scholarly journals Differential Effect of Atpenin A5 on ROS Production from Wild- Type Mitochondrial Complex II in Human Cancer Cells and Normal Cells

2018 ◽  
Author(s):  
Madhavi P. Paranagama ◽  
Kiyoshi Kita
Keyword(s):  
Cancer Cells ◽  
Differential Effect ◽  
Human Cancer ◽  
Ros Production ◽  
Wild Type ◽  
Mitochondrial Complex ◽  
Normal Cells ◽  
Complex Ii ◽  
Human Cancer Cells

scholarly journals N-ω-chloroacetyl-l-ornithine, a new competitive inhibitor of ornithine decarboxylase, induces selective growth inhibition and cytotoxicity on human cancer cells versus normal cells

2014 ◽  
Vol 30 (3) ◽  
pp. 345-353 ◽  
Author(s):  
Miriam Marlene Medina-Enríquez ◽  
Verónica Alcántara-Farfán ◽  
Leopoldo Aguilar-Faisal ◽  
José Guadalupe Trujillo-Ferrara ◽  
Lorena Rodríguez-Páez ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Cancer Cells ◽  
Ornithine Decarboxylase ◽  
Human Cancer ◽  
Competitive Inhibitor ◽  
Selective Growth ◽  
Normal Cells ◽  
Human Cancer Cells

Identification of Parasporin Genes in Vietnamese Isolates of Bacillus thuringiensis

2008 ◽  
Vol 63 (1-2) ◽  
pp. 139-143 ◽  
Author(s):  
Koichi Yasutake ◽  
Akiko Uemori ◽  
Ngo D. Binh ◽  
Eiichi Mizuki ◽  
Michio Ohba
Keyword(s):  
Bacillus Thuringiensis ◽  
Cancer Cells ◽  
Human Cancer ◽  
Nucleotide Sequence Analysis ◽  
Hep G2 ◽  
Normal Cells ◽  
Proteolytic Activation ◽  
Human Cancer Cells ◽  
Genes Encoding

Four genes encoding parasporins, cytotoxins preferentially killing human cancer cells in vitro, were isolated from four Vietnamese strains of Bacillus thuringiensis. Nucleotide sequence analysis revealed that: (1) three genes fall into the two known classes, ps1Aa and ps1Ab, and (2) another one belongs to ps1Ac, a novel gene class established in this study. Upon proteolytic activation, parasporal protein of the organism with ps1Ac exhibited strong cytocidal activity against human cancer cells, HeLa and Hep G2, but not to non-cancer normal cells, UtSMC and HC.

scholarly journals Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
William W Wheaton ◽  
Samuel E Weinberg ◽  
Robert B Hamanaka ◽  
Saul Soberanes ◽  
Lucas B Sullivan ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Progression ◽  
Complex I ◽  
Nadh Dehydrogenase ◽  
Cellular Proliferation ◽  
Human Cancer ◽  
Cellular Respiration ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Human Cancer Cells

Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrogenase) activity and cellular respiration. Metformin inhibited cellular proliferation in the presence of glucose, but induced cell death upon glucose deprivation, indicating that cancer cells rely exclusively on glycolysis for survival in the presence of metformin. Metformin also reduced hypoxic activation of hypoxia-inducible factor 1 (HIF-1). All of these effects of metformin were reversed when the metformin-resistant Saccharomyces cerevisiae NADH dehydrogenase NDI1 was overexpressed. In vivo, the administration of metformin to mice inhibited the growth of control human cancer cells but not those expressing NDI1. Thus, we have demonstrated that metformin's inhibitory effects on cancer progression are cancer cell autonomous and depend on its ability to inhibit mitochondrial complex I.

scholarly journals Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells

Oncogene ◽  
1999 ◽  
Vol 18 (13) ◽  
pp. 2189-2199 ◽  
Author(s):  
Takuya Fukazawa ◽  
Toshiyoshi Fujiwara ◽  
Yoshinori Morimoto ◽  
Jianghua Shao ◽  
Masahiko Nishizaki ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Cancer Cells ◽  
Human Cancer ◽  
P53 Gene ◽  
Wild Type ◽  
Receptor Ligand ◽  
Human Cancer Cells ◽  
Ligand System ◽  
Differential Involvement ◽  
Wild Type P53

scholarly journals Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53

Autophagy ◽  
2011 ◽  
Vol 7 (11) ◽  
pp. 1348-1358 ◽  
Author(s):  
Kaipeng Jing ◽  
Kyoung-Sub Song ◽  
Soyeon Shin ◽  
Nayeong Kim ◽  
Soyeon Jeong ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Cancer Cells ◽  
Human Cancer ◽  
Mtor Signaling ◽  
Wild Type ◽  
Human Cancer Cells ◽  
Wild Type P53
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