scholarly journals Quorum Sensing in Gram-Negative Plant Pathogenic Bacteria

2018 ◽  
Author(s):  
Siphathele Sibanda ◽  
Lucy Novungayo Moleleki ◽  
Divine Yufetar Shyntum ◽  
Teresa Ann Coutinho
Keyword(s):  
Quorum Sensing ◽  
Pathogenic Bacteria ◽  
Gram Negative ◽  
Plant Pathogenic Bacteria

Attenuation of quorum sensing-mediated virulence in Gram-negative pathogenic bacteria: implications for the post-antibiotic era

MedChemComm ◽  
2015 ◽  
Vol 6 (2) ◽  
pp. 259-272 ◽  
Author(s):  
Ravindra Pal Singh
Keyword(s):  
Quorum Sensing ◽  
Pathogenic Bacteria ◽  
Quorum Quenching ◽  
Gram Negative ◽  
Sensing System ◽  
Quorum Sensing System

Quorum quenching compounds blocked quorum sensing system of bacteria by several mechanisms (a, b, c and d).

Plant Pathogenic Bacteria: Role of Quorum Sensing and Biofilm in Disease Development

2017 ◽  
pp. 387-407 ◽  
Author(s):  
Deepak Dwivedi ◽  
Mayuri Khare ◽  
Himani Chaturvedi ◽  
Vinod Singh
Keyword(s):  
Quorum Sensing ◽  
Pathogenic Bacteria ◽  
Disease Development ◽  
Plant Pathogenic Bacteria

scholarly journals Phage-Encoded LuxR-Type Receptors Responsive to Host-Produced Bacterial Quorum-Sensing Autoinducers

2019 ◽  
Author(s):  
Justin E. Silpe ◽  
Bonnie L. Bassler
Keyword(s):  
Quorum Sensing ◽  
Pathogenic Bacteria ◽  
Cell Communication ◽  
Signal Molecules ◽  
Host Bacterium ◽  
Gram Negative ◽  
Collective Behaviors ◽  
Bacterial Quorum Sensing ◽  
Genes Encoding ◽  
Bacterial Quorum

AbstractQuorum sensing (QS) is a process of cell-to-cell communication that bacteria use to orchestrate collective behaviors. QS relies on the cell-density-dependent production, accumulation, and receptor-mediated detection of extracellular signaling molecules called autoinducers (AIs). Gram-negative bacteria commonly use N-acyl homoserine lactones (AHLs) as their AIs and they are detected by LuxR-type receptors. Often, LuxR-type receptors are insoluble when not bound to a cognate AI. In this report, we show that LuxR-type receptors are encoded on phage genomes and, in the cases we tested, the phage LuxR-type receptors bind to and are solubilized specifically by the AHL AI produced by the host bacterium. We do not yet know the viral activities that are controlled by these phage QS receptors, however, our observations, coupled with recent reports, suggest that their occurrence is more widespread than previously appreciated. Using receptor-mediated detection of QS AIs could enable phages to garner information concerning the population density status of their bacterial hosts. We speculate that such information can be exploited by phages to optimize the timing of execution of particular steps in viral infection.ImportanceBacteria communicate with chemical signal molecules to regulate group behaviors in a process called quorum sensing (QS). In this report, we find that genes encoding receptors for Gram-negative bacterial QS communication molecules are present on genomes of viruses that infect these bacteria. These viruses are called phages. We show that two phage-encoded receptors, like their bacterial counterparts, bind to the communication molecule produced by the host bacterium, suggesting that phages can “listen in” on their bacterial hosts. Interfering with bacterial QS and using phages to kill pathogenic bacteria represent attractive possibilities for development of new antimicrobials to combat pathogens that are resistant to traditional antibiotics. Our findings of interactions between phages and QS bacteria need consideration as new antimicrobial therapies are developed.

scholarly journals Specificity and genetic polymorphism in the Vfm quorum sensing system of plant pathogenic bacteria of the genus Dickeya

2022 ◽  
Author(s):  
Nicole Hugouvieux‐Cotte‐Pattat ◽  
Monique Royer ◽  
Erwan Gueguen ◽  
Paul Le Guen ◽  
Roderich D. Süssmuth ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Quorum Sensing ◽  
Pathogenic Bacteria ◽  
Plant Pathogenic Bacteria ◽  
Sensing System ◽  
Quorum Sensing System

Quorum sensing interruption as a tool to control virulence of plant pathogenic bacteria

2019 ◽  
Vol 106 ◽  
pp. 281-291 ◽  
Author(s):  
M.M. Gutiérrez-Pacheco ◽  
A.T. Bernal-Mercado ◽  
F.J. Vázquez-Armenta ◽  
M.A. Mart ínez-Tellez ◽  
G.A. González-Aguilar ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Pathogenic Bacteria ◽  
Plant Pathogenic Bacteria

scholarly journals Quorum sensing signal molecules (acylated homoserine lactones) in Gram-negative fish pathogenic bacteria

2005 ◽  
Vol 65 ◽  
pp. 43-52 ◽  
Author(s):  
JB Bruhn ◽  
I Dalsgaard ◽  
KF Nielsen ◽  
C Buchholtz ◽  
JL Larsen ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Pathogenic Bacteria ◽  
Signal Molecules ◽  
Gram Negative ◽  
Homoserine Lactones ◽  
Acylated Homoserine Lactones

scholarly journals Harpins, Multifunctional Proteins Secreted by Gram-Negative Plant-Pathogenic Bacteria

2013 ◽  
Vol 26 (10) ◽  
pp. 1115-1122 ◽  
Author(s):  
Min-Seon Choi ◽  
Wooki Kim ◽  
Chanhui Lee ◽  
Chang-Sik Oh
Keyword(s):  
Plant Growth ◽  
Pathogenic Bacteria ◽  
Plant Cells ◽  
Defense Responses ◽  
Effector Proteins ◽  
Gram Negative ◽  
Plant Pathogenic Bacteria ◽  
Heat Stable ◽  
Functional Aspects ◽  
A Cell

Harpins are glycine-rich and heat-stable proteins that are secreted through type III secretion system in gram-negative plant-pathogenic bacteria. Many studies show that these proteins are mostly targeted to the extracellular space of plant tissues, unlike bacterial effector proteins that act inside the plant cells. Over the two decades since the first harpin of pathogen origin, HrpN of Erwinia amylovora, was reported in 1992 as a cell-free elicitor of hypersensitive response (HR), diverse functional aspects of harpins have been determined. Some harpins were shown to have virulence activity, probably because of their involvement in the translocation of effector proteins into plant cytoplasm. Based on this function, harpins are now considered to be translocators. Their abilities of pore formation in the artificial membrane, binding to lipid components, and oligomerization are consistent with this idea. When harpins are applied to plants directly or expressed in plant cells, these proteins trigger diverse beneficial responses such as induction of defense responses against diverse pathogens and insects and enhancement of plant growth. Therefore, in this review, we will summarize the functions of harpins as virulence factors (or translocators) of bacterial pathogens, elicitors of HR and immune responses, and plant growth enhancers.

scholarly journals Fabrication of Zinc Oxide-Xanthan Gum Nanocomposite via Green Route: Attenuation of Quorum Sensing Regulated Virulence Functions and Mitigation of Biofilm in Gram-Negative Bacterial Pathogens

Coatings ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1190
Author(s):  
Fohad Mabood Husain ◽  
Imran Hasan ◽  
Faizan Abul Qais ◽  
Rais Ahmad Khan ◽  
Pravej Alam ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Quorum Sensing ◽  
Virulence Factors ◽  
Xanthan Gum ◽  
Pathogenic Bacteria ◽  
Bacterial Pathogens ◽  
Cell Surface Hydrophobicity ◽  
Health Concern ◽  
Gram Negative ◽  
Slow Development

The unabated abuse of antibiotics has created a selection pressure that has resulted in the development of antimicrobial resistance (AMR) among pathogenic bacteria. AMR has become a global health concern in recent times and is responsible for a high number of mortalities occurring across the globe. Owing to the slow development of antibiotics, new chemotherapeutic antimicrobials with a novel mode of action is required urgently. Therefore, in the current investigation, we green synthesized a nanocomposite comprising zinc oxide nanoparticles functionalized with extracellular polysaccharide xanthan gum (ZnO@XG). Synthesized nanomaterial was characterized by structurally and morphologically using UV-visible spectroscopy, XRD, FTIR, BET, SEM and TEM. Subinhibitory concentrations of ZnO@XG were used to determine quorum sensing inhibitory activity against Gram-negative pathogens, Chromobacterium violaceum, and Serratia marcescens. ZnO@XG reduced quorum sensing (QS) regulated virulence factors such as violacein (61%), chitinase (70%) in C. violaceum and prodigiosin (71%) and protease (72%) in S. marcescens at 128 µg/mL concentration. Significant (p ≤ 0.05) inhibition of biofilm formation as well as preformed mature biofilms was also recorded along with the impaired production of EPS, swarming motility and cell surface hydrophobicity in both the test pathogens. The findings of this study clearly highlight the potency of ZnO@XG against the QS controlled virulence factors of drug-resistant pathogens that may be developed as effective inhibitors of QS and biofilms to mitigate the threat of multidrug resistance (MDR). ZnO@XG may be used alone or in combination with antimicrobial drugs against MDR bacterial pathogens. Further, it can be utilized in the food industry to counter the menace of contamination and spoilage caused by the formation of biofilms.

scholarly journals Biofabricated silver nanoparticles exhibit broad-spectrum antibiofilm and antiquorum sensing activity against Gram-negative bacteria

RSC Advances ◽  
2021 ◽  
Vol 11 (23) ◽  
pp. 13700-13710
Author(s):  
Faizan Abul Qais ◽  
Iqbal Ahmad ◽  
Mohammad Altaf ◽  
Salim Manoharadas ◽  
Basel F. Al-Rayes ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Quorum Sensing ◽  
Broad Spectrum ◽  
Pathogenic Bacteria ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Biofilm Development ◽  
Green Synthesized Silver Nanoparticles

Green synthesized silver nanoparticles inhibit the quorum sensing and biofilm development of Gram-negative pathogenic bacteria

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