scholarly journals Nuclear Medicine and Drug Delivery

10.5772/65708 ◽  
2017 ◽  
Author(s):  
Ana Rita Fernandes ◽  
Ana Oliveira ◽  
Jorge Pereira ◽  
Pedro Silva Coelho
Keyword(s):  
Drug Delivery ◽  
Nuclear Medicine

Study of the Internal Exposure Monitoring and the New Monitoring Methods of Thyroid I-131 for Radiological Staff in Nuclear Medicine

2020 ◽  
Author(s):  
Gang Liu ◽  
Ye Li
Keyword(s):  
Drug Delivery ◽  
Nuclear Medicine ◽  
Basic Research ◽  
Medical Personnel ◽  
Gansu Province ◽  
Internal Exposure ◽  
Monitoring Methods ◽  
Simple Method ◽  
Exposure Monitoring ◽  
Activity Measurements

Abstract Background：In general, medical staff dealing with nuclear medicine should be entirely safe in their professional environment. Nevertheless, their exposure to radioactive iodine seems to be partially uncontrolled while they perform their duties, namely while administering iodine in the form of tablets or solutions or while taking care of the patients already treated with the isotope. Purpose: To verify such a hypothesis, develop a simple method for internal exposure monitoring，131I activity measurements in the thyroids of the personnel employed at the three hospitals of Gansu province grade a hospital nuclear medicine. Mastered the internal exposure of nuclear medical personnel.Methods: Choosing 20 employees of the department of three hospitals of gansu province grade a hospital nuclear medicine, which corresponds to circa 100% of all of the all the staff of the nuclear medicine department who carry out iodine therapy. Automatic packaging and drug delivery staffs were 6, manual packaging and drug delivery staffs were 14. According to the rules of the judgment principles proposed in IAEA safety guidelines, An InSpector 1000 portable spectrometer and its supporting software served as the basic research instrument. In four out of twenty examined staff members. The sitting position was adopted with NaI portable spectrometer. The measurement time was 120s. Result: Among the manual packaging and drug delivery staffs was 4 (20.0%) detected 131I in the thyroid, with activity range of 27.6-1030.3Bq. Automatic packaging and drug delivery staffs were not detected. Conclusions: The highest activities in thyroids were detected for the manual packaging and drug delivery staffs, Automatic packaging and drug delivery staffs were not detected. The dose of some workers is high, so the prevention and control of pollution in nuclear medicine discipline needs to be strengthened urgently.

scholarly journals Biomedical Applications of Targeted Drug Delivery, Nanotheranostic and Nuclear Medicine

2021 ◽  
Author(s):  
Idris Sadiq ◽  
Fatima Sadiq Abubakar ◽  
Hassan Aliyu Hassan
Keyword(s):  
Drug Delivery ◽  
Nuclear Medicine ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Inorganic Nanoparticles ◽  
Radioactive Isotopes ◽  
Target Tissue ◽  
Systemic Distribution ◽  
Novel Method ◽  
Targeted Drug

Background: Convectional methods for drug delivery often faces setbacks due to systemic distribution, short half-life and degradation of therapeutics and therefore reduce concentrations of drug available to target tissue. Nanotheranostic provide a novel method for treating and diagnosing diseases Methodology: collection and review of relevant literatureResult: while nanotheranostic offer advantage of personalized medicine and often combines diagnosis and therapy using single molecular approach, nuclear medicine relies on radioactive isotopes to diagnosed and destroys cancer cells. In both cases, nanocarriers such as lipid-based, polymer-based, drug-conjugate, inorganic nanoparticles are used to deliver drugs/probes/isotopes to target site, generating images and thereafter chemotherapy/radiotherapy begins.Conclusion: Nanotheranostic plays important role in diseases diagnostic, therapy, imaging, monitoring of disease progression / response through the use of nanocarriers. This is made possible through nanoparticles/nanocarriers that delivers drug to the target tissues/cells.

scholarly journals Drug Delivery Systems and Theranostic use in Nuclear Medicine

2015 ◽  
Vol 1 (2) ◽  
pp. 109-119 ◽  
Author(s):  
Gülin Uçmak Vural ◽  
A. Yekta Özer
Keyword(s):  
Drug Delivery ◽  
Nuclear Medicine ◽  
Drug Delivery Systems ◽  
Delivery Systems

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Nanotheranostic agents for neurodegenerative diseases

2020 ◽  
Vol 4 (6) ◽  
pp. 645-675
Author(s):  
Parasuraman Padmanabhan ◽  
Mathangi Palanivel ◽  
Ajay Kumar ◽  
Domokos Máthé ◽  
George K. Radda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Cell Types ◽  
Specific Cell ◽  
Ageing Population ◽  
Target Tissue ◽  
Therapeutic Approaches ◽  
Surface Receptors ◽  
Theranostic Agents ◽  
Preclinical Animal Models

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to countries with progressively ageing populations. Parallel with the search for biomarkers for early detection and prediction, the pursuit for therapeutic approaches has become growingly intensive in recent years. Various prospective therapeutic approaches have been explored with an emphasis on early prevention and protection, including, but not limited to, gene therapy, stem cell therapy, immunotherapy and radiotherapy. Many pharmacological interventions have proved to be promising novel avenues, but successful applications are often hampered by the poor delivery of the therapeutics across the blood-brain-barrier (BBB). To overcome this challenge, nanoparticle (NP)-mediated drug delivery has been considered as a promising option, as NP-based drug delivery systems can be functionalized to target specific cell surface receptors and to achieve controlled and long-term release of therapeutics to the target tissue. The usefulness of NPs for loading and delivering of drugs has been extensively studied in the context of NDDs, and their biological efficacy has been demonstrated in numerous preclinical animal models. Efforts have also been made towards the development of NPs which can be used for targeting the BBB and various cell types in the brain. The main focus of this review is to briefly discuss the advantages of functionalized NPs as promising theranostic agents for the diagnosis and therapy of NDDs. We also summarize the results of diverse studies that specifically investigated the usage of different NPs for the treatment of NDDs, with a specific emphasis on AD and PD, and the associated pathophysiological changes. Finally, we offer perspectives on the existing challenges of using NPs as theranostic agents and possible futuristic approaches to improve them.

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