scholarly journals Ovarian Hormonal Change-Related Energy Metabolism and Obesity in Menopausal Women

2020 ◽  
Author(s):  
Jing Zhu ◽  
Mengxia Ji ◽  
Lili Xing ◽  
Zhizhi Yu ◽  
Xiaoyan Guo ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Hormonal Change ◽  
Related Energy ◽  
Menopausal Women

scholarly journals Impact of honey-enriched mulberry diet on the energy metabolism of the silkworm, Bombyx mori

2020 ◽  
Vol 12 (2) ◽  
pp. 133-145
Author(s):  
S. Siva Prasad ◽  
R. Madhavi
Keyword(s):  
Energy Metabolism ◽  
Oxidative Phosphorylation ◽  
Bombyx Mori ◽  
Larval Stage ◽  
Fat Body ◽  
Activity Levels ◽  
Energy Reserves ◽  
Related Energy ◽  
Energy Needs ◽  
Utilization Patterns

The present study was taken-up with a view to clearly define the role of oxidative phosphorylation vis-a-vis transdeamination in Bombyx mori metamorphosis, under the influence of honey-enriched mulberry diet. Therefore, the study examined the accumulation and utilization patterns of carbohydrate (glycogen, trehalose, glucose) and non-carbohydrate energy reserves (proteins, amino acids) in its fat body during larval, pupal and adult stages. In accordance with Hutchinson’s investment principle, the energy reserves invested during larval stage are partly used in pupal stage and those invested during larval and pupal stages are used in adult stage. Their utilization patterns are correlated with the activity levels of succinate (SDH) and glutamate (GDH) dehydrogenases and aspartate (AAT) and alanine (ALAT) aminotransferases and changes thereof were interpreted in terms of glycolytic oxidative phosphorylation and non-glycolytic transdeamination.  The trends in mass incorporation rates vis-à-vis enzyme activities indicated that the metabolism-related energy needs of all metamorphic events are majorly met through a gluconeogenetic mechanism called transdeamination, while the behavioural-related energy demands of larval and pupal stages are fulfilled through glycolytic-based oxidative phosphorylation. The activity trends further indicated that AAT plays major role in meeting the energy needs of larva and pupa, while GDH predominantly meets the energy requirements of reproduction in adults. The honey-enriched mulberry diet showed stage-specific and pathway-specific impacts on energy metabolism. It positively reinforced the energy metabolism in larval stage, but showed no significant effect in pupal and adult stages. Similarly, it showed more promising effect on glycolytic-oxidative phosphorylation and null or neutral effect on transdeamination.

scholarly journals LAIR-1 overexpression inhibits epithelial–mesenchymal transition in osteosarcoma via GLUT1-related energy metabolism

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Jinxue Zhang ◽  
Yuan Zhang ◽  
Shiyang Cheng ◽  
Yang Mu ◽  
Yongming Liu ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Related Energy

scholarly journals Reduction of dietary glycaemic load modifies the expression of microRNA potentially associated with energy balance and cancer pathways in pre-menopausal women

2012 ◽  
Vol 109 (4) ◽  
pp. 585-592 ◽  
Author(s):  
Susan E. McCann ◽  
Song Liu ◽  
Dan Wang ◽  
Jie Shen ◽  
Qiang Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Energy Metabolism ◽  
Energy Balance ◽  
Dietary Intervention ◽  
Differentially Expressed ◽  
Rt Pcr ◽  
Cancer Pathways ◽  
Glycaemic Load ◽  
Menopausal Women ◽  
Differentially Expressed Mirna

Energy metabolism, insulin resistance and adiposity have been implicated in breast cancer, but dietary interventions to reduce breast cancer morbidity and mortality have had limited success. MicroRNA (miRNA) are short, non-coding RNA that participate in the control of metabolic processes through the post-transcriptional modification of RNA. We investigated the effect of a low-glycaemic load dietary intervention on miRNA expression, with subsequent bioinformatics pathway analyses to explore metabolic pathways potentially affected by the diet. Total RNA, including miRNA, was isolated from the serum of fourteen otherwise healthy pre-menopausal women with a high breast cancer risk participating in a 12-month dietary intervention designed to lower glycaemic load by at least 15 % from baseline. Genome-wide miRNA expression was conducted using Illumina BeadChips. In the intervention subjects, three differentially expressed miRNA were validated by real-time (RT)-PCR, and in the twenty control participants, four top differentially expressed miRNA were evaluated to confirm a diet effect. In post-intervention v. baseline serum, twenty miRNA were found to be differentially expressed, with twelve up-regulated and eight down-regulated. These differentially expressed miRNA were predicted to be potentially associated with energy balance and cancer pathways based on exploratory enrichment analysis. Quantitative RT-PCR validations in the controls confirmed that the observed miRNA differential expression was dietary intervention induced. Manipulation of dietary glycaemic load has the potential to modify the expression of multiple miRNA predicted to be involved in energy balance and cancer pathways. Further research is necessary to confirm the role of these miRNA in the control of energy metabolism and relationships with cancer-related processes.

Mitochondrial matrix calcium ions regulate energy production in myocardium: A cytochemical study

1990 ◽  
Vol 48 (2) ◽  
pp. 166-167
Author(s):  
W.A. Jacob ◽  
R. Hertsens ◽  
A. Van Bogaert ◽  
M. De Smet
Keyword(s):  
Energy Metabolism ◽  
Calcium Ions ◽  
Energy Production ◽  
Regulation Of Respiration ◽  
Free Calcium ◽  
Mitochondrial Matrix ◽  
Cytochemical Study ◽  
Nmr Techniques

In the past most studies of the control of energy metabolism focus on the role of the phosphorylation potential ATP/ADP.Pi on the regulation of respiration. Studies using NMR techniques have demonstrated that the concentrations of these compounds for oxidation phosphorylation do not change appreciably throughout the cardiac cycle and during increases in cardiac work. Hence regulation of energy production by calcium ions, present in the mitochondrial matrix, has been the object of a number of recent studies.Three exclusively intramitochondnal dehydrogenases are key enzymes for the regulation of oxidative metabolism. They are activated by calcium ions in the low micromolar range. Since, however, earlier estimates of the intramitochondnal calcium, based on equilibrium thermodynamic considerations, were in the millimolar range, a physiological correlation was not evident. The introduction of calcium-sensitive probes fura-2 and indo-1 made monitoring of free calcium during changing energy metabolism possible. These studies were performed on isolated mitochondria and extrapolation to the in vivo situation is more or less speculative.

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