scholarly journals Environmental Factors and Type 1 Diabetes Mellitus in Pediatric Age Group

10.5772/53267 ◽  
2013 ◽  
Author(s):  
Giuseppe dAnnunzio ◽  
Andrea Accogli ◽  
Ramona Tallone ◽  
Sara Bolloli ◽  
Renata Lorini
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Environmental Factors ◽  
Type 1 Diabetes Mellitus ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group

scholarly journals Environmental Factors and the Risk of Type 1 Diabetes Mellitus-A Case-Control Study

2017 ◽  
Vol 08 (02) ◽  
Author(s):  
Basma Abdelmoez Ali ◽  
Mostafa Ahmed Elfoly ◽  
Eman Ramadan Ghazawy ◽  
Rania Rashad Bersom
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Environmental Factors ◽  
Type 1 Diabetes Mellitus ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Phenotypic and environmental factors associated with elevated autoantibodies at clinical onset of paediatric type 1 diabetes mellitus

2012 ◽  
Vol 2 ◽  
pp. 125-131 ◽  
Author(s):  
Anne-Louise Ponsonby ◽  
Angela Pezic ◽  
Fergus J. Cameron ◽  
Christine Rodda ◽  
Justine A. Ellis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Environmental Factors ◽  
Type 1 Diabetes Mellitus ◽  
Factors Associated ◽  
Clinical Onset

scholarly journals Clinical Profile of Type 1 Diabetes Mellitus in Saudi Children: a Hospital Based Study

2016 ◽  
Vol 22 (4) ◽  
Author(s):  
Muhammad Rafique ◽  
Fouzia Ishaq ◽  
Muhammad Khalid Masood ◽  
Youssef Ali Mohamad Al-Qahtani ◽  
Walaa Ibrahim Ahmed Assiri ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Weight Loss ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Middle Age ◽  
Age Group ◽  
Newly Diagnosed ◽  
Duration Of Symptoms ◽  
Presenting Symptoms

<p><strong>Abstract</strong></p><p><strong>Objective:</strong>  To determine the clinical characteristics of newly diagnosed type 1 diabetes mellitus (T1DM) in children under15 years of age. Cross sectional study conducted at Aseer Central Hospital Abha, South-western Saudi Arabia from June 2011 – May 2015.</p><p><strong>Patients and Methods:</strong><strong>  </strong>Study included 141 Saudi children, &lt; 15 years old with newly diagnosed T1DM. The demographic and laboratory data were collected from file records. The patients were divided into younger (&lt; 5 yr), middle (5 – 10 yr) and older (&gt;10 – 15 yr) age groups. Data were analyzed by using SPSS version 16.</p><p><strong>Results:</strong><strong>  </strong>Age of 141 children at onset of T1DM (mean ± SD) was 6.5 ± 3.2 years and majority 62 (44%) belonged to middle age group. Older 43 (30.5%) age group had female predominance (2:1) (p &lt; 0.0001). Diabetic ketoacidosis (DKA) (39%), obesity (11%) and male predominance (2.6:1) were found in younger 36 (25.5%) age group (p &lt; 0.0001). Family history (F/Hx) of T1DM 29 (20.6%) and HbA1c (10.36 ± 1.8%) successively increased with advancing age of patients. Main presenting symptoms like polyuria (96%), polydipsia (85%), weight loss (62%), nocturia (47%), polyphagia (28%) and DKA (22%),were significantly more frequent in children with F/Hx of T1DM (p &lt; 0.0001). Duration of symptoms at first presentation was 17.3 ± 10.7 days and daily insulin requirement was found 0.82 ± 0.2 units/ Kg.</p><p><strong>Conclusion:</strong><strong>  </strong>Polyuria, polydipsia, weight loss, noctu-ria and polyphagia were the main presenting symptoms and more frequent in middle age group children especially having F/Hx of T1DM. Under five years, obese and male children were found at higher risk for DKA development. Girls usually present late in adolescent age.</p>

scholarly journals The fifty two week study of the effectiveness and safety of Apidra insulin therapy in combination with Lantus insulin in the children and adolescents with type 1 diabetes mellitus and poor glycemic control

2014 ◽  
Vol 60 (6) ◽  
pp. 21-28
Author(s):  
Valentina A Peterkova ◽  
Tamara L Kuraeva ◽  
Elena A Andrianova ◽  
Elena V Titovich ◽  
Galina N Svetlova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Type 1 Diabetes Mellitus ◽  
Glucose Level ◽  
Hba1c Level ◽  
Age Group ◽  
Insulin Glargin

The present multi-center non-randomized open prospective phase IV study was carried out based at 8 clinical centers of the Russian Federation. It included 89 patients at the age from 6 to 17 years suffering from type 1 diabetes mellitus during a period over 1 year. The children treated with Lantus (insulin glargin) in combination with any short-acting insulin in accordance with the basal-bolus regime and having the HbA1c level from=>8% to =<10% were transferred to Apidra (insulin glulisine) therapy in combination with Lantus insulin. The number of patients in the first age group (6-12 years) having the HbA1c level <8% within 12 months after the onset of therapy was 51.1%. However, only 31.1% of them, did not experience episodes of symptomatic hypoglycemia during this period with the blood glucose level =< 3.1 mmol/l. In the age group 2 (13-17 years), 31.1% of the patients reached the target HbA1c level <7.5% during the 12 month treatment period, but only 13.3% had no episodes of symptomatic hypoglycemia of =<3.1 mmol/l during this period. The HbA1c level in groups 1 and 2 decreased from 8.75±0.6 to 8.05 ±1.06% (p=0.046658) and from 8.77±0.58 to 7.96±1.12% (p=0.017533) respectively. The requirements for insulin in either group did not significantly change throughout the study period. A total of 1866 hypoglycemic episodes were recorded (i.e. 20.73 episodes per patient) including 90.8% of daytime and 9.2% of nocturnal hypoglycemia; symptomatic hypoglycemia accounted for 98.8% of all the cases and asymptomatic one for 1.2%. Fifty three (0.35%) cases were interpreted as severe hypoglycemia (blood glucose level ≤2 mmol/l), five (0.27%) patients had to be hospitalized . Hypoglycemic episodes were not documented in 13 children.

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