scholarly journals Ion Channels and Their Regulation in Vascular Smooth Muscle

2020 ◽  
Author(s):  
Arsalan U. Syed ◽  
Thanhmai Le ◽  
Manuel F. Navedo ◽  
Madeline Nieves-Cintrón
Keyword(s):  
Smooth Muscle ◽  
Ion Channels ◽  
Vascular Smooth Muscle

Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle

2001 ◽  
Vol 423 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Kimika Eto ◽  
Yusuke Ohya ◽  
Yoshito Nakamura ◽  
Isao Abe ◽  
Masatoshi Fujishima
Keyword(s):  
Smooth Muscle ◽  
Ion Channels ◽  
Vascular Smooth Muscle ◽  
Insulin Sensitizers

scholarly journals Kv1.3 channel inhibition limits uremia-induced calcification in mouse and human vascular smooth muscle

Function ◽  
2020 ◽  
Author(s):  
Violeta Cazaña-Pérez ◽  
Pilar Cidad ◽  
Juan F Navarro-González ◽  
Jorge Rojo-Mencía ◽  
Frederic Jaisser ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Ion Channels ◽  
Vascular Smooth Muscle ◽  
Ion Channel ◽  
Mineral Metabolism ◽  
K Channel ◽  
Human Aorta ◽  
Genetic Ablation ◽  
Channel Inhibition

Abstract Chronic kidney disease (CKD) significantly increases cardiovascular risk. In advanced CKD stages, accumulation of toxic circulating metabolites and mineral metabolism alterations triggers vascular calcification, characterized by vascular smooth muscle cell (VSMC) transdifferentiation and loss of the contractile phenotype. Phenotypic modulation of VSMC occurs with significant changes in gene expression. Even though ion channels are an integral component of VSMC function, the effects of uremia on ion channel remodeling has not been explored. We used an in vitro model of uremia-induced calcification of human aorta smooth muscle cells (HASMC) to study the expression of 92 ion channel subunit genes. Uremic serum induced extensive remodeling of ion channel expression consistent with loss of excitability but different from the one previously associated to transition from contractile to proliferative phenotypes. Among the ion channels tested, we found increased abundance and activity of voltage-dependent K+ channel Kv1.3. Enhanced Kv1.3 expression was also detected in aorta from a mouse model of CKD. Pharmacological inhibition or genetic ablation of Kv1.3 decreased the amount of calcium phosphate deposition induced by uremia, supporting an important role for this channel on uremia-induced VSMC calcification.

scholarly journals Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3557
Author(s):  
Rosa Edith Grijalva-Guiza ◽  
Aura Matilde Jiménez-Garduño ◽  
Luis Ricardo Hernández
Keyword(s):  
Oxidative Stress ◽  
Smooth Muscle ◽  
Ion Channels ◽  
Vascular Smooth Muscle ◽  
Ion Channel ◽  
Redox Potential ◽  
Related Condition ◽  
Potential Benefits ◽  
Muscle Excitability ◽  
Progression Of Atherosclerosis

Flavonoids are a group of secondary metabolites derived from plant-based foods, and they offer many health benefits in different stages of several diseases. This review will focus on their effects on ion channels expressed in vascular smooth muscle during atherosclerosis. Since ion channels can be regulated by redox potential, it is expected that during the onset of oxidative stress-related diseases, ion channels present changes in their conductive activity, impacting the progression of the disease. A typical oxidative stress-related condition is atherosclerosis, which involves the dysfunction of vascular smooth muscle. We aim to present the state of the art on how redox potential affects vascular smooth muscle ion channel function and summarize if the benefits observed in this disease by using flavonoids involve restoring the ion channel activity.

Activations of ion channels induced by spasmogenic agonists and their interactions in vascular smooth muscle membranes

1992 ◽  
Vol 24 ◽  
pp. 16
Author(s):  
Kenji Kitamura ◽  
Masahiro Oike ◽  
Zhiling Xiong ◽  
Ryuji Inoue ◽  
Hirosi Kuriyama
Keyword(s):  
Smooth Muscle ◽  
Ion Channels ◽  
Vascular Smooth Muscle

scholarly journals Differential Effects of Selective Cyclooxygenase-2 Inhibitors on Vascular Smooth Muscle Ion Channels May Account for Differences in Cardiovascular Risk Profiles

2009 ◽  
Vol 76 (5) ◽  
pp. 1053-1061 ◽  
Author(s):  
Lioubov I. Brueggemann ◽  
Alexander R. Mackie ◽  
Bharath K. Mani ◽  
Leanne L. Cribbs ◽  
Kenneth L. Byron
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Risk ◽  
Ion Channels ◽  
Vascular Smooth Muscle ◽  
Cyclooxygenase 2 ◽  
Risk Profiles ◽  
Differential Effects ◽  
Cyclooxygenase 2 Inhibitors
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