scholarly journals Synthesis, Characterization and Antimicrobial Activity of Methylquinolino[3,2-b][1,5]benzodiazepine and Methylquinolino[3,2-b][1,5]benzoxazepine and its Various Metal Complexes

2007 ◽  
Vol 4 (1) ◽  
pp. 32-38 ◽  
Author(s):  
B. Basavaraju ◽  
H. S. Bhojya Naik ◽  
M. C. Prabhakara
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Antimicrobial Agents ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activity ◽  
H Nmr ◽  
Uv Visible ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal ◽  
Metal Ligand

2-Chloro-6-methylquinoline-3-carbaldehyde was condensed witho-Phenylenediammine and 2-aminophenol in presence of potassium iodide. The resulting Methylquinolino[3,2-b][1,5]benzodiazepine (MQBD) and Methylquinolino[3,2-b][1,5]benzoxazepine(MQBO) were characterized by elemental analysis and spectral studies. The metal chelatesvizPd(II), Rh(III) and Ru(III) of ligands were prepared and characterized by metal-ligand (M:L) ratio, UV-Visible, IR,1H NMR spectroscopes and magnetic properties. The antibacterial and antifungal activity of MQBD, MQBO and its metal complexes were screened against various bacteria and fungi. The results show that all these samples are good antimicrobial agents.

scholarly journals Synthesis and Antimicrobial Activity of Pyrimidine Salts with Chloranilic and Picric Acids

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
C. Mallikarjunaswamy ◽  
D. G. Bhadregowda ◽  
L. Mallesha
Keyword(s):  
Antimicrobial Activity ◽  
The Other ◽  
Spectral Studies ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Uv Visible ◽  
Antibacterial And Antifungal

Pyrimidine salts such as 2-methyl-5-nitro-phenyl-(4-pyridin-3-yl-pyrimidin-2-yl)-amine (1) and 4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-yl-amino)-phenyl-amine (2) with chloranilic and picric acids were synthesized, and theirin vitroantibacterial and antifungal activities were evaluated. The synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, and1H NMR spectral studies. Compound2aexhibited good inhibition towards antimicrobial activity compared to the other compounds.

scholarly journals Transition Metal Complexes of Methyl-quinolino[3,2-b][1,5]benzodiazepine and Methylquinolino [3,2-b][1,5]benzoxazepine: Synthesis, Characterisation and Antimicrobial Studies

2007 ◽  
Vol 4 (1) ◽  
pp. 39-45
Author(s):  
B. Basavaraju ◽  
H. S. Bhojya Naik ◽  
M. C. Prabhakara
Keyword(s):  
Antifungal Activity ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Molar Conductance ◽  
Antibacterial And Antifungal Activity ◽  
Magnetic Studies ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Uv Visible ◽  
Antibacterial And Antifungal

The synthesis and characterisation of title complexes of the ligand Methylquinolino[3,2-b][1,5]benzodiazepine (MQBD) and Methyl-quinolino[3,2-b][1,5]benzoxazepine (MQBO) are reported. The complexes have been characterized by elemental analysis, molar conductance, magnetic studies, IR,1H NMR and UV-visible studies. They have the stoichiometry [ML2Cl2] where M=Co(II)/Ni(II), L=MQBD/MQBO and [MLCl2] where M=Zn(II)/Cd(II), L=MQBD/MQBO. The antibacterial and antifungal activity of the metal complexes has been investigated.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of N1-[(1E)-1-(2-Hydroxyphenyl) ethylidene]-2-oxo-2H-chromene-3-carbohydrazide and its Metal Complexes

2009 ◽  
Vol 6 (3) ◽  
pp. 615-624 ◽  
Author(s):  
K. Siddappa ◽  
K. Mallikarjun ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML, MʹL and M″L [where M=Cu(II), Co(II), Ni(II) and Mn(II), Mʹ=Fe(III) and M″=Zn(II), Cd(II) and Hg(II) and L=N1-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-oxo-2H-chromene- 3-carbohydrazide (HL)] Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly monodentate bridge for metal ions and form mononuclear complexes. The complexes Ni(II), Co(II), Cu(II) Mn(II) and Fe(III) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal complexes were screened for their antimicrobial activity.

scholarly journals Antimicrobial Applications of Transition Metal Complexes of Benzothiazole Based Terpolymer: Synthesis, Characterization, and Effect on Bacterial and Fungal Strains

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Mohamed A. Riswan Ahamed ◽  
Raja S. Azarudeen ◽  
N. Mujafar Kani
Keyword(s):  
Metal Complexes ◽  
Elemental Analysis ◽  
Biological Activities ◽  
Gel Permeation Chromatography ◽  
Spectral Studies ◽  
X Ray Diffraction ◽  
Spectral Techniques ◽  
H Nmr ◽  
Uv Visible ◽  
C Nmr

Terpolymer of 2-amino-6-nitro-benzothiazole-ethylenediamine-formaldehyde (BEF) has been synthesized and characterized by elemental analysis and various spectral techniques like FTIR, UV-Visible, and1H and13C-NMR. The terpolymer metal complexes were prepared with Cu2+, Ni2+, and Zn2+metal ions using BEF terpolymer as a ligand. The complexes have been characterized by elemental analysis and IR, UV-Visible, ESR,1H-NMR, and13C-NMR spectral studies. Gel permeation chromatography was used to determine the molecular weight of the ligand. The surface features and crystalline behavior of the ligand and its complexes were analyzed by scanning electron microscope and X-ray diffraction methods. Thermogravimetric analysis was used to analyze the thermal stability of the ligand and its metal complexes. Kinetic parameters such as activation energy(Ea)and order of reaction (n) and thermodynamic parameters, namely,ΔS,ΔF,S*, andZ, were calculated using Freeman-Carroll (FC), Sharp-Wentworth (SW), and Phadnis-Deshpande (PD) methods. Thermal degradation model of the terpolymer and its metal complexes was also proposed using PD method. Biological activities of the ligand and its complexes were tested againstShigella sonnei,Escherichia coli,Klebsiellaspecies,Staphylococcus aureus,Bacillus subtilis, andSalmonella typhimuriumbacteria andAspergillus flavus,Aspergillus niger,Penicilliumspecies,Candida albicans,Cryptococcus neoformans,Mucor speciesfungi.

scholarly journals Synthesis and Antimicrobial Activity of Some Chalcone Derivatives

2008 ◽  
Vol 5 (3) ◽  
pp. 461-466 ◽  
Author(s):  
Y. Rajendra Prasad ◽  
A. Lakshmana Rao ◽  
R. Rambabu
Keyword(s):  
Aqueous Solution ◽  
Antimicrobial Activity ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Antimicrobial Agents ◽  
Aromatic Aldehydes ◽  
Plate Method ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by means of their IR,1H-NMR spectral data and elemental analysis. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.

scholarly journals SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRAZOLO[3,4-b]PYRIDINES AND THEIR SPIRO-HETEROCYCLIC DERIVATIVES

2014 ◽  
Vol 10 (7) ◽  
pp. 2901-2915 ◽  
Author(s):  
Shawkat A. Abdelmohsen ◽  
Talaat I El Emary
Keyword(s):  
Antimicrobial Activity ◽  
Aromatic Aldehydes ◽  
Antibacterial And Antifungal Activity ◽  
Pyrimidine Derivatives ◽  
Spiro Derivatives ◽  
Heterocyclic Derivatives ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal ◽  
New Compounds ◽  
Hydrazone Derivative

The present work describes the synthesis of a novel series of heterocyclic moieties derived from 5-acetylpyrazolo[3,4-b]pyridine (1). The formation of chalcones (2a-d) was utilized to synthesize pyrazoline, isoxazoline and pyrimidine derivatives (3-10). Thiosemicarbazone and semicarbazone (11, 17) were utilized to synthesize other new triazolethiones, thiadiazole and selenadiazole derivatives (11-19). Some new spiro derivatives (22-25) were synthesized by the reaction of chalcone (21) of 1 and isatine with hydrazines, hydroxyl amines and thiourea. Also, The reaction of 1 with cyanoacetyl hydrazine gave the hydrazide-hydrazone derivative 26, which was allowed to react with aromatic aldehydes and α-cyanocinnamonitrile to afford coumarine and substituted pyridine derivatives (28, 29). The structures of all the new compounds have been established on the basis of their analytical and spectral data. Twenty two of the synthesized compounds were also evaluated for their antibacterial and antifungal activity against various strains of bacteria and fungi and most are found to possess promising antimicrobial activity when compared with Chloramphenicol and Clotrimazole

scholarly journals Synthesis, Characterization and Biological Activity of Ni(II), Cu(II) and Fe(III) Complexes Derived from N2,N6-bis(5-Mercapto-1,3,4-thiadiazol-2-yl)pyridine-2,6-dicarboxamide

2020 ◽  
Vol 32 (7) ◽  
pp. 1691-1696
Author(s):  
Anuroop Kumar ◽  
Netra Pal Singh ◽  
Uma Agrawal ◽  
Kaushal Kumar
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Metal Ion ◽  
Inhibitory Concentration ◽  
Inhibition Zone ◽  
Molar Conductance ◽  
Minimal Bactericidal Concentration ◽  
Spectroscopic Techniques ◽  
Uv Visible ◽  
Bacteria And Fungi

Novel metal complexes of the type [M(L)X] (where M= Cu(II), Ni(II) and Fe(III), L = N2,N6-bis(5-mercapto-1,3,4-thiadiazol-2-yl)pyridine-2,6-dicarboxamide, X= Cl−, CH3COO−) were synthesized by the reaction of pyridine-2,6-dicarboxylic acid and 2-amino-5-mercepto-1,3,4-thiadiazole. The synthesized ligand was reacted in THF with metal salts (Cu, Ni and Fe) to form complexes. Deprotonated ligand shows tridentate nature and coordinate to metal ion to form pincer cavity. In all, complexes metals were surrounded by three nitrogen atom and other site coordinated by other groups (chloride, acetate). All the synthesized complexes were characterized by spectroscopic techniques like UV-visible, 13C NMR and 1HNMR, IR spectroscopy, DSC, elemental analysis and molar conductance measurements. The ligand and its metal complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity and antifungal activity when tested against bacteria and fungi

scholarly journals Synthesis and Antimicrobial Screening of Some Novel 2, 5-Disubstituted 1, 3, 4-oxadiazole Derivatives

2011 ◽  
Vol 8 (s1) ◽  
pp. S149-S154 ◽  
Author(s):  
P. Panneerselvam ◽  
G. Geete Ganesh
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
E Coli ◽  
H Nmr ◽  
Oxadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
New Compounds

The syntheses of series of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives are described. A total of twelve new compounds were synthesized and characterized by IR,1H-NMR and Mass spectral data. All newly synthesized compounds were screened for their antimicrobial activityi.e. antibacterial activity againstS. aureusandE. coliand antifungal activity against fungusA. nigar. CompoundsG5andG7exhibited significant both antibacterial and antifungal activity whileG2,G10andG3,G9showed antibacterial and antifungal activity respectively. These compounds were 2, 5-disubstituted 1, 3, 4-oxadiazole moiety at position two and five showed reasonable antibacterial and antifungal activity.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Ni(II), Zn(II), and Cd(II) Complexes of 3/4-Bromo-Benzoic Acid (Phenyl-Pyridine-2-yl-Methylene)-Hydrazide Ligand

2020 ◽  
Vol 9 (4) ◽  
pp. 1529-1537
Keyword(s):  
Antimicrobial Activity ◽  
Benzoic Acid ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Metal Ion ◽  
Trichophyton Rubrum ◽  
Salmonella Typhi ◽  
Spectral Studies ◽  
Mass Analysis ◽  
Uv Visible

New transition metal complexes [Ni(L)2], [Zn(L)Cl], [Zn(L)2] and [Cd(L)2] were synthesized from 3-bromo-benzoic acid (phenyl-pyridin-2-yl-methylene)-hydrazide (3Bbpph) and 4-bromo-benzoic acid (phenyl-pyridin-2-yl-methylene)-hydrazide (4Bbpph) ligands and were characterized by different physicochemical and spectral studies - IR, elemental, UV Visible, 1H NMR spectra and mass analysis. The data revealed the presence of tetra-coordinate [Zn (L)Cl], whereas [Ni(L)2], [Zn(L)2], and [Cd(L)2] complexes consist of metal ion coordinated with two molecules of ligand to form octahedral geometry. The ligands act as monobasic, tridentate, and coordinated through enolate-O, azomethine-N, and pyridyl-N atoms. The antimicrobial activity of the ligands and metal complexes was investigated against Staphylococcus Aureus, Streptococcus Pyogenes, Escherichia coli, Salmonella typhi, Candida Albicans and Trichophyton Rubrum which revealed that the metal complexes exhibit greater activity than the parent ligands.

scholarly journals Synthesis, Spectral Studies, Antibacterial and Antifungal Activity of 2"-Methoxy-4"-[2 -(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridin-3-yl]-6"-Aryl Nicotinonitrile

2015 ◽  
Vol 49 ◽  
pp. 155-160
Author(s):  
V.V. Bhuva ◽  
V.N. Bhadani ◽  
H.D. Purohit ◽  
Dipak M. Purohit
Keyword(s):  
Biological Activities ◽  
Industrial Applications ◽  
Spectral Studies ◽  
Moderate Activity ◽  
Industrial Chemistry ◽  
Mass Spectral ◽  
H Nmr ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal ◽  
Layer Chromatography

Pyridine nucleus plays an important role in medicine, agriculture and industrial chemistry. With a view of biological activities and variety of industrial applications, some new 2" – methoxy - 4" - [2 - ( 4' -chlorophenyl)-6-methyl imidazo [1, 2-a] pyridin-3-yl]-6"-aryl nicotinonitrile( 4a-4l ) has been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50µg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.

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