scholarly journals The Role of Human IAPP in Stress and Inflammatory Processes in Type 2 Diabetes

10.5772/63010 ◽  
2016 ◽  
Author(s):  
Joel Montane ◽  
Anna Novials
Keyword(s):  
Type 2 Diabetes ◽  
Inflammatory Processes

scholarly journals Experimental and Emerging Free Fatty Acid Receptor Agonists for the Treatment of Type 2 Diabetes

Medicina ◽  
2022 ◽  
Vol 58 (1) ◽  
pp. 109
Author(s):  
Angelo Maria Patti ◽  
Rosaria Vincenza Giglio ◽  
Nikolaos Papanas ◽  
Dragos Serban ◽  
Anca Pantea Stoian ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Body Mass ◽  
Plasma Lipids ◽  
Metabolic Effects ◽  
Receptor Agonists ◽  
Electronic Database Search ◽  
Inflammatory Processes

The current management of Type 2 Diabetes Mellitus (T2DM) includes incretin-based treatments able to enhance insulin secretion and peripheral insulin sensitivity as well as improve body mass, inflammation, plasma lipids, blood pressure, and cardiovascular outcomes. Dietary Free Fatty Acids (FFA) regulate metabolic and anti-inflammatory processes through their action on incretins. Selective synthetic ligands for FFA1-4 receptors have been developed as potential treatments for T2DM. To comprehensively review the available evidence for the potential role of FFA receptor agonists in the treatment of T2DM, we performed an electronic database search assessing the association between FFAs, T2DM, inflammation, and incretins. Evidence indicates that FFA1-4 agonism increases insulin sensitivity, induces body mass loss, reduces inflammation, and has beneficial metabolic effects. There is a strong inter-relationship between FFAs and incretins. FFA receptor agonism represents a potential target for the treatment of T2DM and may provide an avenue for the management of cardiometabolic risk in susceptible individuals. Further research promises to shed more light on this emerging topic.

High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with diabetic nephropathy and the role of netrin-1 levels

2017 ◽  
Author(s):  
Ahmet Kor ◽  
Suleyman Baldane ◽  
Suleyman Hilmi Ipekci ◽  
Kamile Marakoglu ◽  
Ali Altinok ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Lower Extremity ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
High Prevalence ◽  
Artery Disease ◽  
Diabetes Patients

The role of oncostatin m in the development of type 2 diabetes associated with obesity

2018 ◽  
Author(s):  
Siri Taxeras ◽  
Irene Piquer-Garcia ◽  
Silvia Pellitero ◽  
Rocio Puig ◽  
Eva Martinez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Oncostatin M

1709-P: Assessing the Role of 211 “Established” Type 2 Diabetes Variants in American Indians

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1709-P
Author(s):  
ROBERT L. HANSON ◽  
LAUREN E. WEDEKIND ◽  
WEN-CHI HSUEH ◽  
SAYUKO KOBES ◽  
LESLIE J. BAIER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
American Indians

1758-P: Type 2 Diabetes–Associated Mood Disorders: Role of Insulin Resistance in Serotonergic Neurons

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1758-P
Author(s):  
HUGO MARTIN ◽  
SÉBASTIEN BULLICH ◽  
FABIEN DUCROCQ ◽  
MARION GRALAND ◽  
CLARA OLIVRY ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mood Disorders ◽  
Serotonergic Neurons ◽  
P Type
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