scholarly journals Treatment Toxicity: Radiation

2019 ◽  
Author(s):  
Thomas J. FitzGerald ◽  
Maryann Bishop-Jodoin ◽  
Fran Laurie ◽  
Matthew Iandoli ◽  
Ameer Elaimy ◽  
...  
Keyword(s):  
Treatment Toxicity

Lu-177 PSMA I&T Therapy for Prostate Cancer; Treatment Response, Treatment Toxicity, and Survival Results

2019 ◽  
Author(s):  
Emine Acar ◽  
Burak Sönmezer ◽  
Erkan Derebek ◽  
Recep Bekiş ◽  
Özhan Özdoğan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Treatment Response ◽  
Prostate Cancer Treatment ◽  
Treatment Toxicity

scholarly journals TOXview: a novel graphical presentation of cancer treatment toxicity profiles

2019 ◽  
Vol 58 (8) ◽  
pp. 1138-1148 ◽  
Author(s):  
Lok Lam Ngai ◽  
Emil ter Veer ◽  
Héctor G. van den Boorn ◽  
E. Hugo van Herk ◽  
Jessy Joy van Kleef ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Treatment Toxicity ◽  
Graphical Presentation

scholarly journals P2.01-038 Determinants of Frailty and Treatment Toxicity in Non-Small Cell Lung Cancer Patient

2017 ◽  
Vol 12 (11) ◽  
pp. S2083-S2084
Author(s):  
M. Boucher ◽  
L. Mezquita ◽  
E. Auclin ◽  
M. Mons ◽  
J. Marghadi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patient ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Lung Cancer Patient ◽  
Small Cell ◽  
Small Cell Lung ◽  
Treatment Toxicity

scholarly journals Oncothermia in HIV-Positive and -Negative Locally Advanced Cervical Cancer Patients in South Africa

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Carrie A. Strauss ◽  
Jeffrey A. Kotzen ◽  
Ans Baeyens ◽  
Irma Maré
Keyword(s):  
South Africa ◽  
Cervical Cancer ◽  
Cancer Patients ◽  
Standard Treatment ◽  
Locally Advanced ◽  
External Beam Radiation ◽  
Hiv Positive ◽  
Advanced Cervical Cancer ◽  
Treatment Toxicity ◽  
Locally Advanced Cervical Cancer

Aim. Investigate the clinical, economic, and cellular effects of the addition of oncothermia to standard treatment for HIV-positive and -negative locally advanced cervical cancer patients in public healthcare in South Africa. Objectives. Evaluate the effect that the addition of oncothermia has on local disease control, progression-free survival, overall survival at 2 years, treatment toxicity, quality of life, economic impact, and HIV status of participants. Radiobiology investigations will evaluate thermoradiosensitivity and the molecular markers for thermoradiosensitivity. Methodology. Phase III randomised clinical trial involving 236 HIV-negative and -positive stage IIb-III locally advanced cervical cancer patients. Treatment includes cisplatin, external beam radiation, and brachytherapy. The study group will receive oncothermia treatments. Participants will be monitored for two years after completion of treatment. Hypothesis. The addition of oncothermia to standard treatment protocols will result in improved clinical response without increasing treatment toxicity in HIV-positive patients or raising healthcare costs.

scholarly journals The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis

2021 ◽  
Vol 22 (23) ◽  
pp. 12827
Author(s):  
Mahshid Ghasemi ◽  
Tyron Turnbull ◽  
Sonia Sebastian ◽  
Ivan Kempson
Keyword(s):  
Cell Viability ◽  
Single Cell ◽  
Metabolic Activity ◽  
Mtt Assay ◽  
Single Cell Analysis ◽  
Culture Media ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Serum Starvation ◽  
Treatment Toxicity

The MTT assay for cellular metabolic activity is almost ubiquitous to studies of cell toxicity; however, it is commonly applied and interpreted erroneously. We investigated the applicability and limitations of the MTT assay in representing treatment toxicity, cell viability, and metabolic activity. We evaluated the effect of potential confounding variables on the MTT assay measurements on a prostate cancer cell line (PC-3) including cell seeding number, MTT concentration, MTT incubation time, serum starvation, cell culture media composition, released intracellular contents (cell lysate and secretome), and extrusion of formazan to the extracellular space. We also assessed the confounding effect of polyethylene glycol (PEG)-coated gold nanoparticles (Au-NPs) as a tested treatment in PC-3 cells on the assay measurements. We additionally evaluated the applicability of microscopic image cytometry as a tool for measuring intracellular MTT reduction at the single-cell level. Our findings show that the assay measurements are a result of a complicated process dependant on many of the above-mentioned factors, and therefore, optimization of the assay and rational interpretation of the data is necessary to prevent misleading conclusions on variables such as cell viability, treatment toxicity, and/or cell metabolism. We conclude, with recommendations on how to apply the assay and a perspective on where the utility of the assay is a powerful tool, but likewise where it has limitations.

Cancer cachexia and treatment toxicity

2019 ◽  
Vol 13 (4) ◽  
pp. 292-297 ◽  
Author(s):  
Shilpa Mukunda Chowdhry ◽  
Varun Kumar Chowdhry
Keyword(s):  
Cancer Cachexia ◽  
Treatment Toxicity

scholarly journals Overcoming Treatment Toxicity through Sequential Therapy

Cancer Cell ◽  
2019 ◽  
Vol 35 (6) ◽  
pp. 821-822 ◽  
Author(s):  
Jan Benada ◽  
Bent Ejlertsen ◽  
Claus Storgaard Sørensen
Keyword(s):  
Sequential Therapy ◽  
Treatment Toxicity
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