scholarly journals Modulatory Potentials of n-3 Polyunsaturated Fatty Acids in Inflammatory Diseases

2020 ◽  
Author(s):  
Vinayak Uppin ◽  
Pooja Acharya ◽  
Ramaprasad Ravichandra Talahalli
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Inflammatory Diseases

scholarly journals Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
E. Patterson ◽  
R. Wall ◽  
G. F. Fitzgerald ◽  
R. P. Ross ◽  
C. Stanton
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Inflammatory Diseases ◽  
Lipid Mediator ◽  
Omega 3 ◽  
Nonalcoholic Fatty Liver ◽  
Chronic Inflammatory Diseases ◽  
Signalling Molecules ◽  
Omega 6 ◽  
Inflammatory Bowel

Omega-6 (n-6) polyunsaturated fatty acids (PUFA) (e.g., arachidonic acid (AA)) and omega-3 (n-3) PUFA (e.g., eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator signalling molecules, termed “eicosanoids,” which have important roles in the regulation of inflammation. In general, eicosanoids derived from n-6 PUFA are proinflammatory while eicosanoids derived from n-3 PUFA are anti-inflammatory. Dietary changes over the past few decades in the intake of n-6 and n-3 PUFA show striking increases in the (n-6) to (n-3) ratio (~15 : 1), which are associated with greater metabolism of the n-6 PUFA compared with n-3 PUFA. Coinciding with this increase in the ratio of (n-6) : (n-3) PUFA are increases in chronic inflammatory diseases such as nonalcoholic fatty liver disease (NAFLD), cardiovascular disease, obesity, inflammatory bowel disease (IBD), rheumatoid arthritis, and Alzheimer's disease (AD). By increasing the ratio of (n-3) : (n-6) PUFA in the Western diet, reductions may be achieved in the incidence of these chronic inflammatory diseases.

scholarly journals Polyunsaturated Fatty Acids and Inflammatory Diseases

10.5772/25972 ◽  
2011 ◽  
Author(s):  
Antonio Ferrante ◽  
Charles Hii
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Inflammatory Diseases

scholarly journals Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer

2016 ◽  
Vol 4 (7) ◽  
pp. 155 ◽  
Author(s):  
Kazuki Moro ◽  
Masayuki Nagahashi ◽  
Rajesh Ramanathan ◽  
Kazuaki Takabe ◽  
Toshifumi Wakai
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Inflammatory Diseases ◽  
Clinical Implications

Polyunsaturated fatty acids and inflammatory diseases

2002 ◽  
Vol 56 (8) ◽  
pp. 388-396 ◽  
Author(s):  
Á. Gil
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Inflammatory Diseases

Omega-3 Polyunsaturated Fatty Acids in Physical Performance Optimization

2013 ◽  
Vol 23 (1) ◽  
pp. 83-96 ◽  
Author(s):  
Timothy D. Mickleborough
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Exercise Performance ◽  
Performance Optimization ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Omega 3 ◽  
Cell Deformability ◽  
Pufa Supplementation ◽  
The Impact

Increased muscle oxidative stress and inflammatory responses among athletes have been reported consistently. In addition, it is well known that exhaustive or unaccustomed exercise can lead to muscle fatigue, delayed-onset muscle soreness, and a decrement in performance. Omega-3 polyunsaturated fatty acids (PUFAs) have been shown to decrease the production of inflammatory eicosanoids, cytokines, and reactive oxygen species; have immunomodulatory effects; and attenuate inflammatory diseases. While a number of studies have assessed the efficacy of omega-3 PUFA supplementation on red blood cell deformability, muscle damage, inflammation, and metabolism during exercise, only a few have evaluated the impact of omega-3 PUFA supplementation on exercise performance. It has been suggested that the ingestion of EPA and DHA of approximately 1–2 g/d, at a ratio of EPA to DHA of 2:1, may be beneficial in counteracting exercise-induced inflammation and for the overall athlete health. However, the human data are inconclusive as to whether omega-3 PUFA supplementation at this dosage is effective in attenuating the inflammatory and immunomodulatory response to exercise and improving exercise performance. Thus, attempts should be made to establish an optimal omega-3 fatty-acid dosage to maximize the risk-to-reward ratio of supplementation. It should be noted that high omega-3 PUFA consumption may lead to immunosuppression and prolong bleeding time. Future studies investigating the efficacy of omega-3 PUFA supplementation in exercise-trained individuals should consider using an exercise protocol of sufficient duration and intensity to produce a more robust oxidative and inflammatory response.

scholarly journals Omega-3 Polyunsaturated Fatty Acids: The Way Forward in Times of Mixed Evidence

2015 ◽  
Vol 2015 ◽  
pp. 1-24 ◽  
Author(s):  
Karsten H. Weylandt ◽  
Simona Serini ◽  
Yong Q. Chen ◽  
Hui-Min Su ◽  
Kyu Lim ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Dietary Intake ◽  
Clinical Evidence ◽  
Inflammatory Diseases ◽  
Model Systems ◽  
Protective Effects ◽  
Omega 3 ◽  
Medical Institutions

Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several clinical cardiovascular studies demonstrated the beneficial health effects of omega-3 PUFA, leading medical institutions worldwide to publish recommendations for their increased intake. However, particularly in recent years, contradictory results have been obtained in human studies focusing on cardiovascular disease and the clinical evidence in other diseases, particularly chronic inflammatory and neoplastic diseases, was never established to a degree that led to clear approval of treatment with omega-3 PUFA. Recent data not in line with the previous findings have sparked a debate on the health efficacy of omega-3 PUFA and the usefulness of increasing their intake for the prevention of a number of pathologies. In this review, we aim to examine the controversies on the possible use of these fatty acids as preventive/curative tools against the development of cardiovascular, metabolic, and inflammatory diseases, as well as several kinds of cancer.

scholarly journals Omega-3 Polyunsaturated Fatty Acids Intake to RegulateHelicobacter pylori-Associated Gastric Diseases as Nonantimicrobial Dietary Approach

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Jong-Min Park ◽  
Migyeong Jeong ◽  
Eun-Hee Kim ◽  
Young-Min Han ◽  
Sung Hun Kwon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Molecular Mechanisms ◽  
Inflammatory Diseases ◽  
Gastrointestinal Diseases ◽  
Omega 3 ◽  
Gastric Diseases ◽  
Korean Red Ginseng ◽  
H Pylori

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), commonly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been acknowledged as essential long-chain fatty acids imposing either optimal health promotion or the rescuing from chronic inflammatory diseases such as atherosclerosis, fatty liver, and various inflammatory gastrointestinal diseases. Recent studies dealing with EPA and DHA have sparked highest interests because detailed molecular mechanisms had been documented with the identification of its receptor, G protein coupled receptor, and GPR120. In this review article, we have described clear evidences showing that n-3 PUFAs could reduce variousHelicobacter pylori- (H. pylori-) associated gastric diseases and extended to play even cancer preventive outcomes includingH. pylori-associated gastric cancer by influencing multiple targets, including proliferation, survival, angiogenesis, inflammation, and metastasis. Since our previous studies strongly concluded that nonantimicrobial dietary approach for reducing inflammation, for instance, application of phytoceuticals, probiotics, natural products including Korean red ginseng, and walnut plentiful of n-3 PUFAs, might be prerequisite step for preventingH. pylori-associated gastric cancer as well as facilitating the rejuvenation of precancerous atrophic gastritis, these beneficial lipids can restore or modify inflammation-associated lipid distortion and correction of altered lipid rafts to send right signaling to maintain healthy stomach even after chronicH. pyloriinfection.

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