scholarly journals Atrial Fibrillation during Septic Shock

2021 ◽  
Author(s):  
Manuel Vélez-Gimón
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Septic Shock ◽  
Cardiovascular Risk ◽  
Mortality Rate ◽  
Cardiovascular Risk Factors ◽  
Severity Of Illness ◽  
Common Occurrence ◽  
New Onset ◽  
Negative Outcome

Atrial Fibrillation (AF) is an early and common occurrence during septic shock, accounting for 25–30% of admissions. Conventional cardiovascular risk factors do not generally increase its incidence, especially in cases of new-onset AF. Inflammation during the sepsis process has been postulated as a possible trigger. Detrimental effects of AF result in prognosis worsening, even when the probability for a negative outcome has been adjusted for severity of illness. New-onset AF (NOAF) has been associated with greater mortality rate than preexisting chronic AF. Early cardioversion has not uniformly improved hospital outcomes. In this review, the incidence, prognosis and management of AF in septic shock patients are summarized.

scholarly journals Immunothrombosis and new-onset atrial fibrillation in the general population: the Rotterdam Study

2021 ◽  
Author(s):  
Martijn J. Tilly ◽  
Sven Geurts ◽  
Samantha J. Donkel ◽  
M. Arfan Ikram ◽  
Natasja M. S. de Groot ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Cardiovascular Risk ◽  
General Population ◽  
Cardiovascular Risk Factors ◽  
Von Willebrand Factor ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
New Onset

Abstract Background Atrial fibrillation (AF) is the most common age-related cardiac arrhythmia. The etiology underlying AF is still largely unknown. At the intersection of the innate immune system and hemostasis, immunothrombosis may be a possible cause of atrial remodeling, and therefore be an underlying cause of AF. Methods From 1990 to 2014, we followed participants aged 55 and over, free from AF at inclusion. Immunothrombosis factors fibrinogen, von Willebrand factor, ADAMTS13, and neutrophil extracellular traps (NETs) levels were measured at baseline. Participants were followed until either onset of AF, loss-to-follow-up, or reaching the end-date of 01-01-2014. Cox proportional hazard modelling was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for cardiovascular risk factors. Results We followed 6174 participants (mean age 69.1 years, 57% women) for a median follow-up time of 12.8 years. 364 men (13.7%, incidence rate 13.0/1000 person-years) and 365 women (10.4%, incidence rate 8.9/1000 person-years) developed AF. We found no significant association between markers of immunothrombosis and new-onset AF after adjusting for cardiovascular risk factors [HR 1.00 (95% CI 0.93–1.08) for fibrinogen, 1.04 (0.97–1.12) for von Willebrand factor, 1.00 (1.00–1.01) for ADAMTS13, and 1.01 (0.94–1.09) for NETs]. In addition, we found no differences in associations between men and women. Conclusion We found no associations between markers of immunothrombosis and new-onset AF in the general population. Inflammation and immunothrombosis may be associated with AF through other cardiovascular risk factors or predisposing conditions of AF. Our findings challenge the added value of biomarkers in AF risk prediction. Graphic abstract

scholarly journals Immunothrombosis and new-onset atrial fibrillation in the general population

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
M.J Tilly ◽  
S Geurts ◽  
S.J Donkel ◽  
M.A Ikram ◽  
N.M.S De Groot ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Cardiovascular Risk ◽  
General Population ◽  
Cardiovascular Risk Factors ◽  
Von Willebrand Factor ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
New Onset

Abstract Background Atrial fibrillation (AF) is the most common, age-related cardiac arrhythmia. However, the etiology underlying atrial fibrillation is still largely unknown. At the intersection of the innate immune system and hemostasis, immunothrombosis may be a possible cause of atrial remodeling, and therefore be an underlying cause of AF. Purpose We aim to evaluate the association between markers of immunothrombosis and new-onset AF in the general population Methods From 1990 to 2014, we followed 6,174 participants aged 55 and over, free from AF at inclusion. Immunothrombosis factors fibrinogen, von Willebrand factor, ADAMTS13, and neutrophil extracellular traps (NETs) levels were measured at baseline. Participants were followed until either onset of AF, death, loss-to-follow-up, or reaching the end-date of 01–01–2014. Cox proportional hazard modelling was used to calculated hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for cardiovascular risk factors. Results We followed 6,174 participants (mean age 69.1 years, 57% women) for a median follow-up time of 12.8 years. 364 men (13.7%, incidence rate 13.0/100 person-years) and 365 women (10.4%, incidence rate 8.9/1000 person-years) developed AF. We found no significant associations between markers of immunothrombosis and new-onset AF after adjusting for cardiovascular risk factors [HR 1.00 (95% CI 0.93–1.08) for fibrinogen, 1.04 (0.97–1.12) for von Willebrand factor, 1.00 (1.00–1.01) for ADAMTS13, and 1.01 (0.94–1.09) for NETs]. Additionally, we found no significant differences in associations between men and women. Conclusion We found no association between markers of immunothrombosis and new-onset AF in the general population. Our findings imply that inflammation and immunothrombosis may be associated with AF by other cardiovascular risk factors or predisposing conditions of AF. FUNDunding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Netherlands Organization for the Health Research and Development (ZonMw) Erasmus MC Mrace grant

scholarly journals Assessment of Conventional Cardiovascular Risk Factors and Multiple Biomarkers for the Prediction of Incident Heart Failure and Atrial Fibrillation

2010 ◽  
Vol 56 (21) ◽  
pp. 1712-1719 ◽  
Author(s):  
J. Gustav Smith ◽  
Christopher Newton-Cheh ◽  
Peter Almgren ◽  
Joachim Struck ◽  
Nils G. Morgenthaler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Multiple Biomarkers ◽  
Incident Heart Failure

Abstract W P121: Stroke Severity in Men and Women: What Proportion of the Disparity Can Be Explained by Differences in Cardiovascular Risk Factors?

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Karen C Albright ◽  
Amelia K Boehme ◽  
Bisakha Sen ◽  
Monica Aswani ◽  
Michael T Mullen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Sex Differences ◽  
Cardiovascular Risk ◽  
Black Women ◽  
Cardiovascular Risk Factors ◽  
Stroke Severity ◽  
Stroke Subtype ◽  
Oaxaca Decomposition ◽  
Nihss Score

Background: Prior studies have shown that women present with more severe stroke. It has been suggested that sex differences in stroke severity are related to age, stroke subtype, or cardiovascular risk factors. We aimed to determine the proportion of sex disparity in stroke severity that can be explained by differences in these variables using Oaxaca decomposition, an econometric technique which quantifies the differences between groups. Methods: White and Black ischemic stroke patients who presented to two academic medical centers in the US (2004-2011) were identified using prospective stroke registries. In-hospital strokes were excluded. Patient demographics and medical history were collected. Stroke severity was measured by NIHSS. Linear regression was used to determine if female sex was associated with NIHSS score. This model was then adjusted for potential confounders including: age, race, stroke subtype, and cardiovascular risk factors. Oaxaca decomposition was then used to determine the proportion of the observed sex differences in stroke severity that can be explained by these variables. Results: 4925 patients met inclusion criteria. Nearly half (n=2346) were women and 39% (n=1942) were Black. Women presented with more severe strokes (median NIHSS 8 vs. 6). In addition, women were older on average (68 vs. 63 years) with more frequent atrial fibrillation (18% vs. 13%), diabetes (34% vs. 30%), and hypertension (78% vs. 72%). Oaxaca decomposition revealed that age, race, atrial fibrillation, large vessel etiology, diabetes, hypertension account for only 63% of the sex differences seen in NIHSS score on presentation. Conclusion: In our biracial sample, women presented with more severe strokes than men. This difference remained significant even after adjustment for age, stroke subtype, and cardiovascular risk factors. Further, over 1/3 of the observed gender difference in stroke severity was unexplained.. Additional study is warranted to investigate the etiology of the gender differences in stroke severity.

scholarly journals Clinical profile and cardiovascular risk factors of patients treated with novel oral anticoagulants in atrial fibrillation - patterns of use in the European PREFER in AF registry

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P5138-P5138
Author(s):  
L. M. Rincon ◽  
B. Ammentorp ◽  
H. Darius ◽  
R. De Caterina ◽  
P. Kirchhof ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Oral Anticoagulants ◽  
Clinical Profile ◽  
Novel Oral Anticoagulants ◽  
Patterns Of Use

New-Onset Cardiovascular Risk Factors in Lung Transplant Recipients

2005 ◽  
Vol 24 (10) ◽  
pp. 1536-1543 ◽  
Author(s):  
Martin Silverborn ◽  
Anders Jeppsson ◽  
Gunnar Mårtensson ◽  
Folke Nilsson
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Lung Transplant ◽  
Transplant Recipients ◽  
Lung Transplant Recipients ◽  
New Onset

Prevalence of cardiovascular risk factors and financial burden in younger adults hospitalized with atrial fibrillation

Heart & Lung ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 393-397 ◽  
Author(s):  
Jay Shah ◽  
Ashish Kumar ◽  
Monil Majmundar ◽  
Devina Adalja ◽  
Abhi Doshi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Financial Burden ◽  
Younger Adults

scholarly journals Prevalence of cardiovascular risk factors among elderly Brazilians over eighty with ischemic stroke

2008 ◽  
Vol 66 (3a) ◽  
pp. 454-457 ◽  
Author(s):  
Alexandre Pieri ◽  
Mariana Spitz ◽  
Tania Oliveira Lopes ◽  
Claudia Garcia de Barros ◽  
Marcelo Wood Faulhaber ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Oldest Old ◽  
The Elderly ◽  
Catastrophic Event ◽  
Cardiovascular Involvement ◽  
Definition Of

INTRODUCTION: An ischemic stroke is usually a catastrophic event, mostly in the elderly. Cardiovascular involvement is the leading cause of ischemic stroke in this age population and hence the knowledge about its risk factors is important for the definition of specific policies of prevention. PURPOSE: To evaluate the prevalence of cardiovascular risk factors in patients with age equal to or above 80 in a hospital population with ischemic stroke. METHOD: Retrospective study of consecutive patients diagnosed with ischemic stroke admitted to a tertiary health facility. RESULTS: From September 2004 to March 2006, 215 patients were studied. There was a female preponderance (p<0.01). Among patients over eighty, 72% had hypertension and atrial fibrillation was more common among the oldest old (p<0.01). CONCLUSION: Hypertension and atrial fibrillation should be treated aggressively in the elderly. Anticoagulants should be considered more often in these patients.

scholarly journals Five Year Study of Cardiovascular Risk Factors in Japanese People: Implications Concerning New Onset of Metabolic Syndrome

2010 ◽  
Vol 49 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Akiko Suzuki ◽  
Keiichiro Kosuge ◽  
Osamu Nanyu ◽  
Hiroshi Watanabe ◽  
Toru Watanabe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Japanese People ◽  
New Onset

Atrial fibrillation and rheumatoid arthritis are cardiovascular risk factors

BMJ ◽  
2012 ◽  
Vol 344 (mar27 2) ◽  
pp. e2259-e2259 ◽  
Author(s):  
J. Hippisley-Cox ◽  
C. Coupland ◽  
J. Robson ◽  
P. Brindle
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Atrial Fibrillation ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors
Sign in / Sign up

Export Citation Format

Share Document