 5a showed good activity against most bacterial strains. On the other hand, hydrated metal complexes 5b, 5d, 5f, and 5h showed moderate to good antimicrobial activity. In comparison with ascorbic acid, most of the metal complexes showed moderate to good antioxidant activity. The current bioassay was investigated and proved that the compounds 5e and 5c as antimicrobial agents act on highly resistant strains of microbes.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Methylquinolino[3,2-b][1,5]benzodiazepine and Methylquinolino[3,2-b][1,5]benzoxazepine and its Various Metal Complexes

2007 ◽  
Vol 4 (1) ◽  
pp. 32-38 ◽  
Author(s):  
B. Basavaraju ◽  
H. S. Bhojya Naik ◽  
M. C. Prabhakara
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Antimicrobial Agents ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activity ◽  
H Nmr ◽  
Uv Visible ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal ◽  
Metal Ligand

2-Chloro-6-methylquinoline-3-carbaldehyde was condensed witho-Phenylenediammine and 2-aminophenol in presence of potassium iodide. The resulting Methylquinolino[3,2-b][1,5]benzodiazepine (MQBD) and Methylquinolino[3,2-b][1,5]benzoxazepine(MQBO) were characterized by elemental analysis and spectral studies. The metal chelatesvizPd(II), Rh(III) and Ru(III) of ligands were prepared and characterized by metal-ligand (M:L) ratio, UV-Visible, IR,1H NMR spectroscopes and magnetic properties. The antibacterial and antifungal activity of MQBD, MQBO and its metal complexes were screened against various bacteria and fungi. The results show that all these samples are good antimicrobial agents.

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